Promoting PGC-1α-driven mitochondrial biogenesis is detrimental in pressure-overloaded mouse hearts

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 307, Issue 9, 2014, Pages H1307-H1316

  Karamanlidis, Georgios ^a   Garcia Menendez, Lorena ^a   Kolwicz, Stephen C ^a   Lee, Chi Fung ^a   Tian, Rong ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cardiac hypertrophy; Energetics; Heart failure; Mitochondrial biogenesis; Peroxisome proliferator activated receptor coactivator 1

Indexed keywords

CITRATE SYNTHASE; DOBUTAMINE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATE; SUCCINATE DEHYDROGENASE; PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA COACTIVATOR-1; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; BIOGENESIS; CARDIOTOXICITY; CHRONIC STRESS; CONTROLLED STUDY; FEMALE; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; GENE OVEREXPRESSION; HEART FAILURE; HEART FUNCTION; HEART MITOCHONDRION; HEART SIZE; HEART STRESS; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; HIGH ENERGY PHOSPHATE; LONG TERM SURVIVAL; MALE; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL GENE; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL VOLUME; MOUSE; MOUSE MODEL; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; SEX DIFFERENCE; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; GENETICS; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; METABOLISM; MITOCHONDRIAL DYNAMICS; PATHOPHYSIOLOGY; ULTRASTRUCTURE;

ANIMALS; CITRATE (SI)-SYNTHASE; FEMALE; HEART FAILURE; MALE; MICE; MITOCHONDRIA, HEART; MITOCHONDRIAL TURNOVER; MYOCARDIAL CONTRACTION; TRANSCRIPTION FACTORS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84908374171     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00280.2014     Document Type: Article

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