Using the threat probability task to assess anxiety and fear during uncertain and certain threat

Journal of Visualized Experiments

Volumn , Issue 91, 2014, Pages

  Bradford, Daniel E ^a   Magruder, Katherine P ^a   Korhumel, Rachel A ^a   Curtin, John J ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Addiction; Anxiety; Behavior; Electromyography; Fear; Humans; Issue 91; Psychophysiology; Shock; Startle; Translational; Uncertainty

Indexed keywords

ANIMAL; ANXIETY; ELECTROMYOGRAPHY; ELECTROSTIMULATION; FEAR; HUMAN; MOOD DISORDERS; PHYSIOLOGY; PSYCHOLOGY; STARTLE REFLEX; SUBSTANCE-RELATED DISORDERS; UNCERTAINTY;

ANIMALS; ANXIETY; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; FEAR; HUMANS; MOOD DISORDERS; REFLEX, STARTLE; SUBSTANCE-RELATED DISORDERS; UNCERTAINTY;

EID: 84908325139     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/51905     Document Type: Article

References (53)

1. Barlow, D. H. Unraveling the mysteries of anxiety and its disorders from the perspective of emotion theory. The American psychologist. 55 (11), 1247-1263, doi:10.1037/0003-066X.55.11.1247 (2000).
2. Boswell, J. F., Thompson-Hollands, J., Farchione, T. J., & Barlow, D. H. Intolerance of uncertainty: A common factor in the treatment of emotional disorders. Journal of Clinical Psychology. 69 (6), 630-645, doi:10.1002/jclp.21965 (2013).
3. Grillon, C. Models and mechanisms of anxiety: evidence from startle studies. Psychopharmacology. 199(3), 421-437, doi:10.1007/s00213-007-1019-1 (2008).
4. Moberg, C. A., & Curtin, J. J. Alcohol selectively reduces anxiety but not fear: startle response during unpredictable vs. predictable threat. Journal of Abnormal Psychology. 118 (2), 335-347, doi:10.1037/a0015636 (2009).
5. Hefner, K. R., Moberg, C. A., Hachiya, L. Y., & Curtin, J. J. Alcohol stress response dampening during imminent versus distal, uncertain threat. Journal of abnormal psychology. 122 (3), 756-769, doi:10.1037/a0033407 (2013).
6. Hefner, K. R., & Curtin, J. J. Alcohol stress response dampening: Selective reduction of anxiety in the face of uncertain threat. Journal of Psychopharmacology (Oxford, England). 26 (2), 232-244, doi:10.1177/0269881111416691 (2012).
7. Bradford, D. E., Shapiro, B. L., & Curtin, J. J. How bad could it be? Alcohol dampens stress responses to threat of uncertain intensity. Psychological science. 24 (12), 2541-2549, doi:10.1177/0956797613499923 (2013).
8. Koob, G. F., & Volkow, N. D. Neurocircuitry of addiction. Neuropsychopharmacology Reviews. 35 (1), 217-238, doi:10.1038/npp.2009.110 (2010).
9. Mauss, I. B., & Robinson, M. D. Measures of emotion: A review. Cognition & emotion. 23 (2), 209-237, doi:10.1080/02699930802204677 (2009).
10. Lang, P. J., Bradley, M. M., & Cuthbert, B. N. Emotion, attention, and the startle reflex. Psychological Review. 97 (3), 377-395, doi:10.1037/0033-295X.97.3.377 (1990).
11. Lang, P. J. The emotion probe. Studies of motivation and attention. The American psychologist. 50 (5), 372-385 (1995).
12. Vaidyanathan, U., Patrick, C. J., & Cuthbert, B. N. Linking dimensional models of internalizing psychopathology to neurobiological systems: Affect-modulated startle as an indicator of fear and distress disorders and affiliated traits. Psychological bulletin. 135 (6), 909-942, doi:10.1037/a0017222 (2009).
13. Davis, M., Walker, D. L., Miles, L., & Grillon, C. Phasic vs sustained fear in rats and humans: Role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology Reviews. 35, 105-135, doi:doi:10.1037/npp.2009 (2010).
14. Blanchard, R. J., & Blanchard, D. C. Attack and defense in rodents as ethoexperimental models for the study of emotion. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 13, S3-S14 (1989).
15. Cornwell, B. R., Echiverri, A. M., Covington, M. F., & Grillon, C. Modality-specific attention under imminent but not remote threat of shock: Evidence from differential prepulse inhibition of startle. Psychological Science. 19 (6), 615-622, doi:10.1111/j.1467-9280.2008.02131.x (2008).
16. Fanselow, M. S., & Lester, L. S. A functional behavioristic approach to aversively motivated behavior: predatory imminence as a determinant of the topography of defensive behavior. Evolution and Learning., 185-212 (1988).
17. Mobbs, D., Petrovic, P., et al. When fear is near: Threat imminence elicits prefrontal-periaqueductal gray shifts in humans. Science. 317 (5841), 1079-1083, doi:10.1126/science.1144298 (2007).
18. Walker, D., & Davis, M. Role of the extended amygdala in short-duration versus sustained fear: A tribute to Dr. Lennart Heimer. Brain Structure and Function. 213 (1-2), 29-42, doi:10.1007/s00429-008-0183-3 (2008).
19. Davis, M. Neural systems involved in fear and anxiety measured with fear-potentiated startle. American Psychologist. 61 (8), 741-756, doi:10.1037/0003-066X.61.8.741 (2006).
20. Alvarez, R. P., Chen, G., Bodurka, J., Kaplan, R., & Grillon, C. Phasic and sustained fear in humans elicits distinct patterns of brain activity. NeuroImage. 55 (1), 389-400, doi:10.1016/j.neuroimage.2010.11.057 (2011).
21. Schmitz, A., & Grillon, C. Assessing fear and anxiety in humans using the threat of predictable and unpredictable aversive events (the NPU-threat test). Nature Protocols. 7 (3), 527-532, doi:10.1038/nprot.2012.001 (2012).
22. Grillon, C., Lissek, S., Rabin, S., McDowell, D., Dvir, S., & Pine, D. S. Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder. American Journal of Psychiatry. 165 (7), 898-904, doi:10.1176/appi.ajp.2007.07101581 (2008).
23. Grillon, C., Pine, D. S., Lissek, S., Rabin, S., Bonne, O., & Vythilingam, M. Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder. Biological Psychiatry. 66 (1), 47-53, doi:10.1016/j.biopsych.2008.12.028 (2009).
24. Grillon, C., Chavis, C., Covington, M. F., & Pine, D. S. Two-week treatment with the selective serotonin reuptake inhibitor citalopram reduces contextual anxiety but not cued fear in healthy volunteers: A fear-potentiated startle study. Neuropsychopharmacology. 34 (4), 964-971, doi:10.1038/npp.2008.141 (2009).
25. Bradford, D.E., Moberg, C.A., Starr, M.J., Motschman, C.A., Korhumel, R.A., & Curtin, J.J. Alcohol induced stress neuroadaptation: Cross sectional evidence from startle potentiation and ERPs in healthy drinkers and abstinent alcoholics during uncertain threat. Society for Psychophysiological Research, Abstracts for the Fifty-Third Annual Meeting, Firenze Fiera Congress & Exhibition Center, Florence, Italy, October 2-6, 2013 http://onlinelibrary.wiley.com/doi/10.1111/psyp.12111/full (2013).
26. Shankman, S. A., Robison-Andrew, E. J., Nelson, B. D., Altman, S. E., & Campbell, M. L. Effects of predictability of shock timing and intensity on aversive responses. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology. 80 (2), 112-118, doi:10.1016/j.ijpsycho.2011.02.008 (2011).
27. Blumenthal, T. D., Cuthbert, B. N., Filion, D. L., Hackley, S., Lipp, O. V., & van Boxtel, A. Committee report: Guidelines for human startle eyeblink electromyographic studies. Psychophysiology. 42 (1), 1-15, doi:10.1111/j.1469-8986.2005.00271.x (2005).
28. Valsamis, B., & Schmid, S. Habituation and prepulse inhibition of acoustic startle in rodents. Journal of visualized experiments: JoVE. (55), e3446, doi:10.3791/3446 (2011).
29. Gloria, R. Uncovering a potential biological marker for marijuana withdrawal: Startle potentiation to threat.University of Wisconsin-Madison. 70 p. (2011).
30. Curtin, J. J., Lozano, D., & Allen, J. B. The psychophysiology laboratory. Oxford University Press: New York, (2007).
31. Lane, S. T., Franklin, J. C., & Curran, P. J. Clarifying the nature of startle habituation using latent curve modeling. International journal of psychophysiology: official journal of the International Organization of Psychophysiology. 88 (1), 55-63, doi:10.1016/j.ijpsycho.2013.01.010 (2013).
32. Bradford, D. E., Kaye, J. T., & Curtin, J. J. Not just noise: individual differences in general startle reactivity predict startle response to uncertain and certain threat. Psychophysiology., 51(5), 407-411. doi:10.1111/psyp.12193 (2014).
33. Curtin, J. J., Patrick, C. J., Lang, A. R., Cacioppo, J. T., & Birbaumer, N. Alcohol affects emotion through cognition. Psychological Science. 12 (6), 527-531, doi:10.1111/1467-9280.00397 (2001).
34. Hogle, J. M., Kaye, J. T., & Curtin, J. J. Nicotine withdrawal increases threat-induced anxiety but not fear: Neuroadaptation in human addiction. Biological Psychiatry. 68 (8), 687-688, doi:10.1016/j.biopsych.2010.06.003 (2010).
35. Hogle, J. M., & Curtin, J. J. Sex differences in negative affective response during nicotine withdrawal. Psychophysiology. 43 (4), 344-356, doi:10.1111/j.1469-2006.00406.x (2006).
36. Delorme, A., & Makeig, S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Journal of Neuroscience Methods. 134 (1), 9-21, doi:10.1016/j.jneumeth.2003.10.009 (2004).
37. Statistics Toolbox. The Mathworks, Inc. Natick, Massachusetts. (2013).
38. Levenson, R., Sher, K., Grossman, L., Newman, J., & Newlin, D. Alcohol and stress response dampening: Pharmacological effects, expectancy, and tension reduction. Journal of Abnormal Psychology. 89 (4), 528-538, doi:10.1037/0021-843X.89.4.528 (1980).
39. Sher, K. J. Stress response dampening. Psychological Theories of Drinking and Alcoholism. 227-271 (1987).
40. Davis, M., Antoniadis, E., Amaral, D., & Winslow, J. Acoustic startle reflex in rhesus monkeys: A review. Reviews in the Neurosciences. 19, 171-185, doi:10.1515/REVNEURO.2008.19.2-3.171 (2008).
41. Grillon, C., Baas, J. P., Lissek, S., Smith, K., & Milstein, J. Anxious responses to predictable and unpredictable aversive events. Behavioral Neuroscience. 118 (5), 916-924, doi:10.1037/0735-7044.118.5.916 (2004).
42. Grillon, C., & Baas, J. M. A review of the modulation of the startle reflex by affective states and its application in psychiatry. Clinical Neurophysiology. 144 (9), 1557-1579., doi:10.1016/S1388-2457(03)00202-5 (2003).
43. Shankman, S. A., Nelson, B. D., et al. A psychophysiological investigation of threat and reward sensitivity in individuals with panic disorder and/or major depressive disorder. Journal of abnormal psychology. 122 (2), 322-338, doi:10.1037/a0030747 (2013).
44. Moberg, C. A., & Curtin, J. J. Stressing the importance of anxiety in alcoholism. Alcoholism: Clinical and Experimental Research. 36, 60A, doi:10.1111/j.1530-0277.2012.01803.x (2012).
45. McTeague, L. M., & Lang, P. J. The anxiety spectrum and the reflex physiology of defense: from circumscribed fear to broad distress. Depression and anxiety. 29 (4), 264-281, doi:10.1002/da.21891 (2012).
46. Mobbs, D., Marchant, J. L., et al. From Threat to Fear: The Neural Organization of Defensive Fear Systems in Humans. The Journal of Neuroscience. 29 (39), 12236-12243, doi:10.1523/JNEUROSCI.2378-09.2009 (2009).
47. Lissek, S., Bradford, D. E., et al. Neural substrates of classically conditioned fear-generalization in humans: a parametric fMRI study. Social cognitive and affective neuroscience., doi:10.1093/scan/nst096 (2013).
48. Insel, T. Next-generation treatments for mental disorders. Science translational medicine. 4 (155), 155ps19, doi:10.1126/scitranslmed.3004873 (2012).
49. Baker, T. B., Mermelstein, R., et al. New methods for tobacco dependence treatment research. Annals of Behavioral Medicine: A Publication of the Society of Behavioral Medicine. 41 (2), 192-207, doi:10.1007/s12160-010-9252-y (2011).
50. Lerman, C., LeSage, M. G., et al. Translational research in medication development for nicotine dependence. Nature Reviews. Drug Discovery. 6 (9), 746-762, doi:10.1038/nrd2361 (2007).
51. Schmitz, A., Merikangas, K., Swendsen, H., Cui, L., Heaton, L., & Grillon, C. Measuring anxious responses to predictable and unpredictable threat in children and adolescents. Journal of experimental child psychology. 110 (2), 159-170, doi:10.1016/j.jecp.2011.02.014 (2011).
52. Miller, M. W., Curtin, J. J., & Patrick, C. J. A startle probe methodology for investigating the effects of active avoidance on negative emotional reactivity. Biological Psychology. 50 (3), 235-257, doi:doi:10.1016/S0301-0511(99)00011-3 (1999).
53. Hawk, L. W., & Cook, E. W., 3rd Affective modulation of tactile startle. Psychophysiology. 34 (1), 23-31, doi:10.1111/j.1469-8986.1997.tb02412.x (1997).