Holo-retinol-binding protein and its receptor STRA6 drive oncogenic transformation

Cancer Research

Volumn 74, Issue 21, 2014, Pages 6341-6351

  Berry, Daniel C ^a,b   Levi, Liraz ^a,b   Noy, Noa ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOLO RETINOL BINDING PROTEIN; HOLO RETINOL BINDING PROTEIN RECEPTOR; RECEPTOR PROTEIN; RETINOL BINDING PROTEIN; UNCLASSIFIED DRUG; JAK2 PROTEIN, HUMAN; JANUS KINASE 2; MEMBRANE PROTEIN; RETINOL; STRA6 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BREAST TUMOR; CARCINOMA CELL; COLON CARCINOGENESIS; COLON CARCINOMA; COLON TUMOR; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; IN VIVO STUDY; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION; BIOSYNTHESIS; CELL TRANSFORMATION; GENE EXPRESSION REGULATION; GENETICS; HCT116 CELL LINE; HEPG2 CELL LINE; METABOLISM; PATHOLOGY;

CELL TRANSFORMATION, NEOPLASTIC; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HEP G2 CELLS; HUMANS; JANUS KINASE 2; MEMBRANE PROTEINS; RETINOL-BINDING PROTEINS; SIGNAL TRANSDUCTION; VITAMIN A;

EID: 84909592615     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-1052     Document Type: Article

References (36)

1. Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, et al. International Union of Pharmacology. LX. retinoic acid receptors. Pharmacol Rev 2006;58:712-25.
2. Schug TT, Berry DC, Shaw NS, Travis SN, Noy N. Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors. Cell 2007;129:723-33.
3. Raghu P, Sivakumar B. Interactions amongst plasma retinol-binding protein, transthyretin and their ligands: implications in vitamin A homeostasis and transthyretin amyloidosis. Biochim Biophys Acta 2004;1703:1-9.
4. Noy N. Retinoid-binding proteins: mediators of retinoid action. Biochem J 2000;348:481-95.
5. Berry DC, Croniger CM, Ghyselinck NB, Noy N. Transthyretin blocks retinol uptake and cell signalling by the holo-retinol-binding protein receptor STRA6. Mol Cell Biol 2012;32:3851-9.
6. Terra R, Wang X, Hu Y, Charpentier T, Lamarre A, Zhong M, et al. To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses. PLoS ONE 2013;8:e82808.
7. Berry DC, Jacobs H, Marwarha G, Gely-Pernot A, O'Byrne SM, DeSantis D, et al. The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye. J Biol Chem 2013;288: 24528-39.
8. Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, et al. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science 2007;315:820-5.
9. Ruiz A, Mark M, Jacobs H, Klopfenstein M, Hu J, Lloyd M, et al. Retinoid content, visual responses and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6. Invest Ophthalmol Visual Sci 2012;53:3027-39.
10. Berry DC, Jin H, Majumdar A,Noy N. Signaling by vitamin Aand retinolbinding protein regulates gene expression to inhibit insulin responses. Proc Natl Acad Sci U S A 2011;108:4340-5.
11. Berry DC, O'Byrne SM, Vreeland AC, Blaner WS, Noy N. Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6. Mol Cell Biol 2012;32:3164-75.
12. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005;436:356-62.
13. Mody N, Graham TE, Tsuji Y, Yang Q, Kahn BB. Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice. Am J Physiol Endocrinol Metab 2008; 294:E785-93.
14. Szeto W, Jiang W, Tice DA, Rubinfeld B, Hollingshead PG, Fong SE, et al. Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid. Cancer Res 2001;61:4197-205.
15. Koptyra M, Gupta S, Talati P, Nevalainen MT. Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer. Int J Biochem Cell Biol 2011;43:1417-21.
16. Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, Koca C, et al. Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship? Ann New York Acad Sci 2009;1171:59-76.
17. Ferbeyre G, Moriggl R. The role of Stat5 transcription factors as tumor suppressors or oncogenes. Biochim Biophys Acta 2011;1815:104-14.
18. Quesnelle KM, Boehm AL, Grandis JR. STAT-mediated EGFR signaling in cancer. J Cell Biochem 2007;102:311-9.
19. Leeman RJ, Lui VW, Grandis JR. STAT3 as a therapeutic target in head and neck cancer. Expert Opin Biol Ther 2006;6:231-41.
20. Xie Y, Lashuel HA, Miroy GJ, Dikler S, Kelly JW. Recombinant human retinol-binding protein refolding, native disulfide formation, and characterization. Protein Expr Purif 1998;14:31-7.
21. Golczak M, Maeda A, Bereta G, Maeda T, Kiser PD, Hunzelmann S, et al. Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem 2008;283: 9543-54.
22. Zhao Y, Zhang X, Guda K, Lawrence E, Sun Q, Watanabe T, et al. Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. Proc Natl Acad Sci U S A 2010;107:2592-7.
23. Berry DC, DeSantis D, Soltanian H, Croniger CM, Noy N. Retinoic acid upregulates preadipocyte genes to block adipogenesis and suppress diet-induced obesity. Diabetes 2012;61:1112-21.
24. Aslakson CJ, Miller FR. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res 1992;52:1399-405.
25. Kaptein A, Paillard V, Saunders M. Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction. J Biol Chem 1996;271:5961-4.
26. Bromberg J, Darnell JE Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 2000;19:2468-73.
27. Carrera S, Cuadrado-Castano S, Samuel J, Jones GD, Villar E, Lee SW, et al. Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. Cell Death Differ 2013;20: 910-9.
28. Park J, Euhus DM, Scherer PE. Paracrine and endocrine effects of adipose tissue on cancer development and progression. Endocr Rev 2011;32:550-70.
29. Demark-Wahnefried W, Platz EA, Ligibel JA, Blair CK, Courneya KS, Meyerhardt J, et al. The role of obesity in cancer survival and recurrence. Cancer Epidemiol Biomarkers Prev 2012;21:1244-59.
30. Vainio H, Bianchini F, editors. Weight control and physical activity. Lyon, France: IARC Press; 2002.
31. Goodwin PJ, Ennis M, Pritchard KI, Trudeau ME, Koo J, Madarnas Y, et al. Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study. J Clin Oncol 2002;20:42-51.
32. Donohoe CL, Doyle SL, Reynolds JV. Visceral adiposity, insulin resistance and cancer risk. Diabetol Metab Syndr 2011;3:12.
33. Renehan AG, Roberts DL, Dive C. Obesity and cancer: pathophysiological and biological mechanisms. Arch Physiol Biochem 2008;114: 71-83.
34. Zheng Q, Dunlap SM, Zhu J, Downs-Kelly E, Rich J, Hursting SD, et al. Leptin deficiency suppressesMMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival. Endocr Relat Cancer 2011;18:491-503.
35. Hoda MR, Theil G,Mohammed N, Fischer K, Fornara P. The adipocytederived hormone leptin has proliferative actions on androgen-resistant prostate cancer cells linking obesity to advanced stages of prostate cancer. J Oncol 2012;2012:280386.
36. TCGA. The cancer genome atlas[Internet]. Available from: http:// cancergenome.nih.gov/.