Clinically relevant HOCl concentrations reduce clot retraction rate via the inhibition of energy production in platelet mitochondria

Free Radical Research

Volumn 48, Issue 12, 2014, Pages 1443-1453

  Misztal, T ^a   Rusak, T ^a   Tomasiak, M ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Clot retraction; Hypochlorous acid; Mitochondria; Peroxynitrite; Platelets

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE MAGNESIUM; CALCIUM ION; FIBRINOGEN; FIBRINOGEN RECEPTOR; HYPOCHLORITE SODIUM; HYPOCHLOROUS ACID; LACTATE DEHYDROGENASE; LACTIC ACID; PEROXYNITRITE; THROMBIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD CLOT; BLOOD CLOT RETRACTION; BLOOD CLOTTING; BLOOD LEVEL; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOMESTIC PIG; ENERGY YIELD; FEMALE; FIBRIN POLYMERIZATION; HEMOSTASIS; IC50; IN VITRO STUDY; INFLAMMATORY CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXYGEN CONSUMPTION; THROMBOCYTE; THROMBOCYTE ADHESION; THROMBOCYTE FREE PLASMA; THROMBOCYTE FUNCTION; THROMBOCYTE MEMBRANE; THROMBOCYTE RICH PLASMA; ANIMAL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; ENERGY METABOLISM; METABOLISM; PIG; STRUCTURE ACTIVITY RELATION; TIME;

ANIMALS; BLOOD PLATELETS; CLOT RETRACTION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; HYPOCHLOROUS ACID; MITOCHONDRIA; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; TIME FACTORS;

EID: 84908701791     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2014.960866     Document Type: Article

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