Efficacy and safety of pidotimod in the prevention of recurrent respiratory infections in children: A multicentre study

International Journal of Immunopathology and Pharmacology

Volumn 27, Issue 3, 2014, Pages 413-419

  Namazova Baranova, L S ^a   Alekseeva, A A ^a   Kharit, S M ^b   Kozhevnikova, T N ^c   Taranushenko, T E ^d   Tuzankina, I A ^e   Scarci, F ^f  

^a Russian Academy of Medical Sciences   (Russian Federation)

^b Public Health Committee in Vaccinal Prevention ^*  (Russian Federation)

^c Center for Respiratory Pathology of Children   (Russian Federation)

^d KRASNOYARSK STATE MEDICAL UNIVERSITY   (Russian Federation)

^e INSTITUTE OF IMMUNOLOGY AND PHYSIOLOGY   (Russian Federation)

^f Scientific Department Polichem SA   (Switzerland)

Author keywords

Acute respiratory infections; Pidotimod; Prophylaxis; Recurrent respiratory infections

Indexed keywords

BIOLOGICAL MARKER; GAMMA INTERFERON; IMMUNOGLOBULIN A; INTERLEUKIN 8; PIDOTIMOD; DRUG DERIVATIVE; IMMUNOLOGICAL ADJUVANT; PYROGLUTAMIC ACID; THIAZOLIDINE DERIVATIVE;

ANTIBIOTIC THERAPY; ARTICLE; BRONCHITIS; CHILD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OTITIS; RECURRENT INFECTION; RESPIRATORY TRACT INFECTION; RHINOPHARYNGITIS; SYMPTOM; ACUTE DISEASE; BLOOD; IMMUNOLOGY; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE;

ACUTE DISEASE; ADJUVANTS, IMMUNOLOGIC; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INTERLEUKIN-8; MALE; PYRROLIDONECARBOXYLIC ACID; RECURRENCE; RESPIRATORY TRACT INFECTIONS; THIAZOLIDINES;

EID: 84908457964     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463201402700311     Document Type: Article

References (22)

1. Black RE, Cousens S, Johnson HL, et al. Global, regional, and national causes of child mortality in 2008: A systematic analysis. Lancet 2010; 375:1969-87.
2. Hollinghurst S, Gorst C, Fahey T, et al. Measuring the financial burden of acute cough in pre-school children: A cost of illness study. BMC Fam Pract 2008; 9:10.
3. Mikhallova EV. Children's health status under ambient air pollution. Gig Sanit 2005; (2):49-51.
4. Pawlinska-Chmara R, Wronka I. Assessment of the effect of socioeconomic factors on the prevalence of respiratory disorders in children. J Physiol Pharmacol 2007; 58(S):523-9.
5. Jamison DT, Breman JG, Measham AR, et al. Disease Control Priorities in Developing Countries. 2nd edition Washington (DC): World Bank; 2006.
6. Couriel J. Assessment of the child with recurrent chest infections. Brit Med Bull 2002; 61(1): 115-32.
7. Francis NA, Phillips R, Wood F, Hood K, Simpson S, Butler CC. Parents' and clinicians' views of an interactive booklet about respiratory tract infections in children: A qualitative process evaluation of the EQUIP randomised controlled trial. BMC Family Practice 2013; 14:182.
8. Bossuyt X, Moens L, Van-Hoeyveld E, et al. Coexistence of (partial) immune defects and risk of recurrent respiratory infections. Clin Chem 2007; 53(1): 124- 30.
9. Kvestad E, Kvaerner KJ, Reysamb E, Tambs K, Harris JR, Magnus P. Recurrent otitis media and tonsillitis: common disease predisposition. Int J Pediatr Otorhi 2006; 70(9): 1561-68.
10. Don M, Fasoli L, Gregorutti V, Pisa F, Valent F, Prodan M, Canciani M. Recurrent respiratory infections and phagocytosis in childhood. Pediatr Int 2007; 49(1):40-47.
11. Atkinson AP, Cedzynski M, Szemraj J, et al. L-ficolin in children with recurrent respiratory infections. Clin Exp Immunol 2004; 138(3):517-20.
12. Day N, Tangsinmankong N, Ochs H, Rucker R, Picard C, Casanova JL, Haraguchi S. Interleukin receptor-associated kinase (IRAK-4) deficiency associated with bacterial infections and failure to sustain antibody response. J Pediatr 2004; 144(4):524-26.
13. Finocchi A, Angelini F, Chini L, Di Cesare S, Cancrini C, Rossi P, Moschese V. Evaluation of the relevance of humoral immunodeficiencies in a pediatric population affected by recurrent infections. Pediatr Allergy Immu 2002; 13(6):443-47.
14. Ottenhoff TH, Verreck FA, Lichtenauer-Kaligis EG, Hoeve MA, Sanal O, van-Dissel JT. Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae. Nat Genet 2002; 32(1):97-105.
15. Li-Volti G, Malaponte G, Bevelacqua V, Messina A, Bianca S, Mazzarino MC, Li-Volti S. Persistent high plasma levels of interleukin 18 and 4 in children with recurrent infections of the upper respiratory tract. Transplant Proc 2003; 35(8):2911-15.
16. Arden KE. Frequent detection of human rhino viruses, paramyxoviruses, coronaviruses and bocavirus during acute respiratory tract infections. J Med Virol 2006; 78(9): 1232-1240.
17. de Martino M, Balloti S. The child with recurrent respiratory infections: normal or not? Pediatr Allergy Immunol 2007; 18(S):13-8.
18. Schoenborn JR, Wilson CB. Regulation of interfer- on-gamma during innate and adaptive immune responses. Adv Immunol 2007; 96:41-101.
19. Giagulli C, Noerder M, Avolio M, Becker PD, Fiorentini S, Guzman CA, Caruso A. Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level. Int Immunopharmacol 2009; 9(12): 1366-73.
20. Riboldi P, Gerosa M, Meroni PL. Pidotimod: A reprisal. Int J Immupath Ph 2009; 22(2):255-62.
21. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18:767-811.
22. Principi N, Esposito S, Cavagna R, et al. Recurrent respiratory tract infections in pediatric age: A population-based survey of the therapeutic role of macro- lides. J Chemother 2003; 15(1):53-9.