Identification of the structural basis of thermal lability of a virus provides a rationale for improved vaccines

Structure

Volumn 22, Issue 11, 2014, Pages 1560-1570

  Rincón, Verónica ^a   Rodríguez Huete, Alicia ^a   López Argüello, Silvia ^a   Ibarra Molero, Beatriz ^b   Sanchez Ruiz, Jose M ^b   Harmsen, Michiel M ^c   Mateu, Mauricio G ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; NANOPARTICLE; VIRUS RNA; VIRUS VACCINE; CAPSID PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; FOOT AND MOUTH DISEASE VIRUS; GENETIC ALGORITHM; GENETIC STABILITY; HYDROGEN BOND; IONIC STRENGTH; NONHUMAN; STATIC ELECTRICITY; TEMPERATURE DEPENDENCE; THERMOSTABILITY; VIRION; VIRUS CAPSID; VIRUS INFECTIVITY; VIRUS MORPHOLOGY; VIRUS PARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC TRANSFECTION; GENETICS; PHENOTYPE; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; TEMPERATURE; VIRUS DNA CELL DNA INTERACTION;

CAPSID PROTEINS; FOOT-AND-MOUTH DISEASE VIRUS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHENOTYPE; RNA, VIRAL; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; TRANSFECTION; VIRAL VACCINES; VIRION; VIRUS INTEGRATION;

EID: 84908504102     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2014.08.019     Document Type: Article

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