메뉴 건너뛰기




Volumn 6, Issue 4, 2014, Pages 144-153

The evolving role of biomarkers for osteoarthritis

Author keywords

biomarkers; CTX II; osteoarthritis

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; BIOLOGICAL MARKER; CARBOXY TERMINAL TELOPEPTIDE; CARTILAGE OLIGOMERIC MATRIX PROTEIN; COLLAGEN TYPE 2; CRYOPYRIN; FIBULIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; OSTEOCALCIN; RESISTIN; TRANSCRIPTION FACTOR SOX5; TRANSCRIPTION FACTOR SOX6; TRANSCRIPTION FACTOR SOX9;

EID: 84908570298     PISSN: 1759720X     EISSN: 17597218     Source Type: Journal    
DOI: 10.1177/1759720X14541175     Document Type: Review
Times cited : (35)

References (59)
  • 1
    • 1542646352 scopus 로고    scopus 로고
    • Dietary fatty acids and immune reactions in synovial tissue
    • Adam O. (2003) Dietary fatty acids and immune reactions in synovial tissue. Eur J Med Res 8: 381–387.
    • (2003) Eur J Med Res , vol.8 , pp. 381-387
    • Adam, O.1
  • 2
    • 33645047392 scopus 로고    scopus 로고
    • Fibulins 3 and 5 antagonize tumor angiogenesis in vivo
    • Albig A. Neil J. Schiemann W. (2006) Fibulins 3 and 5 antagonize tumor angiogenesis in vivo. Cancer Res 66: 2621–2629.
    • (2006) Cancer Res , vol.66 , pp. 2621-2629
    • Albig, A.1    Neil, J.2    Schiemann, W.3
  • 3
    • 79959834855 scopus 로고    scopus 로고
    • Increased interleukin-1beta gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis
    • Attur M. Belitskaya-Levy I. Oh C. Krasnokutsky S. Greenberg J. Samuels J. et al. (2011) Increased interleukin-1beta gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. Arthritis Rheum 63: 1908–1917.
    • (2011) Arthritis Rheum , vol.63 , pp. 1908-1917
    • Attur, M.1    Belitskaya-Levy, I.2    Oh, C.3    Krasnokutsky, S.4    Greenberg, J.5    Samuels, J.6
  • 5
    • 18244384041 scopus 로고    scopus 로고
    • Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis – results of a 1 year longitudinal arthroscopic study in 422 patients
    • Ayral X. Pickering E. Woodworth T. Mackillop N. Dougados M. (2005) Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis – results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage 13: 361–367.
    • (2005) Osteoarthritis Cartilage , vol.13 , pp. 361-367
    • Ayral, X.1    Pickering, E.2    Woodworth, T.3    Mackillop, N.4    Dougados, M.5
  • 7
    • 84859426389 scopus 로고    scopus 로고
    • Association of plasma N-6 and N-3 polyunsaturated fatty acids with synovitis in the knee: the Most Study
    • Baker K. Matthan N. Lichtenstein A. Niu J. Guermazi A. Roemer F. et al. (2012) Association of plasma N-6 and N-3 polyunsaturated fatty acids with synovitis in the knee: the Most Study. Osteoarthritis Cartilage 20: 382–387.
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. 382-387
    • Baker, K.1    Matthan, N.2    Lichtenstein, A.3    Niu, J.4    Guermazi, A.5    Roemer, F.6
  • 8
    • 33749154105 scopus 로고    scopus 로고
    • Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review
    • Balk E. Lichtenstein A. Chung M. Kupelnick B. Chew P. Lau J. (2006) Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis 189: 19–30.
    • (2006) Atherosclerosis , vol.189 , pp. 19-30
    • Balk, E.1    Lichtenstein, A.2    Chung, M.3    Kupelnick, B.4    Chew, P.5    Lau, J.6
  • 9
    • 84859433312 scopus 로고    scopus 로고
    • Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs
    • Barter M. Bui C. Young D. (2012) Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs. Osteoarthritis Cartilage 20: 339–349.
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. 339-349
    • Barter, M.1    Bui, C.2    Young, D.3
  • 11
    • 79953701048 scopus 로고    scopus 로고
    • Temporal relationship between serum adipokines, biomarkers of bone and cartilage turnover, and cartilage volume loss in a population with clinical knee osteoarthritis
    • Berry P. Jones S. Cicuttini F. Wluka A. Maciewicz R. (2011) Temporal relationship between serum adipokines, biomarkers of bone and cartilage turnover, and cartilage volume loss in a population with clinical knee osteoarthritis. Arthritis Rheum 63: 700–707.
    • (2011) Arthritis Rheum , vol.63 , pp. 700-707
    • Berry, P.1    Jones, S.2    Cicuttini, F.3    Wluka, A.4    Maciewicz, R.5
  • 12
    • 33750961447 scopus 로고    scopus 로고
    • Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study
    • Bingham C. 3rd Buckland-Wright J. Garnero P. Cohen S. Dougados M. Adami S. et al. (2006) Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study. Arthritis Rheum 54: 3494–3507.
    • (2006) Arthritis Rheum , vol.54 , pp. 3494-3507
    • Bingham, C.1    Buckland-Wright, J.2    Garnero, P.3    Cohen, S.4    Dougados, M.5    Adami, S.6
  • 13
    • 33746830525 scopus 로고    scopus 로고
    • N-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases
    • Calder P. (2006) N-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 83: 1505S-1519S.
    • (2006) Am J Clin Nutr , vol.83 , pp. 1505S-1519S
    • Calder, P.1
  • 14
    • 0034852317 scopus 로고    scopus 로고
    • Collagen type II C-telopeptide fragments as an index of cartilage degradation
    • Christgau S. Garnero P. Fledelius C. Moniz C. Ensig M. Gineyts E. et al. (2001) Collagen type II C-telopeptide fragments as an index of cartilage degradation. Bone 29: 209–215.
    • (2001) Bone , vol.29 , pp. 209-215
    • Christgau, S.1    Garnero, P.2    Fledelius, C.3    Moniz, C.4    Ensig, M.5    Gineyts, E.6
  • 15
    • 33750016798 scopus 로고    scopus 로고
    • Reduction of cardiovascular risk factors with longterm fish oil treatment in early rheumatoid arthritis
    • Cleland L. Caughey G. James M. Proudman S. (2006) Reduction of cardiovascular risk factors with longterm fish oil treatment in early rheumatoid arthritis. J Rheumatol 33: 1973–1979.
    • (2006) J Rheumatol , vol.33 , pp. 1973-1979
    • Cleland, L.1    Caughey, G.2    James, M.3    Proudman, S.4
  • 16
    • 84861682120 scopus 로고    scopus 로고
    • Osteoarthritis. Omega-3 fatty acids and synovitis in osteoarthritic knees
    • Cleland L. James M. (2012) Osteoarthritis. Omega-3 fatty acids and synovitis in osteoarthritic knees. Nat Rev Rheumatol 8: 314–315.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 314-315
    • Cleland, L.1    James, M.2
  • 17
    • 84858276425 scopus 로고    scopus 로고
    • Early effect of hyaluronic acid intra-articular injections on serum and urine biomarkers in patients with knee osteoarthritis: an open-label observational prospective study
    • Conrozier T. Balblanc J. Richette P. Mulleman D. Maillet B. Henrotin Y. et al. (2011) Early effect of hyaluronic acid intra-articular injections on serum and urine biomarkers in patients with knee osteoarthritis: an open-label observational prospective study. J Orthop Res 30: 679–685.
    • (2011) J Orthop Res , vol.30 , pp. 679-685
    • Conrozier, T.1    Balblanc, J.2    Richette, P.3    Mulleman, D.4    Maillet, B.5    Henrotin, Y.6
  • 18
    • 37149048078 scopus 로고    scopus 로고
    • Can biochemical markers serve as surrogates for imaging in knee osteoarthritis?
    • Davis C. Karl J. Granell R. Kirwan J. Fasham J. Johansen J. et al. (2007) Can biochemical markers serve as surrogates for imaging in knee osteoarthritis? Arthritis Rheum 56: 4038–4047.
    • (2007) Arthritis Rheum , vol.56 , pp. 4038-4047
    • Davis, C.1    Karl, J.2    Granell, R.3    Kirwan, J.4    Fasham, J.5    Johansen, J.6
  • 19
    • 84863001000 scopus 로고    scopus 로고
    • Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage
    • de Boer T. van Spil W. Huisman A. Polak A. Bijlsma J. Lafeber F. et al. (2012) Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. Osteoarthritis Cartilage 20: 846–853.
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. 846-853
    • de Boer, T.1    van Spil, W.2    Huisman, A.3    Polak, A.4    Bijlsma, J.5    Lafeber, F.6
  • 20
    • 79952137696 scopus 로고    scopus 로고
    • Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation
    • Denoble A. Huffman K. Stabler T. Kelly S. Hershfield M. Mcdaniel G. et al. (2011) Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation. Proc Natl Acad Sci U S A 108: 2088–2093.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 2088-2093
    • Denoble, A.1    Huffman, K.2    Stabler, T.3    Kelly, S.4    Hershfield, M.5    Mcdaniel, G.6
  • 21
    • 0347418277 scopus 로고    scopus 로고
    • Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis
    • Dwyer J. Allayee H. Dwyer K. Fan J. Wu H. Mar R. et al. (2004) Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med 350: 29–37.
    • (2004) N Engl J Med , vol.350 , pp. 29-37
    • Dwyer, J.1    Allayee, H.2    Dwyer, K.3    Fan, J.4    Wu, H.5    Mar, R.6
  • 22
    • 84866438145 scopus 로고    scopus 로고
    • A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years
    • Erhart-Hledik J. Favre J. Asay J. Smith R. Giori N. Mundermann A. et al. (2012) A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years. Osteoarthritis Cartilage 20: 1309–1315.
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. 1309-1315
    • Erhart-Hledik, J.1    Favre, J.2    Asay, J.3    Smith, R.4    Giori, N.5    Mundermann, A.6
  • 25
    • 84861819484 scopus 로고    scopus 로고
    • Potential plasma biomarkers for progression of knee osteoarthritis using glycoproteomic analysis coupled with a 2D-LC-MALDI system
    • Fukuda I. Ishihara T. Ohmachi S. Sakikawa I. Morita A. Ikeda M. et al. (2012) Potential plasma biomarkers for progression of knee osteoarthritis using glycoproteomic analysis coupled with a 2D-LC-MALDI system. Proteome Sci 10: 36.
    • (2012) Proteome Sci , vol.10 , pp. 36
    • Fukuda, I.1    Ishihara, T.2    Ohmachi, S.3    Sakikawa, I.4    Morita, A.5    Ikeda, M.6
  • 27
    • 82955163131 scopus 로고    scopus 로고
    • Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis
    • Hoch J. Mattacola C. Medina Mckeon J. Howard J. Lattermann C. (2011) Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage 19: 1396–1404.
    • (2011) Osteoarthritis Cartilage , vol.19 , pp. 1396-1404
    • Hoch, J.1    Mattacola, C.2    Medina Mckeon, J.3    Howard, J.4    Lattermann, C.5
  • 28
    • 78650727090 scopus 로고    scopus 로고
    • Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity
    • Honsawek S. Chayanupatkul M. (2010) Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity. Arch Med Res 41: 593–598.
    • (2010) Arch Med Res , vol.41 , pp. 593-598
    • Honsawek, S.1    Chayanupatkul, M.2
  • 29
    • 79851512558 scopus 로고    scopus 로고
    • Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis
    • Ishijima M. Watari T. Naito K. Kaneko H. Futami I. Yoshimura-Ishida K. et al. (2011) Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. Arthritis Res Ther 13: R22.
    • (2011) Arthritis Res Ther , vol.13 , pp. R22
    • Ishijima, M.1    Watari, T.2    Naito, K.3    Kaneko, H.4    Futami, I.5    Yoshimura-Ishida, K.6
  • 30
    • 33745725967 scopus 로고    scopus 로고
    • Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men
    • Jordan K. Syddall H. Garnero P. Gineyts E. Dennison E. Sayer A. et al. (2006) Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men. Ann Rheum Dis 65: 871–877.
    • (2006) Ann Rheum Dis , vol.65 , pp. 871-877
    • Jordan, K.1    Syddall, H.2    Garnero, P.3    Gineyts, E.4    Dennison, E.5    Sayer, A.6
  • 31
    • 0347594309 scopus 로고    scopus 로고
    • Increased urinary concentration of collagen type II C-telopeptide fragments in patients with osteoarthritis
    • Jung M. Christgau S. Lukoschek M. Henriksen D. Richter W. (2004) Increased urinary concentration of collagen type II C-telopeptide fragments in patients with osteoarthritis. Pathobiology 71: 70–76.
    • (2004) Pathobiology , vol.71 , pp. 70-76
    • Jung, M.1    Christgau, S.2    Lukoschek, M.3    Henriksen, D.4    Richter, W.5
  • 32
    • 84872356106 scopus 로고    scopus 로고
    • Reference intervals of serum hyaluronic acid corresponding to the radiographic severity of knee osteoarthritis in women
    • Kaneko H. Ishijima M. Doi T. Futami I. Liu L. Sadatsuki R. et al. (2013) Reference intervals of serum hyaluronic acid corresponding to the radiographic severity of knee osteoarthritis in women. BMC Musculoskelet Disord 14: 34.
    • (2013) BMC Musculoskelet Disord , vol.14 , pp. 34
    • Kaneko, H.1    Ishijima, M.2    Doi, T.3    Futami, I.4    Liu, L.5    Sadatsuki, R.6
  • 33
    • 77954579179 scopus 로고    scopus 로고
    • Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis–the effect of sex, Kellgren-Lawrence (KL) score, body mass index (BMI), oral salmon calcitonin (SCT) treatment and diurnal variation
    • Karsdal M. Byrjalsen I. Bay-Jensen A. Henriksen K. Riis B. Christiansen C. (2010) Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis–the effect of sex, Kellgren-Lawrence (KL) score, body mass index (BMI), oral salmon calcitonin (SCT) treatment and diurnal variation. BMC Musculoskelet Disord 11: 125.
    • (2010) BMC Musculoskelet Disord , vol.11 , pp. 125
    • Karsdal, M.1    Byrjalsen, I.2    Bay-Jensen, A.3    Henriksen, K.4    Riis, B.5    Christiansen, C.6
  • 34
    • 81055126964 scopus 로고    scopus 로고
    • Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways
    • Koskinen A. Juslin S. Nieminen R. Moilanen T. Vuolteenaho K. Moilanen E. (2011) Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways. Arthritis Res Ther 13: R184.
    • (2011) Arthritis Res Ther , vol.13 , pp. R184
    • Koskinen, A.1    Juslin, S.2    Nieminen, R.3    Moilanen, T.4    Vuolteenaho, K.5    Moilanen, E.6
  • 35
    • 79955846044 scopus 로고    scopus 로고
    • Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis
    • Kraus V. Burnett B. Coindreau J. Cottrell S. Eyre D. Gendreau M. et al. (2011) Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartilage 19: 515–542.
    • (2011) Osteoarthritis Cartilage , vol.19 , pp. 515-542
    • Kraus, V.1    Burnett, B.2    Coindreau, J.3    Cottrell, S.4    Eyre, D.5    Gendreau, M.6
  • 36
    • 77954028228 scopus 로고    scopus 로고
    • First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis
    • Kraus V. Kepler T. Stabler T. Renner J. Jordan J. (2010 a) First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis. PloS ONE 5: e9739.
    • (2010) PloS ONE , vol.5 , pp. e9739
    • Kraus, V.1    Kepler, T.2    Stabler, T.3    Renner, J.4    Jordan, J.5
  • 37
    • 77952879702 scopus 로고    scopus 로고
    • Summary of the OA Biomarkers Workshop 2009 – biochemical biomarkers: biology, validation, and clinical studies
    • Kraus V. Nevitt M. Sandell L. (2010 b) Summary of the OA Biomarkers Workshop 2009 – biochemical biomarkers: biology, validation, and clinical studies. Osteoarthritis Cartilage 18: 742–745.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 742-745
    • Kraus, V.1    Nevitt, M.2    Sandell, L.3
  • 38
    • 79952108942 scopus 로고    scopus 로고
    • Correlation between synovitis detected on enhanced-magnetic resonance imaging and a histological analysis with a patient-oriented outcome measure for Japanese patients with end-stage knee osteoarthritis receiving joint replacement surgery
    • Liu L. Ishijima M. Futami I. Kaneko H. Kubota M. Kawasaki T. et al. (2010) Correlation between synovitis detected on enhanced-magnetic resonance imaging and a histological analysis with a patient-oriented outcome measure for Japanese patients with end-stage knee osteoarthritis receiving joint replacement surgery. Clin Rheumatol 29: 1185–1190.
    • (2010) Clin Rheumatol , vol.29 , pp. 1185-1190
    • Liu, L.1    Ishijima, M.2    Futami, I.3    Kaneko, H.4    Kubota, M.5    Kawasaki, T.6
  • 39
    • 78650975710 scopus 로고    scopus 로고
    • The bone-cartilage unit in osteoarthritis
    • Lories R. Luyten F. (2011) The bone-cartilage unit in osteoarthritis. Nat Rev Rheumatol 7: 43–49.
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 43-49
    • Lories, R.1    Luyten, F.2
  • 40
    • 84861347338 scopus 로고    scopus 로고
    • Differential protein profiling of synovial fluid from rheumatoid arthritis and osteoarthritis patients using LC-MALDI TOF/TOF
    • Mateos J. Lourido L. Fernandez-Puente P. Calamia V. Fernandez-Lopez C. Oreiro N. et al. (2012) Differential protein profiling of synovial fluid from rheumatoid arthritis and osteoarthritis patients using LC-MALDI TOF/TOF. J Proteomics 75: 2869–2878.
    • (2012) J Proteomics , vol.75 , pp. 2869-2878
    • Mateos, J.1    Lourido, L.2    Fernandez-Puente, P.3    Calamia, V.4    Fernandez-Lopez, C.5    Oreiro, N.6
  • 41
    • 84860456571 scopus 로고    scopus 로고
    • Incidence and risk factors for radiographic knee osteoarthritis and knee pain in japanese men and women: a longitudinal population-based cohort study
    • Muraki S. Akune T. Oka H. Ishimoto Y. Nagata K. Yoshida M. et al. (2012) Incidence and risk factors for radiographic knee osteoarthritis and knee pain in japanese men and women: a longitudinal population-based cohort study. Arthritis Rheum 64: 1447–1456.
    • (2012) Arthritis Rheum , vol.64 , pp. 1447-1456
    • Muraki, S.1    Akune, T.2    Oka, H.3    Ishimoto, Y.4    Nagata, K.5    Yoshida, M.6
  • 42
    • 68749098188 scopus 로고    scopus 로고
    • Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study
    • Muraki S. Oka H. Akune T. Mabuchi A. En-Yo Y. Yoshida M. et al. (2009) Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study. Osteoarthritis Cartilage 17: 1137–1143.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 1137-1143
    • Muraki, S.1    Oka, H.2    Akune, T.3    Mabuchi, A.4    En-Yo, Y.5    Yoshida, M.6
  • 43
    • 80053065838 scopus 로고    scopus 로고
    • Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis
    • Ning L. Ishijima M. Kaneko H. Kurihara H. Arikawa-Hirasawa E. Kubota M. et al. (2011) Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis. Int Orthop 35: 831–838.
    • (2011) Int Orthop , vol.35 , pp. 831-838
    • Ning, L.1    Ishijima, M.2    Kaneko, H.3    Kurihara, H.4    Arikawa-Hirasawa, E.5    Kubota, M.6
  • 45
    • 84856952418 scopus 로고    scopus 로고
    • Genetics and epigenetics of osteoarthritis
    • Reynard L. Loughlin J. (2012) Genetics and epigenetics of osteoarthritis. Maturitas 71: 200–204.
    • (2012) Maturitas , vol.71 , pp. 200-204
    • Reynard, L.1    Loughlin, J.2
  • 47
    • 34447339916 scopus 로고    scopus 로고
    • A 5-yr longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis – association with disease progression
    • Sharif M. Kirwan J. Charni N. Sandell L. Whittles C. Garnero P. (2007) A 5-yr longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis – association with disease progression. Rheumatology (Oxford) 46: 938–943.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 938-943
    • Sharif, M.1    Kirwan, J.2    Charni, N.3    Sandell, L.4    Whittles, C.5    Garnero, P.6
  • 48
    • 84882724897 scopus 로고    scopus 로고
    • The factors associated with pain severity in patients with knee osteoarthritis vary according to the radiographic disease severity: a cross-sectional study
    • Shimura Y. Kurosawa H. Sugawara Y. Tsuchiya M. Sawa M. Kaneko H. et al. (2013) The factors associated with pain severity in patients with knee osteoarthritis vary according to the radiographic disease severity: a cross-sectional study. Osteoarthritis Cartilage 21: 1179-1184.
    • (2013) Osteoarthritis Cartilage , vol.21 , pp. 1179-1184
    • Shimura, Y.1    Kurosawa, H.2    Sugawara, Y.3    Tsuchiya, M.4    Sawa, M.5    Kaneko, H.6
  • 49
    • 70449627161 scopus 로고    scopus 로고
    • Longitudinal changes of serum comp and urinary CTX-II predict X-ray defined knee osteoarthritis severity and stiffness in women
    • Sowers M. Karvonen-Gutierrez C. Yosef M. Jannausch M. Jiang Y. Garnero P. et al. (2009) Longitudinal changes of serum comp and urinary CTX-II predict X-ray defined knee osteoarthritis severity and stiffness in women. Osteoarthritis Cartilage 17: 1609–1614.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 1609-1614
    • Sowers, M.1    Karvonen-Gutierrez, C.2    Yosef, M.3    Jannausch, M.4    Jiang, Y.5    Garnero, P.6
  • 50
    • 68949149834 scopus 로고    scopus 로고
    • Relationship between radiological knee osteoarthritis and biochemical markers of cartilage and bone degradation (Urine CTX-II and NTX-I): the Matsudai Knee Osteoarthritis Survey
    • Tanishi N. Yamagiwa H. Hayami T. Mera H. Koga Y. Omori G. et al. (2009) Relationship between radiological knee osteoarthritis and biochemical markers of cartilage and bone degradation (Urine CTX-II and NTX-I): the Matsudai Knee Osteoarthritis Survey. J Bone Miner Metab 27: 605–612.
    • (2009) J Bone Miner Metab , vol.27 , pp. 605-612
    • Tanishi, N.1    Yamagiwa, H.2    Hayami, T.3    Mera, H.4    Koga, Y.5    Omori, G.6
  • 51
    • 84871088548 scopus 로고    scopus 로고
    • Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis
    • van Spil W. Drossaers-Bakker K. Lafeber F. (2013) Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis. Ann Rheum Dis 72: 29–36.
    • (2013) Ann Rheum Dis , vol.72 , pp. 29-36
    • van Spil, W.1    Drossaers-Bakker, K.2    Lafeber, F.3
  • 52
    • 84862133807 scopus 로고    scopus 로고
    • Clusters within a wide spectrum of biochemical markers for osteoarthritis: data from check, a large cohort of individuals with very early symptomatic osteoarthritis
    • van Spil W. Jansen N. Bijlsma J. Reijman M. Degroot J. Welsing P. et al. (2012 a) Clusters within a wide spectrum of biochemical markers for osteoarthritis: data from check, a large cohort of individuals with very early symptomatic osteoarthritis. Osteoarthritis Cartilage 20: 745–754.
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. 745-754
    • van Spil, W.1    Jansen, N.2    Bijlsma, J.3    Reijman, M.4    Degroot, J.5    Welsing, P.6
  • 53
    • 84866447454 scopus 로고    scopus 로고
    • Cross-sectional and predictive associations between plasma adipokines and radiographic signs of early-stage knee osteoarthritis: data from CHECK
    • van Spil W. Welsing P. Kloppenburg M. Bierma-Zeinstra S. Bijlsma J. Mastbergen S. et al. (2012 b) Cross-sectional and predictive associations between plasma adipokines and radiographic signs of early-stage knee osteoarthritis: data from CHECK. Osteoarthritis Cartilage 20: 1278–1285.
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. 1278-1285
    • van Spil, W.1    Welsing, P.2    Kloppenburg, M.3    Bierma-Zeinstra, S.4    Bijlsma, J.5    Mastbergen, S.6
  • 55
    • 0032810715 scopus 로고    scopus 로고
    • Cyclic compression of articular cartilage explants is associated with progressive consolidation and altered expression pattern of extracellular matrix proteins
    • Wong M. Siegrist M. Cao X. (1999) Cyclic compression of articular cartilage explants is associated with progressive consolidation and altered expression pattern of extracellular matrix proteins. Matrix Biol 18: 391–399.
    • (1999) Matrix Biol , vol.18 , pp. 391-399
    • Wong, M.1    Siegrist, M.2    Cao, X.3
  • 56
    • 79955563063 scopus 로고    scopus 로고
    • Association of knee osteoarthritis with the accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose tolerance in Japanese men and women: the ROAD study
    • Yoshimura N. Muraki S. Oka H. Kawaguchi H. Nakamura K. Akune T. (2011) Association of knee osteoarthritis with the accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose tolerance in Japanese men and women: the ROAD study. J Rheumatol 38: 921–930.
    • (2011) J Rheumatol , vol.38 , pp. 921-930
    • Yoshimura, N.1    Muraki, S.2    Oka, H.3    Kawaguchi, H.4    Nakamura, K.5    Akune, T.6
  • 57
    • 84866464809 scopus 로고    scopus 로고
    • Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study
    • Yoshimura N. Muraki S. Oka H. Tanaka S. Kawaguchi H. Nakamura K. et al. (2012) Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study. Osteoarthritis Cartilage 20: 1217–1226.
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. 1217-1226
    • Yoshimura, N.1    Muraki, S.2    Oka, H.3    Tanaka, S.4    Kawaguchi, H.5    Nakamura, K.6
  • 59
    • 67349266985 scopus 로고    scopus 로고
    • Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis
    • Zainal Z. Longman A. Hurst S. Duggan K. Caterson B. Hughes C. et al. (2009) Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. Osteoarthritis Cartilage 17: 896–905.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 896-905
    • Zainal, Z.1    Longman, A.2    Hurst, S.3    Duggan, K.4    Caterson, B.5    Hughes, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.