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Volumn 9, Issue 10, 2014, Pages

Coxsackievirus A16 infection induces neural cell and non-neural cell apoptosis in vitro

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; PHOSPHATIDYLSERINE; CASPASE;

EID: 84908577205     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111174     Document Type: Article
Times cited : (20)

References (47)
  • 1
    • 0032493525 scopus 로고    scopus 로고
    • Deaths among children during an outbreak of hand, foot, and mouth disease-Taiwan, Republic of China, April-July 1998
    • inst United States Centers for Disease Control and Prevention
    • United States Centers for Disease Control and Prevention (1998) Deaths among children during an outbreak of hand, foot, and mouth disease-Taiwan, Republic of China, April-July 1998. MMWR Morb Mortal Wkly Rep 47: 629-632.
    • (1998) MMWR Morb Mortal Wkly Rep , vol.47 , pp. 629-632
  • 2
    • 0034458548 scopus 로고    scopus 로고
    • Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: Clinical and pathological characteristics of the disease
    • Chan LG, Parashar UD, Lye MS, Ong FG, Zaki SR, et al. (2000) Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group. Clin Infect Dis 31: 678-683.
    • (2000) For the Outbreak Study Group. Clin Infect Dis , vol.31 , pp. 678-683
    • Chan, L.G.1    Parashar, U.D.2    Lye, M.S.3    Ong, F.G.4    Zaki, S.R.5
  • 3
    • 0032879439 scopus 로고    scopus 로고
    • Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997-1998
    • Shimizu H, Utama A, Yoshii K, Yoshida H, Yoneyama T, et al. (1999) Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997-1998. Jpn J Infect Dis 52: 12.
    • (1999) Jpn J Infect Dis , vol.52 , pp. 12
    • Shimizu, H.1    Utama, A.2    Yoshii, K.3    Yoshida, H.4    Yoneyama, T.5
  • 4
    • 64549098243 scopus 로고    scopus 로고
    • Epidemiology and control of hand, foot and mouth disease in Singapore, 2001-2007
    • Ang LW, Koh BK, Chan KP, Chua LT, James L, et al. (2009) Epidemiology and control of hand, foot and mouth disease in Singapore, 2001-2007. Ann Acad Med Singapore 38: 106-112.
    • (2009) Ann Acad Med Singapore , vol.38 , pp. 106-112
    • Ang, L.W.1    Koh, B.K.2    Chan, K.P.3    Chua, L.T.4    James, L.5
  • 5
    • 69449088601 scopus 로고    scopus 로고
    • Genetic changes of coxsackievirus A16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in Toyama, Japan between 1981 and 2007
    • Iwai M, Masaki A, Hasegawa S, Obara M, Horimoto E, et al. (2009) Genetic changes of coxsackievirus A16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in Toyama, Japan between 1981 and 2007. Jpn J Infect Dis 62: 254-259.
    • (2009) Jpn J Infect Dis , vol.62 , pp. 254-259
    • Iwai, M.1    Masaki, A.2    Hasegawa, S.3    Obara, M.4    Horimoto, E.5
  • 6
    • 23744510743 scopus 로고    scopus 로고
    • Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People's Republic of China
    • Li L, He Y, Yang H, Zhu J, Xu X, et al. (2005) Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People's Republic of China. J Clin Microbiol 43: 3835-3839.
    • (2005) J Clin Microbiol , vol.43 , pp. 3835-3839
    • Li, L.1    He, Y.2    Yang, H.3    Zhu, J.4    Xu, X.5
  • 8
    • 33747489214 scopus 로고    scopus 로고
    • Sentinel surveillance for human enterovirus 71 in Sarawak, Malaysia: Lessons from the first 7 years
    • Podin Y, Gias EL, Ong F, Leong YW, Yee SF, et al. (2006) Sentinel surveillance for human enterovirus 71 in Sarawak, Malaysia: lessons from the first 7 years. BMC Public Health 6: 180.
    • (2006) BMC Public Health , vol.6 , pp. 180
    • Podin, Y.1    Gias, E.L.2    Ong, F.3    Leong, Y.W.4    Yee, S.F.5
  • 9
    • 84880123210 scopus 로고    scopus 로고
    • Seroepidemiology of human enterovirus71 and coxsackievirusA16 among children in Guangdong province, China
    • Li W, Yi L, Su J, Lu J, Zeng H, et al. (2013) Seroepidemiology of human enterovirus71 and coxsackievirusA16 among children in Guangdong province, China. BMC Infect Dis 13: 322.
    • (2013) BMC Infect Dis , vol.13 , pp. 322
    • Li, W.1    Yi, L.2    Su, J.3    Lu, J.4    Zeng, H.5
  • 10
    • 0142030092 scopus 로고    scopus 로고
    • Hand, foot and mouth disease in Singapore: A comparison of fatal and non-fatal cases
    • Chong CY, Chan KP, Shah V, Ng W, Lau G, et al. (2003) Hand, foot and mouth disease in Singapore: a comparison of fatal and non-fatal cases. Acta Paediatrica 92: 1163-1169.
    • (2003) Acta Paediatrica , vol.92 , pp. 1163-1169
    • Chong, C.Y.1    Chan, K.P.2    Shah, V.3    Ng, W.4    Lau, G.5
  • 11
    • 84859047239 scopus 로고    scopus 로고
    • Characterization of fulllength enterovirus 71 strains from severe and mild disease patients in northeastern China
    • Wang X, Zhu C, Bao W, Zhao K, Niu J, et al. (2012) Characterization of fulllength enterovirus 71 strains from severe and mild disease patients in northeastern China. PLoS One 7: e32405.
    • (2012) PLoS One , vol.7 , pp. e32405
    • Wang, X.1    Zhu, C.2    Bao, W.3    Zhao, K.4    Niu, J.5
  • 12
    • 84892757355 scopus 로고    scopus 로고
    • The cytokine and chemokine profiles in patients with hand, foot and mouth disease of different severities in Shanghai, China, 2010
    • Zeng M, Zheng X, Wei R, Zhang N, Zhu K, et al. (2013) The cytokine and chemokine profiles in patients with hand, foot and mouth disease of different severities in Shanghai, China, 2010. PLoS Negl Trop Dis 7: e2599.
    • (2013) PLoS Negl Trop Dis , vol.7 , pp. e2599
    • Zeng, M.1    Zheng, X.2    Wei, R.3    Zhang, N.4    Zhu, K.5
  • 13
    • 84891001460 scopus 로고    scopus 로고
    • Prevalence of enteroviruses in children with and without hand, foot, and mouth disease in China
    • Zhang X, Wang H, Ding S, Wang X, Chen X, et al. (2013) Prevalence of enteroviruses in children with and without hand, foot, and mouth disease in China. BMC Infect Dis 13: 606.
    • (2013) BMC Infect Dis , vol.13 , pp. 606
    • Zhang, X.1    Wang, H.2    Ding, S.3    Wang, X.4    Chen, X.5
  • 14
    • 84896348198 scopus 로고    scopus 로고
    • Update of enterovirus 71 infection: Epidemiology, pathogenesis and vaccine
    • Wang SM, Liu CC (2014) Update of enterovirus 71 infection: epidemiology, pathogenesis and vaccine. Expert Rev Anti Infect Ther 12: 447-456.
    • (2014) Expert Rev Anti Infect Ther , vol.12 , pp. 447-456
    • Wang, S.M.1    Liu, C.C.2
  • 15
    • 84898609071 scopus 로고    scopus 로고
    • Update on enterovirus 71 infection
    • Huang PN, Shih SR (2014) Update on enterovirus 71 infection. Curr Opin Virol 5C: 98-104.
    • (2014) Curr Opin Virol , vol.5 C , pp. 98-104
    • Huang, P.N.1    Shih, S.R.2
  • 16
    • 0036057766 scopus 로고    scopus 로고
    • The 3C protease activity of enterovirus 71 induces human neural cell apoptosis
    • Li ML, Hsu TA, Chen TC, Chang SC, Lee JC, et al. (2002) The 3C protease activity of enterovirus 71 induces human neural cell apoptosis. Virology 293: 386-395.
    • (2002) Virology , vol.293 , pp. 386-395
    • Li, M.L.1    Hsu, T.A.2    Chen, T.C.3    Chang, S.C.4    Lee, J.C.5
  • 17
    • 12144273494 scopus 로고    scopus 로고
    • Diverse apoptotic pathways in enterovirus 71-infected cells
    • Chang SC, Lin JY, Lo LY, Li ML, Shih SR (2004) Diverse apoptotic pathways in enterovirus 71-infected cells. J Neurovirol 10: 338-349.
    • (2004) J Neurovirol , vol.10 , pp. 338-349
    • Chang, S.C.1    Lin, J.Y.2    Lo, L.Y.3    Li, M.L.4    Shih, S.R.5
  • 18
    • 84879836582 scopus 로고    scopus 로고
    • Global transcriptomic analysis of human neuroblastoma cells in response to enterovirus type 71 infection
    • Xu LJ, Jiang T, Zhang FJ, Han JF, Liu J, et al. (2013) Global transcriptomic analysis of human neuroblastoma cells in response to enterovirus type 71 infection. PLoS One 8: e65948.
    • (2013) PLoS One , vol.8 , pp. e65948
    • Xu, L.J.1    Jiang, T.2    Zhang, F.J.3    Han, J.F.4    Liu, J.5
  • 19
    • 84879182126 scopus 로고    scopus 로고
    • Calcium flux and calpainmediated activation of the apoptosis-inducing factor contribute to enterovirus 71-induced apoptosis
    • Lu JR, Lu WW, Lai JZ, Tsai FL, Wu SH, et al. (2013) Calcium flux and calpainmediated activation of the apoptosis-inducing factor contribute to enterovirus 71-induced apoptosis. J Gen Virol 94: 1477-1485.
    • (2013) J Gen Virol , vol.94 , pp. 1477-1485
    • Lu, J.R.1    Lu, W.W.2    Lai, J.Z.3    Tsai, F.L.4    Wu, S.H.5
  • 20
    • 84870057807 scopus 로고    scopus 로고
    • Differential apoptosis gene expressions of rhabdomyosarcoma cells in response to enterovirus 71 infection
    • Shi W, Li X, Hou X, Peng H, Jiang Q, et al. (2012) Differential apoptosis gene expressions of rhabdomyosarcoma cells in response to enterovirus 71 infection. BMC Infect Dis 12: 327.
    • (2012) BMC Infect Dis , vol.12 , pp. 327
    • Shi, W.1    Li, X.2    Hou, X.3    Peng, H.4    Jiang, Q.5
  • 21
    • 67549100978 scopus 로고    scopus 로고
    • Coxsackieviruses infection in northern Taiwan-epidemiology and clinical characteristics
    • Yen FB, Chang LY, Kao CL, Lee PI, Chen CM, et al. (2009) Coxsackieviruses infection in northern Taiwan-epidemiology and clinical characteristics. J Microbiol Immunol Infect 42: 38-46.
    • (2009) J Microbiol Immunol Infect , vol.42 , pp. 38-46
    • Yen, F.B.1    Chang, L.Y.2    Kao, C.L.3    Lee, P.I.4    Chen, C.M.5
  • 22
    • 3242704988 scopus 로고    scopus 로고
    • A mouseadapted enterovirus 71 strain causes neurological disease in mice after oral infection
    • Wang YF, Chou CT, Lei HY, Liu CC, Wang SM, et al. (2004) A mouseadapted enterovirus 71 strain causes neurological disease in mice after oral infection. J Virol 78: 7916-7924.
    • (2004) J Virol , vol.78 , pp. 7916-7924
    • Wang, Y.F.1    Chou, C.T.2    Lei, H.Y.3    Liu, C.C.4    Wang, S.M.5
  • 23
    • 0000609793 scopus 로고
    • Fatal infection in an infant associated with Coxsackie virus group A, type 16
    • Wright HT Jr, Landing BH, Lennette EH, McCallister RM (1963) Fatal infection in an infant associated with Coxsackie virus group A, type 16. N Engl J Med 268: 1041-1044.
    • (1963) N Engl J Med , vol.268 , pp. 1041-1044
    • Wright, H.T.1    Landing, B.H.2    Lennette, E.H.3    McCallister, R.M.4
  • 24
    • 84888840384 scopus 로고    scopus 로고
    • Coxsackievirus A16 infection triggers apoptosis in RD cells by inducing ER stress
    • Zhu G, Zheng Y, Zhang L, Shi Y, Li W, et al. (2013) Coxsackievirus A16 infection triggers apoptosis in RD cells by inducing ER stress. Biochem Biophys Res Commun 441: 856-861.
    • (2013) Biochem Biophys Res Commun , vol.441 , pp. 856-861
    • Zhu, G.1    Zheng, Y.2    Zhang, L.3    Shi, Y.4    Li, W.5
  • 25
    • 0141737646 scopus 로고    scopus 로고
    • Cardiomyocyte apoptosis in experimental coxsackievirus B3 myocarditis
    • Saraste A, Arola A, Vuorinen T, Kyto V, Kallajoki M, et al. (2003) Cardiomyocyte apoptosis in experimental coxsackievirus B3 myocarditis. Cardiovasc Pathol 12: 255-262.
    • (2003) Cardiovasc Pathol , vol.12 , pp. 255-262
    • Saraste, A.1    Arola, A.2    Vuorinen, T.3    Kyto, V.4    Kallajoki, M.5
  • 26
    • 0344736838 scopus 로고    scopus 로고
    • Infection and injury of neurons by West Nile encephalitis virus
    • Shrestha B, Gottlieb D, Diamond MS (2003) Infection and injury of neurons by West Nile encephalitis virus. J Virol 77: 13203-13213.
    • (2003) J Virol , vol.77 , pp. 13203-13213
    • Shrestha, B.1    Gottlieb, D.2    Diamond, M.S.3
  • 27
    • 0142027948 scopus 로고    scopus 로고
    • Ways of dying: Multiple pathways to apoptosis
    • Adams JM (2003) Ways of dying: multiple pathways to apoptosis. Genes Dev 17: 2481-2495.
    • (2003) Genes Dev , vol.17 , pp. 2481-2495
    • Adams, J.M.1
  • 28
    • 0029026548 scopus 로고
    • FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
    • Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM (1995) FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505-512.
    • (1995) Cell , vol.81 , pp. 505-512
    • Chinnaiyan, A.M.1    O'rourke, K.2    Tewari, M.3    Dixit, V.M.4
  • 30
    • 0037204952 scopus 로고    scopus 로고
    • The Fas signaling pathway: More than a paradigm
    • Wajant H (2002) The Fas signaling pathway: more than a paradigm. Science 296: 1635-1636.
    • (2002) Science , vol.296 , pp. 1635-1636
    • Wajant, H.1
  • 31
    • 36649016901 scopus 로고    scopus 로고
    • Pseudolaric acid B induces apoptosis, senescence, and mitotic arrest in human breast cancer MCF- 7
    • Yu JH, Cui Q, Jiang YY, Yang W, Tashiro S, et al. (2007) Pseudolaric acid B induces apoptosis, senescence, and mitotic arrest in human breast cancer MCF- 7. Acta Pharmacol Sin 28: 1975-1983.
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1975-1983
    • Yu, J.H.1    Cui, Q.2    Jiang, Y.Y.3    Yang, W.4    Tashiro, S.5
  • 32
    • 0028927607 scopus 로고
    • The Fas death factor
    • Nagata S, Golstein P (1995) The Fas death factor. Science 267: 1449-1456.
    • (1995) Science , vol.267 , pp. 1449-1456
    • Nagata, S.1    Golstein, P.2
  • 33
  • 34
    • 84899679713 scopus 로고    scopus 로고
    • Protection from lethal challenge in a neonatal mouse model by circulating recombinant form coxsackievirus A16 vaccine candidates
    • Li J, Chang J, Liu X, Yang J, Guo H, et al. (2014) Protection from Lethal Challenge in a Neonatal Mouse Model by Circulating Recombinant Form Coxsackievirus A16 Vaccine Candidates. J Gen Virol.
    • (2014) J Gen Virol
    • Li, J.1    Chang, J.2    Liu, X.3    Yang, J.4    Guo, H.5
  • 35
    • 84899732596 scopus 로고    scopus 로고
    • Circulating HFMD-Associated Coxsackievirus A16 is Genetically and Phenotypically Distinct from the Prototype CV-A16
    • Wei W, Guo H, Li J, Ren S, Wei Z, et al. (2014) Circulating HFMD-Associated Coxsackievirus A16 Is Genetically and Phenotypically Distinct from the Prototype CV-A16. PLoS One 9: e94746.
    • (2014) PLoS One , vol.9 , pp. e94746
    • Wei, W.1    Guo, H.2    Li, J.3    Ren, S.4    Wei, Z.5
  • 36
    • 0032784429 scopus 로고    scopus 로고
    • Comparison of enterovirus 71 and coxsackie-virus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998
    • Chang LY, Lin TY, Huang YC, Tsao KC, Shih SR, et al. (1999) Comparison of enterovirus 71 and coxsackie-virus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998. Pediatr Infect Dis J 18: 1092-1096.
    • (1999) Pediatr Infect Dis J , vol.18 , pp. 1092-1096
    • Chang, L.Y.1    Lin, T.Y.2    Huang, Y.C.3    Tsao, K.C.4    Shih, S.R.5
  • 37
    • 80053353966 scopus 로고    scopus 로고
    • Comparisons of epidemiological and clinical characteristics in children with hand-foot-mouth disease caused by Enterovirus 71 and Coxackievirus A16]
    • Jia L, Zhao C, Zhang L, Li S, Zhang D, et al. (2011) Comparisons of epidemiological and clinical characteristics in children with hand-foot-mouth disease caused by Enterovirus 71 and Coxackievirus A16]. Zhongguo dang dai er ke za zhi= Chinese journal of contemporary pediatrics 13: 635.
    • (2011) Zhongguo Dang Dai Er Ke Za Zhi= Chinese Journal of Contemporary Pediatrics , vol.13 , pp. 635
    • Jia, L.1    Zhao, C.2    Zhang, L.3    Li, S.4    Zhang, D.5
  • 38
    • 84860711136 scopus 로고    scopus 로고
    • A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B)
    • Yang E, Zhao H, Zhang Y, Liu J, Liao Y, et al. (2012) A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B). Sci China Life Sci 55: 336-342.
    • (2012) Sci China Life Sci , vol.55 , pp. 336-342
    • Yang, E.1    Zhao, H.2    Zhang, Y.3    Liu, J.4    Liao, Y.5
  • 39
    • 84869214165 scopus 로고    scopus 로고
    • A neonatal mouse model of coxsackievirus a16 for vaccine evaluation
    • Mao Q, Wang Y, Gao R, Shao J, Yao X, et al. (2012) A neonatal mouse model of coxsackievirus a16 for vaccine evaluation. J Virol 86: 11967-11976.
    • (2012) J Virol , vol.86 , pp. 11967-11976
    • Mao, Q.1    Wang, Y.2    Gao, R.3    Shao, J.4    Yao, X.5
  • 40
    • 0033552388 scopus 로고    scopus 로고
    • Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease
    • Chang LY, Lin TY, Hsu KH, Huang YC, Lin KL, et al. (1999) Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease. Lancet 354: 1682-1686.
    • (1999) Lancet , vol.354 , pp. 1682-1686
    • Chang, L.Y.1    Lin, T.Y.2    Hsu, K.H.3    Huang, Y.C.4    Lin, K.L.5
  • 41
    • 34547351304 scopus 로고    scopus 로고
    • Detection of enterovirus 71 and coxsackievirus A16 from children with hand, foot and mouth disease in Shanghai, 2002
    • Yang Z, Zhu Q, Li X, Wang X, Wang J, et al. (2005) [Detection of enterovirus 71 and coxsackievirus A16 from children with hand, foot and mouth disease in Shanghai, 2002]. Zhonghua Er Ke Za Zhi 43: 648.
    • (2005) Zhonghua Er Ke Za Zhi , vol.43 , pp. 648
    • Yang, Z.1    Zhu, Q.2    Li, X.3    Wang, X.4    Wang, J.5
  • 42
    • 84879602943 scopus 로고    scopus 로고
    • Bioluminescence imaging of caspase-3 activity in mouse liver
    • Fu Q, Duan X, Yan S, Wang L, Zhou Y, et al. (2013) Bioluminescence imaging of caspase-3 activity in mouse liver. Apoptosis 18: 998-1007.
    • (2013) Apoptosis , vol.18 , pp. 998-1007
    • Fu, Q.1    Duan, X.2    Yan, S.3    Wang, L.4    Zhou, Y.5
  • 44
    • 78049520062 scopus 로고    scopus 로고
    • Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis
    • Brisac C, Teoule F, Autret A, Pelletier I, Colbere-Garapin F, et al. Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis. J Virol 84: 12226-12235.
    • J Virol , vol.84 , pp. 12226-12235
    • Brisac, C.1    Teoule, F.2    Autret, A.3    Pelletier, I.4    Colbere-Garapin, F.5
  • 45
    • 0030899871 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection
    • Chackerian B, Long EM, Luciw PA, Overbaugh J (1997) Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection. J Virol 71: 3932-3939.
    • (1997) J Virol , vol.71 , pp. 3932-3939
    • Chackerian, B.1    Long, E.M.2    Luciw, P.A.3    Overbaugh, J.4
  • 46
    • 4344601173 scopus 로고    scopus 로고
    • Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone
    • Shih SR, Tsai MC, Tseng SN, Won KF, Shia KS, et al. (2004) Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone. Antimicrob Agents Chemother 48: 3523-3529.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3523-3529
    • Shih, S.R.1    Tsai, M.C.2    Tseng, S.N.3    Won, K.F.4    Shia, K.S.5
  • 47
    • 33748765541 scopus 로고    scopus 로고
    • An aged host promotes the evolution of avirulent coxsackievirus into a virulent strain
    • Gay RT, Belisle S, Beck MA, Meydani SN (2006) An aged host promotes the evolution of avirulent coxsackievirus into a virulent strain. Proc Natl Acad Sci U S A 103: 13825-13830.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 13825-13830
    • Gay, R.T.1    Belisle, S.2    Beck, M.A.3    Meydani, S.N.4


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