Low-level cadmium exposure and effects on kidney function

Occupational and Environmental Medicine

Volumn 71, Issue 12, 2014, Pages 848-854

  Wallin, Maria ^a   Sallsten, Gerd ^a   Lundh, Thomas ^b   Barregard, Lars ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 MICROGLOBULIN; BETA 2 MICROGLOBULIN; CADMIUM; CYSTATIN C; KIDNEY INJURY MOLECULE 1; N ACETYL BETA GLUCOSAMINIDASE; RETINOL BINDING PROTEIN; SERUM ALBUMIN; ACETYLGLUCOSAMINIDASE; ALPHA GLOBULIN; ALPHA-1-MICROGLOBULIN; BIOLOGICAL MARKER; HAVCR1 PROTEIN, HUMAN; HEAVY METAL; MEMBRANE PROTEIN; VIRUS RECEPTOR;

ADULT; AGED; ARTICLE; BLOOD LEVEL; BODY WEIGHT; CADMIUM BLOOD LEVEL; CADMIUM URINE LEVEL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN TISSUE; KIDNEY BIOPSY; KIDNEY DONOR; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; SMOKING; URINARY EXCRETION; URINE FLOW RATE; URINE LEVEL; ADVERSE EFFECTS; BIOPSY; BLOOD; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; INTOXICATION; KIDNEY; METABOLISM; MIDDLE AGED; PROTEINURIA; URINE; YOUNG ADULT;

ACETYLGLUCOSAMINIDASE; ADULT; AGED; ALPHA-GLOBULINS; BETA 2-MICROGLOBULIN; BIOMARKERS; BIOPSY; CADMIUM; CROSS-SECTIONAL STUDIES; CYSTATIN C; ENVIRONMENTAL EXPOSURE; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; MALE; MEMBRANE GLYCOPROTEINS; METALS, HEAVY; MIDDLE AGED; POISONING; PROTEINURIA; RECEPTORS, VIRUS; RETINOL-BINDING PROTEINS; SMOKING; YOUNG ADULT;

EID: 84908573746     PISSN: 13510711     EISSN: 14707926     Source Type: Journal    
DOI: 10.1136/oemed-2014-102279     Document Type: Article

References (29)

1. Nordberg GF, Nogawa K, Nordberg M, et al. Cadmium. In: Nordberg GF, Fowler B, Nordberg M, Friberg LT. eds. Handbook on the toxicology of metals. 3rd edn. Academic Press, Elsevier, 2007:445-86.
2. EFSA. Cadmium in food - scientific opinion of the panel on contaminants in the food chain. EFSA J 2009;980:1-139.
3. World Health Organization. Evaluation of certain food additives and contaminants. Seventy-third report of the Joint FAO/WHO Expert Committee on Food Additives. Geneva, 2011.
4. Jarup L, Akesson A. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 2009;238:201-8.
5. Bernard A. Renal dysfunction induced by cadmium: biomarkers of critical effects. Biometals 2004;17:519-23.
6. Johri N, Jacquillet G, Unwin R. Heavy metal poisoning: the effects of cadmium on the kidney. Biometals 2010;23:783-92.
7. Haddam N, Samira S, Dumont X, et al. Confounders in the assessment of the renal effects associated with low-level urinary cadmium: an analysis in industrial workers. Environ Health 2011;10:37.
8. Bernard A. The determination of beta-2-microglobulin, retinol-binding protein and alpha-1-microglobulin in urine. In: Biological monitoring of chemical exposure in the workplace. Geneva: WHO, 1996:74-90.
9. Olsson MG, Rosenlof LW, Kotarsky H, et al. The radical-binding lipocalin A1M binds to a complex i subunit and protects mitochondrial structure and function. Antioxid Redox Signal 2013;18:2017-28.
10. Stevens LA, Levey AS. Measured GFR as a confirmatory test for estimated GFR. J Am Soc Nephrol 2009;20:2305-13.
11. Murata K, Baumann NA, Saenger AK, et al. Relative performance of the MDRD and CKD-EPI equations for estimating glomerular filtration rate among patients with varied clinical presentations. Clin J Am Soc Nephrol 2011;6:1963-72.
12. Issa N, Meyer KH, Arrigain S, et al. Evaluation of creatinine-based estimates of glomerular filtration rate in a large cohort of living kidney donors. Transplantation 2008;86:223-30.
13. Tent H, Rook M, Stevens LA, et al. Renal function equations before and after living kidney donation: a within-individual comparison of performance at different levels of renal function. Clin J Am Soc Nephrol 2010;5:1960-8.
14. Fassett RG, Venuthurupalli SK, Gobe GC, et al. Biomarkers in chronic kidney disease: a review. Kidney Int 2011;80:806-21.
15. Urbschat A, Obermuller N, Haferkamp A. Biomarkers of kidney injury. Biomarkers 2011;16(Suppl 1):S22-30.
16. Akerstrom M, Sallsten G, Lundh T, et al. Associations between urinary excretion of cadmium and proteins in a nonsmoking population: renal toxicity or normal physiology? Environ Health Perspect 2013;121:187-91.
17. Chaumont A, Nickmilder M, Dumont X, et al. Associations between proteins and heavy metals in urine at low environmental exposures: evidence of reverse causality. Toxicol Lett 2012;210:345-52.
18. Barregard L, Fabricius-Lagging E, Lundh T, et al. Cadmium, mercury, and lead in kidney cortex of living kidney donors: impact of different exposure sources. Environ Res 2010;110:47-54.
19. Akesson A, Lundh T, Vahter M, et al. Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environ Health Perspect 2005;113:1627-31.
20. Navas-Acien A, Tellez-Plaza M, Guallar E, et al. Blood cadmium and lead and chronic kidney disease in US adults: a joint analysis. Am J Epidemiol 2009;170:1156-64.
21. Ferraro PM, Costanzi S, Naticchia A, et al. Low level exposure to cadmium increases the risk of chronic kidney disease: analysis of the NHANES 1999-2006. BMC Public Health 2010;10:304.
22. Chung S, Chung JH, Kim SJ, et al. Blood lead and cadmium levels and renal function in Korean adults. Clin Exp Nephrol 2013. Published Online First: 26 Nov 2013. doi:10.1007/s10157-013-0913-6
23. Stevens LA, Coresh J, Schmid CH, et al. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. Am J Kidney Dis 2008;51:395-406.
24. Hornung RW, Reed LD. Estimation of average concentration in the presence of nondetectable values. Appl Occup Environ Hyg 1990;5:46-51.
25. Akerstrom M, Barregard L, Lundh T, et al. The relationship between cadmium in kidney and cadmium in urine and blood in an environmentally exposed population. Toxicol Appl Pharmacol 2013;268:286-93.
26. Zeier M, Gafter U, Ritz E. Renal function and renal disease in males or females - vive la petite difference. Nephrol Dial Transplant 1998;13:2195-8.
27. Nitsch D, Grams M, Sang Y, et al . Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis. BMJ 2013;346:f324.
28. Akerstrom M, Barregard L, Lundh T, et al. Variability of urinary cadmium excretion in spot urine samples, first morning voids, and 24 h urine in a healthy non-smoking population: implications for study design. J Expo Sci Environ Epidemiol 2014;24:171-9.
29. Greenberg GN, Levine RJ. Urinary creatinine excretion is not stable: a new method for assessing urinary toxic substance concentrations. J Occup Med 1989;31:832-8.