Sun and ski holidays improve vitamin D status, but are associated with high levels of DNA damage

Journal of Investigative Dermatology

Volumn 134, Issue 11, 2014, Pages 2806-2813

  Petersen, Bibi ^a   Wulf, Hans C ^a   Triguero Mas, Margarita ^b,c   Philipsen, Peter A ^a   Thieden, Elisabeth ^a   Olsen, Peter ^a   Heydenreich, Jakob ^a   Dadvand, Payam ^b,c   Basagaña, Xavier ^b,c   Liljendahl, Tove S ^d   Harrison, Graham I ^e   Segerbäck, Dan ^d   Schmalwieser, Alois W ^f   Young, Antony R ^e   Nieuwenhuijsen, Mark J ^b,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^c CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^d KAROLINSKA INSTITUTE   (Sweden)

^e GUY S HOSPITAL   (United Kingdom)

^f UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOBUTANE THYMINE DIMER; DIMER; SUNSCREEN; THYMINE DERIVATIVE; UNCLASSIFIED DRUG; VITAMIN D; PYRIMIDINE DIMER;

ADULT; ARTICLE; BLOOD SAMPLING; BODY SURFACE; DANISH CITIZEN; DNA DAMAGE; DOSIMETRY; EGG; FEMALE; FIELD STUDY; FISH MEAT; FOOD INTAKE; HUMAN; LIMIT OF DETECTION; MALE; PREDICTION; RISK FACTOR; SKIING; SKIN SURFACE; SPANIARD; SUN EXPOSURE; ULTRAVIOLET B RADIATION; URINALYSIS; VITAMIN D DEFICIENCY; BLOOD; CHEMISTRY; LEISURE; MIDDLE AGED; RADIATION RESPONSE; SKIN; SKIN NEOPLASMS; SUNLIGHT; SWIMMING; TIME; ULTRAVIOLET RADIATION;

ADULT; BATHING BEACHES; DNA DAMAGE; FEMALE; HOLIDAYS; HUMANS; MALE; MIDDLE AGED; PYRIMIDINE DIMERS; SKIING; SKIN; SKIN NEOPLASMS; SUNLIGHT; TIME FACTORS; ULTRAVIOLET RAYS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84908574598     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2014.223     Document Type: Article

References (38)

1. Ascherio A, Munger KL, Simon KC (2010) Vitamin D and multiple sclerosis. Lancet Neurol 9:599-612
2. Baczynska K, O'Hagan JB, Pearson AJ., et al (2011) Temperature correction of UV spectral solar measurements for ICEPURE project. Photochem Photobiol 87:1464-7
3. Bikle D (2012) Protective actions of vitamin D in UVB induced skin cancer. Photochem Photobiol Sci 11:1808-16
4. Bogh MK, Schmedes AV, Philipsen PA., et al (2010) Vitamin D production after UVB exposure depends on baseline vitamin D and total cholesterol but not on skin pigmentation. J Invest Dermatol 130:546-53
5. Bogh MK, Schmedes AV, Philipsen PA., et al (2011) Interdependence between body surface area and ultraviolet B dose in vitamin D production: a randomized controlled trial. Br J Dermatol 164:163-9
6. Bogh MK, Schmedes AV, Philipsen PA., et al (2012) A small suberythemal ultraviolet B dose every second week is sufficient to maintain summer vitamin D levels: a randomized controlled trial. Br J Dermatol 166:430-3
7. Boullion R, Eisman J, Garabedian M., et al (2006) Action spectrum for the production of pre-vitamin D in human skin. Commission Internationale de l'Eclairage (CIE) 174:1-12
8. Dadvand P, Basagana X, Barrera-Gomez J., et al (2011) Measurement errors in the assessment of exposure to solar ultraviolet radiation and its impact on risk estimates in epidemiological studies. Photochem Photobiol Sci 10:1161-8
9. Dong KK, Damaghi N, Picart SD., et al (2008) UV-induced DNA damage initiates release of MMP-1 in human skin. Exp Dermatol 17:1037-44
10. Faurschou A, Wulf HC (2007) The relation between sun protection factor and amount of suncreen applied in vivo. Br J Dermatol 156:716-9
11. Fitzpatrick TB (1988) The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol 124:869-71
12. Forsea AM, del MV, de VE., et al (2012) Melanoma incidence and mortality in Europe: new estimates, persitent disparities. Br J Dermatol 167:1124-30
13. Heaney R (2014) The vitamin D requirement in health and disease. J Steroid Biochem Mol Biol 97:13-9
14. Heydenreich J, Wulf HC (2005) Miniature personal electronic UVR dosimeter with erythema response and time-stamped readings in a wristwatch. Photochem Photobiol 81:1138-44
15. Holick MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80:1678S-688SS
16. International Agency for research on Cancer (IARC) (2008) Vitamin D and Cancer
17. Kampmann J, Siersbaek-Nielsen K, Kristensen M., et al (1974) Rapid evaluation of creatinine clearance. Acta Med Scand 196:517-20
18. Kongshoj B, Thorleifsson A, Wulf HC (2006) Pheomelanin and eumelanin in human skin Determined by high-performance liquid chromatography and its relation to in vivo reflectance measurements. Photodermatol Photoimmunol Photomed 22:141-7
19. Kotova N, Hemminki K, Segerback D (2005) Urinary thymidine dimer as a marker of total body burden of UV-inflicted DNA damage in humans. Cancer Epidemiol Biomarkers Prev 14:2868-72
20. Le CF, Hemminki K (2001) Cyclobutane thymidine dimers are present in human urine following sun exposure: quantitation using 32P-postlabeling and high-performance liquid chromatography. J Invest Dermatol 117: 263-8
21. Liljendahl TS, Blomqvist A, Andersson EA., et al (2013) Urinary levels of thymine dimer as a biomarker of exposure to ultraviolet radiation in humans during outdoor activities in the summer. Mutagenesis 28:249-56
22. Liljendahl TS, Kotova N, Segerback D (2012) Quantification of ultraviolet radiation-induced DNA damage in the urine of Swedish adults and children following exposure to sunlight. Biomarkers 17:634-41
23. Ling G, Chadwick CA, Berne B., et al (2001) Epidermal p53 response and repair of thymine dimers in human skin after a single dose of ultraviolet radiation: effects of photoprotection. Acta Derm Venereol 81:81-6
24. Lyhne N, Christensen T, Groth M., et al (2005) Danskernes kostvaner 2000-2002; Hovedresultater. 1 edn. Danmarks f-devareforskning: Denmark
25. Motiwala SR, Wang TJ (2011) Vitamin D and cardiovascular disease. Curr Opin Nephrol Hypertens 20:345-53
26. Mouret S, Baudouin C, Charveron M., et al (2006) Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation. Proc Natl Acad Sci USA 103:13765-70
27. Nishigori C, Yarosh DB, Donawho C., et al (1996) The immune system in ultraviolet carcinogenesis. J Investig Dermatol Symp Proc 1:143-6
28. Norval M, Bjørn L, de Gruijl F (2010) Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct'. Photochem Photobiol Sci 9:11-7
29. Petersen B, Datta P, Philipsen PA., et al (2013) Sunscreen use and failures-on site observations on a sun-holiday. Photochem Photobiol Sci 12:190-6
30. Pfeifer GP, Besaratinia A (2012) UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer. Photochem Photobiol Sci 11:90-7
31. Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K., et al (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73:39-85
32. Seaton B, Ali A (1984) Simplified manual high performance clinical chemistry methods for developing countries. Med Lab Sci 41:327-36
33. Thieden E, Agren MS, Wulf HC (2000) The wrist is a reliable body site for personal dosimetry of ultraviolet radiation. Photodermatol Photoimmunol Photomed 16:57-61
34. Webb AR, DeCosta BR, Holick MF (1989) Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegradation. J Clin Endocrinol Metab 68:882-7
35. Wolpowitz D, Gilchrest BA (2006) The vitamin D questions: how much do you need and how should you get it'. J Am Acad Dermatol 54:301-17
36. Wulf HC (1989) Method and apparatus for determining an individual's ability to stand exposure to ultraviolet radiation. US Patent 4-882 598:1-38
37. Wulf HC, Lock-Andersen J (1997) Measurement of constitutive photo skin type. Springer-Verlag: Berlin Heidelberg
38. Young AR, Chadwick CA, Harrison GI., et al (1998) The similarity of action spectra for thymine dimers in human epidermis and erythema suggests that DNA is the chromophore for erythema. J Invest Dermatol 111:982-8