Drooling in Parkinson's disease: A review

Parkinsonism and Related Disorders

Volumn 20, Issue 11, 2014, Pages 1109-1118

  Srivanitchapoom, Prachaya ^a,b   Pandey, Sanjay ^b,c   Hallett, Mark ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c G B PANT HOSPITAL   (India)

Author keywords

Botulinum toxin; Drooling; Parkinson's disease; Sialorrhea

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR; ATROPINE; BOTULINUM TOXIN A; BOTULINUM TOXIN B; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; GLYCOPYRRONIUM BROMIDE; IPRATROPIUM BROMIDE; MODAFINIL;

BEHAVIOR MODIFICATION; BRAIN DEPTH STIMULATION; CHEWING GUM; CLINICAL ASSESSMENT TOOL; DISEASE ASSOCIATION; DISEASE SEVERITY; DROOLING RATING SCALE; DROOLING SEVERITY AND FREQUENCY SCALE; DRUG EFFICACY; EMOTIONAL STRESS; HUMAN; HYPERSALIVATION; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NEUROPATHOLOGY; NONHUMAN; PARKINSON DISEASE; PATHOPHYSIOLOGY; PREVALENCE; QUALITY OF LIFE; RADIATION DOSE; REVIEW; SALIVARY CLEARANCE; SALIVARY GLAND FUNCTION; SALIVATION; SIALORRHEA CLINICAL SCALE FOR PARKINSON DISEASE; SOCIAL STRESS; SWALLOWING; TREATMENT OUTCOME; UNIFIED PARKINSON DISEASE RATING SCALE; VISUAL ANALOG SCALE; COMPLICATION; SIALORRHEA;

HUMANS; PARKINSON DISEASE; SIALORRHEA;

EID: 84908612839     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2014.08.013     Document Type: Review

References (72)

1. Dand P., Sakel M. The management of drooling in motor neuron disease. Int J Palliat Nurs 2010, 16:560-564.
2. Edwards L.L., Pfeiffer R.F., Quigley E.M.M., Hofman R., Balluff M. Gastrointestinal symptoms in Parkinson's disease. Mov Disord 1991, 6:151-156.
3. Scott B., Borgman A., Engler H., Johnels B., Aquilonius S.M. Gender differences in Parkinson's disease symptom profile. Acta Neurol Scand 2000, 102:37-43.
4. Volonté M.A., Porta M., Comi G. Clinical assessment of dysphagia in early phases of Parkinson's disease. Neurol Sci 2002, 23:S121-S122.
5. Siddiqui M.F., Rast S., Lynn M.J., Auchus A.P., Pfeiffer R.F. Autonomic dysfunction in Parkinson's disease: a comprehensive symptom survey. Parkinsonism Relat Disord 2002, 8:277-284.
6. Kalf J.G., Smit A.M., Bloem B.R., Zwarts M.J., Munneke M. Impact of drooling in Parkinson's disease. JNeurol 2007, 254:1227-1232.
7. Verbaan D., Marinus J., Visser M., van Rooden S.M., Stiggelbout A.M., van Hilten J.J. Patient-reported autonomic symptoms in Parkinson disease. Neurology 2007, 69:333-341.
8. Martinez-Martin P., Schapira A., Stocchi F., Sethi K., Odin P., MacPhee G., et al. Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; study using nonmotor symptoms questionnaire in 545 patients. Mov Disord 2007, 22:1623-1629.
9. Denise Hack Nicaretta D.H., de Rosso A.L.Z., Maliska C., Costa M.M.B. Scintigraphic analysis of the parotid glands in patients with sialorrhea and Parkinson's disease. Parkinsonism Relat Disord 2008, 14:338-341.
10. Cheon S.M., Ha M.S., Park M.J., Kim J.W. Nonmotor symptoms of Parkinson's disease: prevalence and awareness of patients and families. Parkinsonism Relat Disord 2008, 14:286-290.
11. Leibner J., Ramjit A., Sedig L., Dai Y.F., Wu S.S., Jacobson C., et al. The impact of and the factors associated with drooling in Parkinson's disease. Parkinsonism Relat Disord 2010, 16:475-477.
12. Muller B., Larsen J.P., Wentzel-Larsen T., Skeie G.O., Tysnes O.B. Autonomic and sensory symptoms and signs in incident, untreated Parkinson's disease: frequent but mild. Mov Disord 2011, 26:65-72.
13. Perez-Lloret S., Ne'gre-Page's L., Ojero-Senard A., Damier P., Destée A., Tison F., et al. Oro buccal symptoms (dysphagia, dysarthria, and sialorrhea) in patients with Parkinson's disease: preliminary analysis from the French COPARK cohort. Eur J Neurol 2012, 19:28-37.
14. Rana A.Q., Yousuf M.S., Awan N., Fattah A. Impact of progression of Parkinson's disease on drooling in various ethnic groups. Eur Neurol 2012, 67:312-314.
15. Ozdilek B., Gunal D.I. Motor and non-motor symptoms in Turkish patients with Parkinson's disease affecting family caregiver burden and quality of life. JNeuropsychiatry Clin Neurosci 2012, 24:478-483.
16. Damian A., Adlerb C.H., Hentz J.G., Shill H.A., Caviness J.N., Sabbagh M.N., et al. Autonomic function, as self-reported on the SCOPA-autonomic questionnaire, is normal in essential tremor but not in Parkinson's disease. Parkinsonism Relat Disord 2012, 18:1089-1093.
17. Bloem B.R., Kalf J.G., van de Kerkhof P.C.M., Zwarts M.J. Debilitating consequences of drooling. JNeurol 2009, 256:1382-1383.
18. Einarsdóttir E.R., Gunnsteinsdóttir H., Hallsdóttir M.H., Sveinsson Sigurjón, Jónsdóttir S.R., O' lafsson V.G., et al. Dental health of patients with Parkinson's disease in Iceland. Spec Care Dent 2009, 29:123-127.
19. Nóbrega A.C., Rodrigues B., Melo A. Silent aspiration in Parkinson's disease patients with diurnal sialorrhea. Clin Neurol Neurosurg 2008, 110:117-119.
20. Rodrigues B., Nóbrega A.C., Sampaio M., Argolo N., Melo A. Silent saliva aspiration in Parkinson's disease. Mov Disord 2011, 26:138-141.
21. Nóbrega A.C., Rodrigues B., Melo A. Is silent aspiration a risk factor for respiratory infection in Parkinson's disease patients?. Parkinsonism Relat Disord 2008, 14:646-648.
22. Boyce W., Bakheet M.R. Areview of a vexing, often unrecognized sign of oropharyngeal and esophageal disease. JClin Gastroenterol 2005, 39:89-97.
23. Merello M. Sialorrhoea and drooling in patients with Parkinson's disease: epidemiology and management. Drugs Aging 2008, 25:1007-1019.
24. Cersosimo M.G., Benarroch E.E. Neural control of the gastrointestinal tract: implications for Parkinson disease. Mov Disord 2008, 23:1065-1075.
25. Bateson M., Gibberd F.B., Wilson R.S.E. Saliva symptoms in Parkinson disease. Arch Neurol 1973, 29:274-275.
26. Bagheri H., Damase-Michel C., Lapeyre-Mestre M., Cismondo S., O'Connell D., Senard J.M., et al. Astudy of salivary secretion in Parkinson's disease. Clin Neuropharmacol 1999, 22:213-215.
27. Proulx M., de Courval F.P., Wiseman M.A., Panisset M. Salivary production in Parkinson's disease. Mov Disord 2005, 20:204-207.
28. Marg S., Walz B., Blenau W. The effects of dopamine receptor agonists and antagonists on the secretory rate of cockroach (Periplaneta americana) salivary glands. JInsect Physiol 2004, 50:821-830.
29. Koga T., Kobashi M., Mizutani M., Tsukamoto G., Matsuo R. Area postrema mediates gastric motor response induced by apomorphine in rats. Brain Res 2003, 960:122-131.
30. Pazo J.H., Belforte J.E. Basal ganglia and functions of the autonomic nervous system. Cell Mol Neurobiol 2002, 22:645-654.
31. Del Tredici K., Hawkes C.H., Ghebremedhin E., Braak H. Lewy pathology in the submandibular gland of individuals with incidental lewy body disease and sporadic Parkinson's disease. Acta Neuropathol 2010, 119:703-713.
32. Nicaretta D.H., de Rosso A.L., Maliska C., Costa M.M. Scintigraphic analysis of the parotid glands in patients with sialorrhea and Parkinson's disease. Parkinsonism Relat Disord 2008, 14:338-341.
33. Ciucci M.R., Russell J.A., Schaser A.J., Doll E.J., Vinney L.M., Connor N.P. Tongue force and timing deficits in a rat model of Parkinson disease. Behav Brain Res 2011, 222:315-320.
34. Umemoto G., Tsuboi Y., Kitashima A., Furuya H., Kikuta T. Impaired food transportation in Parkinson's disease related to lingual bradykinesia. Dysphagia 2011, 26:250-255.
35. Russell J.A., Ciucci M.R., Hammer M.J., Connor N.P. Videofluorographic assessment of deglutitive behaviors in a rat model of aging and Parkinson disease. Dysphagia 2013, 28:95-104.
36. Nóbrega A.C., Rodrigues B., Torres A.C., Scarpel R.D., Neves C.A., Melo A. Is drooling secondary to a swallowing disorder in patients with Parkinson's disease?. Parkinsonism Relat Disord 2008, 14:243-245.
37. Ali G.N., Wallace K.L., Schwartz R., DeCarle D.J., Zagami A.S., Cook I.J. Mechanisms of oral-pharyngeal dysphagia in patients with Parkinson's disease. Gastroenterology 1996, 110:383-392.
38. Sung H.Y., Kim J.S., Lee K.S., Kim Y.I., Song I.U., Chung S.W., et al. The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease. Mov Disord 2010, 25:2361-2368.
39. Kalf J.G., Munneke M., van den Engel-Hoek L., de Swart B.J., Borm G.F., Bloem B.R., et al. Pathophysiology of diurnal drooling in Parkinson's disease. Mov Disord 2011, 26:1670-1676.
40. Evatt M.L., Chaudhuri K.R., Chou K.L., Cubo E., Hinson V., Kompoliti K., et al. Dysautonomia rating scales in Parkinson's disease: sialorrhea, dysphagia, and constipation-critique and recommendations by movement disorders task force on rating scales for Parkinson's disease. Mov Disord 2009, 24:635-646.
41. Nilsson H., Ekberg O., Olsson R., Hindfelt B. Quantitative assessment of oral and pharyngeal function in Parkinson's disease. Dysphagia 1996, 11:144-150.
42. Johnston B.T., Li Q., Castell J.A., Castell D.O. Swallowing and esophageal function in Parkinson's disease. Am J Gastroenterol 1995, 90:1741-1746.
43. Nagaya M., Kachi T., Yamada T., Igata A. Videofluorographic study of swallowing in Parkinson's disease. Dysphagia 1998, 13:95-100.
44. Troche M.S., Sapienza C.M., Rosenbek J.C. Effects of bolus consistency on timing and safety of swallow in patients with Parkinson's disease. Dysphagia 2008, 23:26-32.
45. Hyson H.C., Johnson A.M., Jog M.S. Sublingual atropine for sialorrhea secondary to parkinsonism: a pilot study. Mov Disord 2002, 17:1318-1320.
46. Thomsen T.R., Galpern W.R., Asante A., Arenovich T., Fox S.H. Ipratropium bromide spray as treatment for sialorrhea in Parkinson's disease. Mov Disord 2007, 22:2268-2273.
47. Arbouw M.E., Movig K.L., Koopmann M., Poels P.J., Guchelaar H.J., Egberts T.C., et al. Glycopyrrolate for sialorrhea in Parkinson disease: a randomized, double-blind, crossover trial. Neurology 2010, 74:1203-1207.
48. Lloret S.P., Nano G., Carrosella A., Gamzu E., Merello M. Adouble-blind, placebo-controlled, randomized, crossover pilot study of the safety and efficacy of multiple doses of intra-oral tropicamide films for the short-term relief of sialorrhea symptoms in Parkinson's disease patients. JNeurol Sci 2011, 310:248-250.
49. Seppi K., Weintraub D., Coelho M., Perez-Lloret S., Fox S.H., Katzenschlager R., et al. The movement disorder society evidence-based medicine review update: treatments for the non-motor symptoms of Parkinson's disease. Mov Disord 2011, 26:S42-S80.
50. Davydov L., Botts S.R. Clozapine-induced hypersalivation. Ann Pharmacother 2000, 34:662-665.
51. Chatelut E., Rispail Y., Berlan M., Montastruc J.L. Yohimbine increases human salivary secretion. Br J Clin Pharmacol 1989, 28:366-368.
52. Chou K.L., Evatt M., Hinson V., Kompoliti K. Sialorrhea in Parkinson's disease: a review. Mov Disord 2007, 22:2306-2313.
53. Jost W.H. Treatment of drooling in Parkinson's disease with botulinum toxin. Mov Disord 1999, 14:1057-1059.
54. Pal P.K., Calne D.B., Calne S., Tsui J.K. Botulinum toxin A as treatment for drooling saliva in Parkinson's disease. Neurology 2000, 54:244-247.
55. Su C.S., Lan M.Y., Liu J.S., Chang C.C., Lai S.L., Wu H.S., et al. Botulinum toxin type A treatment for parkinsonian patients with moderate to severe sialorrhea. Acta Neurol Taiwan 2006, 15:170-176.
56. Santamato A., Ianieri G., Ranieri M., Megna M., Panza F., Fiore P., et al. Botulinum toxin type A in the treatment of sialorrhea in Parkinson's disease. JAm Geriatr Soc 2008, 56:765-767.
57. Friedman A., Potulska A. Quantitative assessment of parkinsonian sialorrhea and results of treatment with botulinum toxin. Parkinsonism Relat Disord 2001, 7:329-332.
58. Dogu O., Apaydin D., Sevim S., Talas D.U., Aral M. Ultrasound-guided versus 'blind' intraparotid injections of botulinum toxin-A for the treatment of sialorrhoea in patients with Parkinson's disease. Clin Neurol Neurosurg 2004, 106:93-96.
59. Lagalla G., Millevolte M., Capecci M., Provinciali L., Ceravolo M.G. Botulinum toxin type A for drooling in Parkinson's disease: a double-blind, randomized, placebo-controlled study. Mov Disord 2006, 21:704-707.
60. Nóbrega A.C., Rodrigues B., Torres A.C., Enzo A., Melo A. Does botulinum toxin decrease frequency and severity of sialorrhea in Parkinson's disease?. JNeurol Sci 2007, 253:85-87.
61. Lipp A., Trottenberg T., Schink T., Kupsch A., Arnold G. Arandomized trial of botulinum toxin A for the treatment of drooling. Neurology 2003, 61:1279-1281.
62. Mancini F., Zangaglia R., Cristina S., Sommaruga M.G., Martignoni E., Nappi G., et al. Double-blind, placebo-controlled study to evaluate the efficacy and safety of botulinum toxin type A in the treatment of drooling in parkinsonism. Mov Disord 2003, 18:685-688.
63. Racette B.A., Good L., Sagitto S., Perlmutter J.S. Botulinum toxin B reduces sialorrhea in parkinsonism. Mov Disord 2003, 18:1059-1061.
64. Contarino M.F., Pompili M., Tittoto P., Vanacore N., Sabatelli M., Cedrone A., et al. Botulinum toxin B ultrasound-guided injections for sialorrhea in amyotrophic lateral sclerosis and Parkinson's disease. Parkinsonism Relat Disord 2007, 13:299-303.
65. Ondo W.G., Hunter C., Moore W. Adouble-blind placebo-controlled trial of botulinum toxin B for sialorrhea in Parkinson's disease. Neurology 2004, 62:37-40.
66. Lagalla G., Millevolte M., Capecci M., Provinciali L., Ceravolo M.G. Long-lasting benefits of botulinum toxin type B in Parkinson's disease-related drooling. JNeurol 2009, 256:563-567.
67. Chinnapongse R., Gullo K., Nemeth P., Zhang Y., Griggs L. Safety and efficacy of botulinum toxin type B for treatment of sialorrhea in Parkinson's disease: a prospective double-blind trial. Mov Disord 2012, 27:219-226.
68. Guidubaldi A., Fasano A., Ialongo T., Piano C., Pompili M., Mascianà R., et al. Botulinum toxin A versus B in sialorrhea: a prospective, randomized, double-blind, crossover pilot study in patients with amyotrophic lateral sclerosis or Parkinson's disease. Mov Disord 2011, 26:313-319.
69. Marks L., Turner K., O'Sullivan J., Deighton B., Lees A. Drooling in Parkinson's disease: a novel speech and language therapy intervention. Int J Lang Commun Disord 2001, 36:282-287.
70. Postma A.G., Heesters M., van Laar T. Radiotherapy to the salivary glands as treatment of sialorrhea in patients with parkinsonism. Mov Disord 2007, 22:2430-2435.
71. Troche M.S., Brandimore A.E., Foote K.D., Okun M.S. Swallowing and deep brain stimulation in Parkinson's disease: a systematic review. Parkinsonism Relat Disord 2013, 19:783-788.
72. Troche M.S., Brandimore A.E., Foote K.D., Morishita T., Chen D., Hegland K.W., et al. Swallowing outcomes following unilateral STN vs. GPi surgery: a retrospective analysis. Dysphagia 2014, 29:425-431.