Synthesis and structure-activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 22, 2014, Pages 6490-6502

  Ireland, Alex W ^a   Gobillot, Theodore A ^a   Gupta, Tushar ^a   Seguin, Sandlin P ^a   Liang, Mary ^a   Resnick, Lynn ^a   Goldberg, Margot T ^a   Manos Turvey, Alexandra ^a   Pipas, James M ^a   Wipf, Peter ^a   Brodsky, Jeffrey L ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

ATPase; Large T antigen; Molecular chaperone; Polyomavirus; Pyrimidinone; SV40; Viral replication

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANTIVIRUS AGENT; BENZYL DERIVATIVE; CARBENE; LR 340001; LR 340003; LR 340006; MAL 211B; MAL 28256; MAL 28266; ML 28256; ML 28259; ML 28260; ML 28261; ML 28266; PYRIMIDINONE DERIVATIVE; STAUROSPORINE; UNCLASSIFIED DRUG; VIRUS LARGE T ANTIGEN; MOLECULAR LIBRARY; PEPTOID; PROTEIN BINDING; VIRUS T ANTIGEN;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; POLYOMA VIRUS; SIMIAN VIRUS 40; STRUCTURE ACTIVITY RELATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HEK293 CELL LINE; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; POLYOMAVIRUS; SYNTHESIS; VIRUS REPLICATION;

ANTIGENS, VIRAL, TUMOR; ANTIVIRAL AGENTS; CELL SURVIVAL; HEK293 CELLS; HUMANS; PEPTOIDS; POLYOMAVIRUS; PROTEIN BINDING; PYRIMIDINONES; SIMIAN VIRUS 40; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84908376619     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.09.019     Document Type: Article

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