BDNF-dependent plasticity induced by peripheral inflammation in the primary sensory and the cingulate cortex triggers cold allodynia and reveals a major role for endogenous BDNF as a tuner of the affective aspect of pain

Journal of Neuroscience

Volumn 34, Issue 44, 2014, Pages 14739-14751

  Thibault, Karine ^a,b,g   Lin, Wee Khang ^c   Rancillac, Armelle ^a,b   Fan, Marie ^a,b   Snollaerts, Thibaut ^d   Sordoillet, Vallier ^a,b   Hamon, Michel ^e   Smith, George M ^f   Lenkei, Zsolt ^a,b   Pezet, Sophie ^a,b  

^a Brain Plasticity Unit   (France)

^b CNRS   (France)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d INSTITUT PASTEUR   (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^f TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Hyperexcitability; Neurotrophic factor; Pain; Viral vector

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLOTRAXIN B; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; TROPOMYOSIN; TROPOMYOSIN RECEPTOR KINASE B; UNCLASSIFIED DRUG; VIRUS VECTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLOPEPTIDE; CYCLOTRAXIN-B;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR CINGULATE; ARTICLE; AVOIDANCE BEHAVIOR; CELL COUNTER; COLD SENSITIVITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HABITUATION; IMMUNOHISTOCHEMISTRY; INFLAMMATORY PAIN; LONG TERM POTENTIATION; MALE; MECHANICAL STIMULUS TEST; MECHANICAL STRESS; NERVE CELL PLASTICITY; NERVE EXCITABILITY; NEUROPATHIC PAIN; NONHUMAN; PROTEIN EXPRESSION; RAT; SENSORY CORTEX; SOMATOSENSORY CORTEX; STEREOTACTIC TREATMENT; UPREGULATION; AFFECT; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CINGULATE GYRUS; DRUG EFFECTS; GENETICS; HYPERALGESIA; INFLAMMATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

AFFECT; ANIMALS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; GYRUS CINGULI; HYPERALGESIA; INFLAMMATION; MALE; NEURONAL PLASTICITY; PEPTIDES, CYCLIC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKB; SOMATOSENSORY CORTEX; UP-REGULATION;

EID: 84908314987     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0860-14.2014     Document Type: Article

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