Metabolite profiles of epimedin C in rat plasma and bile by ultra-performance liquid chromatography coupled with quadrupole-TOF-MS

Biomedical Chromatography

Volumn 28, Issue 10, 2014, Pages 1306-1312

  Cui, Li ^a   Sun, E ^a   Zhang, Zhenhai ^a   Tan, Xiaobin ^a   Xu, Fengjuan ^a   Jia, Xiaobin ^a  

^a KEY LABORATORY OF NEW DRUG DELIVERY SYSTEM OF CHINESE MATERIA MEDICA   (China)

Author keywords

Epimedin C; Metabolic pathway; UPLC Q TOF MS

Indexed keywords

BIOMOLECULES; BODY FLUIDS; COLUMN CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; RATS;

BIOACTIVES; EPIMEDIN C; HERBA EPIMEDII; METABOLIC PATHWAYS; METABOLITE PROFILES; QUADRUPOLES; RAT PLASMA; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPLC Q-TOF MS; UPLC-Q-TOF/MS;

METABOLISM;

DRUG METABOLITE; EPIMEDIN C; NATURAL PRODUCT; RHAMNOSE; UNCLASSIFIED DRUG; FLAVONOID;

ANIMAL EXPERIMENT; ARTICLE; BILE; BLOOD SAMPLING; CONTROLLED STUDY; DEHYDROGENATION; DEMETHYLATION; DRUG BLOOD LEVEL; DRUG METABOLISM; GLUCURONIDATION; HYDROGENATION; HYDROXYLATION; IN VIVO STUDY; MALE; MASS SPECTROMETRY; NONHUMAN; OXIDATION; PRECIPITATION; QUADRUPOLE TIME OF FLIGHT MASS SPECTROMETRY; RAT; SINGLE DRUG DOSE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ORAL DRUG ADMINISTRATION; PROCEDURES; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BILE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVONOIDS; MALE; MASS SPECTROMETRY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84908337311     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3174     Document Type: Article

References (16)

1. Aida S, Alba M, Romero MP, Jordi R, Nadia O and Motilva MJ. Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids. Food Chemistry 2012; 130: 383-393.
2. Andrea JD, Bao YP, Morgan MR and Gary W. Conjugation position of quercetin glucuronides and effect on biological activity. Free Radical Biology and Medicine 2000; 29: 1234-1243.
3. Aura A. Microbial metabolism of dietary phenolic compounds in the colon. Phytochemistry Reviews 2008; 7: 407-429.
4. Chen Y, Zhao YH, Jia XB and Hu M. Absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo). Pharmaceutical Research 2008; 25: 2190-2199.
5. Cui L, Sun E, Zhang ZH, Qian Q, Tan XB, Xu FJ and Jia XB. Metabolite profiles of epimedin B in rats by ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry. Journal of Agricultural and Food Chemistry 2013; 61: 3589-3599.
6. Fu ML, Wang W, Chen F, Dong YC, Liu XJ, Ni H and Chen QH. Production of 8-prenylnaringenin from isoxanthohumol through biotransformation by fungi cells. Journal of Agricultural and Food Chemistry 2011; 59: 7419-7426.
7. Li F, Lu X, Liu H, Liu M and Xiong Z. A pharmaco-metabonomic study on the therapeutic basis and metabolic effects of Epimedium brevicornum Maxim. on hydrocortisone-induced rat using UPLC-MS. Biomedical Chromatography 2007; 21: 397-405.
8. Li YB, Xiong ZL and Li FM. Determination of epimedin C in rat plasma by reversed-phase high-performance chromatography after oral administration of Herba Epimedii extract. Journal of Chromatography B 2005; 821: 235-239.
9. Liang HR, Vuorela P, Vuorela H and Hiltunen R. Isolation and immunomo-dulatory effect offlavonol glyco sides from Epimedium hunanense. Planta Medica 1997; 63: 316-319.
10. Liu M, Wang H, Zhao S, Shi X, Zhang Y, Xu H, Wang Y, Li X and Zhang L. Studies on target tissue distribution of ginsenosides and epimedium flavonoids in rats after intravenous administration of Jiweiling freeze-dried powder. Biomedical Chromatography 2011; 25: 1260-1272.
11. Meng FH, Li YB, Xiong ZL, Jiang ZM and Li FM. Osteoblastic proliferative activity of Epimedium brevicornum Maxim. Phytomedicine 2005; 12: 189-193.
12. Pozharitskaya ON, Karlina MV, Shikov AN, Kosman VM, Makarova MN and Makarov VG. Determination of icariin in rat plasma by reverse-phase high-performance liquid chromatography after oral administration of a lipid-based suspension of Epimedium koreanum extract. Biomedical Chromatography 2008; 22(6): 625-629.
13. Qian Q, Li SL, Sun E, Zhang KR, Tan XB, Wei YJ, Fan HW, Cui L and Jia XB. Metabolite profiles of icariin in rat plasma by ultra-fast liquid chromatography coupled to triple-quadrupole/time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2012; 66: 392-398.
14. Shen P, Wong SP and Yong EL. Sensitive and rapid method to quantify icaritin and desmethylicaritin in human serum using gas chromatography-mass spectrometry. Journal of Chromatography B 2007; 857: 47-52.
15. Wu CS, Zhang JL, Zhou TH, Guo BL, Wang YL and Hou JF. Simultaneous determination of seven flavonoids in dog plasma by ultra-performance liquid chromatography-tandem mass spectrometry and its application to a bioequivalence study of bioactive components in Herba Epimedii and Er-Xian Decoction. Journal of Pharmaceutical and Biomedical Analysis 2011; 54: 186-191.
16. Zhao HY, Sun JH, Fan MX, Fan L, Zhou L, Li Z, Han J, Wang BR and Guo DA. Analysis of phenolic compounds in Epimediumplants using liquid chromatography coupled with electrospray ionization mass spectrometry. Journal of Chromatography A 2008; 1190: 157-181.