Dimerization of simian virus 40 T-antigen hexamers activates T-antigen DNA helicase activity

Journal of Virology

Volumn 71, Issue 11, 1997, Pages 8766-8773

  Smelkova, Natalia V ^a   Borowiec, James A ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; SINGLE STRANDED DNA; VIRUS DNA; VIRUS LARGE T ANTIGEN;

ARTICLE; DIMERIZATION; DNA BINDING; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; SIMIAN VIRUS 40; VIRUS REPLICATION;

EID: 0030840509     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.11.8766-8773.1997     Document Type: Article

References (42)

1. Bear, D. G., and D. S. Peabody. 1988. The E. coli Rho protein: an ATPase that terminates transcription. Trends Biochem. Sci. 13:343-347.
2. Berezney, R., M. J. Mortillaro, H. Ma, X. Wei, and J. Samarabandu. 1995. The nuclear matrix: a structural milieu for genomic function. Int. Rev. Cytol. 162A:1-65.
3. Borowiec, J. 1992. Inhibition of structural changes in the simian virus 40 core origin of replication by mutation of essential origin sequences. J. Virol. 66:5248-5255.
4. Borowiec, J. A., and J. Hurwitz. 1988. ATP stimulates the binding of simian virus 40 (SV40) large tumor antigen to the SV40 origin of replication. Proc. Natl. Acad. Sci. USA 85:64-68.
5. Bujalowski, W., and M. M. Klonowska. 1993. Negative cooperativity in the binding of nucleotides to Escherichia coli replicative helicase DnaB protein. Interactions with fluorescent nucleotide analogs. Biochemistry 32:5888-5900.
6. Dean, F. B., P. Bullock, Y. Murakami, C. R. Wobbe, L. Weissbach, and J. Hurwitz. 1987. Simian virus 40 (SV40) DNA replication: SV40 large T antigen unwinds DNA containing the SV40 origin of replication. Proc. Natl. Acad. Sci. USA 84:16-20.
7. Dean, F. B., M. Dodson, H. Echols, and J. Hurwitz. 1987. ATP-dependent formation of a specialized nucleoprotein structure by simian virus 40 (SV40) large tumor antigen at the SV40 replication origin. Proc. Natl. Acad. Sci. USA 84:8981-8985.
8. Deb, S., and P. Tegtmeyer. 1987. ATP enhances the binding of simian virus 40 large T antigen to the origin of replication. J. Virol. 61:3649-3654.
9. Dong, F., E. P. Gogol, and P. H. von Hippel. 1995. The phage T4-coded DNA replication helicase (gp41) forms a hexamer upon activation by nucleoside triphosphate. J. Mol. Biol. 270:7462-7473.
10. Egelman, E. H., X. Yu, R. Wild, M. M. Hingorani, and S. S. Patel. 1995. Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicases. Proc. Natl. Acad. Sci. USA 92:3869-3873.
11. Fanning, E., and R. Knippers. 1992. Structure and function of simian virus 40 large tumor antigen. Annu. Rev. Biochem. 61:55-85.
12. Geiselmann, J., T. D. Yager, S. C. Gill, P. Calmettes, and P. H. von Hippel. 1992. Physical properties of the Escherichia coli transcription termination factor rho. 1. Association states and geometry of the rho hexamer. Biochemistry 31:111-121.
13. Goetz, G. S., F. B. Dean, J. Hurwitz, and S. W. Matson. 1988. The unwinding of duplex regions in DNA by the simian virus 40 large tumor antigen-associated DNA helicase activity. J. Biol. Chem. 263:383-392.
14. Hingorani, M. M., and S. S. Patel. 1993. Interactions of bacteriophage T7 DNA primase/helicase protein with single-stranded and double-stranded DNAs. Biochemistry 32:12478-12487.
15. Hozák, P., A. B. Hassan, D. A. Jackson, and P. R. Cook. 1993. Visualization of replication factories attached to a nucleoskeleton. Cell 73:361-373.
16. Hozák, P., D. A. Jackson, and P. R. Cook. 1994. Replication factories and nuclear bodies: the ultrastructural characterization of replication sites during the cell cycle. J. Cell Sci. 107:2191-2202.
17. Hurwitz, J., F. B. Dean, A. D. Kwong, and S.-H. Lee. 1990. The in vitro replication of DNA containing the SV40 origin. J. Biol. Chem. 265:18043-18046.
18. Jackson, D. A. 1995. Nuclear organization: uniting replication foci, chromatin domains and chromosome structure. Bioessays 17:587-591.
19. Jenkins, H., T. Hölman, C. Lyon, B. Lane, R. Stick, and C. Hutchison. 1993. Nuclei that lack a lamina accumulate karyophilic proteins and assemble a nuclear matrix. J. Cell Sci. 106:275-285.
20. Klausing, K., K.-H. Scheidtmann, E. A. Baumann, and R. Knippers. 1988. Effects of in vitro dephosphorylation on DNA-binding and DNA helicase activities of simian virus 40 large tumor antigen. J. Virol. 62:1258-1265.
21. Lee, S.-H., T. Eki, and J. Hurwitz. 1989. Synthesis of DNA containing the simian virus 40 origin of replication by the combined action of DNA polymerases α and δ. Proc. Natl. Acad. Sci. USA 86:7361-7365.
22. Lohman, T. M. 1993. Helicase-catalyzed DNA unwinding. J. Biol. Chem. 268:2269-2272.
23. Mastrangelo, I. A., P. V. C. Hough, J. S. Wall, M. Dodson, F. B. Dean, and J. Hurwitz. 1989. ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication. Nature 338:658-662.
24. Mitchell, A. H., and S. C. West. 1994. Hexameric rings of Escherichia coli RuvB protein. Cooperative assembly, processivity and ATPase activity. J. Mol. Biol. 243:208-215.
25. Nakayasu, H., and R. Berezney. 1989. Mapping replicational sites in the eukaryotic cell nucleus. J. Cell Biol. 108:1-11.
26. Parsons, R. E., J. E. Stenger, S. Ray, R. Welker, M. E. Anderson, and P. Tegtmeyer. 1991. Cooperative assembly of simian virus 40 T-antigen hexamers on functional halves of the replication origin. J. Virol. 65:2798-2806.
27. Reha-Krantz, L. J., and J. Hurwitz. 1978. The dnaB gene product of Escherichia coli. I. Purification, homogeneity, and physical properties. J. Biol. Chem. 253:4043-4050.
28. Reynisdóttir, I., H. E. Lorimer, P. N. Friedman, E. H. Wang, and C. Prives. 1993. Phosphorylation and active ATP hydrolysis are not required for SV40 T antigen hexamer formation. J. Biol. Chem. 268:24647-24654.
29. Schirmbeck, R., and W. Deppert. 1991. Structural topography of simian virus 40 DNA replication. J. Virol. 65:2578-2588.
30. Schirmbeck, R., A. von der Weth, and W. Deppert. 1993. Structural requirements for simian virus 40 replication and virion maturation. J. Virol. 67:894-901.
31. SenGupta, D., and J. A. Borowiec. 1992. Strand-specific recognition of a synthetic DNA replication fork by the SV40 large tumor antigen. Science 256:1656-1661.
32. SenGupta, D. J., and J. A. Borowiec. 1994. Strand and face: the topography of interactions between the SV40 origin of replication and T antigen during the initiation of replication. EMBO J. 13:982-992.
33. Stahl, H., P. Dröge, and R. Knippers. 1986. DNA helicase activity of SV40 large tumor antigen. EMBO J. 5:1939-1944.
34. Stasiak, A., I. R. Tsaneva, S. C. West, C. J. B. Benson, X. Yu, and E. H. Egelman. 1994. The Escherichia coli RuvB branch migration protein forms double hexameric rings around DNA. Proc. Natl. Acad. Sci. USA 91:7618-7622.
35. Stillman, B. 1994. Smart machines at the DNA replication fork. Cell 78:725-728.
36. Tsurimoto, T., and B. Stillman. 1989. Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, α and δ. EMBO J. 8:3883-3889.
37. Virshup, D. M., A. A. R. Russo, and T. J. Kelly. 1992. Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A. Mol. Cell. Biol. 12:4883-4895.
38. Waga, S., and B. Stillman. 1994. Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro. Nature 369:207-212.
39. Weinberg, D. H., and T. J. Kelly. 1989. Requirement for two DNA polymerases in the replication of simian virus 40 DNA in vitro. Proc. Natl. Acad. Sci. USA 86:9742-9746.
40. Wessel, R., J. Schweizer, and H. Stahl. 1992. Simian virus 40 T-antigen DNA helicase is a hexamer which forms a binary complex during bidirectional unwinding from the viral origin of DNA replication. J. Virol. 66:804-815.
41. Wiekowski, M., M. W. Schwarz, and H. Stahl. 1988. Simian virus 40 large T antigen DNA helicase. J. Biol. Chem. 263:436-442.
42. Wold, M. S., J. J. Li, and T. J. Kelly. 1987. Initiation of simian virus 40 DNA replication in vitro: large-tumor-antigen- and origin-dependent unwinding of the template. Proc. Natl. Acad. Sci. USA 84:3643-3647.