Quantitative analysis of exhaled carbonyl compounds distinguishes benign from malignant pulmonary disease

Journal of Thoracic and Cardiovascular Surgery

Volumn 148, Issue 3, 2014, Pages 1074-1081

  Bousamra II, Michael ^a   Schumer, Erin ^a   Li, Mingxiao ^b   Knipp, Ralph J ^c   Nantz, Michael H ^c   Van Berkel, Victor ^a   Fu, Xiao An ^b  

^a University of Louisville School of Medicine   (United States)

^b University of Louisville   (United States)

^c UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BUTANONE; ACETALDEHYDE; ACETOIN; CARBONYL DERIVATIVE; GLYCOLALDEHYDE; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; BREATH ANALYSIS; BRONCHOSCOPY; CANCER STAGING; CANCER SURGERY; COMPARATIVE STUDY; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; EXPIRED AIR; FEMALE; HUMAN; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG DISEASE; LUNG GRANULOMATOSIS; LUNG METASTASIS; LUNG NODULE; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; LYMPHADENOPATHY; MAJOR CLINICAL STUDY; MALE; PNEUMONIA; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; TUMOR BIOPSY;

ADULT; AGED; BREATH TESTS; CASE-CONTROL STUDIES; DIAGNOSIS, DIFFERENTIAL; EXHALATION; FOURIER ANALYSIS; HUMANS; LUNG NEOPLASMS; MASS SPECTROMETRY; MICROCHIP ANALYTICAL PROCEDURES; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; SOLITARY PULMONARY NODULE; TUMOR MARKERS, BIOLOGICAL; VOLATILE ORGANIC COMPOUNDS;

EID: 84908519216     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2014.06.006     Document Type: Conference Paper

References (32)

1. National Lung Screening Trial Research Team D.R. Aberle, A.M. Adams, C.D. Berg, W.C. Black, and J.D. Clapp et al. Reduced lung-cancer mortality with low-dose computed tomographic screening N Engl J Med 365 2011 395 409
2. S.C. Van't Westeinde, and R.J. van Klaveren Screening and early detection of lung cancer Cancer J 17 2011 3 10
3. N. Savage Early detection: spotting the first signs Nature 471 2011 S14 S15
4. Early warnings Nature 458 2009 679
5. M. Hakim, Y.Y. Broza, O. Barash, N. Peled, M. Phillips, and A. Amann et al. Volatile organic compounds of lung cancer and possible biochemical pathways Chem Rev 112 2012 5949 5966
6. L. Pauling, A.B. Robinson, R. Teranishi, and P. Cary Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography Proc Natl Acad Sci U S A 68 1971 2374 2376
7. Z.M. Zhang, Y.J. Ma, and G.K. Li Progress on the analytical methodology for biological volatile organic compounds Anal Methods 5 2013 20 29
8. P. Spanel, and D. Smith Volatile compounds in health and disease Curr Opin Clin Nutr Metab Care 14 2011 455 460
9. P.J. Mazzone, X.F. Wang, Y. Xu, T. Mekhail, M.C. Beukemann, and J. Na et al. Exhaled breath analysis with a colorimetric sensor array for the identification and characterization of lung cancer J Thorac Oncol 7 2012 137 142
10. N. Peled, M. Hakim, P.A. Bunn Jr., Y.E. Miller, T.C. Kennedy, and J. Mattei et al. Non-invasive breath analysis of pulmonary nodules J Thorac Oncol 7 2012 1528 1533
11. G. Peng, M. Hakim, Y.Y. Broza, S. Billan, R. Abdah-Bortnyak, and A. Kuten et al. Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors Br J Cancer 103 2010 542 551
12. G. Peng, U. Tisch, O. Adams, M. Hakim, N. Shehada, and Y.Y. Broza et al. Diagnosing lung cancer in exhaled breath using gold nanoparticles Nat Nanotechnol 4 2009 669 673
13. M. Hakim, S. Billan, U. Tisch, G. Peng, I. Dvrokind, and O. Marom et al. Diagnosis of head-and-neck cancer from exhaled breath Br J Cancer 104 2011 1649 1655
14. K. Schwarz, W. Filipiak, and A. Amann Determining concentration patterns of volatile compounds in exhaled breath by PTR-MS J Breath Res 3 2009 027002
15. C. Brunner, W. Szymczak, V. Hollriegl, S. Mortl, H. Oelmez, and A. Bergner et al. Discrimination of cancerous and non-cancerous cell lines by headspace-analysis with PTR-MS Anal Bioanal Chem 397 2010 2315 2324
16. P. Spanel, and D. Smith Progress in SIFT-MS: breath analysis and other applications Mass Spectrom Rev 30 2011 236 267
17. P. Cap, K. Dryahina, F. Pehal, and P. Spanel Selected ion flow tube mass spectrometry of exhaled breath condensate headspace Rapid Commun Mass Spectrom 22 2008 2844 2850
18. G. Song, T. Qin, H. Liu, G.B. Xu, Y.Y. Pan, and F.X. Xiong et al. Quantitative breath analysis of volatile organic compounds of lung cancer patients Lung Cancer 67 2010 227 231
19. A. Bajtarevic, C. Ager, M. Pienz, M. Klieber, K. Schwarz, and M. Ligor et al. Noninvasive detection of lung cancer by analysis of exhaled breath BMC Cancer 9 2009 348
20. P. Fuchs, C. Loeseken, J.K. Schubert, and W. Miekisch Breath gas aldehydes as biomarkers of lung cancer Int J Cancer 126 2010 2663 2670
21. D. Poli, M. Goldoni, M. Corradi, O. Acampa, P. Carbognani, and E. Internullo et al. Determination of aldehydes in exhaled breath of patients with lung cancer by means of on-fiber-derivatisation SPME-GC/MS J Chromatogr B Analyt Technol Biomed Life Sci 878 2010 2643 2651
22. M. Phillips, N. Altorki, J.H. Austin, R.B. Cameron, R.N. Cataneo, and R. Kloss et al. Detection of lung cancer using weighted digital analysis of breath biomarkers Clin Chim Acta 393 2008 76 84
23. T. Ligor, M. Ligor, A. Amann, C. Ager, M. Bachler, and A. Dzien et al. The analysis of healthy volunteers' exhaled breath by the use of solid-phase microextraction and GC-MS J Breath Res 2 2008 046006
24. H.P. Chan, C. Lewis, and P.S. Thomas Oxidative stress and exhaled breath analysis: a promising tool for detection of lung cancer Cancers 2 2010 32 42
25. P.J. Mazzone Exhaled breath volatile organic compound biomarkers in lung cancer J Breath Res 6 2012 027106
26. A. Amann, M. Corradi, P. Mazzone, and A. Mutti Lung cancer biomarkers in exhaled breath Expert Rev Mol Diagn 11 2011 207 217
27. X.A. Fu, M. Li, R.J. Knipp, M.H. Nantz, and M. Bousamra Noninvasive detection of lung cancer using exhaled breath Cancer Med 3 2014 174 181
28. X.A. Fu, M. Li, S. Biswas, M.H. Nantz, and R.M. Higashi A novel microreactor approach for analysis of ketones and aldehydes in breath Analyst 136 2011 4662 4666
29. M. Li, S. Biswas, M.H. Nantz, R.M. Higashi, and X.A. Fu Preconcentration and analysis of trace volatile carbonyl compounds Anal Chem 84 2012 1288 1293
30. Y.Y. Broza, R. Kremer, U. Tisch, A. Gevorkyan, A. Shiban, and L.A. Best et al. A nanomaterial-based breath test for short-term follow-up after lung tumor resection Nanomedicine 9 2013 15 21
31. I. Horvath, Z. Lazar, N. Gyulai, M. Kollai, and G. Losonczy Exhaled biomarkers in lung cancer Eur Respir J 34 2009 261 275
32. M. Ligor, T. Ligor, A. Bajtarevic, C. Ager, M. Pienz, and M. Klieber et al. Determination of volatile organic compounds in exhaled breath of patients with lung cancer using solid phase microextraction and gas chromatography mass spectrometry Clin Chem Lab Med 47 2009 550 560