Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus

FEBS Journal

Volumn 281, Issue 18, 2014, Pages 4224-4239

  Wang, Fengbin ^a   Singh, Shanteri ^b   Zhang, Jianjun ^b   Huber, Tyler D ^b   Helmich, Kate E ^c   Sunkara, Manjula ^d   Hurley, Katherine A ^c   Goff, Randal D ^e   Bingman, Craig A ^c   Morris, Andrew J ^d   Thorson, Jon S ^b   Phillips, George N ^a,c  

^a RICE UNIVERSITY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

^e Western Wyoming Community College   (United States)

Author keywords

enzyme engineering; methionine adenosyltransferase; natural product; S adenosylmethionine; X ray diffraction

Indexed keywords

ADENOSINE TRIPHOSPHATE; METHIONINE ADENOSYLTRANSFERASE; METHIONINE DERIVATIVE; S ADENOSYLETHIONINE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG; ARCHAEAL PROTEIN; METHIONINE; PROTEIN BINDING;

ALKYLATION; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFRACTION; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SYNTHESIS; ESCHERICHIA COLI; MOLECULAR RECOGNITION; NONHUMAN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY; SULFOLOBUS SOLFATARICUS; THERMOPHILIC ARCHAEON; THERMOSTABILITY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; KINETICS; PROTEIN MOTIF; PROTEIN QUATERNARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

SULFOLOBUS SOLFATARICUS;

AMINO ACID MOTIFS; ARCHAEAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; KINETICS; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; SUBSTRATE SPECIFICITY; SULFOLOBUS SOLFATARICUS;

EID: 84909946420     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12784     Document Type: Article

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