Simultaneous determination of seven flavonoids in dog plasma by ultra-performance liquid chromatography-tandem mass spectrometry and its application to a bioequivalence study of bioactive components in Herba Epimedii and Er-Xian Decoction

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 1, 2011, Pages 186-191

  Wu, Caisheng ^a   Zhang, Jinlan ^a   Zhou, Tonghui ^a   Guo, Baolin ^b   Wang, Yilin ^a   Hou, Jinfeng ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Bioequivalence study; Dog plasma; Er Xian Decoction; Flavonoid; Herba Epimedii; Ultra performance liquid chromatography tandem mass spectrometry

Indexed keywords

2'' O RHAMNOSYLICARISIDE II; ACETIC ACID; ACETONITRILE; BAOHUOSIDE I; CHINESE DRUG; EPIMEDII WUSHANENSE EXTRACT; EPIMEDIN A; EPIMEDIN B; EPIMEDIN C; ER XIAN DECOCTION; FLAVONOID; ICARIIN; PLANT MEDICINAL PRODUCT; SAGITTATOSIDE B; UNCLASSIFIED DRUG;

ANALYTICAL EQUIPMENT; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BERBERIDACEAE; BIOEQUIVALENCE; DRUG BLOOD LEVEL; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; EPIMEDII WUSHANENSE; EXPERIMENTAL DOG; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DOGS; DRUGS, CHINESE HERBAL; EPIMEDIUM; FLAVONOIDS; MALE; MASS SPECTROMETRY; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; TIME FACTORS;

EID: 77957018728     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.07.010     Document Type: Article

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