Discovery and structure-activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 21, 2014, Pages 5988-6003

  Zhulenkovs, Dmitrijs ^a,b   Rudevica, Zhanna ^a   Jaudzems, Kristaps ^c   Turks, Maris ^d   Leonchiks, Ainars ^a  

^a LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE   (Latvia)

^b UNIVERSITY OF LATVIA   (Latvia)

^c LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^d RIGA TECHNICAL UNIVERSITY   (Latvia)

Author keywords

High throughput screening; Inhibitor; Sortase A; Structure activity relationship

Indexed keywords

1 (3,4 DICHLOROPHENYL) 3 (DIMETHYLAMINO)PROPAN 1 ONE; ACYLTRANSFERASE INHIBITOR; BENZISOTHIAZOLINONE DERIVATIVE; BENZOTHIAZOLINE DERIVATIVE; METHYL 3 [3 (3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)PROPANAMIDO]ADAMANTANE 1 CARBOXYLATE; METHYL 3 [3 (4 FLUORO 3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)PROPANAMIDO]ADAMANTANE 1 CARBOXYLATE; N (3 HYDROXY 5,7 DIMETHYLADAMANTAN 1 YL) 2 (3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)ACETAMIDE; N (3 HYDROXY 5,7 DIMETHYLADAMANTAN 1 YL) 3 (3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)PROPANAMIDE; N (3 HYDROXY 5,7 DIMETHYLADAMANTAN 1 YL) 3 (4 FLUORO 3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)PROPANAMIDE; N (3 HYDROXYADAMANTAN 1 YL) 3 (3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)PROPANAMIDE; N (3 HYDROXYADAMANTAN 1 YL) 3 (4 FLUORO 3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)PROPANAMIDE; N (3,5 DIMETHYLADAMANTAN 1 YL) 3 (3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)ACETAMIDE; N (3,5 DIMETHYLADAMANTAN 1 YL) 3 (3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)PROPANAMIDE; N (3,5 DIMETHYLADAMANTAN 1 YL) 3 (4 FLUORO 3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)PROPANAMIDE; N (ADAMANTAN 1 YL) 2 (1 OXOISOINDOLIN 2 YL)ACETAMIDE; N (ADAMANTAN 1 YL) 3 (4 FLUORO 3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)PROPANAMIDE; N ADAMANTAN 1 YL 3 (3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)PROPANAMIDE; N' [2 (3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)ACETYL]ADAMANTANE 1 CARBOHYDRAZIDE; N' [3 (3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)PROPANOYL]ADAMANTANE 1 CARBOHYDRAZIDE; N' [3 (4 FLUORO 3 OXOBENZO[D]ISOTHIAZOL 2(3H)YL)PROPANOYL]ADAMANTANE 1 CARBOHYDRAZIDE; PHENYLVINYLSULFONE; RECOMBINANT ENZYME; SORTASE; SORTASE A; UNCLASSIFIED DRUG; 1,2-BENZISOTHIAZOLINE-3-ONE; AMINOACYLTRANSFERASE; BACTERIAL PROTEIN; CYSTEINE PROTEINASE; ENZYME INHIBITOR; THIAZOLE DERIVATIVE;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; EMBRYO; ENZYME INHIBITION; ESCHERICHIA COLI; FIBROBLAST; FLUORESCENCE RESONANCE ENERGY TRANSFER; IC50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR DOCKING; STAPHYLOCOCCAL INFECTIONS;

AMINOACYLTRANSFERASES; BACTERIAL PROTEINS; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR DOCKING SIMULATION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84908453532     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.09.011     Document Type: Article

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