Aged kidneys are refractory to ischemic postconditioning in a rat model

Renal Failure

Volumn 36, Issue 10, 2014, Pages 1575-1580

  Chen, Hui ^a   Xing, Bianzhi ^a   Wang, Lei ^a   Weng, Xiaodong ^a   Chen, Zhiyuan ^a   Liu, Xiuheng ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Aged rats; Ischemia reperfusion; Ischemic postconditioning; Kidney

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; MALONALDEHYDE; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE;

ADULT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ISCHEMIC POSTCONDITIONING; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY PARENCHYMA; KIDNEY PERFUSION; KIDNEY PRESERVATION; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; RENAL PROTECTION; REPERFUSION INJURY; UPREGULATION; UREA NITROGEN BLOOD LEVEL; YOUNG ADULT; ACUTE KIDNEY INJURY; ANIMAL; DISEASE MODEL; KIDNEY; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; TREATMENT FAILURE; VASCULARIZATION; WISTAR RAT;

ACUTE KIDNEY INJURY; AGING; ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; ISCHEMIC POSTCONDITIONING; KIDNEY; MALE; OXIDATIVE STRESS; RANDOM ALLOCATION; RATS, WISTAR; REPERFUSION INJURY; TREATMENT FAILURE;

EID: 84908576478     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/0886022X.2014.949769     Document Type: Article

References (26)

1. Wang HJ, Varner A, AbouShwareb T, et al. Ischemia/reperfusioninduced renal failure in rats as a model for evaluating cell therapies. Ren Fail. 2012;34:1324-1332
2. Liu X, Chen H, Zhan B, et al. Attenuation of reperfusion injury by renal ischemic postconditioning: The role of NO. Biochem Biophys Res Commun. 2007;359:628-634
3. Chen H, Xing B, Liu X, et al. Ischemic postconditioning inhibits apoptosis after renal ischemia/reperfusion injury in rat. Transpl Int. 2008;21:364-371
4. Weng X, Shen H, Kuang Y, et al. Ischemic postconditioning inhibits the renal fibrosis induced by ischemia-reperfusion injury in rats. Urology. 2012;80:484e1-484e7
5. Jiang B, Liu X, Chen H, et al. Ischemic postconditioning attenuates renal ischemic/reperfusion injury in mongrel dogs. Urology. 2010; 76:1519e1-1519e7
6. Jiang B, Chen Q, Liu X, et al. Ischemic postconditioning protects renal function after 24 hours of cold preservation in a canine autotransplantation model. Transplant Proc. 2012;44:1776-1781
7. Wang W, Tang T, Zhang P, et al. Postconditioning attenuates renal ischemia-reperfusion injury by preventing DAF down-regulation. J Urol. 2010;183:2424-2431
8. Zhang WL, Zhao YL, Liu XM, et al. Protective role of mitochondrial K-ATP channel and mitochondrial membrane transport pore in rat kidney ischemic postconditioning. Chin Med J (Engl). 2011; 124:2191-2195
9. Serviddio G, Romano AD, Gesualdo L, et al. Postconditioning is an effective strategy to reduce renal ischemia/reperfusion injury. Nephrol Dial Transplant. 2008;23:1504-1512
10. Eldaif SM, Deneve JA, Wang NP, et al. Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation. Transpl Int. 2010;23: 217-226
11. Yun Y, Duan WG, Chen P, et al. Ischemic postconditioning modified renal oxidative stress and lipid peroxidation caused by ischemic reperfusion injury in rats. Transplant Proc. 2009;41: 3597-3602
12. Yun Y, Duan WG, Chen P, et al. Down-regulation of cyclooxygenase-2 is involved in ischemic postconditioning protection against renal ischemia reperfusion injury in rats. Transplant Proc. 2009;41:3585-3589
13. Van den Akker EK, Hesselink DA, Manintveld OC, et al. Ischemic postconditioning in human DCD kidney transplantation is feasible and appears safe. Transpl Int. 2014;27:226-234
14. Jablonski P, Howden BO, Rae DA, et al. An experimental model for assessment of renal recovery from warm ischemia. Transplantation. 1983;35:198-204
15. Matsumori Y, Hong SM, Aoyama K, et al. Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury. J Cereb Blood Flow Metab. 2005;25:899-910
16. Staat P, Rioufol G, Piot C, et al. Postconditioning the human heart. Circulation. 2005;112:2143-2138
17. Hausenloy DJ, Yellon DM. The therapeutic potential of ischemic conditioning: An update. Nat Rev Cardiol. 2011;8:619-629
18. Xing B, Chen H, Zhang M, et al. Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. Stroke. 2008;39:2362-2369
19. Boengler K, Buechert A, Heinen Y, et al. Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice. Circ Res. 2008;102:131-135
20. Przyklenk K, Maynard M, Darling CE, et al. Aging mouse hearts are refractory to infarct size reduction with post-conditioning. J Am Coll Cardiol. 2008;51:1393-1398
21. Kusaka J, Koga H, Hagiwara S, et al. Age-dependent responses to renal ischemia-reperfusion injury. J Surg Res. 2012;172:153-158
22. Qiao X, Chen X, Wu D, et al. Mitochondrial pathway is responsible for aging-related increase of tubular cell apoptosis in renal ischemia/reperfusion injury. J Gerontol A Biol Sci Med Sci. 2005; 60:830-839
23. Xu X, Fan M, He X, et al. Aging aggravates long-term renal ischemia-reperfusion injury in a rat mode. J Surg Res. 2014;187: 289-296
24. Padanilam BJ. Cell death induced by acute renal injury: A perspective on the contributions of apoptosis and necrosis. Am J Physiol Renal Physiol. 2003;284:608-627
25. Shimizu S, Narita M, Tsujimoto Y, et al. Bcl-2 family pro-teins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature. 1999;399:483-487
26. Li P, Nijhawan D, Budihardio I, et al. Cytochrome c and dATPdependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997;91:479-489