Interplay between childhood trauma and BDNF val66met variants on blood BDNF mRNA levels and on hippocampus subfields volumes in schizophrenia spectrum and bipolar disorders

Journal of Psychiatric Research

Volumn 59, Issue , 2014, Pages 14-21

  Aas, Monica ^a,b   Haukvik, Unn K ^a,c   Djurovic, Srdjan ^a,b   Tesli, Martin ^a,b   Athanasiu, Lavinia ^a,b   Bjella, Thomas ^b   Hansson, Lars ^b   Cattaneo, Annamaria ^d,e   Agartz, Ingrid ^a,c   Andreassen, Ole A ^a,b   Melle, Ingrid ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c DIAKONHJEMMET HOSPITAL   (Norway)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e IRCCS Fatebenefratelli Brescia   (Italy)

Author keywords

BDNF RNA; BDNF val66met; Childhood trauma; Hippocampal subfields; Psychosis

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; LITHIUM; MESSENGER RNA; MOOD STABILIZER; NEUROLEPTIC AGENT; METHIONINE; VALINE;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; BIPOLAR DISORDER; BRAIN SIZE; CHILD SEXUAL ABUSE; CHILDHOOD INJURY; CHILDHOOD TRAUMA QUESTIONNAIRE; CLINICAL ASSESSMENT; DENTATE HILUS; DNA DETERMINATION; EMOTIONAL ABUSE; FEMALE; FUNCTIONAL GENOMICS; GENE EXPRESSION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HETEROZYGOTE; HIPPOCAMPAL CA2 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; NEGLECT; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PHYSICAL ABUSE; PROTEIN BLOOD LEVEL; RNA ANALYSIS; SCHIZOPHRENIA; SEXUAL ABUSE; ADOLESCENT; AGED; BLOOD; CHILD ABUSE; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; QUESTIONNAIRE; RETROSPECTIVE STUDY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD ABUSE; FEMALE; GENE-ENVIRONMENT INTERACTION; GENOTYPE; HIPPOCAMPUS; HUMANS; MALE; METHIONINE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; QUESTIONNAIRES; RETROSPECTIVE STUDIES; RNA, MESSENGER; SCHIZOPHRENIA; VALINE; YOUNG ADULT;

EID: 84908317801     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2014.08.011     Document Type: Article

References (53)

1. Aas M., Dazzan P., Mondelli V., Melle I., Murray R.M., Pariante C.M. Asystematic review of cognitive function in first-episode psychosis, including a discussion on childhood trauma, stress, and inflammation. Front Psychiatry 2014, 4:182.
2. Aas M., Djurovic S., Athanasiu L., Steen N.E., Agartz I., Lorentzen S., et al. Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders. Schizophr Bull 2012, 38:15-22.
3. Aas M., Haukvik U.K., Djurovic S., Bergmann O., Athanasiu L., Tesli M.S., et al. BDNF val66met modulates the association between childhood trauma, cognitive and brain abnormalities in psychoses. Prog Neuropsychopharmacol Biol Psychiatry 2013, 46C:181-188.
4. Aas M., Navari S., Gibbs A., Mondelli V., Fisher H.L., Morgan C., et al. Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?. Schizophr Res 2012, 137(1-3):73-79.
5. Baker L.M., Williams L.M., Korgaonkar M.S., Cohen R.A., Heaps J.M., Paul R.H. Impact of early vs. late childhood early life stress on brain morphometrics. Brain Imaging Behav 2013, 7:196-203.
6. Bernstein D.P., Stein J.A., Newcomb M.D., Walker E., Pogge D., Ahluvalia T., et al. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl 2003, 27:169-190.
7. Buckley P.F., Pillai A., Evans D., Stirewalt E., Mahadik S. Brain derived neurotropic factor in first-episode psychosis. Schizophr Res 2007, 91:1-5.
8. Buckley P.F., Pillai A., Howell K.R. Brain-derived neurotrophic factor: findings in schizophrenia. Curr Opin Psychiatry 2011, 24:122-127.
9. Bus B.A., Molendijk M.L., Penninx B.J., Buitelaar J.K., Kenis G., Prickaerts J., et al. Determinants of serum brain-derived neurotrophic factor. Psychoneuroendocrinology 2011, 36:228-239.
10. Calabrese F., Molteni R., Racagni G., Riva M.A. Neuronal plasticity: a link between stress and mood disorders. Psychoneuroendocrinology 2009, 34(Suppl.1):S208-S216.
11. Carballedo A., Morris D., Zill P., Fahey C., Reinhold E., Meisenzahl E., et al. Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume. Am J Med Genet B Neuropsychiatr Genet 2013, 162B:183-190.
12. Carrion V.G., Weems C.F., Eliez S., Patwardhan A., Brown W., Ray R.D., et al. Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder. Biol Psychiatry 2001, 50:943-951.
13. De Bellis M.D., Keshavan M.S., Clark D.B., Casey B.J., Giedd J.N., Boring A.M., et al. A.E. Bennett Research Award. Developmental traumatology. Part II: brain development. Biol Psychiatry 1999, 45:1271-1284.
14. De Bellis M.D., Kuchibhatla M. Cerebellar volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol Psychiatry 2006, 60:697-703.
15. Djurovic S., Gustafsson O., Mattingsdal M., Athanasiu L., Bjella T., Tesli M., et al. Agenome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample. JAffect Disord 2010, 126:312-316.
16. Durany N., Michel T., Zochling R., Boissl K.W., Cruz-Sanchez F.F., Riederer P., et al. Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr Res 2001, 52:79-86.
17. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112:257-269.
18. Eisenberg D.P., Ianni A.M., Wei S.M., Kohn P.D., Kolachana B., Apud J., et al. Brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia. Mol Psychiatry 2013, 18:713-720.
19. Elzinga B.M., Molendijk M.L., Oude Voshaar R.C., Bus B.A., Prickaerts J., Spinhoven P., et al. The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val66Met. Psychopharmacol Berl 2011, 214:319-328.
20. Fischl B. FreeSurfer. Neuroimage 2012, 62:774-781.
21. Fisher H.L., Craig T.K., Fearon P., Morgan K., Dazzan P., Lappin J., et al. Reliability and comparability of psychosis patients' retrospective reports of childhood abuse. Schizophr Bull 2011, 37:546-553.
22. Harrisberger F., Spalek K., Smieskova R., Schmidt A., Coynel D., Milnik A., et al. The association of the BDNF Val66Met polymorphism and the hippocampal volumes in healthy humans: a joint meta-analysis of published and new data. Neurosci Biobehav Rev 2014, 42C:267-278.
23. Haukvik U.K., Westlye L.T., Mørch-Johnsen L., Jørgensen K.N., Lange E.H., Dale A.M., et al. Invivo hippocampal subfield volumes in schizophrenia and bipolar disorder. Biol Psychiatry 2014, 10.1016/j.biopsych.2014.06.020.
24. Herpfer I., Hezel H., Reichardt W., Clark K., Geiger J., Gross C.M., et al. Early life stress differentially modulates distinct forms of brain plasticity in young and adult mice. PLoS One 2012, 7:e46004.
25. Hoy K., Barrett S., Shannon C., Campbell C., Watson D., Rushe T., et al. Childhood trauma and hippocampal and amygdalar volumes in first-episode psychosis. Schizophr Bull 2012, 38:1162-1169.
26. Ikeda Y., Yahata N., Ito I., Nagano M., Toyota T., Yoshikawa T., et al. Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia. Schizophr Res 2008, 101:58-66.
27. Jensen C.L., Neugut Y.D., Champagne F.A. Sensitive periods for the impact of materinal care on offsprings behavior and region-specific gene expression. Society for Neuroscience 2012, 122:RR17.
28. Kauer-Sant'Anna M., Tramontina J., Andreazza A.C., Cereser K., da C.S., Santin A., et al. Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology. Bipolar Disord 2007, 9(Suppl.1):128-135.
29. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987, 13:261-276.
30. Luykx J.J., Boks M.P., Breetvelt E.J., Aukes M.F., Strengman E., da P.E., et al. BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects. Prog Neuropsychopharmacol Biol Psychiatry 2013, 43:185-187.
31. McEwen B.S. The neurobiology of stress: from serendipity to clinical relevance. Brain Res 2000, 886:172-189.
32. McEwen B.S. Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. Neurobiol Aging 2002, 23:921-939.
33. Mondelli V., Cattaneo A., Belvederi M.M., Di F.M., Handley R., Hepgul N., et al. Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume. JClin Psychiatry 2011, 72:1677-1684.
34. Purcell S.M., Wray N.R., Stone J.L., Visscher P.M., O'Donovan M.C., Sullivan P.F., et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460:748-752.
35. Read J., van O.J., Morrison A.P., Ross C.A. Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr Scand 2005, 112:330-350.
36. Richter-Schmidinger T., Alexopoulos P., Horn M., Maus S., Reichel M., Rhein C., et al. Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults. JNeural Transm 2011, 118:249-257.
37. Rimol L.M., Hartberg C.B., Nesvag R., Fennema-Notestine C., Hagler D.J., Pung C.J., et al. Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder. Biol Psychiatry 2010, 68:41-50.
38. Ringen P.A., Lagerberg T.V., Birkenaes A.B., Engn J., Faerden A., Jonsdottir H., et al. Differences in prevalence and patterns of substance use in schizophrenia and bipolar disorder. Psychol Med 2008, 38:1241-1249.
39. Roth T.L., Lubin F.D., Funk A.J., Sweatt J.D. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry 2009, 65:760-769.
40. Roy A., Hu X.Z., Janal M.N., Goldman D. Interaction between childhood trauma and serotonin transporter gene variation in suicide. Neuropsychopharmacology 2007, 32:2046-2052.
41. Sapolsky R.M., Krey L.C., McEwen B.S. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev 1986, 7:284-301.
42. Shrout P.E., Fleiss J.L. Intraclass correlations: uses in assessing rater reliability. Psychol Bull 1979, 86:420-428.
43. Simonsen C., Sundet K., Vaskinn A., Birkenaes A.B., Engh J.A., Faerden A., et al. Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophr Bull 2011, 37:73-83.
44. Streiner D., Normann G. Health measurement scales: a practical guide to their development and use 1989, Oxford University Press.
45. Suarez-Pinilla P., Roiz-Santianez R., de la Foz V.O., Mata I., Fananas L., Brambilla P., et al. BDNF Val66Met variants and brain volume changes in non-affective psychosis patients and healthy controls: a 3 year follow-up study. Prog Neuropsychopharmacol Biol Psychiatry 2013, 45:201-206.
46. Teicher M.H., Anderson C.M., Polcari A. Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum. Proc Natl Acad Sci U S A 2012, 109:E563-E572.
47. Teicher M.H., Ito Y., Glod C.A., Andersen S.L., Dumont N., Ackerman E. Preliminary evidence for abnormal cortical development in physically and sexually abused children using EEG coherence and MRI. Ann N Y Acad Sci 1997, 821:160-175.
48. Van L.K., Bakkour A., Benner T., Wiggins G., Wald L.L., Augustinack J., et al. Automated segmentation of hippocampal subfields from ultra-high resolution invivo MRI. Hippocampus 2009, 19:549-557.
49. Veijola J., Guo J.Y., Moilanen J.S., Jaaskelainen E., Miettunen J., Kyllonen M., et al. Longitudinal changes in total brain volume in schizophrenia: relation to symptom severity, cognition and antipsychotic medication. PLoS One 2014, 9:e101689.
50. Vermetten E., Schmahl C., Lindner S., Loewenstein R.J., Bremner J.D. Hippocampal and amygdalar volumes in dissociative identity disorder. Am J Psychiatry 2006, 163:630-636.
51. Wolf O.T. HPA axis and memory. Best Pract Res Clin Endocrinol Metab 2003, 17:287-299.
52. Woon F.L., Hedges D.W. Hippocampal and amygdala volumes in children and adults with childhood maltreatment-related posttraumatic stress disorder: a meta-analysis. Hippocampus 2008, 18:729-736.
53. Yang J.L., Lin Y.T., Chuang P.C., Bohr V.A., Mattson M.P. BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of Apurinic/Apyrimidinic Endonuclease 1. Neuromolecular Med 2014, 16:161-174.