Early spatial memory deficit induced by 2,5-hexanedione in the rat

Toxicology Letters

Volumn 128, Issue 1-3, 2002, Pages 107-115

  Carney, R ^a   Dardis, C ^a   Cullen, W K ^a   Felipo, V ^b   Anwyl, R ^a   Rowan, M J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b Laboratorio de Neurobiologia de Prince Felipe Research Centre   (Spain)

Author keywords

2,5 Hexanedione; Cognition; Memory; Motor activity; n Hexane metabolite; Spatial navigation

Indexed keywords

ACETONYLACETONE;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; ESCAPE BEHAVIOR; LATENT PERIOD; MALE; MAZE TEST; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECALL; SENSORIMOTOR FUNCTION; SPATIAL MEMORY; WEIGHT REDUCTION;

ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; COGNITION; DRINKING; HEXANONES; MALE; MAZE LEARNING; MEMORY DISORDERS; PILOT PROJECTS; RATS; RATS, WISTAR; SPATIAL BEHAVIOR;

ANIMALIA;

EID: 0037051180     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00538-0     Document Type: Article

References (38)

1. Cholinesterases in blood plasma and tissues of rats treated with n-hexane or with its neurotoxic metabolite 2,5-hexanedione
2. Neurobehavioural effects in workers in a video tape manufacturing factory in Singapore
3. Toxicity and metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone, and 2,5-hexanedione
4. Neuropsychological function in retired workers with previous long-term occupational exposure to solvents
5. Regioselective binding of 2,5-hexanedione to high molecular weight rat neurofilament proteins in vitro
6. Cholinergic fiber perturbations and neuritic outgrowth produced by intrafimbrial infusion of the neurofilament-disrupting agent 2,5-hexanedione
7. Short duration exposures to organic solvents: The relationship between neurobehavioral test results and other indicators
8. Influence of 2,5-hexanedione on rat brain amine synthesis and metabolism
9. Pathogenic studies of hexane and carbon-disufide neurotoxicity
10. Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory
11. Behavioral effects of long-term exposure to a mixture of organic solvents
12. Insights into the role of the cholinergic component of the septohippocampal pathway: What have we learned from experimental lesion studies?
13. Changes in acetylcholine metabolism in rat brain after a short-term exposure to toluene and n-hexane
14. Acute neurobehavioral effects of co-inhalation of toluene and n-hexane on schedule-controlled behavior in rats
15. Mechanisms of toxic injury in the peripheral nervous system: Neuropathologic considerations
16. The relative neurotoxicity of methyl n-butyl ketone, n-hexane and their metabolites
17. n-Hexane neuropathy caused by addictive inhalation: Clinical and electrophysiological features
18. Acetone potentiation and influence on the reversibility of 2,5-hexanedione-induced neurotoxicity studied with behavioural and morphometric methods in rats
19. Effects of 2,5-hexanedione alone and in combination with acetone on radial arm maze behavior, the "brain-swelling" reaction and synaptosomal functions
20. Redefining toxic axonopathies
21. Effects of acute n-hexane and 2,5-hexanedione treatment on the striatal dopaminergic system in mice
22. The role of cortical cholinergic afferent projections in cognition: Impact of new selective immunotoxins
23. Neurotoxic interactions of industrially used ketones
24. Dissociation of hippocampus and caudate-nucleus memory-systems by posttraining intracerebral injection of dopamine agonists
25. Effects of chronic treatment with 2,5-hexanedione on several behavioral measures in rats
26. Atropine reverses antinociception induced by 2,5-hexanedione in rats
27. n-Hexane induces parkinsonsism in rodents
28. Hydrocarbon exposure and Parkinson's disease
29. Interactive effects of toluene and hexane on behavior and neurophysiologic responses in Fischer-344 rats
30. D-1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat
31. Effects of neurotoxic industrial solvents on cultured neuroblastoma cells: Metyl n-butyl ketone, n-hexane and derivatives
32. Neurotoxicity of acrylamide and 2,5-hexanedione in rats evaluated using a functional observational battery and pathological examination
33. The enlarging view of hexacarbon neurotoxicity
34. Neurofilaments are non-essential elements of toxicant-induced reductions in fast axonal transport: Pulse labeling in CNS neurons
35. Neurofilaments are nonessential to the pathogenesis of toxicant-induced axonal degeneration
36. Neurobehavioral effects of occupational exposure to low-level organic solvents among Taiwanese workers in paint factories
37. Solvents and neurotoxicity
38. The same chemicals induce different neurotoxicity when administered in high doses for short term or low doses for long term to rats and dogs