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Volumn 8, Issue October, 2014, Pages

Stem cell-based treatments against stroke: Observations from human proof-of-concept studies and considerations regarding clinical applicability

Author keywords

Mesenchymal stem cells; Neural progenitor cells; Stem cells; Stroke; Trials

Indexed keywords

5' NUCLEOTIDASE; ENDOGLIN; TECHNETIUM 99M; THY 1 ANTIGEN;

EID: 84908373496     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00357     Document Type: Review
Times cited : (35)

References (68)
  • 1
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal, S., and Pittenger, M. F. (2005). Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105, 1815-1822. doi: 10.1182/blood-2004-04-1559
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 2
    • 0036470478 scopus 로고    scopus 로고
    • Neurogenesis in adult sub-ventricular zone
    • Alvarez-Buylla, A., and Garcia-Verdugo, J. M. (2002). Neurogenesis in adult sub-ventricular zone. J. Neurosci. 22, 629-634
    • (2002) J. Neurosci , vol.22 , pp. 629-634
    • Alvarez-Buylla, A.1    Garcia-Verdugo, J.M.2
  • 3
    • 0036735672 scopus 로고    scopus 로고
    • Neuronal replacement from endogenous precursors in the adult brain after stroke
    • Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., and Lindvall, O. (2002). Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 8, 963-970. doi: 10.1038/nm747
    • (2002) Nat. Med , vol.8 , pp. 963-970
    • Arvidsson, A.1    Collin, T.2    Kirik, D.3    Kokaia, Z.4    Lindvall, O.5
  • 4
    • 38049069788 scopus 로고    scopus 로고
    • Neural stem/precursor cells for the treatment of ischemic stroke
    • Bacigaluppi, M., Pluchino, S., Martino, G., Kilic, E., and Hermann, D. M. (2008). Neural stem/precursor cells for the treatment of ischemic stroke. J. Neurol. Sci. 265, 73-77. doi: 10.1016/j.jns.2007.06.012
    • (2008) J. Neurol. Sci , vol.265 , pp. 73-77
    • Bacigaluppi, M.1    Pluchino, S.2    Martino, G.3    Kilic, E.4    Hermann, D.M.5
  • 5
    • 67749143855 scopus 로고    scopus 로고
    • Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms
    • Bacigaluppi, M., Pluchino, S., Peruzzotti Jametti, L., Kilic, E., Kilic, U., Salani, G., et al. (2009). Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain 132, 2239-2251. doi: 10.1093/brain/awp174
    • (2009) Brain , vol.132 , pp. 2239-2251
    • Bacigaluppi, M.1    Pluchino, S.2    Peruzzotti Jametti, L.3    Kilic, E.4    Kilic, U.5    Salani, G.6
  • 6
    • 84874798889 scopus 로고    scopus 로고
    • The potential benefit of stem cell therapy after stroke: An update
    • Banerjee, S., Williamson, D. A., Habib, N., and Chataway, J. (2012). The potential benefit of stem cell therapy after stroke: an update. Vasc. Health Risk Manag. 8, 569-580. doi: 10.2147/VHRM.s25745
    • (2012) Vasc. Health Risk Manag , vol.8 , pp. 569-580
    • Banerjee, S.1    Williamson, D.A.2    Habib, N.3    Chataway, J.4
  • 7
    • 20444419744 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell transplantation in stroke patients
    • Bang, O. Y., Lee, J. S., Lee, P. H., and Lee, G. (2005). Autologous mesenchymal stem cell transplantation in stroke patients. Ann. Neurol. 57, 874-882. doi: 10. 1002/ana.20501
    • (2005) Ann. Neurol , vol.57 , pp. 874-882
    • Bang, O.Y.1    Lee, J.S.2    Lee, P.H.3    Lee, G.4
  • 8
    • 72749123129 scopus 로고    scopus 로고
    • Migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection
    • Barbosa da Fonseca, L. M., Gutfilen, B., Rosado de Castro, P. H., Battistella, V., Goldenberg, R. C., Kasai-Brunswick, T., et al. (2010). Migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection. Exp. Neurol. 221, 122-128. doi: 10.1016/j.expneurol.2009. 10.010
    • (2010) Exp. Neurol , vol.221 , pp. 122-128
    • Barbosa Da Fonseca, L.M.1    Gutfilen, B.2    Rosado De Castro, P.H.3    Battistella, V.4    Goldenberg, R.C.5    Kasai-Brunswick, T.6
  • 9
    • 78650668601 scopus 로고    scopus 로고
    • Safetyofautologousbone marrowmononuclear cell transplantation in patients with nonacute ischemic stroke
    • Battistella, V., de Freitas, G. R., da Fonseca, L. M., Mercante, D., Gutfilen, B., Goldenberg, R. C., etal. (2011). Safetyofautologousbone marrowmononuclear cell transplantation in patients with nonacute ischemic stroke. Regen. Med. 6, 45-52. doi: 10.2217/rme.10.97
    • (2011) Regen. Med , vol.6 , pp. 45-52
    • Battistella, V.1    De Freitas, G.R.2    Da Fonseca, L.M.3    Mercante, D.4    Gutfilen, B.5    Goldenberg, R.C.6
  • 10
    • 14944339174 scopus 로고    scopus 로고
    • Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness.
    • Beyth, S., Borovsky, Z., Mevorach, D., Liebergall, M., Gazit, Z., Aslan, H., et al. (2005). Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 105, 2214-2219. doi: 10.1182/blood-2004-07-2921
    • (2005) Blood , vol.105 , pp. 2214-2219
    • Beyth, S.1    Borovsky, Z.2    Mevorach, D.3    Liebergall, M.4    Gazit, Z.5    Aslan, H.6
  • 13
    • 72749121996 scopus 로고    scopus 로고
    • Optimizing the success of cell transplantation therapy for stroke
    • Bliss, T. M., Andres, R. H., and Steinberg, G. K. (2010). Optimizing the success of cell transplantation therapy for stroke. Neurobiol. Dis. 37, 275-283. doi: 10. 1016/j.nbd.2009.10.003
    • (2010) Neurobiol. Dis , vol.37 , pp. 275-283
    • Bliss, T.M.1    Res, R.H.2    Steinberg, G.K.3
  • 14
    • 33846705350 scopus 로고    scopus 로고
    • Cell transplantation therapy for stroke
    • Bliss, T., Guzman, R., Daadi, M., and Steinberg, G. K. (2007). Cell transplantation therapy for stroke. Stroke 38, 817-826. doi: 10.1161/01.str.0000247888. 25985.62
    • (2007) Stroke , vol.38 , pp. 817-826
    • Bliss, T.1    Guzman, R.2    Daadi, M.3    Steinberg, G.K.4
  • 15
    • 46449113364 scopus 로고    scopus 로고
    • The tumorigenicityofhuman embryonic stem cells
    • Blum, B., and Benvenisty, N. (2008). The tumorigenicityofhuman embryonic stem cells. Adv. Cancer Res. 100, 133-158. doi: 10.1016/S0065-230X(08)00005-5
    • (2008) Adv. Cancer Res , vol.100 , pp. 133-158
    • Blum, B.1    Benvenisty, N.2
  • 16
    • 74849135201 scopus 로고    scopus 로고
    • The tumorigenicity of diploid and aneuploid human pluripotent stem cells
    • Blum, B., and Benvenisty, N. (2009). The tumorigenicity of diploid and aneuploid human pluripotent stem cells. Cell Cycle 8, 3822-3830. doi: 10.4161/cc.8.23. 10067
    • (2009) Cell Cycle , vol.8 , pp. 3822-3830
    • Blum, B.1    Benvenisty, N.2
  • 17
    • 84900036105 scopus 로고    scopus 로고
    • Adult neurogenesis: Mechanisms and functional significance
    • Braun, S. M., and Jessberger, S. (2014). Adult neurogenesis: mechanisms and functional significance. Development 141, 1983-1986. doi: 10.1242/dev.104596
    • (2014) Development , vol.141 , pp. 1983-1986
    • Braun, S.M.1    Jessberger, S.2
  • 18
    • 58449135981 scopus 로고    scopus 로고
    • Why are MSCs therapeutic? New data: New insight
    • Caplan, A. I. (2009). Why are MSCs therapeutic? New data: new insight. J. Pathol.217, 318-324. doi: 10.1002/path.2469
    • (2009) J. Pathol , vol.217 , pp. 318-324
    • Caplan, A.I.1
  • 19
    • 0035075998 scopus 로고    scopus 로고
    • Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats
    • Chen, J., Li, Y., Wang, L., Zhang, Z., Lu, D., Lu, M., et al. (2001). Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32, 1005-1011. doi: 10.1161/01.str.32.4.1005
    • (2001) Stroke , vol.32 , pp. 1005-1011
    • Chen, J.1    Li, Y.2    Wang, L.3    Zhang, Z.4    Lu, D.5    Lu, M.6
  • 20
    • 84856214781 scopus 로고    scopus 로고
    • Adverse effects ofbone marrowstromal cell treatment ofstroke in diabeticrats
    • Chen, J., Ye, X., Yan, T., Zhang, C., Yang, X. P., Cui, X., et al. (2011). Adverse effects ofbone marrowstromal cell treatment ofstroke in diabeticrats. Stroke 42, 3551-3558. doi: 10.1161/STR0KEAHA.111.627174
    • (2011) Stroke , vol.42 , pp. 3551-3558
    • Chen, J.1    Ye, X.2    Yan, T.3    Zhang, C.4    Yang, X.P.5    Cui, X.6
  • 21
    • 0037418936 scopus 로고    scopus 로고
    • Intravenous administration ofhuman bone marrowstromal cells induces angio-genesis in the ischemic boundaryzone after stroke in rats
    • Chen, J., Zhang, Z. G., Li, Y., Wang, L., Xu, Y. X., Gautam, S. C., et al. (2003). Intravenous administration ofhuman bone marrowstromal cells induces angio-genesis in the ischemic boundaryzone after stroke in rats. Circ. Res. 92, 692-699. doi: 10.1161/01.res.0000063425.51108.8d
    • (2003) Circ. Res , vol.92 , pp. 692-699
    • Chen, J.1    Zhang, Z.G.2    Li, Y.3    Wang, L.4    Xu, Y.X.5    Gautam, S.C.6
  • 22
    • 84873988875 scopus 로고    scopus 로고
    • Proximity of brain infarcts to regions of endogenous neurogenesis and involvement of striatum in ischaemic stroke
    • Delavaran, H., Sjunnesson, H., Arvidsson, A., Lindvall, O., Norrving, B., van Westen, D., et al. (2013). Proximity of brain infarcts to regions of endogenous neurogenesis and involvement of striatum in ischaemic stroke. Eur. J. Neurol. 20, 473-479. doi: 10.1111/j.1468-1331.2012.03877.x
    • (2013) Eur. J. Neurol , vol.20 , pp. 473-479
    • Delavaran, H.1    Sjunnesson, H.2    Arvidsson, A.3    Lindvall, O.4    Norrving, B.5    Van Westen, D.6
  • 23
    • 62149092900 scopus 로고    scopus 로고
    • TAT-Bcl-x(L) improves survival of neuronal precursor cells in the lesioned striatum after focal cerebral ischemia
    • Doeppner, T. R., Dietz, G. P., El Aanbouri, M., Gerber, J., Witte, O. W., Bahr, M., et al. (2009). TAT-Bcl-x(L) improves survival of neuronal precursor cells in the lesioned striatum after focal cerebral ischemia. Neurobiol. Dis. 34, 87-94. doi: 10. 1016/j.nbd.2008.12.013
    • (2009) Neurobiol. Dis , vol.34 , pp. 87-94
    • Doeppner, T.R.1    Dietz, G.P.2    El Aanbouri, M.3    Gerber, J.4    Witte, O.W.5    Bahr, M.6
  • 24
    • 77955846317 scopus 로고    scopus 로고
    • Transplantation of TAT-Bcl-xL-transduced neural precursor cells: Long-term neuroprotection after stroke
    • Doeppner, T. R., El Aanbouri, M., Dietz, G. P., Weise, J., Schwarting, S., and Bähr, M. (2010). Transplantation of TAT-Bcl-xL-transduced neural precursor cells: long-term neuroprotection after stroke. Neurobiol. Dis. 40, 265-276. doi: 10. 1016/j.nbd.2010.05.033
    • (2010) Neurobiol. Dis , vol.40 , pp. 265-276
    • Doeppner, T.R.1    El Aanbouri, M.2    Dietz, G.P.3    Weise, J.4    Schwarting, S.5    Bähr, M.6
  • 25
    • 84861900370 scopus 로고    scopus 로고
    • Transduction of neural precursor cells with TAT-heat shock protein 70 chaperone: Therapeutic potential against ischemic stroke after intrastriatal and systemic transplantation
    • Doeppner, T. R., Ewert, T. A., Tönges, L., Herz, J., Zechariah, A., Elali, A., et al. (2012). Transduction of neural precursor cells with TAT-heat shock protein 70 chaperone: therapeutic potential against ischemic stroke after intrastriatal and systemic transplantation. Stem Cells 30, 1297-1310. doi: 10.1002/stem.1098
    • (2012) Stem Cells , vol.30 , pp. 1297-1310
    • Doeppner, T.R.1    Ewert, T.A.2    Tönges, L.3    Herz, J.4    Zechariah, A.5    Elali, A.6
  • 26
    • 79953052361 scopus 로고    scopus 로고
    • Mesenchymal stem cells in the treatment of ischemic stroke: Progress and possibilities
    • Doeppner, T. R., and Hermann, D. M. (2010). Mesenchymal stem cells in the treatment of ischemic stroke: progress and possibilities. Stem Cells Cloning 3, 157-163. doi: 10.2147/SCCAA.s7820
    • (2010) Stem Cells Cloning , vol.3 , pp. 157-163
    • Doeppner, T.R.1    Hermann, D.M.2
  • 27
    • 0033040497 scopus 로고    scopus 로고
    • Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
    • Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., and Alvarez-Buylla, A. (1999). Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97, 703-716. doi: 10.1016/s0092-8674(00)80783-7
    • (1999) Cell , vol.97 , pp. 703-716
    • Doetsch, F.1    Caillé, I.2    Lim, D.A.3    García-Verdugo, J.M.4    Alvarez-Buylla, A.5
  • 28
    • 0030979469 scopus 로고    scopus 로고
    • Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain
    • Doetsch, F., García-Verdugo, J. M., and Alvarez-Buylla, A. (1997). Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J. Neurosci. 17, 5046-5061
    • (1997) J. Neurosci , vol.17 , pp. 5046-5061
    • Doetsch, F.1    García-Verdugo, J.M.2    Alvarez-Buylla, A.3
  • 29
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The international societyfor cellular therapyposition statement
    • Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F., Krause, D., et al. (2006). Minimal criteria for defining multipotent mesenchymal stromal cells. The international societyfor cellular therapyposition statement. Cytother-apy 8, 315-317. doi: 10.1080/14653240600855905
    • (2006) Cytother-Apy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3    Slaper-Cortenbach, I.4    Marini, F.5    Krause, D.6
  • 30
    • 13944250206 scopus 로고    scopus 로고
    • Adult stem cell therapy in stroke
    • Haas, S., Weidner, N., and Winkler, J. (2005). Adult stem cell therapy in stroke. Curr. Opin. Neurol. 18, 59-64. doi: 10.1097/00019052-200502000-00012
    • (2005) Curr. Opin. Neurol , vol.18 , pp. 59-64
    • Haas, S.1    Weidner, N.2    Winkler, J.3
  • 31
    • 84858601983 scopus 로고    scopus 로고
    • Promoting brain remodelling and plasticity for stroke recovery: Therapeutic promise and potential pitfalls of clinical translation
    • Hermann, D. M., and Chopp, M. (2012). Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation. Lancet Neurol. 11, 369-380. doi: 10.1016/S1474-4422(12) 70039-X
    • (2012) Lancet Neurol , vol.11 , pp. 369-380
    • Hermann, D.M.1    Chopp, M.2
  • 32
    • 79957796744 scopus 로고    scopus 로고
    • Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke
    • Honmou, O., Houkin, K., Matsunaga, T., Niitsu, Y., Ishiai, S., Onodera, R., et al. (2011). Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain 134, 1790-1807. doi: 10.1093/brain/awr063
    • (2011) Brain , vol.134 , pp. 1790-1807
    • Honmou, O.1    Houkin, K.2    Matsunaga, T.3    Niitsu, Y.4    Ishiai, S.5    Onodera, R.6
  • 33
    • 84908486307 scopus 로고    scopus 로고
    • Adult neurogenesis: Bridging the gap between mice and humans
    • Jessberger, S., and Gage, F. H. (2014).Adult neurogenesis: bridging the gap between mice and humans. Trends Cell Biol. 24, 558-563. doi: 10.1016/j.tcb.2014.07.003
    • (2014) Trends Cell Biol , vol.24 , pp. 558-563
    • Jessberger, S.1    Gage, F.H.2
  • 34
    • 24944466539 scopus 로고    scopus 로고
    • Neurotransplantation for patients with subcortical motor stroke: A phase 2 randomized trial
    • Kondziolka, D., Steinberg, G. K., Wechsler, L., Meltzer, C. C., Elder, E., Gebel, J., et al. (2005). Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial. J. Neurosurg. 103, 38-45. doi: 10.3171/jns.2005.103.1. 0038
    • (2005) J. Neurosurg , vol.103 , pp. 38-45
    • Kondziolka, D.1    Steinberg, G.K.2    Wechsler, L.3    Meltzer, C.C.4    Elder, E.5    Gebel, J.6
  • 35
    • 0033845975 scopus 로고    scopus 로고
    • Transplantation of cultured human neuronal cells for patients with stroke.
    • Kondziolka, D., Wechsler, L., Goldstein, S., Meltzer, C., Thulborn, K. R., Gebel, J., et al. (2000). Transplantation of cultured human neuronal cells for patients with stroke. Neurology 55, 565-569. doi: 10.1212/wnl.55.4.565
    • (2000) Neurology , vol.55 , pp. 565-569
    • Kondziolka, D.1    Wechsler, L.2    Goldstein, S.3    Meltzer, C.4    Thulborn, K.R.5    Gebel, J.6
  • 36
    • 75349097509 scopus 로고    scopus 로고
    • Transplantation of placenta-derived mesenchymal stromal cells upon experimental stroke in rats
    • Kranz, A., Wagner, D. C., Kamprad, M., Scholz, M., Schmidt, U. R., Nitzsche, F., et al. (2010). Transplantation of placenta-derived mesenchymal stromal cells upon experimental stroke in rats. Brain Res. 1315, 128-136. doi: 10.1016/j. brainres.2009.12.001
    • (2010) Brain Res , vol.1315 , pp. 128-136
    • Kranz, A.1    Wagner, D.C.2    Kamprad, M.3    Scholz, M.4    Schmidt, U.R.5    Nitzsche, F.6
  • 37
    • 19944406772 scopus 로고    scopus 로고
    • Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model
    • Kurozumi, K., Nakamura, K., Tamiya, T., Kawano, Y., Ishii, K., Kobune, M., et al. (2005). Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. Mol. Ther. 11, 96-104. doi: 10.1016/j.ymthe.2004.09.020
    • (2005) Mol. Ther , vol.11 , pp. 96-104
    • Kurozumi, K.1    Nakamura, K.2    Tamiya, T.3    Kawano, Y.4    Ishii, K.5    Kobune, M.6
  • 38
    • 84868091993 scopus 로고    scopus 로고
    • Safety of cell therapy with mesenchymal stromal cells (SafeCell): A systematic review and meta-analysis of clinical trials
    • Lalu, M. M., McIntyre, L., Pugliese, C., Fergusson, D., Winston, B. W., Marshall, J. C., et al. (2012). Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS One 7:e47559. doi: 10.1371/journal.pone.0047559
    • (2012) Plos One , pp. 7
    • Lalu, M.M.1    McIntyre, L.2    Pugliese, C.3    Fergusson, D.4    Winston, B.W.5    Marshall, J.C.6
  • 39
    • 48649088234 scopus 로고    scopus 로고
    • Concise review: Adult multipotent stromal cells and cancer: Risk or benefit?
    • Lazennec, G., and Jorgensen, C. (2008). Concise review: adult multipotent stromal cells and cancer: risk or benefit? Stem cells 26,1387-1394. doi: 10.1634/stemcells. 2007-1006
    • (2008) Stem Cells , vol.26 , pp. 1387-1394
    • Lazennec, G.1    Jorgensen, C.2
  • 40
    • 77956638921 scopus 로고    scopus 로고
    • A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke
    • Lee, J. S., Hong, J. M., Moon, G. J., Lee, P. H., Ahn, Y. H., Bang, O. Y., et al. (2010).   A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells 28, 1099-1106. doi: 10.1002/stem.430
    • (2010) Stem Cells , vol.28 , pp. 1099-1106
    • Lee, J.S.1    Hong, J.M.2    Moon, G.J.3    Lee, P.H.4    Ahn, Y.H.5    Bang, O.Y.6
  • 41
    • 84872101947 scopus 로고    scopus 로고
    • Human adult dental pulp stem cells enhance poststroke functional recovery through non-neural replacement mechanisms
    • Leong, W. K., Henshall, T. L., Arthur, A., Kremer, K. L., Lewis, M. D., Helps, S. C., et al. (2012). Human adult dental pulp stem cells enhance poststroke functional recovery through non-neural replacement mechanisms. Stem Cells Transl. Med. 1, 177-187. doi: 10.5966/sctm.2011-0039
    • (2012) Stem Cells Transl. Med , vol.1 , pp. 177-187
    • Leong, W.K.1    Henshall, T.L.2    Arthur, A.3    Kremer, K.L.4    Lewis, M.D.5    Helps, S.C.6
  • 42
    • 0037183512 scopus 로고    scopus 로고
    • Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery
    • Li, Y., Chen, J., Chen, X. G., Wang, L., Gautam, S. C., Xu, Y. X., et al. (2002). Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology 59, 514-523. doi: 10.1212/wnl.59.4.514
    • (2002) Neurology , vol.59 , pp. 514-523
    • Li, Y.1    Chen, J.2    Chen, X.G.3    Wang, L.4    Gautam, S.C.5    Xu, Y.X.6
  • 43
    • 0032189609 scopus 로고    scopus 로고
    • Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils
    • Liu, J., Solway, K., Messing, R. O., and Sharp, F. R. (1998). Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J. Neurosci. 18, 7768-7778
    • (1998) J. Neurosci , vol.18 , pp. 7768-7778
    • Liu, J.1    Solway, K.2    Messing, R.O.3    Sharp, F.R.4
  • 44
    • 84887549825 scopus 로고    scopus 로고
    • Human bone marrow mesenchymal stem/stromal cells produce efficient localization in the brain and enhanced angiogenesis after intra-arterial delivery in rats with cerebral ischemia, but this is not translated to behavioral recovery
    • Mitkari, B., Nitzsche, F., Kerkela, E., Kuptsova, K., Huttunen, J., Nystedt, J., et al. (2014). Human bone marrow mesenchymal stem/stromal cells produce efficient localization in the brain and enhanced angiogenesis after intra-arterial delivery in rats with cerebral ischemia, but this is not translated to behavioral recovery. Behav. Brain Res. 259, 50-59. doi: 10.1016/j.bbr.2013.10.030
    • (2014) Behav. Brain Res , vol.259 , pp. 50-59
    • Mitkari, B.1    Nitzsche, F.2    Kerkela, E.3    Kuptsova, K.4    Huttunen, J.5    Nystedt, J.6
  • 45
    • 84864284648 scopus 로고    scopus 로고
    • Intra-arterial bone marrow mononuclear cells in ischemic stroke: A pilot clinical trial
    • Moniche, F., Gonzalez, A., Gonzalez-Marcos, J. R., Carmona, M., Piñero, P., Espi-gado, I., et al. (2012). Intra-arterial bone marrow mononuclear cells in ischemic stroke: a pilot clinical trial. Stroke 43, 2242-2244. doi: 10.1161/STR0KEAHA. 112.659409
    • (2012) Stroke , vol.43 , pp. 2242-2244
    • Moniche, F.1    Gonzalez, A.2    Gonzalez-Marcos, J.R.3    Carmona, M.4    Piñero, P.5    Espi-Gado, I.6
  • 47
    • 38549154182 scopus 로고    scopus 로고
    • Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia
    • Onda, T., Honmou, O., Harada, K., Houkin, K., Hamada, H., and Kocsis, J. D. (2008). Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia. J. Cereb. Blood FlowMetab. 28, 329-340. doi: 10.1038/sj.jcbfm.9600527
    • (2008) J. Cereb. Blood Flowmetab , vol.28 , pp. 329-340
    • Onda, T.1    Honmou, O.2    Harada, K.3    Houkin, K.4    Hamada, H.5    Kocsis, J.D.6
  • 48
    • 0041306120 scopus 로고    scopus 로고
    • Injury-induced neurogenesis in the adult mammalian brain
    • Parent, J. M. (2003). Injury-induced neurogenesis in the adult mammalian brain. Neuroscientist 9,261-272. doi: 10.1177/1073858403252680
    • (2003) Neuroscientist , vol.9 , pp. 261-272
    • Parent, J.M.1
  • 49
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., et al. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147. doi: 10.1126/science.284.5411.143
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3    Jaiswal, R.K.4    Douglas, R.5    Mosca, J.D.6
  • 51
    • 23844487540 scopus 로고    scopus 로고
    • Neurotransplantation offetal porcine cells in patients with basal ganglia infarcts: A preliminary safety and feasibility study
    • Savitz, S. I., Dinsmore, J., Wu, J., Henderson, G. V., Stieg, P., and Caplan, L. R. (2005). Neurotransplantation offetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study. Cerebrovasc. Dis. 20, 101-107. doi: 10.1159/000086518
    • (2005) Cerebrovasc. Dis , vol.20 , pp. 101-107
    • Savitz, S.I.1    Dinsmore, J.2    Wu, J.3    Henderson, G.V.4    Stieg, P.5    Caplan, L.R.6
  • 52
    • 79960826161 scopus 로고    scopus 로고
    • Intravenous autologous bone marrow mononuclear cells for ischemic stroke
    • Savitz, S. I., Misra, V., Kasam, M., Juneja, H., Cox, C. S. Jr., Alderman, S., et al. (2011).           Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Ann. Neurol. 70, 59-69. doi: 10.1002/ana.22458
    • (2011) Ann. Neurol , vol.70 , pp. 59-69
    • Savitz, S.I.1    Misra, V.2    Kasam, M.3    Juneja, H.4    Cox, C.S.5    Alderman, S.6
  • 53
    • 84898035672 scopus 로고    scopus 로고
    • Vascular regulation of adult neurogenesis under physiological and pathological conditions
    • Sawada, M., Matsumoto, M., and Sawamoto, K. (2014). Vascular regulation of adult neurogenesis under physiological and pathological conditions. Front. Neurosci. 8:53. doi: 10.3389/fnins.2014.00053
    • (2014) Front. Neurosci , vol.8
    • Sawada, M.1    Matsumoto, M.2    Sawamoto, K.3
  • 54
    • 54049158893 scopus 로고    scopus 로고
    • Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury.
    • Schwarting, S., Litwak, S., Hao, W., Bähr, M., Weise, J., and Neumann, H. (2008). Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury. Stroke 39, 2867-2875. doi: 10.1161/strokeaha.108.513978
    • (2008) Stroke , vol.39 , pp. 2867-2875
    • Schwarting, S.1    Litwak, S.2    Hao, W.3    Bähr, M.4    Weise, J.5    Neumann, H.6
  • 55
    • 79151471989 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation modulates neuroinflammation in focal cerebral ischemia: Contribution of fractalkine and IL-5
    • Sheikh, A. M., Nagai, A., Wakabayashi, K., Narantuya, D., Kobayashi, S., Yamaguchi, S., et al. (2011). Mesenchymal stem cell transplantation modulates neuroinflammation in focal cerebral ischemia: contribution of fractalkine and IL-5, Neurobiol. Dis. 41, 717-724. doi: 10.1016/j.nbd.2010.12.009
    • (2011) Neurobiol. Dis , vol.41 , pp. 717-724
    • Sheikh, A.M.1    Nagai, A.2    Wakabayashi, K.3    Narantuya, D.4    Kobayashi, S.5    Yamaguchi, S.6
  • 56
    • 33845783926 scopus 로고    scopus 로고
    • Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke
    • Shen, L. H., Li, Y., Chen, J., Zacharek, A., Gao, Q., Kapke, A., et al. (2007). Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke. J. Cereb. BloodFlowMetab. 27, 6-13. doi: 10.1038/sj.jcbfm.9600311
    • (2007) J. Cereb. Bloodflowmetab , vol.27 , pp. 6-13
    • Shen, L.H.1    Li, Y.2    Chen, J.3    Zacharek, A.4    Gao, Q.5    Kapke, A.6
  • 57
    • 84887411205 scopus 로고    scopus 로고
    • Adult neural stem cells and their niche: A dynamic duo during homeostasis, regeneration and aging
    • Silva-Vargas, V., Crouch, E. E., and Doetsch, F. (2013). Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration and aging. Curr. Opin. Neurobiol. 23, 935-942. doi: 10.1016/j.conb.2013.09.004
    • (2013) Curr. Opin. Neurobiol , vol.23 , pp. 935-942
    • Silva-Vargas, V.1    Crouch, E.E.2    Doetsch, F.3
  • 58
    • 2442713904 scopus 로고    scopus 로고
    • Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy
    • Spees, J. L., Gregory, C. A., Singh, H., Tucker, H. A., Peister, A., Lynch, P. J., et al. (2004). Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy. Mol. Ther. 9, 747-756. doi: 10. 1016/j.ymthe.2004.02.012
    • (2004) Mol. Ther , vol.9 , pp. 747-756
    • Spees, J.L.1    Gregory, C.A.2    Singh, H.3    Tucker, H.A.4    Peister, A.5    Lynch, P.J.6
  • 59
    • 84858152974 scopus 로고    scopus 로고
    • Systemically administered human bone marrow-derived mesenchymal stem home into peripheral organs but do not induce neuroprotective effects in the MCAo-mouse model for cerebral ischemia
    • Steiner, B., Roch, M., Holtkamp, N., and Kurtz, A. (2012). Systemically administered human bone marrow-derived mesenchymal stem home into peripheral organs but do not induce neuroprotective effects in the MCAo-mouse model for cerebral ischemia. Neurosci. Lett. 513, 25-30. doi: 10.1016/j.neulet.2012. 01.078
    • (2012) Neurosci. Lett , vol.513 , pp. 25-30
    • Steiner, B.1    Roch, M.2    Holtkamp, N.3    Kurtz, A.4
  • 61
    • 0037106145 scopus 로고    scopus 로고
    • Adult neurogenesis and neural stem cells of the central nervous system in mammals
    • Taupin, P., and Gage, F. H. (2002). Adult neurogenesis and neural stem cells of the central nervous system in mammals. J. Neurosci. Res. 69, 745-749. doi: 10. 1002/jnr.10378
    • (2002) J. Neurosci. Res , vol.69 , pp. 745-749
    • Taupin, P.1    Gage, F.H.2
  • 62
    • 0038407855 scopus 로고    scopus 로고
    • Differential proliferative response in the postischemic hippocampus, temporal cortex and olfactory bulb of young adult macaque monkeys
    • Tonchev, A. B., Yamashima, T., Zhao, L., and Okano, H. (2003). Differential proliferative response in the postischemic hippocampus, temporal cortex and olfactory bulb of young adult macaque monkeys. Glia 42, 209-224. doi: 10. 1002/glia.10209
    • (2003) Glia , vol.42 , pp. 209-224
    • Tonchev, A.B.1    Yamashima, T.2    Zhao, L.3    Okano, H.4
  • 63
    • 34247118300 scopus 로고    scopus 로고
    • Mesenchymal stem cells derived from peripheral blood protects against ischemia
    • Ukai, R., Honmou, O., Harada, K., Houkin, K., Hamada, H., and Kocsis, J. D. (2007). Mesenchymal stem cells derived from peripheral blood protects against ischemia. J. Neurotrauma 24, 508-520. doi: 10.1089/neu.2006.0161
    • (2007) J. Neurotrauma , vol.24 , pp. 508-520
    • Ukai, R.1    Honmou, O.2    Harada, K.3    Houkin, K.4    Hamada, H.5    Kocsis, J.D.6
  • 64
    • 33745776761 scopus 로고    scopus 로고
    • Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum
    • Yamashita, T., Ninomiya, M., Hernández Acosta, P., García-Verdugo, J. M., Suna-bori, T., Sakaguchi, M., et al. (2006). Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. J. Neurosci. 26, 6627-6636. doi: 10.1523/jneurosci.0149-06.2006
    • (2006) J. Neurosci , vol.26 , pp. 6627-6636
    • Yamashita, T.1    Ninomiya, M.2    Hernández Acosta, P.3    García-Verdugo, J.M.4    Suna-Bori, T.5    Sakaguchi, M.6
  • 65
    • 84889245910 scopus 로고    scopus 로고
    • Intra-arterial delivery is not superior to intravenous delivery of autologous bone marrow mononuclear cells in acute ischemic stroke
    • Yang, B., Migliati, E., Parsha, K., Schaar, K., Xi, X., Aronowski, J., et al. (2013). Intra-arterial delivery is not superior to intravenous delivery of autologous bone marrow mononuclear cells in acute ischemic stroke. Stroke 44, 3463-3472. doi: 10.1161/strokeaha.111.000821
    • (2013) Stroke , vol.44 , pp. 3463-3472
    • Yang, B.1    Migliati, E.2    Parsha, K.3    Schaar, K.4    Xi, X.5    Aronowski, J.6
  • 66
    • 51949107296 scopus 로고    scopus 로고
    • Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model
    • Yoo, S. W., Kim, S. S., Lee, S. Y., Lee, H. S., Kim, H. S., Lee, Y. D., et al. (2008). Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model. Exp. Mol. Med. 40, 387-397. doi: 10.3858/emm.2008.40.4.387
    • (2008) Exp. Mol. Med , vol.40 , pp. 387-397
    • Yoo, S.W.1    Kim, S.S.2    Lee, S.Y.3    Lee, H.S.4    Kim, H.S.5    Lee, Y.D.6
  • 67
    • 84881512042 scopus 로고    scopus 로고
    • Cell-based therapy for ischemic stroke
    • Zhang, J., and Chopp, M. (2013). Cell-based therapy for ischemic stroke. Expert Opin. Biol. Ther. 13, 1229-1240. doi: 10.1517/14712598.2013.804507
    • (2013) Expert Opin. Biol. Ther , vol.13 , pp. 1229-1240
    • Zhang, J.1    Chopp, M.2
  • 68
    • 73149097202 scopus 로고    scopus 로고
    • Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia
    • Zheng, W., Honmou, O., Miyata, K., Harada, K., Suzuki, J., Liu, H., et al. (2010). Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia. Brain Res. 1310, 8-16. doi: 10.1016/j. brainres.2009.11.012
    • (2010) Brain Res , vol.1310 , pp. 8-16
    • Zheng, W.1    Honmou, O.2    Miyata, K.3    Harada, K.4    Suzuki, J.5    Liu, H.6


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