The metabolically healthy but obese phenotype is associated with lower plasma levels of persistent organic pollutants as compared to the metabolically abnormal obese phenotype

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 6, 2014, Pages

  Gauthier, Marie Soleil ^a,b   Rabasa Lhoret, Rémi ^a,b,c,d   Prud'homme, Denis ^e   Karelis, Antony D ^f   Geng, Dawei ^g   Van Bavel, Bert ^g   Ruzzin, Jérôme ^h  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d UNIVERSITY OF OTTAWA   (Canada)

^e INSTITUT DU SAVOIR MONTFORT   (Canada)

^f UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^g ÖREBRO UNIVERSITY   (Sweden)

^h UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

DIOXIN; POLYCHLORINATED BIPHENYL;

ADULT; ARTICLE; BLOOD LEVEL; BODY MASS; CARDIOMETABOLIC RISK; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FAT MASS; HUMAN; HYPERINSULINEMIA; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; METABOLIC DISORDER; OBESITY; ORGANIC POLLUTANT; PHENOTYPE; POLLUTANT; POSTMENOPAUSE; PRIORITY JOURNAL; RISK ASSESSMENT;

AGED; BODY MASS INDEX; CARDIOVASCULAR DISEASES; ENVIRONMENTAL POLLUTANTS; FEMALE; HEALTH; HUMANS; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; ORGANIC CHEMICALS; OVERWEIGHT; PHENOTYPE; RISK FACTORS;

EID: 84899864055     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-3935     Document Type: Article

References (20)

1. Wildman RP, Muntner P, Reynolds K, et al. The obese without cardiometabolic risk factor clustering and the normal weight with card iometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med. 2008;168:1617-1624.
2. Messier V, Karelis AD, Prud 'homm e D, Primeau V, Brochu M, Rabasa-Lhoret R. Identifying metabolically healthy but obese individuals in sedentary postmenopausal women. Obesity. 2010;18: 911-917.
3. Karelis AD. To be obese-d oes it matter if you are metabolically healthy? Nat Rev Endocrinol. 2011;7:699-700.
4. Ruzzin J. Public health concern behind the exposure to persistent organic pollutants and the risk of metabolic diseases. BMC Public Health. 2012;12:298-302.
5. Schecter A, Colacino J, Haffner D, et al. Perfluorinated compounds, polychlorinated biphenyls, and organochlorine pesticide contamination in composite food samples from Dallas, Texas, USA. Environ Health Perspect. 2010;118:796-802.
6. Ruzzin J, Petersen R, Meugnier E, et al. Persistent organic pollutant exposure leads to insulin resistance syndrome. Environ Health Perspect. 2010;118:465-471.
7. Ibrahim MM, Fjaere E, Lock EJ, et al. Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice. Plos One. 2011;6:e25170.
8. Brochu M, Malita MF, Messier V, et al. Resistance training does not contribute to improving the metabolic profile after a 6-month weight loss program in overweight and obese postmenopausal women. J Clin Endoc rinol Metab. 2009;94:3226-3233.
9. Lavoie ME,Rabasa-Lhoret R,Doucet E,et al Association between physical activity energy expenditure and inflammatory markers in sedentary overweight and obese wome n Int J Obes (Lond). 2010 34 1387-1395.
10. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 2010;303: 235-241.
11. Karelis AD, Faraj M, Bastard JP, et al. The metabolically healthy but obese individual presents a favorable inflammation profile. J Clin Endocrinol Metab. 2005;90:4145-4150.
12. Karelis AD, Brochu M, Rabasa-Lhoret R. Can we identify metabolically healthy but obese individuals (MHO)? Diabetes Metab. 2004;30:569-572.
13. Salihovic S, Mattioli L, Linds tröm G, Lind L, Lind PM, van Bavel B. A rapid method for screening of the Stockholm Convention POPs in small amounts of human plasma using SPE and HRGC/HRMS. Chemosphere. 2012;86:747-753.
14. Sc histerman EF, Whitcomb BW, Louis GM, Louis TA. Lipid adjustment in the analysis of environmental contaminants and human health risks. Environ Health Perspect. 2005;113:853-857.
15. Guo YL, Em mett EA, Pellizzari ED, Rohde CA. Influence of serum cholesterol and albumin on partitioning of PCB congeners between human serum and adipose tissue. Toxicol Appl Pharmacol. 1987; 87:48-56.
16. Lee D H, Lee IK, Jin SH, Steffes M, Jacobs DR Jr. Association between serum concentrations of persistent organic pollutants and insulin resistance among nondiabetic adults: results from the National Health and Nutrition Examination Survey 19 99-2002. Diabetes Care. 2007;30:622-628.
17. Lee DH, Lee IK, Porta M, Steffes M, Jacobs DR Jr. Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002. Diabetologia. 2007;50:1841-1851.
18. Lee DH, Lee IK, Song K, et al . A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002. Diabetes Care. 2006;29:1638-1644.
19. Lee DH, Lind PM, Jacobs DR Jr., Salihovic S, van Bavel B, Lind L. Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investiga tion of the vasculature in Uppsala Seniors (PIVUS) study. Diabetes Care. 2011;34:1778-1784.
20. Lee DH, Lind L, Jacobs DR Jr., Salihovic S, van Bavel B, Lind PM. Associations of persisten t organic pollutants with abdominal obesity in the elderly: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Environ Int. 2012;40:170-178.