Design, synthesis, and evaluation of prodrugs of ertapenem

ACS Medicinal Chemistry Letters

Volumn 4, Issue 8, 2013, Pages 715-719

  Singh, Sheo B ^a   Rindgen, Diane ^a   Bradley, Prudence ^a   Cama, Lovji ^a   Sun, Wanying ^a   Hafey, Michael J ^a   Suzuki, Takao ^b   Wang, Nengxue ^b   Wu, Hao ^b   Zhang, Basheng ^b   Wang, Li ^b   Ji, Chongmin ^b   Yu, Hongshi ^b   Soll, Richard ^b   Olsen, David B ^a   Meinke, Peter T ^a   Nicoll Griffith, Deborah A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b WUXI APPTEC   (China)

Author keywords

antibiotics; carbapenem; Ertapenem; ertapenem bis lactone; ertapenem bis pivoxyl; ertapenem diethyl ester; intraduodenal dosing; prodrugs

Indexed keywords

ERTAPENEM; TEBIPENEM;

AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG HYDROLYSIS; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CANIS FAMILIARIS; RATTUS;

EID: 84881450079     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400092n     Document Type: Article

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