-
1
-
-
84974798740
-
-
accessed on 3 November 2014)
-
World Health Organization. WHO hepatitis c fact sheet no 164. Available online: http://www.who.int/mediacentre/factsheets/fs164/en/ (accessed on 3 November 2014).
-
WHO hepatitis c fact sheet no 164
-
-
-
2
-
-
84901241878
-
Emerging trends in hepatocellular carcinoma: Focus on diagnosis and therapeutics
-
Flores, A.; Marrero, J.A. Emerging trends in hepatocellular carcinoma: Focus on diagnosis and therapeutics. Clin. Med. Insights Oncol. 2014, 8, 71–76.
-
(2014)
Clin. Med. Insights Oncol.
, vol.8
, pp. 71-76
-
-
Flores, A.1
Marrero, J.A.2
-
3
-
-
84902654355
-
Burden of disease and cost of chronic hepatitis c infection in canada
-
Myers, R.P.; Krajden, M.; Bilodeau, M.; Kaita, K.; Marotta, P.; Peltekian, K.; Ramji, A.; Estes, C.; Razavi, H.; Sherman, M. Burden of disease and cost of chronic hepatitis c infection in canada. Can. J. Gastroenterol. Hepatol. 2014, 28, 243–250.
-
(2014)
Can. J. Gastroenterol. Hepatol.
, vol.28
, pp. 243-250
-
-
Myers, R.P.1
Krajden, M.2
Bilodeau, M.3
Kaita, K.4
Marotta, P.5
Peltekian, K.6
Ramji, A.7
Estes, C.8
Razavi, H.9
Sherman, M.10
-
4
-
-
33644639990
-
Sch 503034, a mechanism-based inhibitor of hepatitis c virus ns3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells
-
Malcolm, B.A.; Liu, R.; Lahser, F.; Agrawal, S.; Belanger, B.; Butkiewicz, N.; Chase, R.; Gheyas, F.; Hart, A.; Hesk, D. et al. Sch 503034, a mechanism-based inhibitor of hepatitis c virus ns3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells. Antimicrob. Agents Chemother. 2006, 50, 1013–1020.
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, pp. 1013-1020
-
-
Malcolm, B.A.1
Liu, R.2
Lahser, F.3
Agrawal, S.4
Belanger, B.5
Butkiewicz, N.6
Chase, R.7
Gheyas, F.8
Hart, A.9
Hesk, D.10
-
5
-
-
84928203902
-
Simeprevir (tmc435) once daily with peginterferon-alpha-2b and ribavirin in patients with genotype 1 hepatitis c virus infection: The concerto-4 study
-
Kumada, H.; Hayashi, N.; Izumi, N.; Okanoue, T.; Tsubouchi, H.; Yatsuhashi, H.; Kato, M.; Rito, K.; Komada, Y.; Seto, C. et al. Simeprevir (tmc435) once daily with peginterferon-alpha-2b and ribavirin in patients with genotype 1 hepatitis c virus infection: The concerto-4 study. Hepatol. Res. 2014, doi:10.1111/hepr.12375.
-
(2014)
Hepatol. Res
-
-
Kumada, H.1
Hayashi, N.2
Izumi, N.3
Okanoue, T.4
Tsubouchi, H.5
Yatsuhashi, H.6
Kato, M.7
Rito, K.8
Komada, Y.9
Seto, C.10
-
6
-
-
84906899657
-
-
accessed on 3 November 2014
-
US Food and Drug Administration, FDA approves new treatment for hepatitis c virus. Available online: http://www.fda.gov/newsevents/newsroom/pressannouncements/ucm376449.htm (accessed on 3 November 2014).
-
FDA approves new treatment for hepatitis c virus
-
-
-
8
-
-
84871814966
-
Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis c
-
Gane, E.J.; Stedman, C.A.; Hyland, R.H.; Ding, X.; Svarovskaia, E.; Symonds, W.T.; Hindes, R.G.; Berrey, M.M. Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis c. N. Engl. J. Med. 2013, 368, 34–44.
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 34-44
-
-
Gane, E.J.1
Stedman, C.A.2
Hyland, R.H.3
Ding, X.4
Svarovskaia, E.5
Symonds, W.T.6
Hindes, R.G.7
Berrey, M.M.8
-
9
-
-
77952035218
-
Chemical genetics strategy identifies an hcv ns5a inhibitor with a potent clinical effect
-
Gao, M.; Nettles, R.E.; Belema, M.; Snyder, L.B.; Nguyen, V.N.; Fridell, R.A.; Serrano-Wu, M.H.; Langley, D.R.; Sun, J.H.; O’Boyle, D.R., II et al. Chemical genetics strategy identifies an hcv ns5a inhibitor with a potent clinical effect. Nature 2010, 465, 96–100.
-
(2010)
Nature
, vol.465
, pp. 96-100
-
-
Gao, M.1
Nettles, R.E.2
Belema, M.3
Snyder, L.B.4
Nguyen, V.N.5
Fridell, R.A.6
Serrano-Wu, M.H.7
Langley, D.R.8
Sun, J.H.9
O’boyle, D.R.10
-
10
-
-
78649430973
-
Hepatitis c virus nonstructural protein 5a: Biochemical characterization of a novel structural class of RNA-binding proteins
-
Hwang, J.; Huang, L.; Cordek, D.G.; Vaughan, R.; Reynolds, S.L.; Kihara, G.; Raney, K.D.; Kao, C.C.; Cameron, C.E. Hepatitis c virus nonstructural protein 5a: Biochemical characterization of a novel structural class of RNA-binding proteins. J. Virol. 2010, 84, 12480–12491.
-
(2010)
J. Virol.
, vol.84
, pp. 12480-12491
-
-
Hwang, J.1
Huang, L.2
Cordek, D.G.3
Vaughan, R.4
Reynolds, S.L.5
Kihara, G.6
Raney, K.D.7
Kao, C.C.8
Cameron, C.E.9
-
11
-
-
0028978937
-
Phosphorylation of hepatitis c virus-encoded nonstructural protein ns5a
-
Tanji, Y.; Kaneko, T.; Satoh, S.; Shimotohno, K. Phosphorylation of hepatitis c virus-encoded nonstructural protein ns5a. J. Virol. 1995, 69, 3980–3986.
-
(1995)
J. Virol.
, vol.69
, pp. 3980-3986
-
-
Tanji, Y.1
Kaneko, T.2
Satoh, S.3
Shimotohno, K.4
-
12
-
-
84906871865
-
Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein
-
Cordek, D.G.; Croom-Perez, T.J.; Hwang, J.; Hargittai, M.R.; Subba-Reddy, C.V.; Han, Q.; Lodeiro, M.F.; Ning, G.; McCrory, T.S.; Arnold, J.J. et al. Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein. J. Biol. Chem. 2014, 289, 24397–24416.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 24397-24416
-
-
Cordek, D.G.1
Croom-Perez, T.J.2
Hwang, J.3
Hargittai, M.R.4
Subba-Reddy, C.V.5
Han, Q.6
Lodeiro, M.F.7
Ning, G.8
McCrory, T.S.9
Arnold, J.J.10
-
13
-
-
34249664478
-
Phosphorylation of hepatitis c virus ns5a nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication
-
Huang, Y.; Staschke, K.; De Francesco, R.; Tan, S.L. Phosphorylation of hepatitis c virus ns5a nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication? Virology 2007, 364, 1–9.
-
(2007)
Virology
, vol.364
, pp. 1-9
-
-
Huang, Y.1
Staschke, K.2
De Francesco, R.3
Tan, S.L.4
-
14
-
-
84878499077
-
The lipid kinase phosphatidylinositol-4 kinase iii alpha regulates the phosphorylation status of hepatitis c virus ns5a
-
Reiss, S.; Harak, C.; Romero-Brey, I.; Radujkovic, D.; Klein, R.; Ruggieri, A.; Rebhan, I.; Bartenschlager, R.; Lohmann, V. The lipid kinase phosphatidylinositol-4 kinase iii alpha regulates the phosphorylation status of hepatitis c virus ns5a. PLoS Pathog. 2013, 9, e1003359.
-
(2013)
PLoS Pathog
, vol.9
-
-
Reiss, S.1
Harak, C.2
Romero-Brey, I.3
Radujkovic, D.4
Klein, R.5
Ruggieri, A.6
Rebhan, I.7
Bartenschlager, R.8
Lohmann, V.9
-
15
-
-
4644260669
-
Structure and function of the membrane anchor domain of hepatitis c virus nonstructural protein 5a
-
Penin, F.; Brass, V.; Appel, N.; Ramboarina, S.; Montserret, R.; Ficheux, D.; Blum, H.E.; Bartenschlager, R.; Moradpour, D. Structure and function of the membrane anchor domain of hepatitis c virus nonstructural protein 5a. J. Biol. Chem. 2004, 279, 40835–40843.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 40835-40843
-
-
Penin, F.1
Brass, V.2
Appel, N.3
Ramboarina, S.4
Montserret, R.5
Ficheux, D.6
Blum, H.E.7
Bartenschlager, R.8
Moradpour, D.9
-
16
-
-
10344221613
-
The ns5a protein of hepatitis c virus is a zinc metalloprotein
-
Tellinghuisen, T.L.; Marcotrigiano, J.; Gorbalenya, A.E.; Rice, C.M. The ns5a protein of hepatitis c virus is a zinc metalloprotein. J. Biol. Chem. 2004, 279, 48576–48587.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 48576-48587
-
-
Tellinghuisen, T.L.1
Marcotrigiano, J.2
Gorbalenya, A.E.3
Rice, C.M.4
-
17
-
-
84901598261
-
The crystal structure of ns5a domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors
-
Lambert, S.M.; Langley, D.R.; Garnett, J.A.; Angell, R.; Hedgethorne, K.; Meanwell, N.A.; Matthews, S.J. The crystal structure of ns5a domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors. Protein Sci. 2014, 23, 723–734.
-
(2014)
Protein Sci
, vol.23
, pp. 723-734
-
-
Lambert, S.M.1
Langley, D.R.2
Garnett, J.A.3
Angell, R.4
Hedgethorne, K.5
Meanwell, N.A.6
Matthews, S.J.7
-
18
-
-
66149115122
-
Crystal structure of a novel dimeric form of ns5a domain i protein from hepatitis c virus
-
Love, R.A.; Brodsky, O.; Hickey, M.J.; Wells, P.A.; Cronin, C.N. Crystal structure of a novel dimeric form of ns5a domain i protein from hepatitis c virus. J. Virol. 2009, 83, 4395–4403.
-
(2009)
J. Virol.
, vol.83
, pp. 4395-4403
-
-
Love, R.A.1
Brodsky, O.2
Hickey, M.J.3
Wells, P.A.4
Cronin, C.N.5
-
19
-
-
19644393931
-
Structure of the zinc-binding domain of an essential component of the hepatitis c virus replicase
-
Tellinghuisen, T.L.; Marcotrigiano, J.; Rice, C.M. Structure of the zinc-binding domain of an essential component of the hepatitis c virus replicase. Nature 2005, 435, 374–379.
-
(2005)
Nature
, vol.435
, pp. 374-379
-
-
Tellinghuisen, T.L.1
Marcotrigiano, J.2
Rice, C.M.3
-
20
-
-
77958037203
-
The domain 2 of the hcv ns5a protein is intrinsically unstructured
-
Hanoulle, X.; Badillo, A.; Verdegem, D.; Penin, F.; Lippens, G. The domain 2 of the hcv ns5a protein is intrinsically unstructured. Protein Pept. Lett. 2010, 17, 1012–1018.
-
(2010)
Protein Pept. Lett.
, vol.17
, pp. 1012-1018
-
-
Hanoulle, X.1
Badillo, A.2
Verdegem, D.3
Penin, F.4
Lippens, G.5
-
21
-
-
62649145466
-
Domain 3 of non-structural protein 5a from hepatitis c virus is natively unfolded
-
Hanoulle, X.; Verdegem, D.; Badillo, A.; Wieruszeski, J.M.; Penin, F.; Lippens, G. Domain 3 of non-structural protein 5a from hepatitis c virus is natively unfolded. Biochem. Biophys. Res. Commun. 2009, 381, 634–638.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.381
, pp. 634-638
-
-
Hanoulle, X.1
Verdegem, D.2
Badillo, A.3
Wieruszeski, J.M.4
Penin, F.5
Lippens, G.6
-
22
-
-
4544336360
-
Hepatitis c virus ns5a: Tales of a promiscuous protein
-
Macdonald, A.; Harris, M. Hepatitis c virus ns5a: Tales of a promiscuous protein. J. Gen. Virol. 2004, 85, 2485–2502.
-
(2004)
J. Gen. Virol.
, vol.85
, pp. 2485-2502
-
-
Macdonald, A.1
Harris, M.2
-
23
-
-
84952980130
-
Targeting the ns5a protein of hcv: An emerging option
-
Cordek, D.G.; Bechtel, J.T.; Maynard, A.T.; Kazmierski, W.M.; Cameron, C.E. Targeting the ns5a protein of hcv: An emerging option. Drugs Futur. 2011, 36, 691–711.
-
(2011)
Drugs Futur
, vol.36
, pp. 691-711
-
-
Cordek, D.G.1
Bechtel, J.T.2
Maynard, A.T.3
Kazmierski, W.M.4
Cameron, C.E.5
-
24
-
-
55549117151
-
Hepatitis c virus infection protein network
-
De Chassey, B.; Navratil, V.; Tafforeau, L.; Hiet, M.S.; Aublin-Gex, A.; Agaugue, S.; Meiffren, G.; Pradezynski, F.; Faria, B.F.; Chantier, T. et al. Hepatitis c virus infection protein network. Mol. Syst. Biol. 2008, 4, 230.
-
(2008)
Mol. Syst. Biol.
, vol.4
, pp. 230
-
-
De Chassey, B.1
Navratil, V.2
Tafforeau, L.3
Hiet, M.S.4
Aublin-Gex, A.5
Agaugue, S.6
Meiffren, G.7
Pradezynski, F.8
Faria, B.F.9
Chantier, T.10
-
25
-
-
84871790760
-
Hepatitis c virus ns5b and host cyclophilin a share a common binding site on ns5a
-
Rosnoblet, C.; Fritzinger, B.; Legrand, D.; Launay, H.; Wieruszeski, J.M.; Lippens, G.; Hanoulle, X. Hepatitis c virus ns5b and host cyclophilin a share a common binding site on ns5a. J. Biol. Chem. 2012, 287, 44249–44260.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 44249-44260
-
-
Rosnoblet, C.1
Fritzinger, B.2
Legrand, D.3
Launay, H.4
Wieruszeski, J.M.5
Lippens, G.6
Hanoulle, X.7
-
26
-
-
78149434641
-
Deb025 (alisporivir) inhibits hepatitis c virus replication by preventing a cyclophilin a induced cis-trans isomerisation in domain ii of ns5a
-
Coelmont, L.; Hanoulle, X.; Chatterji, U.; Berger, C.; Snoeck, J.; Bobardt, M.; Lim, P.; Vliegen, I.; Paeshuyse, J.; Vuagniaux, G. et al. Deb025 (alisporivir) inhibits hepatitis c virus replication by preventing a cyclophilin a induced cis-trans isomerisation in domain ii of ns5a. PLoS One 2010, 5, e13687.
-
(2010)
PLoS One
, vol.5
-
-
Coelmont, L.1
Hanoulle, X.2
Chatterji, U.3
Berger, C.4
Snoeck, J.5
Bobardt, M.6
Lim, P.7
Vliegen, I.8
Paeshuyse, J.9
Vuagniaux, G.10
-
27
-
-
84882870729
-
Characterizations of HCV NS5a replication complex inhibitors
-
O'Boyle Ii, D.R.; Sun, J.H.; Nower, P.T.; Lemm, J.A.; Fridell, R.A.; Wang, C.; Romine, J.L.; Belema, M.; Nguyen, V.N.; Laurent, D.R. et al. Characterizations of HCV NS5a replication complex inhibitors. Virology 2013, 444, 343–354.
-
(2013)
Virology
, vol.444
, pp. 343-354
-
-
O'Boyle Ii, D.R.1
Sun, J.H.2
Nower, P.T.3
Lemm, J.A.4
Fridell, R.A.5
Wang, C.6
Romine, J.L.7
Belema, M.8
Nguyen, V.N.9
Laurent, D.R.10
-
28
-
-
84899059740
-
Potent hepatitis c inhibitors bind directly to NS5a and reduce its affinity for RNA
-
Ascher, D.B.; Wielens, J.; Nero, T.L.; Doughty, L.; Morton, C.J.; Parker, M.W. Potent hepatitis c inhibitors bind directly to NS5a and reduce its affinity for RNA. Sci. Rep. 2014, 4, 4765.
-
(2014)
Sci. Rep.
, vol.4
, pp. 4765
-
-
Ascher, D.B.1
Wielens, J.2
Nero, T.L.3
Doughty, L.4
Morton, C.J.5
Parker, M.W.6
-
29
-
-
80053951840
-
The effects of NS5a inhibitors on NS5a phosphorylation, polyprotein processing and localization
-
Qiu, D.; Lemm, J.A.; O’Boyle, D.R., II; Sun, J.H.; Nower, P.T.; Nguyen, V.; Hamann, L.G.; Snyder, L.B.; Deon, D.H.; Ruediger, E. et al. The effects of NS5a inhibitors on NS5a phosphorylation, polyprotein processing and localization. J. Gen. Virol. 2011, 92, 2502–2511.
-
(2011)
J. Gen. Virol.
, vol.92
, pp. 2502-2511
-
-
Qiu, D.1
Lemm, J.A.2
O’boyle, D.R.3
Sun, J.H.4
Nower, P.T.5
Nguyen, V.6
Hamann, L.G.7
Snyder, L.B.8
Deon, D.H.9
Ruediger, E.10
-
30
-
-
84908295905
-
Daclatasvir-like inhibitors of NS5a block early biogenesis of hepatitis c virus-induced membranous replication factories, independent of RNA replication
-
Berger, C.; Romero-Brey, I.; Radujkovic, D.; Terreux, R.; Zayas, M.; Paul, D.; Harak, C.; Hoppe, S.; Gao, M.; Penin, F. et al. Daclatasvir-like inhibitors of NS5a block early biogenesis of hepatitis c virus-induced membranous replication factories, independent of RNA replication. Gastroenterology 2014, 147, 1094–1105.e25.
-
(2014)
Gastroenterology
, vol.147
, pp. 1094-1105.e25
-
-
Berger, C.1
Romero-Brey, I.2
Radujkovic, D.3
Terreux, R.4
Zayas, M.5
Paul, D.6
Harak, C.7
Hoppe, S.8
Gao, M.9
Penin, F.10
-
31
-
-
84904730378
-
Kinetic analyses reveal potent and early blockade of hepatitis c virus assembly by NS5a inhibitors
-
McGivern, D.R.; Masaki, T.; Williford, S.; Ingravallo, P.; Feng, Z.; Lahser, F.; Asante-Appiah, E.; Neddermann, P.; De Francesco, R.; Howe, A.Y. et al. Kinetic analyses reveal potent and early blockade of hepatitis c virus assembly by NS5a inhibitors. Gastroenterology 2014, 147, 453–462.e7.
-
(2014)
Gastroenterology
, vol.147
, pp. 453-462.e7
-
-
McGivern, D.R.1
Masaki, T.2
Williford, S.3
Ingravallo, P.4
Feng, Z.5
Lahser, F.6
Asante-Appiah, E.7
Neddermann, P.8
De Francesco, R.9
Howe, A.Y.10
-
32
-
-
84880929503
-
Understanding triphasic HCV decline during treatment in the era of il28b polymorphisms and direct acting antiviral agents via mathematical modeling
-
Dahari, H.; Cotler, S.J.; Layden, T.J.; Perelson, A.S. Understanding triphasic HCV decline during treatment in the era of il28b polymorphisms and direct acting antiviral agents via mathematical modeling. J. Hepatol. 2013, 58, 840–842.
-
(2013)
J. Hepatol.
, vol.58
, pp. 840-842
-
-
Dahari, H.1
Cotler, S.J.2
Layden, T.J.3
Perelson, A.S.4
-
33
-
-
84874644131
-
Modeling shows that the NS5a inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis c virus half-life
-
Guedj, J.; Dahari, H.; Rong, L.; Sansone, N.D.; Nettles, R.E.; Cotler, S.J.; Layden, T.J.; Uprichard, S.L.; Perelson, A.S. Modeling shows that the NS5a inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis c virus half-life. Proc. Natl. Acad. Sci. USA 2013, 110, 3991–3996.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 3991-3996
-
-
Guedj, J.1
Dahari, H.2
Rong, L.3
Sansone, N.D.4
Nettles, R.E.5
Cotler, S.J.6
Layden, T.J.7
Uprichard, S.L.8
Perelson, A.S.9
-
34
-
-
82455192239
-
Genotypic and phenotypic analysis of variants resistant to hepatitis c virus nonstructural protein 5a replication complex inhibitor bms-790052 in humans: In vitro and in vivo correlations
-
Fridell, R.A.; Wang, C.; Sun, J.H.; O’Boyle, D.R., II; Nower, P.; Valera, L.; Qiu, D.; Roberts, S.; Huang, X.; Kienzle, B. et al. Genotypic and phenotypic analysis of variants resistant to hepatitis c virus nonstructural protein 5a replication complex inhibitor bms-790052 in humans: In vitro and in vivo correlations. Hepatology 2011, 54, 1924–1935.
-
(2011)
Hepatology
, vol.54
, pp. 1924-1935
-
-
Fridell, R.A.1
Wang, C.2
Sun, J.H.3
O’boyle, D.R.4
Nower, P.5
Valera, L.6
Qiu, D.7
Roberts, S.8
Huang, X.9
Kienzle, B.10
-
35
-
-
84876246624
-
Persistence of resistant variants in hepatitis c virus-infected patients treated with the NS5a replication complex inhibitor daclatasvir
-
Wang, C.; Sun, J.H.; O’Boyle, D.R., II; Nower, P.; Valera, L.; Roberts, S.; Fridell, R.A.; Gao, M. Persistence of resistant variants in hepatitis c virus-infected patients treated with the NS5a replication complex inhibitor daclatasvir. Antimicrob. Agents Chemother. 2013, 57, 2054–2065.
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 2054-2065
-
-
Wang, C.1
Sun, J.H.2
O’boyle, D.R.3
Nower, P.4
Valera, L.5
Roberts, S.6
Fridell, R.A.7
Gao, M.8
-
36
-
-
77956116880
-
Resistance analysis of the hepatitis c virus NS5a inhibitor bms-790052 in an in vitro replicon system
-
Fridell, R.A.; Qiu, D.; Wang, C.; Valera, L.; Gao, M. Resistance analysis of the hepatitis c virus NS5a inhibitor bms-790052 in an in vitro replicon system. Antimicrob. Agents Chemother. 2010, 54, 3641–3650.
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 3641-3650
-
-
Fridell, R.A.1
Qiu, D.2
Wang, C.3
Valera, L.4
Gao, M.5
-
37
-
-
72849113547
-
Identification of hepatitis c virus NS5a inhibitors
-
Lemm, J.A.; O’Boyle, D., II; Liu, M.; Nower, P.T.; Colonno, R.; Deshpande, M.S.; Snyder, L.B.; Martin, S.W.; St Laurent, D.R.; Serrano-Wu, M.H. et al. Identification of hepatitis c virus NS5a inhibitors. J. Virol. 2010, 84, 482–491.
-
(2010)
J. Virol.
, vol.84
, pp. 482-491
-
-
Lemm, J.A.1
O’boyle, D.2
Liu, M.3
Nower, P.T.4
Colonno, R.5
Deshpande, M.S.6
Snyder, L.B.7
Martin, S.W.8
St Laurent, D.R.9
Serrano-Wu, M.H.10
-
38
-
-
84896055529
-
Approaches to hepatitis c treatment and cure using NS5a inhibitors
-
Kohler, J.J.; Nettles, J.H.; Amblard, F.; Hurwitz, S.J.; Bassit, L.; Stanton, R.A.; Ehteshami, M.; Schinazi, R.F. Approaches to hepatitis c treatment and cure using NS5a inhibitors. Infect. Drug Resist. 2014, 7, 41–56.
-
(2014)
Infect. Drug Resist.
, vol.7
, pp. 41-56
-
-
Kohler, J.J.1
Nettles, J.H.2
Amblard, F.3
Hurwitz, S.J.4
Bassit, L.5
Stanton, R.A.6
Ehteshami, M.7
Schinazi, R.F.8
-
39
-
-
84901687280
-
Hepatitis c NS5a protein: Two drug targets within the same protein with different mechanisms of resistance
-
Lim, P.J.; Gallay, P.A. Hepatitis c NS5a protein: Two drug targets within the same protein with different mechanisms of resistance. Curr. Opin. Virol. 2014, 8C, 30–37.
-
(2014)
Curr. Opin. Virol.
, vol.8C
, pp. 30-37
-
-
Lim, P.J.1
Gallay, P.A.2
-
40
-
-
84901278663
-
The combination of alisporivir plus an NS5a inhibitor provides additive to synergistic anti-hepatitis c virus activity without detectable cross-resistance
-
Chatterji, U.; Garcia-Rivera, J.A.; Baugh, J.; Gawlik, K.; Wong, K.A.; Zhong, W.; Brass, C.A.; Naoumov, N.V.; Gallay, P.A. The combination of alisporivir plus an NS5a inhibitor provides additive to synergistic anti-hepatitis c virus activity without detectable cross-resistance. Antimicrob. Agents Chemother. 2014, 58, 3327–3334.
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 3327-3334
-
-
Chatterji, U.1
Garcia-Rivera, J.A.2
Baugh, J.3
Gawlik, K.4
Wong, K.A.5
Zhong, W.6
Brass, C.A.7
Naoumov, N.V.8
Gallay, P.A.9
-
41
-
-
84873978406
-
Profile of alisporivir and its potential in the treatment of hepatitis c
-
Gallay, P.A.; Lin, K. Profile of alisporivir and its potential in the treatment of hepatitis c. Drug Des. Dev. Ther. 2013, 7, 105–115.
-
(2013)
Drug Des. Dev. Ther.
, vol.7
, pp. 105-115
-
-
Gallay, P.A.1
Lin, K.2
-
42
-
-
78649447153
-
Il28b polymorphisms and chronic hepatitis c
-
Chevaliez, S.; Hezode, C. Il28b polymorphisms and chronic hepatitis c. Gastroenterol. Clin. Biol. 2010, 34, 587–589.
-
(2010)
Gastroenterol. Clin. Biol.
, vol.34
, pp. 587-589
-
-
Chevaliez, S.1
Hezode, C.2
-
43
-
-
64249090485
-
Pegylated interferon-alpha-based treatment for chronic hepatitis c in renal transplant recipients: An open pilot study
-
Pageaux, G.P.; Hilleret, M.N.; Garrigues, V.; Bismuth, M.; Audin-Mamlouk, H.; Zarski, J.P.; Mourad, G. Pegylated interferon-alpha-based treatment for chronic hepatitis c in renal transplant recipients: An open pilot study. Transpl. Int. 2009, 22, 562–567.
-
(2009)
Transpl. Int.
, vol.22
, pp. 562-567
-
-
Pageaux, G.P.1
Hilleret, M.N.2
Garrigues, V.3
Bismuth, M.4
Audin-Mamlouk, H.5
Zarski, J.P.6
Mourad, G.7
-
44
-
-
84871244927
-
Boceprevir: A review of its use in the management of genotype 1 chronic hepatitis c
-
Garnock-Jones, K. Boceprevir: A review of its use in the management of genotype 1 chronic hepatitis c. Drugs 2012, 72, 2431–2456.
-
(2012)
Drugs
, vol.72
, pp. 2431-2456
-
-
Garnock-Jones, K.1
-
45
-
-
84858779357
-
Telaprevir: A review of its use in the management of genotype 1 chronic hepatitis c
-
Perry, C.M. Telaprevir: A review of its use in the management of genotype 1 chronic hepatitis c. Drugs 2012, 72, 619–641.
-
(2012)
Drugs
, vol.72
, pp. 619-641
-
-
Perry, C.M.1
-
46
-
-
79952296871
-
Recombinant HCV variants with NS5a from genotypes 1-7 have different sensitivities to an NS5a inhibitor but not interferon-alpha
-
Scheel, T.K.; Gottwein, J.M.; Mikkelsen, L.S.; Jensen, T.B.; Bukh, J. Recombinant HCV variants with NS5a from genotypes 1-7 have different sensitivities to an NS5a inhibitor but not interferon-alpha. Gastroenterology 2011, 140, 1032–1042.
-
(2011)
Gastroenterology
, vol.140
, pp. 1032-1042
-
-
Scheel, T.K.1
Gottwein, J.M.2
Mikkelsen, L.S.3
Jensen, T.B.4
Bukh, J.5
-
47
-
-
84906087908
-
Comparison of daclatasvir resistance barrier on NS5a from HCV genotypes 1–6: Implications for cross-genotype activity
-
Wang, C.; Jia, L.; O’Boyle, D.R., II; Sun, J.H.; Rigat, K.; Valera, L.; Nower, P.; Huang, X.; Kienzle, B.; Roberts, S. et al. Comparison of daclatasvir resistance barrier on NS5a from HCV genotypes 1–6: Implications for cross-genotype activity. Antimicrob. Agents Chemother. 2014, 58, 5155–5163.
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 5155-5163
-
-
Wang, C.1
Jia, L.2
O’boyle, D.R.3
Sun, J.H.4
Rigat, K.5
Valera, L.6
Nower, P.7
Huang, X.8
Kienzle, B.9
Roberts, S.10
-
48
-
-
79960390342
-
Distinct functions of NS5a in hepatitis c virus RNA replication uncovered by studies with the NS5a inhibitor bms-790052
-
Fridell, R.A.; Qiu, D.; Valera, L.; Wang, C.; Rose, R.E.; Gao, M. Distinct functions of NS5a in hepatitis c virus RNA replication uncovered by studies with the NS5a inhibitor bms-790052. J. Virol. 2011, 85, 7312–7320.
-
(2011)
J. Virol.
, vol.85
, pp. 7312-7320
-
-
Fridell, R.A.1
Qiu, D.2
Valera, L.3
Wang, C.4
Rose, R.E.5
Gao, M.6
-
49
-
-
84872021404
-
In vitro activity of daclatasvir on hepatitis c virus genotype 3 NS5a
-
Wang, C.; Valera, L.; Jia, L.; Kirk, M.J.; Gao, M.; Fridell, R.A. In vitro activity of daclatasvir on hepatitis c virus genotype 3 NS5a. Antimicrob. Agents Chemother. 2013, 57, 611–613.
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 611-613
-
-
Wang, C.1
Valera, L.2
Jia, L.3
Kirk, M.J.4
Gao, M.5
Fridell, R.A.6
-
50
-
-
84863156581
-
In vitro activity of bms-790052 on hepatitis c virus genotype 4 NS5a. ns5a
-
Wang, C.; Jia, L.; Huang, H.; Qiu, D.; Valera, L.; Huang, X.; Sun, J.H.; Nower, P.T.; O’Boyle, D.R., II; Gao, M. et al. In vitro activity of bms-790052 on hepatitis c virus genotype 4 NS5a. ns5a. Antimicrob. Agents Chemother. 2012, 56, 1588–1590.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 1588-1590
-
-
Wang, C.1
Jia, L.2
Huang, H.3
Qiu, D.4
Valera, L.5
Huang, X.6
Sun, J.H.7
Nower, P.T.8
O’boyle, D.R.9
Gao, M.10
-
51
-
-
84908690704
-
-
version 5.5.8; Biomatters Ltd: Auckland, New Zealand
-
Geneious Basic, version 5.5.8; Biomatters Ltd: Auckland, New Zealand, 2012.
-
(2012)
Geneious Basic
-
-
-
52
-
-
84889888952
-
Discovery of mk-8742: An HCV NS5a inhibitor with broad genotype activity
-
Coburn, C.A.; Meinke, P.T.; Chang, W.; Fandozzi, C.M.; Graham, D.J.; Hu, B.; Huang, Q.; Kargman, S.; Kozlowski, J.; Liu, R. et al. Discovery of mk-8742: An HCV NS5a inhibitor with broad genotype activity. ChemMedChem 2013, 8, 1930–1940.
-
(2013)
ChemMedChem
, vol.8
, pp. 1930-1940
-
-
Coburn, C.A.1
Meinke, P.T.2
Chang, W.3
Fandozzi, C.M.4
Graham, D.J.5
Hu, B.6
Huang, Q.7
Kargman, S.8
Kozlowski, J.9
Liu, R.10
-
53
-
-
84923332243
-
A refined model of the HCV NS5a protein bound to daclatasvir explains drug-resistant mutations and activity against divergent genotypes
-
Barakat, K.H.; Anwar-Mohamed, A.; Tuszynski, J.A.; Robins, M.J.; Tyrrell, D.L.; Houghton, M. A refined model of the HCV NS5a protein bound to daclatasvir explains drug-resistant mutations and activity against divergent genotypes. J. Chem. Inf. Model. 2014, doi:10.1021/ci400631n.
-
(2014)
J. Chem. Inf. Model
-
-
Barakat, K.H.1
Anwar-Mohamed, A.2
Tuszynski, J.A.3
Robins, M.J.4
Tyrrell, D.L.5
Houghton, M.6
-
54
-
-
84901378315
-
A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis c viral fitness and drug sensitivity
-
Qi, H.; Olson, C.A.; Wu, N.C.; Ke, R.; Loverdo, C.; Chu, V.; Truong, S.; Remenyi, R.; Chen, Z.; Du, Y. et al. A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis c viral fitness and drug sensitivity. PLoS Pathog. 2014, 10, e1004064.
-
(2014)
PLoS Pathog
, vol.10
-
-
Qi, H.1
Olson, C.A.2
Wu, N.C.3
Ke, R.4
Loverdo, C.5
Chu, V.6
Truong, S.7
Remenyi, R.8
Chen, Z.9
Du, Y.10
-
55
-
-
84867398802
-
The distinct contributions of fitness and genetic barrier to the development of antiviral drug resistance
-
Gotte, M. The distinct contributions of fitness and genetic barrier to the development of antiviral drug resistance. Curr. Opin. Virol. 2012, 2, 644–650.
-
(2012)
Curr. Opin. Virol.
, vol.2
, pp. 644-650
-
-
Gotte, M.1
-
56
-
-
84855509792
-
Contribution of a mutational bias in hepatitis c virus replication to the genetic barrier in the development of drug resistance
-
Powdrill, M.H.; Tchesnokov, E.P.; Kozak, R.A.; Russell, R.S.; Martin, R.; Svarovskaia, E.S.; Mo, H.; Kouyos, R.D.; Gotte, M. Contribution of a mutational bias in hepatitis c virus replication to the genetic barrier in the development of drug resistance. Proc. Natl. Acad. Sci. USA 2011, 108, 20509–20513.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 20509-20513
-
-
Powdrill, M.H.1
Tchesnokov, E.P.2
Kozak, R.A.3
Russell, R.S.4
Martin, R.5
Svarovskaia, E.S.6
Mo, H.7
Kouyos, R.D.8
Gotte, M.9
-
57
-
-
84892761609
-
Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and bms-791325 in treatment-naive patients with HCV genotype 1 infection
-
Everson, G.T.; Sims, K.D.; Rodriguez-Torres, M.; Hezode, C.; Lawitz, E.; Bourliere, M.; Loustaud-Ratti, V.; Rustgi, V.; Schwartz, H.; Tatum, H. et al. Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and bms-791325 in treatment-naive patients with HCV genotype 1 infection. Gastroenterology 2014, 146, 420–429.
-
(2014)
Gastroenterology
, vol.146
, pp. 420-429
-
-
Everson, G.T.1
Sims, K.D.2
Rodriguez-Torres, M.3
Hezode, C.4
Lawitz, E.5
Bourliere, M.6
Loustaud-Ratti, V.7
Rustgi, V.8
Schwartz, H.9
Tatum, H.10
-
58
-
-
84892619580
-
Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection
-
Sulkowski, M.S.; Gardiner, D.F.; Rodriguez-Torres, M.; Reddy, K.R.; Hassanein, T.; Jacobson, I.; Lawitz, E.; Lok, A.S.; Hinestrosa, F.; Thuluvath, P.J. et al. Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N. Engl. J. Med. 2014, 370, 211–221.
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 211-221
-
-
Sulkowski, M.S.1
Gardiner, D.F.2
Rodriguez-Torres, M.3
Reddy, K.R.4
Hassanein, T.5
Jacobson, I.6
Lawitz, E.7
Lok, A.S.8
Hinestrosa, F.9
Thuluvath, P.J.10
-
62
-
-
84908667013
-
-
accessed on 3 November 2014
-
Bristol-Myers Squibb. A phase 3 evaluation of daclatasvir plus sofosbuvir in treatment-naïve and treatment-experienced chronic hepatitis c (genotype 1, 2, 3, 4, 5, or 6) subjects coinfected with human immunodeficiency virus (HIV). Available online: http://clinicaltrials.gov/ct2/show/NCT02032888 (accessed on 3 November 2014).
-
A phase 3 evaluation of daclatasvir plus sofosbuvir in treatment-naïve and treatment-experienced chronic hepatitis c (genotype 1, 2, 3, 4, 5, or 6) subjects coinfected with human immunodeficiency virus (HIV)
-
-
-
66
-
-
84908668961
-
-
accessed on 3 November 2014
-
US Food and Drug Administration. FDA approves first combination pill to treat hepatitis c. Available online: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm418365.htm (accessed on 3 November 2014).
-
FDA approves first combination pill to treat hepatitis c.
-
-
-
67
-
-
84900339263
-
Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection
-
Afdhal, N.; Zeuzem, S.; Kwo, P.; Chojkier, M.; Gitlin, N.; Puoti, M.; Romero-Gomez, M.; Zarski, J.P.; Agarwal, K.; Buggisch, P. et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N. Engl. J. Med. 2014, 370, 1889–1898.
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 1889-1898
-
-
Afdhal, N.1
Zeuzem, S.2
Kwo, P.3
Chojkier, M.4
Gitlin, N.5
Puoti, M.6
Romero-Gomez, M.7
Zarski, J.P.8
Agarwal, K.9
Buggisch, P.10
-
75
-
-
84908674537
-
-
accessed on 3 November 2014
-
Theravance Biopharma Antibiotics Inc. Theravance Biopharma R & D, I. A double-blinded, randomized, placebo-controlled, multiple dose study to evaluate the safety, tolerability, pharmacokinetic, and antiviral activity of td-6450, a NS5a inhibitor, in treatment naïve subjects with genotype 1, 2 or 3 chronic hepatitis c virus (HCV). Available online: http://clinicaltrials.gov/ct2/show/NCT02116543 (accessed on 3 November 2014).
-
Theravance Biopharma R & D, I. A double-blinded, randomized, placebo-controlled, multiple dose study to evaluate the safety, tolerability, pharmacokinetic, and antiviral activity of td-6450, a NS5a inhibitor, in treatment naïve subjects with genotype 1, 2 or 3 chronic hepatitis c virus (HCV)
-
-
-
76
-
-
84908690700
-
Td-6450, a heterodimeric HCV NS5a inhibitor with a high barrier to resistance and pan-genotypic potency
-
HI, USA, 8–12 December
-
Budman, J.; Waltman, C.E.; Krey-Epstein, W.; Chang, R.; Smith, S.; Amrite, A.; Mammen, M.; McKinnell, M. Td-6450, a heterodimeric HCV NS5a inhibitor with a high barrier to resistance and pan-genotypic potency. In Proceedings of HEPDART 2013: Frontiers in Drug Development for Viral Hepatitis, Conference Reports for NATAP: Big Island, HI, USA, 8–12 December 2013.
-
(2013)
Proceedings of HEPDART 2013: Frontiers in Drug Development for Viral Hepatitis, Conference Reports for NATAP: Big Island
-
-
Budman, J.1
Waltman, C.E.2
Krey-Epstein, W.3
Chang, R.4
Smith, S.5
Amrite, A.6
Mammen, M.7
McKinnell, M.8
-
77
-
-
84908665804
-
-
accessed on 3 November 2014
-
Janssen R&D Ireland. A phase ib, randomized, double-blind, placebo-controlled trial in asian genotype 1 chronic HCV-infected subjects to determine the safety, tolerability, pharmacokinetics and antiviral activity of repeated doses of jnj-47910382 given in different doses and dose regimens. Available online: http://clinicaltrials.gov/ct2/show/NCT01586325 (accessed on 3 November 2014).
-
A phase ib, randomized, double-blind, placebo-controlled trial in asian genotype 1 chronic HCV-infected subjects to determine the safety, tolerability, pharmacokinetics and antiviral activity of repeated doses of jnj-47910382 given in different doses and dose regimens
-
-
|