Impairment of hepatic and renal functions by 2,5-hexanedione is accompanied by oxidative stress in rats

Journal of Toxicology

Volumn 2014, Issue , 2014, Pages

  Adedara, Isaac A ^a   Abolaji, Amos O ^a   Odion, Blessing E ^a   Okwudi, Isioma J ^a   Omoloja, Abiola A ^a   Farombi, Ebenezer O ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONYLACETONE; ALBUMIN; ALKALINE PHOSPHATASE; AMINOTRANSFERASE; BILIRUBIN; CATALASE; CHOLESTEROL; CREATININE; DRINKING WATER; ELECTROLYTE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HIGH DENSITY LIPOPROTEIN; HYDROGEN PEROXIDE; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UREA;

ADULT; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ATROPHY; BILIRUBIN BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EXPOSURE; DRUG MECHANISM; ELECTROLYTE BLOOD LEVEL; ENZYME ACTIVITY; KIDNEY ATROPHY; KIDNEY FUNCTION; LIVER ATROPHY; LIVER FUNCTION; LIVER TOXICITY; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; UREA BLOOD LEVEL; WISTAR RAT;

RATTUS;

EID: 84908374040     PISSN: 16878191     EISSN: 16878205     Source Type: Journal    
DOI: 10.1155/2014/239240     Document Type: Article

References (41)

1. Cheng X., Wang G., Ma Z.-L., Exposure to 2,5-hexanedione can induce neural malformations in chick embryos. NeuroToxicology 2012 33 5 1239 1247 10.1016/j.neuro.2012.07.005 2-s2.0-84867233553
2. Bus J. S., White E. L., Tyl R. W., Barrow C. S., Perinatal toxicity and metabolism of n-hexane in Fischer-344 rats after inhalation exposure during gestation. Toxicology and Applied Pharmacology 1979 51 2 295 302 10.1016/0041-008X(79)90472-1 2-s2.0-0018574694
3. Skowroń J., Miranowicz-Dzierzawska K., Zapór L., Gołofit-Szymczak M., Starek A., Interactions of some organic solvents: hydrocarbons and chloroalkene. International Journal of Occupational Safety and Ergonomics 2001 7 1 35 47 2-s2.0-0035229731
4. Carney R., Dardis C., Cullen W. K., Felipo V., Anwyl R., Rowan M. J., Early spatial memory deficit induced by 2,5-hexanedione in the rat. Toxicology Letters 2002 128 1-3 107 115 10.1016/S0378-4274(01)00538-0 2-s2.0-0037051180
5. Boekelheide K., Fleming S. L., Allio T., Embree-Ku M. E., Hall S. J., Johnson K. J., Kwon E. J., Patel S. R., Rasoulpour R. J., Schoenfeld H. A., Thompson S., 2,5 -Hexanedione-induced testicular injury. Annual Review of Pharmacology and Toxicology 2003 43 125 147 10.1146/annurev.pharmtox.43.100901.135930 2-s2.0-0041350371
6. Zhang Y., Liu Q., Duan H., Cheng J., Jiang S., Huang X., Leng S., He F., Zheng Y., Association between metabolic gene polymorphisms and susceptibility to peripheral nerve damage in workers exposed to n-hexane: a preliminary study. Biomarkers 2006 11 1 61 69 10.1080/13547500500451176 2-s2.0-32844458942
7. Adedara I. A., Farombi E. O., Influence of kolaviron and vitamin E on ethylene glycol monoethyl ether-induced haematotoxicity and renal apoptosis in rats. Cell Biochemistry and Function 2014 32 1 31 38 10.1002/cbf.2968 2-s2.0-84891833447
8. Huang C.-C., Polyneuropathy induced by n-hexane intoxication in Taiwan. Acta Neurologica Taiwanica 2008 17 1 3 10 2-s2.0-41749088042
9. Liu C.-M., Ma J.-Q., Sun Y.-Z., Quercetin protects the rat kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead. Environmental Toxicology and Pharmacology 2010 30 3 264 271 10.1016/j.etap.2010.07.002 2-s2.0-77957326877
10. Adedara I. A., Teberen R., Ebokaiwe A. P., Ehwerhemuepha T., Farombi E. O., Induction of oxidative stress in liver and kidney of rats exposed to Nigerian bonny light crude oil. Environmental Toxicology 2012 27 6 372 379 10.1002/tox.20660 2-s2.0-84860629488
11. Nose K., Role of reactive oxygen species in the regulation of physiological functions. Biological and Pharmaceutical Bulletin 2000 23 8 897 903 10.1248/bpb.23.897 2-s2.0-0033834255
12. Polidori M. C., Stahl W., Eichler O., Niestroj I., Sies H., Profiles of antioxidants in human plasma. Free Radical Biology and Medicine 2001 30 5 456 462 10.1016/S0891-5849(00)00345-2 2-s2.0-0035282571
13. Public Health Service, Policy on Humane Care and Use of Laboratory Animals 1996 Washington, DC, USA US Department of Health and Human Services
14. Campion S. N., Houseman E. A., Sandrof M. A., Hensley J. B., Sui Y., Gaido K. W., Wu Z., Boekelheide K., Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathways. Toxicological Sciences 2010 117 2 457 465 10.1093/toxsci/kfq204 2-s2.0-77956929094
15. Reitmann S., Frankel S., A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. American Journal of Clinical Pathology 1957 28 1 56 63 2-s2.0-66349129125
16. Recommendation of German Society of Clinical Chemistry (Rec.Gscc), Optimized standard colorimetric methods. Journal of Clinical Chemistry and Clinical Biochemistry 1972 10, article 182
17. Fawcett J. K., Scott J. E., A rapid and precise method for the determination of urea. Journal of Clinical Pathology 1960 13 156 159 10.1136/jcp.13.2.156 2-s2.0-72949127206
18. Henry R. J., Clinical Chemistry, Principles and Techniques 1974 2nd Hagerstown, Md, USA Harper and Row
19. Jendrassik L. P., Grof P., Vereinfachte photometrische methoden zur bestimmung des blutbilirubins. Biochemische Zeitschrift Band 1983 297 81 89
20. Misra H. P., Fridovich I., The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. The Journal of Biological Chemistry 1972 247 10 3170 3175 2-s2.0-0015523099
21. Clairborne A., Greewald A. R., Catalase activity. Handbook of Methods for Oxygen Radical Research 1995 Boca Raton, Fla, USA CRC Press 237 242
22. Lowry O. H., Rosenbrough N. J., Farr A. L., Randall R. J., Protein measurement with the Folin phenol reagent. The Journal of Biological Chemistry 1951 193 1 265 275 2-s2.0-71849104860
23. Jollow D. J., Mitchell J. R., Zampaglione N., Gillette J. R., Bromobenzene induced liver necrosis. Protective role of glutathione and evidence for 3,4 bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 1974 11 3 151 169 10.1159/000136485 2-s2.0-0016151122
24. Rotruck J. T., Pope A. L., Ganther H. E., Swanson A. B., Hafeman D. G., Hoekstra W. G., Selenium: biochemical role as a component of glutathione peroxidase. Science 1973 179 4073 588 590 10.1126/science.179.4073.588 2-s2.0-0015918166
25. Habig W. H., Pabst M. J., Jakoby W. B., Glutathione S transferases. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry 1974 249 22 7130 7139 2-s2.0-0016275313
26. Wolff S. P., Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. Methods in Enzymology 1994 233 182 189 10.1016/S0076-6879(94)33021-2 2-s2.0-0028306066
27. Farombi E. O., Tahnteng J. G., Agboola A. O., Nwankwo J. O., Emerole G. O., Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron-a Garcinia kola seed extract. Food and Chemical Toxicology 2000 38 6 535 541 10.1016/S0278-6915(00)00039-9 2-s2.0-0034077371
28. Songur A., Akpolat N., Kus I., Ozen O. A., Zararsiz I., Sarsilmaz M., The effects of the inhaled formaldehyde during the early postnatal period in the hippocampus of rats: a morphological and immunohistochemical study. Neuroscience Research Communications 2003 33 3 168 178 10.1002/nrc.10093 2-s2.0-0347004624
29. Bryant B. H., Yamasaki H., Sandrof M. A., Boekelheide K., Spermatid head retention as a marker of 2,5-hexanedione-induced testicular toxicity in the rat. Toxicologic Pathology 2008 36 4 552 559 10.1177/0192623308317426 2-s2.0-49749094771
30. Amresh G., Singh P. N., Rao C. V., Toxicological screening of traditional medicine Laghupatha (Cissampelos pareira) in experimental animals. Journal of Ethnopharmacology 2008 116 3 454 460 10.1016/j.jep.2007.12.008 2-s2.0-40249108246
31. Moore K. L., Dalley A. F., Clinical Oriented Anatomy 1999 4th Philadelphia, Pa, USA Lippincot Williams and Williams
32. Kaplan M. M., Schiff L., Schiff E. R., Laboratory tests. Diseases of the Liver 1993 7th Philadephia, Pa, USA J. B. Lippincott 108 144
33. Jesse B., Animal Anatomy and Physiology 1982 Reston, Va, USA Reston Publishing Company
34. Yakubu M. T., Akanji M. A., Oladiji A. T., Alterations in serum lipid profile of male rats by oral administration of aqueous extract of Fadogia agrestis stem. Research Journal of Medicinal Plant 2008 2 66 73
35. Stacchiotti A., Borsani E., Rodella L., Rezzani R., Bianchi R., Lavazza A., Dose-dependent mercuric chloride tubular injury in rat kidney. Ultrastructural Pathology 2003 27 4 253 259 10.1080/01913120309921 2-s2.0-0041334075
36. Rodriguez C., Mayo J. C., Sainz R. M., Antolín I., Herrera F., Martín V., Reiter R. J., Regulation of antioxidant enzymes: a significant role for melatonin. Journal of Pineal Research 2004 36 1 1 9 10.1046/j.1600-079X.2003.00092.x 2-s2.0-1642562820
37. Jacob R. A., The integrated antioxidant system. Nutrition Research 1995 15 5 755 766 10.1016/0271-5317(95)00041-G 2-s2.0-0029002501
38. Adedara I. A., Farombi E. O., Induction of oxidative damage in the testes and spermatozoa and hematotoxicity in rats exposed to multiple doses of ethylene glycol monoethyl ether. Human & Experimental Toxicology 2010 29 10 801 812 10.1177/0960327109360115 2-s2.0-78649938864
39. Masella R., Di Benedetto R., Varì R., Filesi C., Giovannini C., Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. Journal of Nutritional Biochemistry 2005 16 10 577 586 10.1016/j.jnutbio.2005.05.013 2-s2.0-25144482448
40. Kohen R., Nyska A., Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicologic Pathology 2002 30 6 620 650 10.1080/01926230290166724 2-s2.0-0036867895
41. Marnett L. J., Lipid peroxidation-DNA damage by malondialdehyde. Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis 1999 424 1-2 83 95 10.1016/S0027-5107(99)00010-X 2-s2.0-0033535371