Trial of the route of early nutritional support in Critically ill adults

New England Journal of Medicine

Volumn 371, Issue 18, 2014, Pages 1673-1684

  Harvey, Sheila E ^a   Parrott, Francesca ^a   Harrison, David A ^a   Bear, Danielle E ^b   Segaran, Ella ^c   Beale, Richard ^b,d   Bellingan, Geoff ^e   Leonard, Richard ^c,f,g   Mythen, Michael G ^e   Rowan, Kathryn M ^a  

^a and London School of Hygiene Tropical Medicine   (United Kingdom)

^b Department of Nutrition Dietetics   (United Kingdom)

^c GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^d IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^g IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL DISTENSION; ADULT; ARTICLE; CALORIC INTAKE; CAUSE OF DEATH; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CRITICALLY ILL PATIENT; EARLY INTERVENTION; ELECTROLYTE DISTURBANCE; ENTERIC FEEDING; FEMALE; FOOD ASPIRATION; GASTROINTESTINAL HEMORRHAGE; HEART INFARCTION; HUMAN; HYPOGLYCEMIA; INTENSIVE CARE UNIT; INTERMETHOD COMPARISON; INTESTINE ISCHEMIA; JAUNDICE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NUTRITIONAL SUPPORT; NUTRITIONAL VALUE; OUTCOME ASSESSMENT; PARENTERAL NUTRITION; PATIENT COMPLIANCE; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; RISK REDUCTION; VOMITING; AGED; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CRITICAL ILLNESS; MIDDLE AGED; MORTALITY;

ADULT; AGED; CRITICAL ILLNESS; ENERGY INTAKE; ENTERAL NUTRITION; FEMALE; HUMANS; HYPOGLYCEMIA; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PARENTERAL NUTRITION; VOMITING;

EID: 84908406451     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1409860     Document Type: Article

References (31)

1. Gramlich L, Kichian K, Pinilla J, Rodych NJ, Dhaliwal R, Heyland DK. Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? A systematic review of the literature. Nutrition 2004; 20: 843-8.
2. Heyland DK, Dhaliwal R, Drover JW, Gramlich L, Dodek P. Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr 2003;27: 355-73.
3. Simpson F, Doig GS. Parenteral vs. enteral nutrition in the critically ill patient: A meta-analysis of trials using the intention to treat principle. Intensive Care Med 2005;31: 12-23.
4. Martindale RG, McClave SA, Vanek VW, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition: Executive summary. Crit Care Med 2009;37: 1757-61.
5. Singer P, Berger MM, Van Den Berghe G, et al. ESPEN guidelines on parenteral nutrition: Intensive care. Clin Nutr 2009; 28: 387-400.
6. De Jonghe B, Appere-De-Vechi C, Fournier M, et al. A prospective survey of nutritional support practices in intensive care unit patients: What is prescribed? What is delivered? Crit Care Med 2001; 29: 8-12.
7. Engel JM, Muhling J, Junger A, Menges T, Karcher B, Hempelmann G. Enteral nutrition practice in a surgical intensive care unit: What proportion of energy expenditure is delivered enterally? Clin Nutr 2003;22: 187-92.
8. Boitano M, Bojak S, McCloskey S, Mc-Caul DS, McDonough M. Improving the safety and effectiveness of parenteral nutrition: Results of a quality improvement collaboration. Nutr Clin Pract 2010;25: 663-71.
9. Naylor CJ, Griffiths RD, Fernandez RS. Does a multidisciplinary total parenteral nutrition team improve patient outcomes? A systematic review. JPEN J Parenter Enteral Nutr 2004;28: 251-8.
10. Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med 2011; 365: 506-17.
11. Heidegger CP, Berger MM, Graf S, et al. Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: A randomised controlled clinical trial. Lancet 2013;381: 385-93.
12. Harrison DA, Brady AR, Rowan K. Case mix, outcome and length of stay for admissions to adult, general critical care units in England, Wales and Northern Ireland: The Intensive Care National Audit and Research Centre Case Mix Programme Database. Crit Care 2004;8: R99-R111.
13. High impact intervention no 1: Central venous catheter care bundle. London: National Health Service, 2007 (http://webarchive.nationalarchives.gov.uk/20130107105354/http://www.dh.gov.uk/prod-consum-dh/groups/dh-digitalassets/@dh/@en/documents/digitalasset/dh -078120.pdf).
14. Reducing the harm caused by misplaced nasogastric feeding tubes-patient safety alert. London: National Patient Safety Agency, February 2005 (http://www.nrls.npsa.nhs.uk/resources/?EntryId 45=59794).
15. How to confirm the correct position of nasogastric feeding tubes in infants, children and adults-interim advice for healthcare staff. London: National Patient Safety Agency, 2005 (http://www.nrls.npsa .nhs.uk/resources/?EntryId45=59794).
16. Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41: 580-637.
17. Harvey S, Harrison DA, Singer M, et al. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): A randomised controlled trial. Lancet 2005;366: 472-7.
18. Grant AM, Altman DG, Babiker AB, et al. Issues in data monitoring and interim analysis of trials. Health Technol Assess 2005;9: 1-238.
19. Harvey SE, Parrott F, Harrison DA, Mythen M, Rowan KM. The CALORIES trial statistical analysis plan. Crit Care Resusc (in press).
20. Harrison DA, Parry GJ, Carpenter JR, Short A, Rowan K. A new risk prediction model for critical care: The Intensive Care National Audit and Research Centre (ICNARC) model. Crit Care Med 2007;35: 1091-8.
21. van Buuren S, Boshuizen HC, Knook DL. Multiple imputation of missing blood pressure covariates in survival analysis. Stat Med 1999;18: 681-94.
22. Thompson SG, Barber JA. How should cost data in pragmatic randomised trials be analysed? BMJ 2000;320: 1197-200.
23. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: A severity of disease classification system. Crit Care Med 1985;13: 818-29.
24. Fischer K, Goetghebeur E, Vrijens B, White IR. A structural mean model to allow for noncompliance in a randomized trial comparing 2 active treatments. Biostatistics 2011;12: 247-57.
25. Greenland S. An introduction to instrumental variables for epidemiologists. Int J Epidemiol 2000;29: 722-9.
26. Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med 1996; 22: 707-10.
27. Bion J, Richardson A, Hibbert P, et al. 'Matching Michigan': A 2-year stepped interventional programme to minimise central venous catheter-blood stream infections in intensive care units in England. BMJ Qual Saf 2013;22: 110-23.
28. High impact intervention no 5: Care bundle for ventilated patients (or tracheostomy where appropriate). London: National Health Service, 2007 (http://webarchive .nationalarchives.gov.uk/20130107105354/http://www.dh.gov.uk/prod-consum-dh/groups/dh-digitalassets/@dh/@en/documents/digitalasset/dh-078124.pdf).
29. Reignier J, Mercier E, Le Gouge A, et al. Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: A randomized controlled trial. JAMA 2013; 309: 249-56.
30. Casaer MP, Wilmer A, Hermans G, Wouters PJ, Mesotten D, Van Den Berghe G. Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: A post hoc analysis. Am J Respir Crit Care Med 2013;187: 247-55.
31. Doig GS, Simpson F, Sweetman EA, et al. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: A randomized controlled trial. JAMA 2013;309: 2130-8.