TRAP1 Shows Clinical Significance and Promotes Cellular Migration and Invasion through STAT3/MMP2 Pathway in Human Esophageal Squamous Cell Cancer

Journal of Genetics and Genomics

Volumn 41, Issue 10, 2014, Pages 529-537

  Ou, Yunwei ^a,b   Liu, Lingyan ^b   Xue, Liyan ^b   Zhou, Wei ^b   Zhao, Zitong ^b   Xu, Bainan ^a   Song, Yongmei ^b   Zhan, Qimin ^b  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

Clinical; EMT; ESCC; Invasion; Migration; MMP 2; NSCLC; TRAP1

Indexed keywords

CISPLATIN; GELATINASE A; MOLECULAR MARKER; STAT3 PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; ANTINEOPLASTIC AGENT; HEAT SHOCK PROTEIN 90; MMP2 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN; TRAP1 PROTEIN, HUMAN; TUMOR MARKER;

ADULT; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER PATIENT; CANCER PROGNOSIS; CARCINOGENESIS; CELL DIFFERENTIATION; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INDUCTION; EPITHELIAL MESENCHYMAL TRANSITION; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; FOLLOW UP; GENE SILENCING; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; WNT SIGNALING PATHWAY; CARCINOMA, SQUAMOUS CELL; CELL MOTION; DRUG EFFECTS; ESOPHAGEAL NEOPLASMS; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS; TUMOR CELL LINE; TUMOR INVASION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOMARKERS, TUMOR; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; CISPLATIN; ESOPHAGEAL NEOPLASMS; FEMALE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; MIDDLE AGED; NEOPLASM INVASIVENESS; PROGNOSIS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84908501752     PISSN: 16738527     EISSN: 18735533     Source Type: Journal    
DOI: 10.1016/j.jgg.2014.08.004     Document Type: Article

References (21)

1. Agorreta J., Hu J., Liu D., Delia D., Turley H., Ferguson D.J., Iborra F., Pajares M.J., Larrayoz M., Zudaire I., Pio R., Montuenga L.M., Harris A.L., Gatter K., Pezzella F. TRAP1 regulates proliferation, mitochondrial function, and has prognostic significance in NSCLC. Mol. Cancer Res. 2014, 12:660-669.
2. Aust S., Bachmayr-Heyda A., Pateisky P., Tong D., Darb-Esfahani S., Denkert C., Chekerov R., Sehouli J., Mahner S., Van Gorp T., Vergote I., Speiser P., Horvat R., Zeillinger R., Pils D. Role of TRAP1 and estrogen receptor alpha in patients with ovarian cancer - A study of the OVCAD consortium. Mol. Cancer 2012, 11:69.
3. Brivanlou A.H., Darnell J.E. Signal transduction and the control of gene expression. Science 2002, 295:813-818.
4. Costantino E., Maddalena F., Calise S., Piscazzi A., Tirino V., Fersini A., Ambrosi A., Neri V., Esposito F., Landriscina M. TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptosis in human colorectal carcinoma cells. Cancer Lett. 2009, 279:39-46.
5. Gao J.Y., Song B.R., Peng J.J., Lu Y.M. Correlation between mitochondrial TRAP-1 expression and lymph node metastasis in colorectal cancer. World J. Gastroenterol. 2012, 18:5965-5971.
6. Hsu J.M., Chen C.T., Chou C.K., Kuo H.P., Li L.Y., Lin C.Y., Lee H.J., Wang Y.N., Liu M., Liao H.W., Shi B., Lai C.C., Bedford M.T., Tsai C.H., Hung M.C. Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat. Cell Biol. 2011, 13:174-181.
7. Im C.N., Seo J.S. Overexpression of tumor necrosis factor receptor-associated protein 1 (TRAP1), leads to mitochondrial aberrations in mouse fibroblast NIH/3T3 cells. BMB Rep. 2014, 47:280-285.
8. Landriscina M., Amoroso M.R., Piscazzi A., Esposito F. Heat shock proteins, cell survival and drug resistance: the mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy. Gynecol. Oncol. 2010, 117:177-182.
9. Leav I., Plescia J., Goel H.L., Li J., Jiang Z., Cohen R.J., Languino L.R., Altieri D.C. Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. Am. J. Pathol. 2010, 176:393-401.
10. Maddalena F., Sisinni L., Lettini G., Condelli V., Matassa D.S., Piscazzi A., Amoroso M.R., La Torre G., Esposito F., Landriscina M. Resistance to paclitxel in breast carcinoma cells requires a quality control of mitochondrial antiapoptotic proteins by TRAP1. Mol. Oncol. 2013, 7:895-906.
11. Matassa D.S., Amoroso M.R., Agliarulo I., Maddalena F., Sisinni L., Paladino S., Romano S., Romano M.F., Sagar V., Loreni F., Landriscina M., Esposito F. Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1. Cell Death Dis. 2013, 4:e851.
12. Montesano Gesualdi N., Chirico G., Pirozzi G., Costantino E., Landriscina M., Esposito F. Tumor necrosis factor-associated protein 1 (TRAP-1) protects cells from oxidative stress and apoptosis. Stress 2007, 10:342-350.
13. Ou Y., Ma L., Dong L., Zhao Z., Zhou W., Fan J., Wu C., Yu C., Zhan Q., Song Y. Migfilin protein promotes migration and invasion in human glioma through epidermal growth factor receptor-mediated phospholipase C-gamma and STAT3 protein signaling pathways. J. Biol. Chem. 2012, 287:32394-32405.
14. Plescia J., Salz W., Xia F., Pennati M., Zaffaroni N., Daidone M.G., Meli M., Dohi T., Fortugno P., Nefedova Y., Gabrilovich D.I., Colombo G., Altieri D.C. Rational design of shepherdin, a novel anticancer agent. Cancer Cell 2005, 7:457-468.
15. Song Y., Li L., Ou Y., Gao Z., Li E., Li X., Zhang W., Wang J., Xu L., Zhou Y., Ma X., Liu L., Zhao Z., Huang X., Fan J., Dong L., Chen G., Ma L., Yang J., Chen L., He M., Li M., Zhuang X., Huang K., Qiu K., Yin G., Guo G., Feng Q., Chen P., Wu Z., Wu J., Zhao J., Luo L., Fu M., Xu B., Chen B., Li Y., Tong T., Wang M., Liu Z., Lin D., Zhang X., Yang H., Zhan Q. Identification of genomic alterations in oesophageal squamous cell cancer. Nature 2014, 509:91-95.
16. Wittchen E.S., Hartnett M.E. The small GTPase Rap1 is a novel regulator of RPE cell barrier function. Invest. Ophthalmol. Vis. Sci. 2011, 52:7455-7463.
17. Woessner J.F. Role of matrix proteases in processing enamel proteins. Connect. Tissue Res. 1998, 39:69-73. discussion 141-149.
18. Xie T.X., Wei D., Liu M., Gao A.C., Ali-Osman F., Sawaya R., Huang S. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 2004, 23:3550-3560.
19. Xu Y., Yu X., Chen Q., Mao W. Neoadjuvant versus adjuvant treatment: which one is better for resectable esophageal squamous cell carcinoma?. World J. Surg. Oncol. 2012, 10:173.
20. Zhang S.W., Zhang M., Li G.L., Wei W.Q., Meng F.S., Liu Z.C., Zheng R.S., Li N., Cheng W.Q. An analysis of incidence and mortality of esophageal cancer in China, 2003-2007. China Cancer 2012, 21:241-247.
21. Zhou B.B., Zhang H., Damelin M., Geles K.G., Grindley J.C., Dirks P.B. Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nat. Rev. Drug Discov. 2009, 8:806-823.