The effects of vitamin d on skeletal muscle strength, muscle mass, and muscle power: A systematic review and meta-analysis of randomized controlled trials

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 11, 2014, Pages 4336-4345

  Beaudart, Charlotte ^a   Buckinx, Fanny ^a   Rabenda, Véronique ^a   Gillain, Sophie ^b   Cavalier, Etienne ^b   Slomian, Justine ^a   Petermans, Jean ^b   Reginster, Jean Yves ^a,b   Bruyère, Olivier ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; PLACEBO; VITAMIN D;

AGE; DATA EXTRACTION; HUMAN; META ANALYSIS; MUSCLE FUNCTION; MUSCLE MASS; MUSCLE STRENGTH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SKELETAL MUSCLE; SYSTEMATIC REVIEW; VITAMIN SUPPLEMENTATION; DIET SUPPLEMENTATION; DRUG EFFECTS; MIDDLE AGED; PHYSIOLOGY;

DIETARY SUPPLEMENTS; HUMANS; MIDDLE AGED; MUSCLE STRENGTH; MUSCLE, SKELETAL; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VITAMIN D;

EID: 84910001117     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-1742     Document Type: Review

References (57)

1. Reginster JY. The high prevalence of inadequate serum vitamin D levels and implications for bone health. Current Med Res Opin. 2005;21: 579-586.
2. Autier P, BoniolM, Pizot C, Mullie P. VitaminDstatus and ill health: a systematic review. The Lancet Diabetes, Endocrinology. 2014;2: 76-89.
3. Body JJ, Bergmann P, Boonen S, et al. Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications. Osteoporosis Int. 23 Suppl. 2012;1: S1-S23.
4. Bischoff-Ferrari HA. Relevance of vitamin D in muscle health. Rev Endocrine, Metabolic Disorders. 2012;13: 71-77.
5. Al-Shoha A, Qiu S, Palnitkar S, Rao DS. Osteomalacia with bone marrow fibrosis due to severe vitamin D deficiency after a gastrointestinal bypass operation for severe obesity. Endocrine Practice. 2009;15: 528-533.
6. Annweiler C, Schott AM, Berrut G, Fantino B, Beauchet O. Vitamin D-related changes in physical performance: a systematic review. J Nutrition, Health, Aging. 2009;13: 893-898.
7. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson- Hughes B. Estimation of optimal serum concentrations of 25- hydroxyvitamin D for multiple health outcomes. Am J Clin Nutrition. 2006;84: 18-28.
8. Dukas L, Staehelin HB, Schacht E, Bischoff HA. Better functional mobility in community-dwelling elderly is related to D-hormone serum levels and to daily calcium intake. J Nutrition, Health, Aging. 2005;9: 347-351.
9. Gallagher JC. The effects of calcitriol on falls and fractures and physical performance tests. J Steroid Biochem Mol Biol. 2004;90: 497-501.
10. Wicherts IS, van Schoor NM, Boeke AJ, et al. Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrin Metab. 2007;92: 2058-2065.
11. Simpson RU, Thomas GA, Arnold AJ. Identification of 1, 25-dihydroxyvitamin D3 receptors and activities in muscle. J Biol Chem. 1985;260: 8882-8891.
12. Muir SW, Montero-OdassoM.Effect of vitaminDsupplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. J Am Geriatrics Soc. 2011;59: 2291-2300.
13. Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporosis Int. 2011;22: 859-871.
14. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiology. 2009;62: e1-e34.
15. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Controlled Clin Trials. 1996;17: 1-12.
16. Brozek JL, Akl EA, Jaeschke R, et al. Grading quality of evidence and strength of recommendations in clinical practice guidelines: Part 2 of 3. The GRADE approach to grading quality of evidence about diagnostic tests and strategies. Allergy. 2009;64: 1109-1116.
17. Berkey CS, Hoaglin DC, Mosteller F, Colditz GA. A random-effects regression model for meta-analysis. Stat Med. 1995;14: 395-411.
18. Higgins JP, Thompson SG. Quantifying heterogeneity in a metaanalysis. Stat Med. 2002;21: 1539-1558.
19. Barker T, Martins TB, Hill HR, et al. Different doses of supplemental vitamin D maintain interleukin-5 without altering skeletal muscle strength: a randomized, double-blind, placebo-controlled study in vitamin D sufficient adults. Nutrition Metab. 2012;9: 16.
20. Binder EF. Implementing a structured exercise program for frail nursing home residents with dementia: issues and challenge. JAPA. 1996;3: 383-395.
21. Bischoff HA, Stahelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Mineral Res. 2003;18: 343-351.
22. Brunner RL, Cochrane B, Jackson RD, et al. Calcium, vitamin D supplementation, and physical function in the Women's Health Initiative. J Am Diet Assoc. 2008;108: 1472-1479.
23. Bunout D, Barrera G, Leiva L, et al. Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Exp Gerontology. 2006;41: 746-752.
24. Carrillo AE, Flynn MG, Pinkston C, et al. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr. 2013;32: 375-381.
25. Close GL, Russell J, Cobley JN, et al. Assessment of vitamin D concentration in non-supplemented professional athletes and healthy adults during the winter months in the UK: implications for skeletal muscle function. J Sports Sci. 2013;31: 344-353.
26. Dhesi JK, Jackson SH, BearneLM, et al. VitaminDsupplementation improves neuromuscular function in older people who fall. Age and Aging. 2004;33: 589-595.
27. El-Hajj Fuleihan G, Nabulsi M, Tamim H, et al. Effect of vitamin D replacement on musculoskeletal parameters in school children: a randomized controlled trial. J Clin Endocrin Metab. 2006;91: 405-412.
28. Glendenning P, Zhu K, Inderjeeth C, Howat P, Lewis JR, Prince RL. Effects of three-monthly oral 150, 000 IU cholecalciferol supplementation on falls, mobility, and muscle strength in older postmenopausal women: a randomized controlled trial. J Bone Mineral Res. 2012;27: 170-176.
29. Goswami R, Vatsa M, Sreenivas V, et al. Skeletal muscle strength in young Asian Indian females after vitamin D and calcium supplementation: a double-blind randomized controlled clinical trial. J Clin Endocrin Metab. 2012;97: 4709-4716.
30. Grady D, Halloran B, Cummings S, et al. 1, 25-Dihydroxyvitamin D3 and muscle strength in the elderly: a randomized controlled trial. J Clin Endocrin Metab. 1991;73: 1111-1117.
31. Gupta R, Sharma U, Gupta N, et al. Effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in vitamin D-deficient Asian Indians: a randomized, controlled trial. Clin. Endocrinology. 2010;73: 445-451.
32. Hara S, Kishimoto KN, Okuno H, et al. Effects of alfacalcidol on back extensor strength gained through back extensor exercise in postmenopausal women with osteoporosis. Am J Phys Med Rehabilitation/Association of Academic Physiatrists. 2013;92: 101-110.
33. Hornikx M, Van Remoortel H, Lehouck A, et al. Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial. Respiratory Res. 2012;13: 84.
34. Janssen HC, Samson MM, Verhaar HJ. Muscle strength and mobility in vitamin D-insufficient female geriatric patients: a randomized controlled trial on vitamin D and calcium supplementation. Aging Clinical Exp Res. 2010;22: 78-84.
35. Kampman MT, Steffensen LH, Mellgren SI, Jørgensen L. Effect of vitamin D3 supplementation on relapses, disease progression, and measures of function in persons with multiple sclerosis: exploratory outcomes from a double-blind randomised controlled trial. Mult Scler. 2012;18: 1144-1151.
36. Kenny AM, Biskup B, Robbins B, Marcella G, Burleson JA. Effects of vitamin D supplementation on strength, physical function, and health perception in older, community-dwelling men. J Am Geriatrics Soc. 2003;51: 1762-1767.
37. Knutsen KV, Madar AA, Lagerløv P, et al. Does vitamin D improve muscle strength in adults? A randomized, double-blind, placebocontrolled trial among ethnic minorities in Norway. J Clin Endocrinology Metab. 2014;99: 194-202.
38. Kukuljan S, Nowson CA, Sanders K, Daly RM. Effects of resistance exercise and fortified milk on skeletal muscle mass, muscle size, and functional performance in middle-aged and older men: an 18-mo randomized controlled trial. J Appl Physiol (1985). 2009;107: 1864-1873.
39. LathamNK, Anderson CS, Lee A, BennettDA, Moseley A, Cameron ID. A randomized, controlled trial of quadriceps resistance exercise and vitaminDin frail older people: the Frailty Interventions Trial in Elderly Subjects (FITNESS). JAmGeriatrics Soc. 2003;51: 291-299.
40. Manios Y, Moschonis G, Koutsikas K, et al. Changes in body composition following a dietary and lifestyle intervention trial: the postmenopausal health study. Maturitas. 2009;62: 58-65.
41. Pfeifer M, Begerow B, Minne HW, Suppan K, Fahrleitner-Pammer A, Dobnig H. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in communitydwelling older individuals. Osteoporosis Int. 2009;20: 315-322.
42. Sato Y, Iwamoto J, Kanoko T, Satoh K. Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures inwomen after stroke: a randomized controlled trial. Cerebrovasc Dis. 2005; 20: 187-192.
43. Smedshaug GB, Pedersen IP, Meyer HE. Can vitaminDsupplementation improve grip strength in elderly nursing home residents? A double-blinded controlled trial. Scand J Food, Nutrition. 2007;51: 74-78.
44. Songpatanasilp T, Chailurkit LO, Nichachotsalid A, Chantarasorn M. Combination of alfacalcidol with calcium can improve quadriceps muscle strength in elderly ambulatory Thai women who have hypovitaminosis D: a randomized controlled trial. J Med Assoc Thailand = Chotmaihet thangphaet 92 Suppl. 2009;5: S30-S41.
45. Verhaar HJ, Samson MM, Jansen PA, de Vreede PL, Manten JW, Duursma SA. Muscle strength, functional mobility and vitaminDin older women. Aging (Milano). 2000;12: 455-460.
46. Ward KA, Das G, Roberts SA, et al. A randomized, controlled trial of vitamin D supplementation upon musculoskeletal health in postmenarchal females. J Clin Endocrinology Metab. 2010;95: 4643-4651.
47. Wood AD, Secombes KR, Thies F, et al. A parallel group doubleblind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity? Osteoporosis Int. 2014;25: 305-315.
48. Zhu K, Austin N, Devine A, Bruce D, Prince RL. A randomized controlled trial of the effects of vitamin D on muscle strength and mobility in older women with vitamin D insufficiency. J Am Geriatrics Soc. 2010;58: 2063-2068.
49. Rantanen T, Guralnik JM, Ferrucci L, et al. Coimpairments as predictors of severe walking disability in older women. J AmGeriatrics Soc. 2001;49: 21-27.
50. Rantanen T, Guralnik JM, Foley D, et al. Midlife hand grip strength as a predictor of old age disability. JAMA. 1999;281: 558-560.
51. Balsamo S, da Mota LM, de Carvalho JF, et al. Low dynamic muscle strength and its associations with fatigue, functional performance, and quality of life in premenopausal patients with systemic lupus erythematosus and low disease activity: a case-control study. BMC Musculoskeletal Disorders. 2013;14: 263.
52. Stenholm S, Mehta NK, Elo IT, Heliövaara M, Koskinen S, Aromaa A. 2013 Obesity and muscle strength as long-term determinants of all-cause mortality-a 33-year follow-up of the Mini-Finland Health Examination Survey. Int J Obes (Lond). 2014;38(8): 1126-1132.
53. Kalyani RR, Stein B, Valiyil R, Manno R, Maynard JW, Crews DC. Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis. J Am Geriatrics Soc. 2010;58: 1299-1310.
54. Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of vitamin D on falls: a meta-analysis. JAMA. 2004;291: 1999-2006.
55. Murad MH, Elamin KB, Abu Elnour NO, et al. Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis. J Clin Endocrin Metab. 2011;96: 2997-3006.
56. Scott D, Stuart AL, Kay D, Ebeling PR, Nicholson G, Sanders KM. Investigating the predictive ability of gait speed and quadriceps strength for incident falls in community-dwelling older women at high risk of fracture. Arch Gerontol Geriatr. 2014;58(3): 308-313.
57. Ioannidis JP, Trikalinos TA. The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey. CMAJ: Canadian Medical Association journal = Journal de l'Association Medicale Canadienne. 2007;176: 1091-1096.