메뉴 건너뛰기




Volumn 135, Issue 10, 2014, Pages 2370-2379

Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating T-cells in chronic lymphocytic leukemia

Author keywords

CLL; MBL; Multidimensional analysis; Regulatory T cells; T cell profiling

Indexed keywords

AGED; ARTICLE; B LYMPHOCYTE; CANCER CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CD3+ CD56+ T CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHRONIC LYMPHATIC LEUKEMIA; CIRCULATING T CELL; COHORT ANALYSIS; CONTROLLED STUDY; DONOR; FEMALE; FLOW CYTOMETRY; GAMMA DELTA T LYMPHOCYTE; GRANULOCYTE; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MONOCLONAL B CELL LYMPHOCYTOSIS; MONOCYTE; NATURAL KILLER T CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PREDICTION; PRINCIPAL COORDINATE ANALYSIS; PROGNOSIS; REGULATORY T LYMPHOCYTE; SCORING SYSTEM; T CELL SCORE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; BLOOD; CASE CONTROL STUDY; CLL; COMPARATIVE STUDY; DISEASE COURSE; FOLLOW UP; IMMUNOLOGY; MBL; MIDDLE AGED; MORTALITY; MULTIDIMENSIONAL ANALYSIS; MULTIVARIATE ANALYSIS; PATHOLOGY; REGULATORY T-CELLS; SURVIVAL RATE; T-CELL PROFILING;

EID: 84909981772     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28884     Document Type: Article
Times cited : (25)

References (45)
  • 1
    • 40749132494 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia
    • Dighiero G, Hamblin TJ. Chronic lymphocytic leukaemia. Lancet 2008;371:1017-29.
    • (2008) Lancet , vol.371 , pp. 1017-1029
    • Dighiero, G.1    Hamblin, T.J.2
  • 2
    • 67650922158 scopus 로고    scopus 로고
    • Monoclonal B lymphocytosis in the general population
    • Dagklis A, Fazi C, Scarfo L, et al. Monoclonal B lymphocytosis in the general population. Leuk Lymphoma 2009;50:490-2.
    • (2009) Leuk Lymphoma , vol.50 , pp. 490-492
    • Dagklis, A.1    Fazi, C.2    Scarfo, L.3
  • 3
    • 80054691036 scopus 로고    scopus 로고
    • General population low-count CLL-like MBL persist over time without clinical progression, though carrying the same cytogenetic abnormalities of CLL
    • Fazi C, Scarfo L, Pecciarini L, et al. General population low-count CLL-like MBL persist over time without clinical progression, though carrying the same cytogenetic abnormalities of CLL. Blood 2011;118:6618-25.
    • (2011) Blood , vol.118 , pp. 6618-6625
    • Fazi, C.1    Scarfo, L.2    Pecciarini, L.3
  • 4
    • 84860897508 scopus 로고    scopus 로고
    • Monoclonal B-cell lymphocytosis: Right track or red herring?
    • Ghia P, Caligaris-Cappio F. Monoclonal B-cell lymphocytosis: right track or red herring? Blood 2012;119:4358-62.
    • (2012) Blood , vol.119 , pp. 4358-4362
    • Ghia, P.1    Caligaris-Cappio, F.2
  • 5
    • 49249119141 scopus 로고    scopus 로고
    • Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia
    • Rawstron AC, Bennett FL, O'Connor SJ, et al. Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med 2008;359:575-83.
    • (2008) N Engl J Med , vol.359 , pp. 575-583
    • Rawstron, A.C.1    Bennett, F.L.2    O'Connor, S.J.3
  • 6
    • 77956578519 scopus 로고    scopus 로고
    • Different biology and clinical outcome according to the absolute numbers of clonal B-cells in monoclonal B-cell lymphocytosis (MBL)
    • Rawstron AC, Shanafelt T, Lanasa MC, et al. Different biology and clinical outcome according to the absolute numbers of clonal B-cells in monoclonal B-cell lymphocytosis (MBL). Cytometry B Clin Cytom 2010;78 (Suppl 1):S19-S23.
    • (2010) Cytometry B Clin Cytom , vol.78 , pp. S19-S23
    • Rawstron, A.C.1    Shanafelt, T.2    Lanasa, M.C.3
  • 7
    • 77949422979 scopus 로고    scopus 로고
    • Monoclonal B-cell lymphocytosis (MBL): Biology, natural history and clinical management
    • Shanafelt TD, Ghia P, Lanasa MC, et al. Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management. Leukemia 2010;24:512-20.
    • (2010) Leukemia , vol.24 , pp. 512-520
    • Shanafelt, T.D.1    Ghia, P.2    Lanasa, M.C.3
  • 8
    • 79956275845 scopus 로고    scopus 로고
    • A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease
    • Bagnara D, Kaufman MS, Calissano C, et al. A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease. Blood 2011;117:5463-72.
    • (2011) Blood , vol.117 , pp. 5463-5472
    • Bagnara, D.1    Kaufman, M.S.2    Calissano, C.3
  • 9
    • 70350734809 scopus 로고    scopus 로고
    • The microenvironment in mature B-cell malignancies: A target for new treatment strategies
    • Burger JA, Ghia P, Rosenwald A, et al. The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 2009;114:3367-75.
    • (2009) Blood , vol.114 , pp. 3367-3375
    • Burger, J.A.1    Ghia, P.2    Rosenwald, A.3
  • 10
    • 79953814653 scopus 로고    scopus 로고
    • Definition and characterization of the systemic T-cell dysregulation in untreated indolent B-cell lymphoma and very early CLL
    • Christopoulos P, Pfeifer D, Bartholome K, et al. Definition and characterization of the systemic T-cell dysregulation in untreated indolent B-cell lymphoma and very early CLL. Blood 2011;117:3836-46.
    • (2011) Blood , vol.117 , pp. 3836-3846
    • Christopoulos, P.1    Pfeifer, D.2    Bartholome, K.3
  • 11
    • 0029051433 scopus 로고
    • Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells
    • Ranheim EA, Cantwell MJ, Kipps TJ. Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells. Blood 1995;85:3556-65.
    • (1995) Blood , vol.85 , pp. 3556-3565
    • Ranheim, E.A.1    Cantwell, M.J.2    Kipps, T.J.3
  • 12
    • 0027499535 scopus 로고
    • Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal
    • Ranheim EA, Kipps TJ. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J Exp Med 1993;177:925-35.
    • (1993) J Exp Med , vol.177 , pp. 925-935
    • Ranheim, E.A.1    Kipps, T.J.2
  • 14
    • 0030989818 scopus 로고    scopus 로고
    • CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules
    • Van den Hove LE, Van Gool SW, Vandenberghe P, et al. CD40 triggering of chronic lymphocytic leukemia B cells results in efficient alloantigen presentation and cytotoxic T lymphocyte induction by up-regulation of CD80 and CD86 costimulatory molecules. Leukemia 1997;11:572-80.
    • (1997) Leukemia , vol.11 , pp. 572-580
    • Van Den Hove, L.E.1    Van Gool, S.W.2    Vandenberghe, P.3
  • 15
    • 0028365149 scopus 로고
    • T lymphocyte T cell-B cell-activating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/BB-1) and enhance their costimulatory activity
    • Yellin MJ, Sinning J, Covey LR, et al. T lymphocyte T cell-B cell-activating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/BB-1) and enhance their costimulatory activity. J Immunol 1994;153:666-74.
    • (1994) J Immunol , vol.153 , pp. 666-674
    • Yellin, M.J.1    Sinning, J.2    Covey, L.R.3
  • 16
    • 0028927836 scopus 로고
    • Failure of B cells of chronic lymphocytic leukemia in presenting soluble and alloantigens
    • Dazzi F, D'Andrea E, Biasi G, et al. Failure of B cells of chronic lymphocytic leukemia in presenting soluble and alloantigens. Clin Immunol Immunopathol 1995;75:26-32.
    • (1995) Clin Immunol Immunopathol , vol.75 , pp. 26-32
    • Dazzi, F.1    D'Andrea, E.2    Biasi, G.3
  • 18
    • 0030036067 scopus 로고    scopus 로고
    • B7-mediated costimulation and the immune response
    • Schultze J, Nadler LM, Gribben JG. B7-mediated costimulation and the immune response. Blood Rev 1996;10:111-27.
    • (1996) Blood Rev , vol.10 , pp. 111-127
    • Schultze, J.1    Nadler, L.M.2    Gribben, J.G.3
  • 19
    • 0037348740 scopus 로고    scopus 로고
    • Abnormal T-cell function in B-cell chronic lymphocytic leukaemia
    • Scrivener S, Goddard RV, Kaminski ER, et al. Abnormal T-cell function in B-cell chronic lymphocytic leukaemia. Leuk Lymphoma 2003;44:383-9.
    • (2003) Leuk Lymphoma , vol.44 , pp. 383-389
    • Scrivener, S.1    Goddard, R.V.2    Kaminski, E.R.3
  • 20
    • 34247639475 scopus 로고    scopus 로고
    • CD200 expression on tumor cells suppresses antitumor immunity: New approaches to cancer immunotherapy
    • Kretz-Rommel A, Qin F, Dakappagari N, et al. CD200 expression on tumor cells suppresses antitumor immunity: new approaches to cancer immunotherapy. J Immunol 2007;178:5595-605.
    • (2007) J Immunol , vol.178 , pp. 5595-5605
    • Kretz-Rommel, A.1    Qin, F.2    Dakappagari, N.3
  • 21
    • 32244442244 scopus 로고    scopus 로고
    • Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation
    • McWhirter JR, Kretz-Rommel A, Saven A, et al. Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation. Proc Natl Acad Sci USA 2006;103:1041-6.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1041-1046
    • McWhirter, J.R.1    Kretz-Rommel, A.2    Saven, A.3
  • 22
    • 58549108182 scopus 로고    scopus 로고
    • Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade
    • Pallasch CP, Ulbrich S, Brinker R, et al. Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade. Leuk Res 2009;33:460-4.
    • (2009) Leuk Res , vol.33 , pp. 460-464
    • Pallasch, C.P.1    Ulbrich, S.2    Brinker, R.3
  • 23
    • 0030846220 scopus 로고    scopus 로고
    • Acquired CD40-ligand deficiency in chronic lymphocytic leukemia
    • Cantwell M, Hua T, Pappas J, et al. Acquired CD40-ligand deficiency in chronic lymphocytic leukemia. Nat Med 1997;3:984-9.
    • (1997) Nat Med , vol.3 , pp. 984-989
    • Cantwell, M.1    Hua, T.2    Pappas, J.3
  • 24
    • 84865165316 scopus 로고    scopus 로고
    • Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: Establishing a reversible immune evasion mechanism in human cancer
    • Ramsay AG, Clear AJ, Fatah R, et al. Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. Blood 2012;120:1412-21.
    • (2012) Blood , vol.120 , pp. 1412-1421
    • Ramsay, A.G.1    Clear, A.J.2    Fatah, R.3
  • 25
    • 84878263355 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells induce defective LFA-1-directed T cell motility by altering Rho GTPase signaling that is reversible with lenalidomide
    • Ramsay AG, Evans R, Kiaii S, et al. Chronic lymphocytic leukemia cells induce defective LFA-1-directed T cell motility by altering Rho GTPase signaling that is reversible with lenalidomide. Blood 2013;121:2704-14.
    • (2013) Blood , vol.121 , pp. 2704-2714
    • Ramsay, A.G.1    Evans, R.2    Kiaii, S.3
  • 26
    • 70349153856 scopus 로고    scopus 로고
    • Immune dysfunction in chronic lymphocytic leukemia T cells and lenalidomide as an immunomodulatory drug
    • Ramsay AG, Gribben JG. Immune dysfunction in chronic lymphocytic leukemia T cells and lenalidomide as an immunomodulatory drug. Haematologica 2009;94:1198-202.
    • (2009) Haematologica , vol.94 , pp. 1198-1202
    • Ramsay, A.G.1    Gribben, J.G.2
  • 27
    • 46749132717 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
    • Ramsay AG, Johnson AJ, Lee AM, et al. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest 2008;118:2427-37.
    • (2008) J Clin Invest , vol.118 , pp. 2427-2437
    • Ramsay, A.G.1    Johnson, A.J.2    Lee, A.M.3
  • 28
    • 84861348588 scopus 로고    scopus 로고
    • A shorter time to the first treatment may be predicted by the absolute number of regulatory T-cells in patients with Rai stage 0 chronic lymphocytic leukemia
    • D'Arena G, D'Auria F, Simeon V, et al. A shorter time to the first treatment may be predicted by the absolute number of regulatory T-cells in patients with Rai stage 0 chronic lymphocytic leukemia. Am J Hematol 2012;87:628-31.
    • (2012) Am J Hematol , vol.87 , pp. 628-631
    • D'Arena, G.1    D'Auria, F.2    Simeon, V.3
  • 29
    • 79952100710 scopus 로고    scopus 로고
    • Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease
    • D'Arena G, Laurenti L, Minervini MM, et al. Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease. Leuk Res 2011;35:363-8.
    • (2011) Leuk Res , vol.35 , pp. 363-368
    • D'Arena, G.1    Laurenti, L.2    Minervini, M.M.3
  • 30
    • 84856577660 scopus 로고    scopus 로고
    • Circulating regulatory T cells in "clinical" monoclonal B-cell lymphocytosis
    • D'Arena G, Rossi G, Minervini MM, et al. Circulating regulatory T cells in "clinical" monoclonal B-cell lymphocytosis. Int J Immunopathol Pharmacol 2011;24:915-23.
    • (2011) Int J Immunopathol Pharmacol , vol.24 , pp. 915-923
    • D'Arena, G.1    Rossi, G.2    Minervini, M.M.3
  • 31
    • 84878659585 scopus 로고    scopus 로고
    • Regulatory T-cells in chronic lymphocytic leukemia: Actor or innocent bystander?
    • D'Arena G, Simeon V, D'Auria F, et al. Regulatory T-cells in chronic lymphocytic leukemia: actor or innocent bystander? Am J blood Res 2013;3:52-7.
    • (2013) Am J Blood Res , vol.3 , pp. 52-57
    • D'Arena, G.1    Simeon, V.2    D'Auria, F.3
  • 32
    • 68449083231 scopus 로고    scopus 로고
    • Expansion of regulatory T cells in B chronic lymphocytic leukemia: Enhanced 'brakes' on host immunity
    • Deutsch V, Perry C, Polliack A. Expansion of regulatory T cells in B chronic lymphocytic leukemia: enhanced 'brakes' on host immunity. Leuk Lymphoma 2009;50:687-8.
    • (2009) Leuk Lymphoma , vol.50 , pp. 687-688
    • Deutsch, V.1    Perry, C.2    Polliack, A.3
  • 33
    • 79955500329 scopus 로고    scopus 로고
    • Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia
    • Weiss L, Melchardt T, Egle A, et al. Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia. Cancer 2011;117:2163-9.
    • (2011) Cancer , vol.117 , pp. 2163-2169
    • Weiss, L.1    Melchardt, T.2    Egle, A.3
  • 34
    • 84868087332 scopus 로고    scopus 로고
    • Dysfunctional Vgamma9Vdelta2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells
    • Coscia M, Vitale C, Peola S, et al. Dysfunctional Vgamma9Vdelta2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells. Blood 2012;120:3271-9.
    • (2012) Blood , vol.120 , pp. 3271-3279
    • Coscia, M.1    Vitale, C.2    Peola, S.3
  • 35
    • 2642574503 scopus 로고    scopus 로고
    • Vienna, Austria: R Foundation for Statistical Computing, Available at
    • R Core Team. A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2013. Available at: http://www.R-project.org/.
    • (2013) A Language and Environment for Statistical Computing
  • 36
    • 43449101911 scopus 로고    scopus 로고
    • Prognostic importance of T and NK-cells in a consecutive series of newly diagnosed patients with chronic lymphocytic leukaemia
    • Palmer S, Hanson CA, Zent CS, et al. Prognostic importance of T and NK-cells in a consecutive series of newly diagnosed patients with chronic lymphocytic leukaemia. Br J Haematol 2008;141:607-14.
    • (2008) Br J Haematol , vol.141 , pp. 607-614
    • Palmer, S.1    Hanson, C.A.2    Zent, C.S.3
  • 37
    • 63349094915 scopus 로고    scopus 로고
    • Expression levels of CD38 on leukemic B cells but not on non-leukemic T cells are comparably stable over time and predict the course of disease in patients with chronic lymphocytic leukemia
    • Eisele L, Haddad T, Sellmann L, et al. Expression levels of CD38 on leukemic B cells but not on non-leukemic T cells are comparably stable over time and predict the course of disease in patients with chronic lymphocytic leukemia. Leuk Res 2009;33:775-8.
    • (2009) Leuk Res , vol.33 , pp. 775-778
    • Eisele, L.1    Haddad, T.2    Sellmann, L.3
  • 38
    • 84864981585 scopus 로고    scopus 로고
    • Increased CD39 expression on CD4(1) T lymphocytes has clinical and prognostic significance in chronic lymphocytic leukemia
    • Perry C, Hazan-Halevy I, Kay S, et al. Increased CD39 expression on CD4(1) T lymphocytes has clinical and prognostic significance in chronic lymphocytic leukemia. Ann Hematol 2012;91:1271-9.
    • (2012) Ann Hematol , vol.91 , pp. 1271-1279
    • Perry, C.1    Hazan-Halevy, I.2    Kay, S.3
  • 39
    • 84876478036 scopus 로고    scopus 로고
    • T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production
    • Riches JC, Davies JK, McClanahan F, et al. T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production. Blood 2013;121:1612-21.
    • (2013) Blood , vol.121 , pp. 1612-1621
    • Riches, J.C.1    Davies, J.K.2    McClanahan, F.3
  • 40
    • 84873570544 scopus 로고    scopus 로고
    • Infectious complications among individuals with clinical monoclonal B-cell lymphocytosis (MBL): A cohort study of newly diagnosed cases compared to controls
    • Moreira J, Rabe KG, Cerhan JR, et al. Infectious complications among individuals with clinical monoclonal B-cell lymphocytosis (MBL): a cohort study of newly diagnosed cases compared to controls. Leukemia 2012;27:136-41.
    • (2012) Leukemia , vol.27 , pp. 136-141
    • Moreira, J.1    Rabe, K.G.2    Cerhan, J.R.3
  • 41
    • 49749119446 scopus 로고    scopus 로고
    • Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people
    • Koch S, Larbi A, Derhovanessian E, et al. Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people. Immun Ageing 2008;5:6.
    • (2008) Immun Ageing , vol.5 , pp. 6
    • Koch, S.1    Larbi, A.2    Derhovanessian, E.3
  • 42
    • 80055021878 scopus 로고    scopus 로고
    • Biological effects and clinical significance of lenalidomide-induced tumour flare reaction in patients with chronic lymphocytic leukaemia: In vivo evidence of immune activation and antitumour response
    • Chanan-Khan AA, Chitta K, Ersing N, et al. Biological effects and clinical significance of lenalidomide-induced tumour flare reaction in patients with chronic lymphocytic leukaemia: in vivo evidence of immune activation and antitumour response. Br J Haematol 2011;155:457-67.
    • (2011) Br J Haematol , vol.155 , pp. 457-467
    • Chanan-Khan, A.A.1    Chitta, K.2    Ersing, N.3
  • 43
    • 80051928145 scopus 로고    scopus 로고
    • Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia
    • Lee BN, Gao H, Cohen EN, et al. Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia. Cancer 2011;117:3999-4008.
    • (2011) Cancer , vol.117 , pp. 3999-4008
    • Lee, B.N.1    Gao, H.2    Cohen, E.N.3
  • 44
    • 65549151712 scopus 로고    scopus 로고
    • E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction
    • Gorgun G, Ramsay AG, Holderried TA, et al. E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction. Proc Natl Acad Sci USA 2009;106:6250-5.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6250-6255
    • Gorgun, G.1    Ramsay, A.G.2    Holderried, T.A.3
  • 45
    • 70349150560 scopus 로고    scopus 로고
    • Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia
    • Aue G, Njuguna N, Tian X, et al. Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia. Haematologica 2009;94:1266-73.
    • (2009) Haematologica , vol.94 , pp. 1266-1273
    • Aue, G.1    Njuguna, N.2    Tian, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.