SCOPUS 정보 검색 플랫폼

Volumn 22, Issue 21, 2014, Pages 6256-6269

Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping

(15) Doig, Peter a Boriack Sjodin, P Ann a Dumas, Jacques a Hu, Jun a Itoh, Kenji b Johnson, Kenneth a Kazmirski, Steven a Kinoshita, Tomohiko b Kuroda, Satoru b Sato, Tomo O b Sugimoto, Kaori b Tohyama, Katsumi b Aoi, Hiroshi b Wakamatsu, Kazusa b Wang, Hongming a

a ASTRAZENECA (United Kingdom)

b WAKUNAGA PHARMACEUTICAL CO LTD (Japan)

Author keywords

Aminoquinazoline; Cell wall biosynthesis; GlmU; N Acetylglucosamine 1 phosphate; Uridyltransferase; Virtual screening

Indexed keywords

ANTIINFECTIVE AGENT; BENZAMIDE; HEXOSE 1 PHOSPHATE URIDYLYLTRANSFERASE; N ACETYLGLUCOSAMINE; PROTEIN GLMU; UNCLASSIFIED DRUG; URACIL; 4-AMINOQUINAZOLINE; ENZYME INHIBITOR; ESCHERICHIA COLI PROTEIN; GLMU PROTEIN, E COLI; MULTIENZYME COMPLEX; QUINAZOLINE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; ENZYME INHIBITION; IC50; MEDICINAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL WALL; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR DOCKING;

ANIMALS; ANTI-BACTERIAL AGENTS; CELL WALL; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; MOLECULAR DOCKING SIMULATION; MULTIENZYME COMPLEXES; QUINAZOLINES;

EID: 84908431008 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2014.08.017 Document Type: Article

Times cited : (12)

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