Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 20, 2014, Pages 4818-4821

  Wang, Yue Hu ^a,b   Goto, Masuo ^a   Wang, Li Ting ^a   Hsieh, Kan Yen ^a   Morris Natschke, Susan L ^a   Tang, Gui Hua ^c   Long, Chun Lin ^b,d   Lee, Kuo Hsiung ^a,e  

^a UNC Hamner Institute for Drug Safety Sciences   (United States)

^b KUNMING INSTITUTE OF BOTANY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d MINZU UNIVERSITY OF CHINA   (China)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Amide alkaloids; Cytotoxicity; Multidrug resistance; Piper; Piperaceae

Indexed keywords

ALKALOID; AMIDE; ANTINEOPLASTIC AGENT;

CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; HUMAN; ISOLATION AND PURIFICATION; MCF 7 CELL LINE; MULTIDRUG RESISTANCE; PIPER (PLANT); STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ALKALOIDS; AMIDES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; MOLECULAR STRUCTURE; PIPER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908691602     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.08.063     Document Type: Article

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