Zuo-Gui and You-Gui pills, two traditional Chinese herbal formulas, downregulated the expression of NogoA, NgR, and RhoA in rats with experimental autoimmune encephalomyelitis

Journal of Ethnopharmacology

Volumn 158, Issue PART A, 2014, Pages 102-112

  Kou, Shuang ^a,b   Zheng, Qi ^a   Wang, Yizhou ^a   Zhao, Hui ^a   Zhang, Qiuxia ^a   Li, Ming ^a   Qi, Fang ^a   Fang, Ling ^a   Liu, Lei ^a   Ouyang, Junyao ^a   Zhao, Haiyu ^b   Wang, Lei ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHINESE DRUG; HERBACEOUS AGENT; MYELIN BASIC PROTEIN; NEUROPROTECTIVE AGENT; PREDNISONE ACETATE; PROTEIN; PROTEIN NGR; PROTEIN NOGOA; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; YOU GUI PILL; ZUO GUI PILL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CAPILLARY; CHINESE MEDICINE; CONTROLLED STUDY; DEMYELINATION; DOWN REGULATION; DRUG MECHANISM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; HERBAL MEDICINE; HISTOLOGY; IMMUNIZATION; MITOCHONDRION; MYELIN SHEATH; NERVE FIBER; NEUROPROTECTION; NONHUMAN; PILL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPINAL CORD; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; WEIGHT REDUCTION; WESTERN BLOTTING; WHITE MATTER;

EID: 84908607235     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.10.007     Document Type: Article

References (39)

1. W.B. Cafferty, P. Duffy, E. Huebner, and S.M. Strittmatter MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma Journal of Neuroscience 30 2010 6825 6837
2. A.G. Dasilva, and V.W. Yong Expression and regulation of matrix metalloproteinase-12 in experimental autoimmune encephalomyelitis and by bone marrow derived macrophages in vitro Journal of Neuroimmunology 199 2008 24 34
3. Y.P. Fan, P. Wang, X.H. Zhang, H.Y. Gong, L. Zhou, X.Z. Liu, and L. Wang Treatment of relapsing multiple sclerosis with Erhuang Formula Journal of Beijing University on Traditional Chinese Medicine 29 273-276 2006 280
4. P. Fontoura, P.P. Ho, J. DeVoss, B. Zheng, B.J. Lee, B.A. Kidd, H. Garren, R.A. Sobel, W.H. Robinson, M. Tessier-Lavigne, and L. Steinman Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis Journal of Immunology 173 2004 6981 6992
5. P. Fontoura, and L. Steinman Nogo in multiple sclerosis: growing roles of a growth inhibitor Journal of the Neurological Sciences 245 2006 201 210
6. A.E. Fournier, T. GrandPre, and S.M. Strittmatter Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration Nature 409 2001 341 346
7. C. Gao, L. Huang, Y. Long, J. Zheng, J. Yang, S. Pu, and L. Xie Y-39983, a selective Rho-kinase inhibitor, attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination Neuroimmunomodulation 20 2013 334 340
8. P. Heraud, S. Caine, N. Campanale, T. Karnezis, D. McNaughton, B.R. Wood, M.J. Tobin, and C.C. Bernard Early detection of the chemical changes occurring during the induction and prevention of autoimmune-mediated demyelination detected by FT-IR imaging Neuroimage 49 2010 1180 1189
9. J. Herz, F. Zipp, and V. Siffrin Neurodegeneration in autoimmune CNS inflammation Experimental Neurology 225 2010 9 17
10. T. Karnezis, W. Mandemakers, J.L. McQualter, B. Zheng, P.P. Ho, K.A. Jordan, B.M. Murray, B. Barres, M. Tessier-Lavigne, and C.C. Bernard The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination Nature Neuroscience 7 2004 736 744
11. B.M. Keegan, and J.H. Noseworthy Multiple sclerosis Annual Review of Medicine 53 2002 285 302
12. S. Kou, Y.Z. Wang, M. Li, Q.F., Q. Zheng, H. Zhao, and L. Wang Effects of Zuogui Pill and Yougui Pill on expression of apoptosis protein fas and bax of brain tissue in rat with experimental autoimmune encephalomyelitis Journal of Liaoning University on Tradittion Medicine 13 2011 61 65
13. T. Kubo, and T. Yamashita Rho-ROCK inhibitors for the treatment of CNS injury Recent Patents on CNS Drug Discovery 2 2007 173 179
14. H. Lassmann Axonal and neuronal pathology in multiple sclerosis: what have we learnt from animal models Experimental Neurology 225 2010 2 8
15. J. Liu, Y. Gao, B.H. Kan, and L. Zhou Systematic review and meta-analysis of randomized controlled trials of Chinese herbal medicine in treatment of multiple sclerosis Journal of Chinese Integrative Medicine 10 2012 141 153
16. Y.S. Mao, C.Z. Lu, X. Wang, and B.G. Xiao Induction of experimental autoimmune encephalomyelitis in Lewis rats by a viral peptide with limited homology to myelin basic protein Experimental Neurology 206 2007 231 239
17. S. Mi, X. Lee, Z. Shao, G. Thill, B. Ji, J. Relton, M. Levesque, N. Allaire, S. Perrin, B. Sands, T. Crowell, R.L. Cate, J.M. McCoy, and R.B. Pepinsky LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex Nature Neuroscience 7 2004 221 228
18. P. Pifarre, M. Gutierrez-Mecinas, J. Prado, L. Usero, C. Roura-Mir, M. Giralt, J. Hidalgo, and A. Garcia Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions Experimental Neurology 251 2014 58 71
19. X.D. Qin, L.Y. Kang, Y. Liu, Y. Huang, S. Wang, and J.Q. Zhu Chinese medicines intervention effect on Nogo-A/NgR Evidence-Based Complementary and Alternative Medicine 2012 2012 528482 10.1155/2012/528482 (ID)
20. J. Satoh, H. Onoue, K. Arima, and T. Yamamura Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis Journal of Neuropathology and Experimental Neurology 64 2005 129 138
21. J. Satoh, H. Tabunoki, T. Yamamura, K. Arima, and H. Konno TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions Neuropathology and Applied Neurobiology 33 2007 99 107
22. S.B. Simmons, E.R. Pierson, S.Y. Lee, and J.M. Goverman Modeling the heterogeneity of multiple sclerosis in animals Trends in Immunology 34 2013 410 422
23. L.J. Song, and Y.P. Fan Influence of treatment based on syndrome differentiation mainly with tonifying the kidney on cytokines in plasm of multiple sclerosis at acute stage China Journal of Traditional Chinese Medicine and Pharmacy 25 2010 745 748
24. F.Y. Teng, and B.L. Tang Nogo signaling and non-physical injury-induced nervous system pathology Journal of Neuroscience Research. 79 2005 273 278
25. P. Theotokis, A. Lourbopoulos, O. Touloumi, R. Lagoudaki, E. Kofidou, E. Nousiopoulou, K.N. Poulatsidou, E. Kesidou, N. Tascos, E. Spandou, and N. Grigoriadis Time course and spatial profile of Nogo-A expression in experimental autoimmune encephalomyelitis in C57BL/6 mice Journal of Neuropathology and Experimental Neurology 71 2012 907 920
26. B.D. Trapp, and K.A. Nave Multiple sclerosis: an immune or neurodegenerative disorder Annual Review of Neuroscience 31 2008 247 269
27. A Van der Walt, H. Butzkueven, S. Kolbe, M. Marriott, E. Alexandrou, M. Gresle, G. Egan, and T. Kilpatrick Neuroprotection in multiple sclerosis: a therapeutic challenge for the next decade Pharmacology and Therapeutics 126 2010 82 93
28. K.C. Wang, J.A. Kim, R. Sivasankaran, R. Segal, and Z. He P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp Nature 420 2002 74 78
29. L. Wang, H. Zhao, Y.P. Fan, H.Y. Gong, M. Li, F. Qi, and Y. Liu Research on the mechanism of Zuogui Pill and Yougui Pill in promoting axonal regeneration in model rats of autoimmune encephalomyelitis Journal of Chinese Integrative Medicine 16 2010 167 172
30. Y.Z. Wang, S. Kou, L.Y. Gu, Q. Zheng, M. Li, F. Qi, H. Zhao, and L. Wang Effects of Zuogui Pill and Yougui Pill on the expression of brain-derived neurotrophic factor and cyclic adenosine monophosphate/protein kinase a signaling transduction pathways of axonal regeneration in model rats with experimental autoimmune encephalomyelitis Journal of Chinese Integrative Medicine 20 2014 24 30
31. L. Wang, Y.P. Fan, H.Y. Gong, M. Ye, L. Zhou, H. Zhao, Y. Mu, and X.Y. Yan Effect of Zuogui Pill and Yougui Pill on remyelination and axonal regeneration in rats with experimental allergic encephalomyelitis China Journal of Experimental Traditional Medical Formulae. 4 2008 42 45
32. Y.Z. Wang, S. Kou, C.C. Yan, Q. Zheng, Q. Zhang, H. Zhao, and L. Wang Effects of Zuogui Pill and Yougui Pill on the expression of APP and GAP-43 Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease 9 2011 1221 1224
33. A. Weaver, D.S.A. Goncalves, R.K. Nuttall, D.R. Edwards, S.D. Shapiro, S. Rivest, and V.W. Yong An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization The FASEB Journal 19 2005 1668 1670
34. S.Y. Xu, R.L. Bian, and X. Chen Methodology of Pharmacological Experiment 3rd 2005 Peoples Medicinal Publishing House Beijing 202 204
35. T. Yamashita, and M. Tohyama The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI Nature Neuroscience 6 2003 461 467
36. Y. Yang, Y. Liu, P. Wei, H. Peng, R. Winger, R.Z. Hussain, L.H. Ben, P.D. Cravens, A.R. Gocke, K. Puttaparthi, M.K. Racke, D.M. McTigue, and A.E. Lovett-Racke Silencing Nogo-A promotes functional recovery in demyelinating disease Annals of Neurology 67 2010 498 507
37. E. Zappia, S. Casazza, E. Pedemonte, F. Benvenuto, I. Bonanni, E. Gerdoni, D. Giunti, A. Ceravolo, F. Cazzanti, F. Frassoni, G. Mancardi, and A. Uccelli Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy Blood 106 2005 1755 1761
38. J. Zhang, E.G. Kramer, L. Asp, D.J. Dutta, K. Navrazhina, T. Pham, J.N. Mariani, A.T. Argaw, C.V. Melendez-Vasquez, and G.R. John Promoting myelin repair and return of function in multiple sclerosis FEBS Letters 585 2011 3813 3820
39. Z. Zhang, J. Schittenhelm, R. Meyermann, and H.J. Schluesener Lesional accumulation of RhoA(+) cells in brains of experimental autoimmune encephalomyelitis and multiple sclerosis Neuropathology and Applied Neurobiology 34 2008 231 240