The effects of intra-operative dexmedetomidine on postoperative pain, side-effects and recovery in colorectal surgery

Anaesthesia

Volumn 69, Issue 11, 2014, Pages 1214-1221

  Cheung, C W ^a   Qiu, Q ^a   Ying, A C L ^b   Choi, S W ^a   Law, W L ^a   Irwin, M G ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DEXMEDETOMIDINE; MORPHINE; ANALGESIC AGENT;

ADULT; AGED; ARTICLE; BOLUS INJECTION; BRADYCARDIA; COLORECTAL SURGERY; CONTINUOUS INFUSION; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HOSPITALIZATION; HUMAN; INTRAOPERATIVE PERIOD; LAPAROSCOPIC SURGERY; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; NAUSEA; PAIN ASSESSMENT; PATIENT CONTROLLED ANALGESIA; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RECOVERY ROOM; RESPIRATION DEPRESSION; TACHYCARDIA; TREATMENT OUTCOME; VOMITING; COLON; LAPAROSCOPY; MIDDLE AGED; PAIN, POSTOPERATIVE; RECTUM; SURGERY;

AGED; ANALGESICS, NON-NARCOTIC; COLON; DEXMEDETOMIDINE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTRAOPERATIVE PERIOD; LAPAROSCOPY; MALE; MIDDLE AGED; MORPHINE; PAIN, POSTOPERATIVE; RECTUM;

EID: 84908545416     PISSN: 00032409     EISSN: 13652044     Source Type: Journal    
DOI: 10.1111/anae.12759     Document Type: Article

References (25)

1. Unlugenc H, Gunduz M, Guler T, Yagmur O, Isik G,. The effect of pre-anaesthetic administration of intravenous dexmedetomidine on postoperative pain in patients receiving patient-controlled morphine. European Journal of Anaesthesiology 2005; 22: 386-91.
2. Tufanogullari B, White PF, Peixoto MP, et al. Dexmedetomidine infusion during laparoscopic bariatric surgery: the effect on recovery outcome variables. Anesthesia and Analgesia 2008; 106: 1741-8.
3. 2-adrenoceptor agonists and the cardiac patient. European Journal of Anaesthesiology 2006; 23: 361-72.
4. Schnabel A, Meyer-Friessem CH, Reichl SU, Zahn PK, Pogatzki-Zahn EM,. Is intraoperative dexmedetomidine a new option for postoperative pain treatment? A meta-analysis of randomized controlled trials. Pain 2013; 154: 1140-9.
5. Lui F, Ng KFJ,. Adjuvant analgesics in acute pain. Expert Opinion on Pharmacotherapy 2011; 12: 363-85.
6. Morris C, Gold S,. Enhanced recovery programmes; coming to a hospital near you! Anaesthesia 2011; 66: 864-8.
7. Poon JTC, Cheung CW, Fan JKM, Lo OSH, Law WL,. Single-incision versus conventional laparoscopic colectomy for colonic neoplasm: a randomized, controlled trial. Surgical Endoscopy 2012; 26: 2729-34.
8. Cheung CW, Ying CLA, Lee LHY, Tsang SF, Tsui SL, Irwin MG,. An audit of postoperative intravenous patient-controlled analgesia with morphine: evolution over the last decade. European Journal of Pain 2009; 13: 464-71.
9. Schulzer M, Mancini GBJ,. 'Unqualified success' and 'unmitigated failure': number-needed-to-treat-related concepts for assessing treatment efficacy in the presence of treatment-induced adverse events. International Journal of Epidemiology 1996; 25: 704-12.
10. Chan AKM, Cheung CW, Chong YK,. Alpha-2 agonists in acute pain management. Expert Opinion on Pharmacotherapy 2010; 11: 2849-68.
11. Neugebauer EAM, Wilkinson RC, Kehlet H, Schug SA,. PROSPECT: a practical method for formulating evidence-based expert recommendations for the management of postoperative pain. Surgical Endoscopy 2007; 21: 1047-53.
12. Schug SA, Chong C,. Pain management after ambulatory surgery. Current Opinion in Anesthesiology 2009; 22: 738-43.
13. Buvanendran A, Kroin JS,. Multimodal analgesia for controlling acute postoperative pain. Current Opinion in Anesthesiology 2009; 22: 588-93.
14. Hospira, Inc. Precedex (Dexmedetomidine Hydrochloride injection), 2008. http://www.precedex.com (accessed 25/04/2014).
15. Gurbet A, Basagan-Mogol E, Turker G, Ugun F, Kaya FN, Ozcan B,. Intraoperative infusion of dexmedetomidine reduces perioperative analgesic requirements. Canadian Journal of Anesthesia 2006; 53: 646-52.
16. 2-adrenoceptor agonist in mice. Journal of Pain 2010; 11: 71-8.
17. Ossipov MH, Lopez Y, Bian D, Nichols ML, Porreca F,. Synergistic antinociceptive interactions of morphine and clonidine in rats with nerve-ligation injury. Anesthesiology 1997; 86: 196-204.
18. Sullivan AF, Kalso EA, McQuay HJ, Dickenson AH,. The antinociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anaesthetized rat. European Journal of Pharmacology 1992; 215: 127-33.
19. Ulger F, Bozkurt A, Bilge SS, et al. The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors. Anesthesia and Analgesia 2009; 109: 616-22.
20. Arain SR, Ruehlow RM, Uhrich TD, Ebert TJ,. The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery. Anesthesia and Analgesia 2004; 98: 153-8.
21. Bloor BC, Ward DS, Belleville JP, Maze M,. Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes. Anesthesiology 1992; 77: 1134-42.
22. Jalonen J, Hynynen M, Kuitunen A, et al. Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Anesthesiology 1997; 86: 331-45.
23. Biccard BM, Goga S, de Beurs J,. Dexmedetomidine and cardiac protection for non-cardiac surgery: a meta-analysis of randomised controlled trials. Anaesthesia 2008; 63: 4-14.
24. Maze M, Tranquilli W,. Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia. Anesthesiology 1991; 74: 581-605.
25. Memis D, Dokmeci D, Karamanlioglu B, Turan A, Ture M,. A comparison of the effect on gastric emptying of propofol or dexmedetomidine in critcally ill patients: preliminary study. European Journal of Anaesthesiology 2006; 23: 700-4.