Design, synthesis, structure-function relationship, bioconversion, and pharmacokinetic evaluation of ertapenem prodrugs

Journal of Medicinal Chemistry

Volumn 57, Issue 20, 2014, Pages 8421-8444

  Singh, Sheo B ^a,b   Rindgen, Diane ^a   Bradley, Prudence ^a   Suzuki, Takao ^b   Wang, Nengxue ^b   Wu, Hao ^b   Zhang, Basheng ^b   Wang, Li ^b   Ji, Chongmin ^b   Yu, Hongshi ^b   Soll, Richard M ^b   Olsen, David B ^a   Meinke, Peter T ^a   Nicoll Griffith, Deborah A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b WUXI APPTEC   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ERTAPENEM; ERTAPENEM BIS 1 (PIVALOYLOXY)ETHYL ESTER; ERTAPENEM BIS ACETOXYMETHYL ESTER; ERTAPENEM BIS(5 METHYL 2 OXO 1,3 DIOXOL 4YL)METHYL ESTER; ERTAPENEM BIS(ISOBUTANOYLOXY)METHYL ESTER; ERTAPENEM BIS(PIVALOYLOXY)METHYL ESTER; ERTAPENEM BIS(PROPIONYLOXY)METHYL ESTER; ERTAPENEM BIS[(2 ETHYLBUTANOYL)OXY]METHYL ESTER; ERTAPENEM BIS[(CYCLOHEXANECARBONYL)OXY]METHYL ESTER; ERTAPENEM BIS[(CYCLOHEXYLCARBONYL)OXY]METHYL ESTER; ERTAPENEM BIS[(ETHOXYCARBONYL)OXY]METHYL ESTER; ERTAPENEM BIS[(ISOPROPOXYCARBONYL)OXY]METHYL ESTER; ERTAPENEM BIS[(METHOXYCARBONYL)OXY]METHYL ESTER; ERTAPENEM BIS[(TERT BUTOXYCARBONYL)OXY]METHYL ESTER; ERTAPENEM C 3 METHYL 2 ETHYLBUTANOATE SODIUM SALT; ERTAPENEM C 3 METHYL ACETATE CARBONATE SODIUM SALT; ERTAPENEM C 3 METHYL CYCLOXEXYL CARBONATE SODIUM SALT; ERTAPENEM C 3 METHYL ISOBUTYRATESODIUM SALT; ERTAPENEM C 3 METHYL PIVALATE; ERTAPENEM C 3 METHYL PROPIONATE CARBONATE SODIUM SALT; ERTAPENEM C 3 SODIUM CARBOXYL (ISOBUTYLOXY) METHYLBENZOATE; ERTAPENEM C 3 SODIUM CARBOXYL METHYL PIVALATE; ERTAPENEM C 3 SODIUM CARBOXYL(4 METHYL 5 METHYL 1,3 DIOXOL 2 ONE)BENZOATE; ERTAPENEM C 3 [(CYCLOHEXANECARBONYL)OXY]METHYL ESTER SODIUM SALT; ERTAPENEM C 3 [(ISOPROPOXYCARBONYL)OXY]METHYL ESTER SODIUM SALT; ERTAPENEM C 3 [(TERT BUTYLCARBONYL)OXY]METHYL ESTER SODIUM SALT; ERTAPENEM DIISOPROPYL ESTER; N ALLYLOXYCARBONYL ERTAPENEM; PRODRUG; UNCLASSIFIED DRUG; UNINDEXED DRUG; BETA LACTAM; ESTER;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG DESIGN; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; DRUG TRANSFORMATION; GASTROINTESTINAL TRACT; MALE; NONHUMAN; RAT; SIMULATION; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; DOG; HUMAN; HYDROLYSIS; SPRAGUE DAWLEY RAT; SYNTHESIS;

ANIMALS; BETA-LACTAMS; CHEMISTRY TECHNIQUES, SYNTHETIC; DOGS; DRUG DESIGN; DRUG STABILITY; ESTERS; HUMANS; HYDROLYSIS; MALE; PRODRUGS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908372758     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500879a     Document Type: Article

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