Cytoplasmic HIV-RNA in monocytes determines microglial activation and neuronal cell death in HIV-associated neurodegeneration

Experimental Neurology

Volumn 261, Issue , 2014, Pages 685-697

  Faissner, Simon ^a   Ambrosius, Björn ^a   Schanzmann, Kirsten ^a   Grewe, Bastian ^b   Potthoff, Anja ^a   Münch, Jan ^c   Sure, Ulrich ^d   Gramberg, Thomas ^e   Wittmann, Sabine ^e   Brockmeyer, Norbert ^a   Überla, Klaus ^b   Gold, Ralf ^a   Grunwald, Thomas ^b,f   Chan, Andrew ^a  

^a ST JOSEF HOSPITAL   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c UNIVERSITY OF ULM   (Germany)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

^e UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^f FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

Author keywords

Cytokines; Glial activation; HIV related neurological diseases; HIV RNA; Microglia; Neurodegeneration; Neuroinflammation

Indexed keywords

EFAVIRENZ; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; VIRUS RNA; CYTOKINE; GAG PROTEIN;

ADULT; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL DIVISION; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; FEMALE; FETUS; FLOW CYTOMETRY; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MICROGLIA; MIDDLE AGED; MONOCYTE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROFILAMENT; NEUROFILAMENT H; NEUROTOXICITY; NONHUMAN; PLASMID; PLEOCYTOSIS; PROTEIN SECRETION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS LOAD; ANIMAL; ANIMAL EMBRYO; BRAIN CORTEX; CELL CULTURE; CELL CYCLE; CHEMISTRY; COCULTURE; CYTOLOGY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; NERVE CELL; PHYSIOLOGY; VIROLOGY;

ANIMALS; CELL CYCLE; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; CEREBROSPINAL FLUID; COCULTURE TECHNIQUES; CYTOKINES; EMBRYO, MAMMALIAN; FETUS; HIV; HIV CORE PROTEIN P24; HIV INFECTIONS; HUMANS; MICROGLIA; MONOCYTES; NEURONS; RATS; RNA, VIRAL;

EID: 84908326939     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.08.011     Document Type: Article

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