Association of HLA-DP/DQ and STAT4 polymorphisms with HBV infection outcomes and a mini meta-analysis

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Liao, Yun ^a   Cai, Bei ^a   Li, Yi ^a   Chen, Jie ^a   Tao, Chuanmin ^a   Huang, Hengjian ^a   Wang, Lanlan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DP ANTIGEN; HLA DQ ANTIGEN; STAT4 PROTEIN;

ADULT; ARTICLE; CARCINOGENESIS; CHINESE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; HAPLOTYPE; HEPATITIS B; HLA DP GENE; HLA DQ GENE; HUMAN; INFECTION SENSITIVITY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM; STAT4 GENE; VIRAL CLEARANCE; ALLELE; CASE CONTROL STUDY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; LIVER TUMOR; META ANALYSIS; MIDDLE AGED; OUTCOME ASSESSMENT; PATHOLOGY; PROGNOSIS; RISK;

HEPATITIS B VIRUS;

ADULT; ALLELES; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HEPATITIS B; HLA-DP ANTIGENS; HLA-DQ ANTIGENS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; ODDS RATIO; PATIENT OUTCOME ASSESSMENT; POLYMORPHISM, GENETIC; PROGNOSIS; STAT4 TRANSCRIPTION FACTOR;

EID: 84909606653     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111677     Document Type: Article

References (27)

1. Lai CL, Ratziu V, Yuen MF, Poynard T (2003) Viral hepatitis B. Lancet 362: 2089-2094.
2. Dienstag JL (2008) Hepatitis B virus infection. N Engl J Med 359: 1486-1500.
3. Ganem D, Prince AM (2004) Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med 350: 1118-1129.
4. Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, et al. (2009) A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet 41: 591-595.
5. Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, et al. (2011) A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Hum Mol Genet 20: 3884-3892.
6. Guo X, Zhang Y, Li J, Ma J, Wei Z, et al. (2011) Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. Hepatology 53: 422-428.
7. Hu L, Zhai X, Liu J, Chu M, Pan S, et al. (2012) Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development. Hepatology 55: 1426-1431.
8. An P, Winkler C, Guan L, O'Brien SJ, Zeng Z (2011) A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese. J Infect Dis 203: 943-947.
9. Cheng HR, Liu CJ, Tseng TC, Su TH, Yang HI, et al. (2013) Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients. PLoS One 8: e53008.
10. Seto WK, Wong DK, Kopaniszen M, Proitsi P, Sham PC, et al. (2013) HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B. Clin Infect Dis 56: 1695-1703.
11. Li S, Qian J, Yang Y, Zhao W, Dai J, et al. (2012) GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. PLoS Genet 8: e1002791.
12. Jiang DK, Sun J, Cao G, Liu Y, Lin D, et al. (2013) Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Nat Genet 45: 72-75.
13. Zhang H, Zhai Y, Hu Z, Wu C, Qian J, et al. (2010) Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet 42: 755-758.
14. Clark A, Gerlach F, Tong H, Hoan NX, Song le H, et al. (2013) A trivial role of STAT4 variant in chronic hepatitis B induced hepatocellular carcinoma. Infect Genet Evol 18: 257-261.
15. Chen K, Shi W, Xin Z, Wang H, Zhu X, et al. (2013) Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci in a Chinese population. PLoS One 8: e77315.
16. Bruix J, Sherman M (2005) Management of hepatocellular carcinoma. Hepatology 42: 1208-1236.
17. Lok ASF, McMahon BJ (2007) Chronic hepatitis B. Hepatology 45: 507-539.
18. Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25: 603-605.
19. Shi YY, He L (2005) SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15: 97-98.
20. Li J, Yang D, He Y, Wang M, Wen Z, et al. (2011) Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. PLoS One 6: e24221.
21. Al-Qahtani AA, Al-Anazi MR, Abdo AA, Sanai FM, Al-Hamoudi W, et al. (2014) Association between HLA Variations and Chronic Hepatitis B Virus Infection in Saudi Arabian Patients. PLoS One 9: e80445.
22. O'Brien TR, Kohaar I, Pfeiffer RM, Maeder D, Yeager M, et al. (2011) Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. Genes Immun 12: 428-433.
23. Diaz G, Amicosante M, Jaraquemada D, Butler RH, Guillen MV, et al. (2003) Functional analysis of HLA-DP polymorphism: a crucial role for DPbeta residues 9, 11, 35, 55, 56, 69 and 84-87 in T cell allorecognition and peptide binding. Int Immunol 15: 565-576.
24. Zhang Q, Yin J, Zhang Y, Deng Y, Ji X, et al. (2013) HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations. J Virol 87: 12176-12186.
25. Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, et al. (1996) Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382: 171-174.
26. Nguyen KB, Watford WT, Salomon R, Hofmann SR, Pien GC, et al. (2002) Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science 297: 2063-2066.
27. Yu H, Pardoll D, Jove R (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9: 798-809.