메뉴 건너뛰기




Volumn 5, Issue OCT, 2014, Pages

Stem cells can form gap junctions with cardiac myocytes and exert pro-arrhythmic effects

Author keywords

Arrhythmias; Cardiomyocytes; Clinical trials; Electrotonic connections; Stem cells

Indexed keywords

ARRHYTHMOGENESIS; ARTICLE; CARDIOVASCULAR RISK; CELL INTERACTION; GAP JUNCTION; HEART ARRHYTHMIA; HEART AUTOMATICITY; HEART DEPOLARIZATION; HEART MUSCLE CELL; HUMAN; NONHUMAN; PARACRINE SIGNALING; PATIENT SAFETY; STEM CELL TRANSPLANTATION; SYMPATHETIC INNERVATION; TREATMENT OUTCOME;

EID: 84908370291     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2014.00419     Document Type: Article
Times cited : (21)

References (67)
  • 1
    • 22744447315 scopus 로고    scopus 로고
    • Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation
    • Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, et al. 2005. Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ. Res. 97 (2): 159-167.
    • (2005) Circ. Res , vol.97 , Issue.2 , pp. 159-167
    • Abraham, M.R.1    Henrikson, C.A.2    Tung, L.3    Chang, M.G.4    Aon, M.5    Xue, T.6
  • 2
    • 84878103966 scopus 로고    scopus 로고
    • Engraftment patterns of human adult mesenchymal stem cells expose electrotonic and paracrine proarrhythmic mechanisms in myocardial cell cultures
    • Askar SF, Ramkisoensing AA, Atsma DE, Schalij MJ, de Vries AA, and Pijnappels DA. 2013. Engraftment patterns of human adult mesenchymal stem cells expose electrotonic and paracrine proarrhythmic mechanisms in myocardial cell cultures. Circ. Arrhythm. Electrophysiol. 6 (2): 380-391.
    • (2013) Circ. Arrhythm. Electrophysiol , vol.6 , Issue.2 , pp. 380-391
    • Askar, S.F.1    Ramkisoensing, A.A.2    Atsma, D.E.3    Schalij, M.J.4    de Vries, A.A.5    Pijnappels, D.A.6
  • 4
    • 82255175382 scopus 로고    scopus 로고
    • Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial
    • Bolli R, Chugh AR, D'Amario D, Loughran JH, Stoddard MF, Ikram S, et al. 2011. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet 378 (9806): 1847-1857.
    • (2011) Lancet , vol.378 , Issue.9806 , pp. 1847-1857
    • Bolli, R.1    Chugh, A.R.2    D'Amario, D.3    Loughran, J.H.4    Stoddard, M.F.5    Ikram, S.6
  • 5
    • 77649331404 scopus 로고    scopus 로고
    • Characterizing functional stem cell cardiomyocyte interactions
    • Bursac N, Kirkton RD, McSpadden LC, and Liau B. 2010. Characterizing functional stem cell cardiomyocyte interactions. Regen. Med. 5 (1): 87-105.
    • (2010) Regen. Med , vol.5 , Issue.1 , pp. 87-105
    • Bursac, N.1    Kirkton, R.D.2    McSpadden, L.C.3    Liau, B.4
  • 7
    • 33646199622 scopus 로고    scopus 로고
    • Proarrhythmic potential of mesenchymal stem cell transplantation revealed in an in vitro coculture model
    • Chang MG, Tung L, Sekar RB, Chang CY, Cysyk J, Dong P, Marban E, et al. 2006. Proarrhythmic potential of mesenchymal stem cell transplantation revealed in an in vitro coculture model. Circulation 113 (15): 1832-1841.
    • (2006) Circulation , vol.113 , Issue.15 , pp. 1832-1841
    • Chang, M.G.1    Tung, L.2    Sekar, R.B.3    Chang, C.Y.4    Cysyk, J.5    Dong, P.6    Marban, E.7
  • 8
    • 84902312015 scopus 로고    scopus 로고
    • Human embryonic stem-cell-derived cardiomyocytes regenerate non-human primate hearts
    • Chong JJ, Yang X, Don CW, Minami E, Liu YW, Weyers JJ, et al. 2014. Human embryonic stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature 510 (7504): 273-277.
    • (2014) Nature , vol.510 , Issue.7504 , pp. 273-277
    • Chong, J.J.1    Yang, X.2    Don, C.W.3    Minami, E.4    Liu, Y.W.5    Weyers, J.J.6
  • 9
    • 84866458852 scopus 로고    scopus 로고
    • Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance
    • Circulation
    • Chugh AR, Beache GM, Loughran JH, Mewton N, Elmore JB, Kajstura J, et al. 2012. Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation 126 (11 Suppl 1): S54-S64.
    • (2012) , vol.126 , Issue.11 , pp. S54-S64
    • Chugh, A.R.1    Beache, G.M.2    Loughran, J.H.3    Mewton, N.4    Elmore, J.B.5    Kajstura, J.6
  • 12
    • 77951909702 scopus 로고    scopus 로고
    • The pathophysiologic basis of fractionated and complex electrograms and the impact of recording techniques on their detection and interpretation
    • de Bakker JM, and Wittkampf FH. 2010. The pathophysiologic basis of fractionated and complex electrograms and the impact of recording techniques on their detection and interpretation. Circ. Arrhythm. Electrophysiol. 3 (2): 204-213.
    • (2010) Circ. Arrhythm. Electrophysiol , vol.3 , Issue.2 , pp. 204-213
    • de Bakker, J.M.1    Wittkampf, F.H.2
  • 14
    • 58149138828 scopus 로고    scopus 로고
    • Electrophysiological consequences of acute regional ischemia/reperfusion in neonatal rat ventricular myocyte monolayers
    • de Diego C, Pai RK, Chen F, Xie LH, De LJ, Weiss JN, et al. 2008. Electrophysiological consequences of acute regional ischemia/reperfusion in neonatal rat ventricular myocyte monolayers. Circulation 118 (23): 2330-2337.
    • (2008) Circulation , vol.118 , Issue.23 , pp. 2330-2337
    • de Diego, C.1    Pai, R.K.2    Chen, F.3    Xie, L.H.4    De, L.J.5    Weiss, J.N.6
  • 15
    • 84900422755 scopus 로고    scopus 로고
    • Intracoronary stem cell infusion after acute myocardial infarction: a meta-analysis and update on clinical trials
    • de Jong R, Houtgraaf JH, Samiei S, Boersma E, and Duckers HJ. 2014. Intracoronary stem cell infusion after acute myocardial infarction: a meta-analysis and update on clinical trials. Circ. Cardiovasc. Interv. 7 (2): 156-167.
    • (2014) Circ. Cardiovasc. Interv , vol.7 , Issue.2 , pp. 156-167
    • de Jong, R.1    Houtgraaf, J.H.2    Samiei, S.3    Boersma, E.4    Duckers, H.J.5
  • 16
    • 1942470638 scopus 로고    scopus 로고
    • Pharmacology of gap junctions in the cardiovascular system
    • Dhein S. 2004. Pharmacology of gap junctions in the cardiovascular system. Cardiovasc. Res. 62 (2): 287-298.
    • (2004) Cardiovasc. Res , vol.62 , Issue.2 , pp. 287-298
    • Dhein, S.1
  • 17
    • 41449104964 scopus 로고    scopus 로고
    • Cardiac connections--the antiarrhythmic solution? N
    • Duffy HS. 2008. Cardiac connections--the antiarrhythmic solution? N. Engl. J. Med. 358 (13): 1397-1398.
    • (2008) Engl. J. Med , vol.358 , Issue.13 , pp. 1397-1398
    • Duffy, H.S.1
  • 18
    • 50649104813 scopus 로고    scopus 로고
    • Skeletal myoblast transplantation: no MAGIC bullet for ischemic cardiomyopathy
    • Eisen HJ. 2008. Skeletal myoblast transplantation: no MAGIC bullet for ischemic cardiomyopathy. Nat. Clin. Pract. Cardiovasc. Med. 5 (9): 520-521.
    • (2008) Nat. Clin. Pract. Cardiovasc. Med , vol.5 , Issue.9 , pp. 520-521
    • Eisen, H.J.1
  • 20
    • 58149347238 scopus 로고    scopus 로고
    • Paracrine mechanisms in adult stem cell signaling and therapy
    • Gnecchi M, Zhang Z, Ni A, and Dzau VJ. 2008. Paracrine mechanisms in adult stem cell signaling and therapy. Circ. Res. 103 (11): 1204-1219.
    • (2008) Circ. Res , vol.103 , Issue.11 , pp. 1204-1219
    • Gnecchi, M.1    Zhang, Z.2    Ni, A.3    Dzau, V.J.4
  • 21
    • 0034804291 scopus 로고    scopus 로고
    • Influence of dynamic gap junction resistance on impulse propagation in ventricular myocardium: a computer simulation study
    • Henriquez AP, Vogel R, Muller-Borer BJ, Henriquez CS, Weingart R, and Cascio WE. 2001. Influence of dynamic gap junction resistance on impulse propagation in ventricular myocardium: a computer simulation study. Biophys. J. 81 (4): 2112-2121.
    • (2001) Biophys. J , vol.81 , Issue.4 , pp. 2112-2121
    • Henriquez, A.P.1    Vogel, R.2    Muller-Borer, B.J.3    Henriquez, C.S.4    Weingart, R.5    Cascio, W.E.6
  • 23
    • 0035901578 scopus 로고    scopus 로고
    • Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic
    • Hondeghem LM, Carlsson L, and Duker G. 2001. Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic. Circulation 103 (15): 2004-2013.
    • (2001) Circulation , vol.103 , Issue.15 , pp. 2004-2013
    • Hondeghem, L.M.1    Carlsson, L.2    Duker, G.3
  • 24
    • 41249100788 scopus 로고    scopus 로고
    • Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study
    • Hubbard ML, Ying W, and Henriquez CS. 2007. Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study. Europace. 9 Suppl 6: vi20-vi28.
    • (2007) Europace , vol.9 , pp. vi20-vi28
    • Hubbard, M.L.1    Ying, W.2    Henriquez, C.S.3
  • 25
    • 0034705469 scopus 로고    scopus 로고
    • Gap junctions in cardiovascular disease
    • Jongsma HJ, and Wilders R. 2000. Gap junctions in cardiovascular disease. Circ. Res. 86 (12): 1193-1197.
    • (2000) Circ. Res , vol.86 , Issue.12 , pp. 1193-1197
    • Jongsma, H.J.1    Wilders, R.2
  • 26
    • 83055173972 scopus 로고    scopus 로고
    • Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes
    • Jonsson MK, Wang QD, and Becker B. 2011. Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes. Assay. Drug Dev. Technol. 9 (6): 589-599.
    • (2011) Assay. Drug Dev. Technol , vol.9 , Issue.6 , pp. 589-599
    • Jonsson, M.K.1    Wang, Q.D.2    Becker, B.3
  • 27
    • 0034812869 scopus 로고    scopus 로고
    • The role of myocardial gap junctions in electrical conduction and arrhythmogenesis
    • Kanno S, and Saffitz JE. 2001. The role of myocardial gap junctions in electrical conduction and arrhythmogenesis. Cardiovasc. Pathol. 10 (4): 169-177.
    • (2001) Cardiovasc. Pathol , vol.10 , Issue.4 , pp. 169-177
    • Kanno, S.1    Saffitz, J.E.2
  • 28
    • 0037358335 scopus 로고    scopus 로고
    • Histological study on the distribution of autonomic nerves in the human heart
    • Kawano H, Okada R, and Yano K. 2003. Histological study on the distribution of autonomic nerves in the human heart. Heart Vessels 18 (1): 32-39.
    • (2003) Heart Vessels , vol.18 , Issue.1 , pp. 32-39
    • Kawano, H.1    Okada, R.2    Yano, K.3
  • 29
    • 0034904645 scopus 로고    scopus 로고
    • Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes
    • Kehat I, Kenyagin-Karsenti D, Snir M, Segev H, Amit M, Gepstein A, et al. 2001. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J. Clin. Invest 108 (3): 407-414.
    • (2001) J. Clin. Invest , vol.108 , Issue.3 , pp. 407-414
    • Kehat, I.1    Kenyagin-Karsenti, D.2    Snir, M.3    Segev, H.4    Amit, M.5    Gepstein, A.6
  • 30
    • 5044221669 scopus 로고    scopus 로고
    • Electromechanical integration of cardiomyocytes derived from human embryonic stem cells
    • Kehat I, Khimovich L, Caspi O, Gepstein A, Shofti R, Arbel G, et al. 2004. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat. Biotechnol. 22 (10): 1282-1289.
    • (2004) Nat. Biotechnol , vol.22 , Issue.10 , pp. 1282-1289
    • Kehat, I.1    Khimovich, L.2    Caspi, O.3    Gepstein, A.4    Shofti, R.5    Arbel, G.6
  • 31
    • 77953620382 scopus 로고    scopus 로고
    • Cardiac cell therapy with mesenchymal stem cell induces cardiac nerve sprouting, angiogenesis, and reduced connexin43-positive gap junctions, but concomitant electrical pacing increases connexin43-positive gap junctions in canine heart
    • Kim SK, Pak HN, Park JH, Fang YF, Kim GI, Park YD, et al. 2010. Cardiac cell therapy with mesenchymal stem cell induces cardiac nerve sprouting, angiogenesis, and reduced connexin43-positive gap junctions, but concomitant electrical pacing increases connexin43-positive gap junctions in canine heart. Cardiol. Young. 20 (3): 308-317.
    • (2010) Cardiol. Young , vol.20 , Issue.3 , pp. 308-317
    • Kim, S.K.1    Pak, H.N.2    Park, J.H.3    Fang, Y.F.4    Kim, G.I.5    Park, Y.D.6
  • 32
    • 18844479760 scopus 로고    scopus 로고
    • Basic mechanisms of cardiac impulse propagation and associated arrhythmias
    • Kléber AG, and Rudy Y. 2004. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev. 84 (2): 431-488.
    • (2004) Physiol Rev , vol.84 , Issue.2 , pp. 431-488
    • Kléber, A.G.1    Rudy, Y.2
  • 33
    • 84875129870 scopus 로고    scopus 로고
    • Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model?
    • Knollmann BC. 2013. Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model? Circ. Res. 112 (6): 969-976.
    • (2013) Circ. Res , vol.112 , Issue.6 , pp. 969-976
    • Knollmann, B.C.1
  • 34
    • 34948891467 scopus 로고    scopus 로고
    • Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
    • Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK, et al. 2007. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat. Biotechnol. 25 (9): 1015-1024.
    • (2007) Nat. Biotechnol , vol.25 , Issue.9 , pp. 1015-1024
    • Laflamme, M.A.1    Chen, K.Y.2    Naumova, A.V.3    Muskheli, V.4    Fugate, J.A.5    Dupras, S.K.6
  • 35
    • 0025044073 scopus 로고
    • Quantification of spatial inhomogeneity in conduction and initiation of reentrant atrial arrhythmias.
    • H1254-H1263
    • Lammers WJ, Schalij MJ, Kirchhof CJ, and Allessie MA. 1990. Quantification of spatial inhomogeneity in conduction and initiation of reentrant atrial arrhythmias. Am. J. Physiol 259 (4 Pt 2): H1254-H1263.
    • (1990) Am. J. Physiol , vol.259 , Issue.4
    • Lammers, W.J.1    Schalij, M.J.2    Kirchhof, C.J.3    Allessie, M.A.4
  • 37
    • 84862020324 scopus 로고    scopus 로고
    • Gene-and cell-based bio-artificial pacemaker: what basic and translational lessons have we learned?
    • Li RA. 2012. Gene- and cell-based bio-artificial pacemaker: what basic and translational lessons have we learned? Gene Ther. 19 (6): 588-595.
    • (2012) Gene Ther , vol.19 , Issue.6 , pp. 588-595
    • Li, R.A.1
  • 38
    • 84858019974 scopus 로고    scopus 로고
    • Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
    • Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, et al. 2012. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet 379 (9819): 895-904.
    • (2012) Lancet , vol.379 , Issue.9819 , pp. 895-904
    • Makkar, R.R.1    Smith, R.R.2    Cheng, K.3    Malliaras, K.4    Thomson, L.E.5    Berman, D.6
  • 40
    • 19744378213 scopus 로고    scopus 로고
    • Heart failure
    • McMurray JJ, and Pfeffer MA. 2005. Heart failure. Lancet 365 (9474): 1877-1889.
    • (2005) Lancet , vol.365 , Issue.9474 , pp. 1877-1889
    • McMurray, J.J.1    Pfeffer, M.A.2
  • 41
    • 41149106402 scopus 로고    scopus 로고
    • The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation
    • Menasche P, Alfieri O, Janssens S, McKenna W, Reichenspurner H, Trinquart L, et al. 2008. The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation 117 (9): 1189-1200.
    • (2008) Circulation , vol.117 , Issue.9 , pp. 1189-1200
    • Menasche, P.1    Alfieri, O.2    Janssens, S.3    McKenna, W.4    Reichenspurner, H.5    Trinquart, L.6
  • 42
    • 33645743539 scopus 로고    scopus 로고
    • Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial
    • Meyer GP, Wollert KC, Lotz J, Steffens J, Lippolt P, Fichtner S, et al. 2006. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation 113 (10): 1287-1294.
    • (2006) Circulation , vol.113 , Issue.10 , pp. 1287-1294
    • Meyer, G.P.1    Wollert, K.C.2    Lotz, J.3    Steffens, J.4    Lippolt, P.5    Fichtner, S.6
  • 43
    • 10744224147 scopus 로고    scopus 로고
    • Mesenchymal stem cell injection induces cardiac nerve sprouting and increased tenascin expression in a Swine model of myocardial infarction
    • Pak HN, Qayyum M, Kim DT, Hamabe A, Miyauchi Y, Lill MC, et al. 2003. Mesenchymal stem cell injection induces cardiac nerve sprouting and increased tenascin expression in a Swine model of myocardial infarction. J. Cardiovasc. Electrophysiol. 14 (8): 841-848.
    • (2003) J. Cardiovasc. Electrophysiol , vol.14 , Issue.8 , pp. 841-848
    • Pak, H.N.1    Qayyum, M.2    Kim, D.T.3    Hamabe, A.4    Miyauchi, Y.5    Lill, M.C.6
  • 44
    • 68949155547 scopus 로고    scopus 로고
    • Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes
    • Pedrotty DM, Klinger RY, Kirkton RD, and Bursac N. 2009. Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes. Cardiovasc. Res. 83 (4): 688-697.
    • (2009) Cardiovasc. Res , vol.83 , Issue.4 , pp. 688-697
    • Pedrotty, D.M.1    Klinger, R.Y.2    Kirkton, R.D.3    Bursac, N.4
  • 45
    • 33749452234 scopus 로고    scopus 로고
    • Progressive increase in conduction velocity across human mesenchymal stem cells is mediated by enhanced electrical coupling
    • Pijnappels DA, Schalij MJ, van TJ, Ypey DL, de Vries AA, van der Wall EE, et al. 2006.Progressive increase in conduction velocity across human mesenchymal stem cells is mediated by enhanced electrical coupling. Cardiovasc. Res. 72 (2): 282-291.
    • (2006) Cardiovasc. Res , vol.72 , Issue.2 , pp. 282-291
    • Pijnappels, D.A.1    Schalij, M.J.2    van, T.J.3    Ypey, D.L.4    de Vries, A.A.5    van der Wall, E.E.6
  • 47
    • 33746302842 scopus 로고    scopus 로고
    • Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties
    • Price MJ, Chou CC, Frantzen M, Miyamoto T, Kar S, Lee S, et al. 2006. Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties. Int. J. Cardiol. 111 (2): 231-239.
    • (2006) Int. J. Cardiol , vol.111 , Issue.2 , pp. 231-239
    • Price, M.J.1    Chou, C.C.2    Frantzen, M.3    Miyamoto, T.4    Kar, S.5    Lee, S.6
  • 49
    • 0032897904 scopus 로고    scopus 로고
    • Cardiac electrical restitution properties and stability of reentrant spiral waves: a simulation study
    • H269-H283
    • Qu Z, Weiss JN, and Garfinkel A. 1999. Cardiac electrical restitution properties and stability of reentrant spiral waves: a simulation study. Am. J. Physiol 276 (1 Pt 2): H269-H283.
    • (1999) Am. J. Physiol , vol.276 , Issue.1
    • Qu, Z.1    Weiss, J.N.2    Garfinkel, A.3
  • 50
    • 77949913309 scopus 로고    scopus 로고
    • Effects of adipose tissue-derived stem cell therapy after myocardial infarction: impact of the route of administration
    • Rigol M, Solanes N, Farre J, Roura S, Roque M, Berruezo A, et al. 2010. Effects of adipose tissue-derived stem cell therapy after myocardial infarction: impact of the route of administration. J. Card Fail. 16 (4): 357-366.
    • (2010) J. Card Fail , vol.16 , Issue.4 , pp. 357-366
    • Rigol, M.1    Solanes, N.2    Farre, J.3    Roura, S.4    Roque, M.5    Berruezo, A.6
  • 51
    • 36949035990 scopus 로고    scopus 로고
    • Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia
    • Roell W, Lewalter T, Sasse P, Tallini YN, Choi BR, Breitbach M, et al. 2007. Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia. Nature 450 (7171): 819- 824.
    • (2007) Nature , vol.450 , Issue.7171 , pp. 819- 824
    • Roell, W.1    Lewalter, T.2    Sasse, P.3    Tallini, Y.N.4    Choi, B.R.5    Breitbach, M.6
  • 52
    • 1942438688 scopus 로고    scopus 로고
    • Role of gap junctions in the propagation of the cardiac action potential
    • Rohr S. 2004. Role of gap junctions in the propagation of the cardiac action potential. Cardiovasc. Res. 62 (2): 309-322.
    • (2004) Cardiovasc. Res , vol.62 , Issue.2 , pp. 309-322
    • Rohr, S.1
  • 54
    • 0037790712 scopus 로고    scopus 로고
    • Physiological coupling of donor and host cardiomyocytes after cellular transplantation
    • Rubart M, Pasumarthi KB, Nakajima H, Soonpaa MH, Nakajima HO, and Field LJ. 2003. Physiological coupling of donor and host cardiomyocytes after cellular transplantation. Circ. Res. 92 (11): 1217-1224.
    • (2003) Circ. Res , vol.92 , Issue.11 , pp. 1217-1224
    • Rubart, M.1    Pasumarthi, K.B.2    Nakajima, H.3    Soonpaa, M.H.4    Nakajima, H.O.5    Field, L.J.6
  • 55
    • 0031015477 scopus 로고    scopus 로고
    • Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure.
    • Shaw RM, and Rudy Y. 1997. Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure. Circ. Res. 80 (1): 124-138.
    • (1997) Circ. Res , vol.80 , Issue.1 , pp. 124-138
    • Shaw, R.M.1    Rudy, Y.2
  • 56
    • 84866150446 scopus 로고    scopus 로고
    • Human ES-cell derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts
    • Shiba Y, Fernandes S, Zhu WZ, Filice D, Muskheli V, Kim J, et al. 2012. Human ES-cell derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature 489 (7415): 322-325.
    • (2012) Nature , vol.489 , Issue.7415 , pp. 322-325
    • Shiba, Y.1    Fernandes, S.2    Zhu, W.Z.3    Filice, D.4    Muskheli, V.5    Kim, J.6
  • 57
    • 56649117342 scopus 로고    scopus 로고
    • Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells
    • Sundelacruz S, Levin M, and Kaplan DL. 2008. Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells. PLoS. One. 3 (11): e3737.
    • (2008) PLoS. One , vol.3 , Issue.11 , pp. e3737
    • Sundelacruz, S.1    Levin, M.2    Kaplan, D.L.3
  • 58
    • 0025195331 scopus 로고
    • Electrotonic influences on action potentials from isolated ventricular cells
    • Tan RC, and Joyner RW. 1990. Electrotonic influences on action potentials from isolated ventricular cells. Circ. Res. 67 (5): 1071-1081.
    • (1990) Circ. Res , vol.67 , Issue.5 , pp. 1071-1081
    • Tan, R.C.1    Joyner, R.W.2
  • 59
    • 33746104916 scopus 로고    scopus 로고
    • Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro
    • Tolmachov O, Ma YL, Themis M, Patel P, Spohr H, Macleod KT, et al. 2006. Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro. BMC. Cardiovasc. Disord. 6: 25.
    • (2006) BMC. Cardiovasc. Disord , vol.6 , Issue.25
    • Tolmachov, O.1    Ma, Y.L.2    Themis, M.3    Patel, P.4    Spohr, H.5    Macleod, K.T.6
  • 60
    • 37649006844 scopus 로고    scopus 로고
    • Vulnerability to re-entry in simulated two-dimensional cardiac tissue: effects of electrical restitution and stimulation sequence
    • Tran DX, Yang MJ, Weiss JN, Garfinkel A, and Qu Z. 2007. Vulnerability to re-entry in simulated two-dimensional cardiac tissue: effects of electrical restitution and stimulation sequence. Chaos. 17 (4): 043115.
    • (2007) Chaos , vol.17 , Issue.4 , pp. 043115
    • Tran, D.X.1    Yang, M.J.2    Weiss, J.N.3    Garfinkel, A.4    Qu, Z.5
  • 61
    • 35948999615 scopus 로고    scopus 로고
    • Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction
    • Valina C, Pinkernell K, Song YH, Bai X, Sadat S, Campeau RJ, et al. 2007. Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction. Eur. Heart J. 28 (21): 2667-2677.
    • (2007) Eur. Heart J , vol.28 , Issue.21 , pp. 2667-2677
    • Valina, C.1    Pinkernell, K.2    Song, Y.H.3    Bai, X.4    Sadat, S.5    Campeau, R.J.6
  • 62
    • 12144286490 scopus 로고    scopus 로고
    • Human mesenchymal stem cells make cardiac connexins and form functional gap junctions
    • Valiunas V, Doronin S, Valiuniene L, Potapova I, Zuckerman J, Walcott B, et al. 2004. Human mesenchymal stem cells make cardiac connexins and form functional gap junctions. J. Physiol 555 (Pt 3): 617-626.
    • (2004) J. Physiol , vol.555 , pp. 617-626
    • Valiunas, V.1    Doronin, S.2    Valiuniene, L.3    Potapova, I.4    Zuckerman, J.5    Walcott, B.6
  • 64
    • 1542328965 scopus 로고    scopus 로고
    • Plasticity of adult stem cells
    • Wagers AJ, and Weissman IL. 2004. Plasticity of adult stem cells. Cell 116 (5): 639-648.
    • (2004) Cell , vol.116 , Issue.5 , pp. 639-648
    • Wagers, A.J.1    Weissman, I.L.2
  • 65
    • 50949118037 scopus 로고    scopus 로고
    • Transmural dispersion of refractoriness and conduction velocity is associated with heterogeneously reduced connexin43 in a rabbit model of heart failure
    • Wiegerinck RF, van Veen TA, Belterman CN, Schumacher CA, Noorman M, de Bakker JM, et al. 2008. Transmural dispersion of refractoriness and conduction velocity is associated with heterogeneously reduced connexin43 in a rabbit model of heart failure. Heart Rhythm. 5 (8): 1178-1185.
    • (2008) Heart Rhythm , vol.5 , Issue.8 , pp. 1178-1185
    • Wiegerinck, R.F.1    van Veen, T.A.2    Belterman, C.N.3    Schumacher, C.A.4    Noorman, M.5    de Bakker, J.M.6
  • 66
    • 3042710733 scopus 로고    scopus 로고
    • Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial
    • Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C, et al. 2004. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 364 (9429): 141-148.
    • (2004) Lancet , vol.364 , Issue.9429 , pp. 141-148
    • Wollert, K.C.1    Meyer, G.P.2    Lotz, J.3    Ringes-Lichtenberg, S.4    Lippolt, P.5    Breidenbach, C.6
  • 67
    • 70350484963 scopus 로고    scopus 로고
    • Effects of fibroblast myocyte coupling on cardiac conduction and vulnerability to reentry: A computational study
    • Xie Y, Garfinkel A, Camelliti P, Kohl P, Weiss JN, and Qu Z. 2009. Effects of fibroblast myocyte coupling on cardiac conduction and vulnerability to reentry: A computational study. Heart Rhythm. 6 (11): 1641-1649.
    • (2009) Heart Rhythm , vol.6 , Issue.11 , pp. 1641-1649
    • Xie, Y.1    Garfinkel, A.2    Camelliti, P.3    Kohl, P.4    Weiss, J.N.5    Qu, Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.