A GAPDH-mediated trans-nitrosylation pathway is required for feedback inhibition of bile salt synthesis in rat liver

Gastroenterology

Volumn 147, Issue 5, 2014, Pages 1084-1093

  Rodríguez Ortigosa, Carlos M ^a   Celay, Jon ^a   Olivas, Israel ^a   Juanarena, Nerea ^a   Arcelus, Sara ^a   Uriarte, Iker ^a   Marín, José Juan G ^b,c   Avila, Matias A ^a   Medina, Juan F ^a   Prieto, Jesus ^a,d  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Cholestasis; Cholesterol 7 Hydroxylase; Histone Deacetylase; Nitric Oxide

Indexed keywords

BILE SALT; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID; DITHIOTHREITOL; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HISTONE DEACETYLASE 2; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; SIRTUIN 1; SMALL INTERFERING RNA; BILE ACID; CELL RECEPTOR; CHOLIC ACID DERIVATIVE; CYP7A1 PROTEIN, RAT; ENZYME INHIBITOR; HDAC2 PROTEIN, RAT; NITRIC OXIDE SYNTHASE; NUCLEAR RECEPTOR SUBFAMILY 0, GROUP B, MEMBER 2; SIRT1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE LEVEL; BILE SECRETION; BIOSYNTHESIS; CHOLESTASIS; CHROMATIN IMMUNOPRECIPITATION; DIET SUPPLEMENTATION; DOWN REGULATION; ENZYME ACTIVITY; GLYCOLYSIS; HOMEOSTASIS; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; LIVER CELL; LIVER CELL CULTURE; LIVER PARENCHYMA; MALE; NEGATIVE FEEDBACK; NITROSYLATION; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; WISTAR RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; LIVER; METABOLISM; RNA INTERFERENCE; TIME;

ANIMALS; BILE ACIDS AND SALTS; CELLS, CULTURED; CHOLATES; CHOLESTASIS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HEPATOCYTES; HISTONE DEACETYLASE 2; HUMANS; LIVER; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SIRTUIN 1; TIME FACTORS; TRANSFECTION;

EID: 84908291988     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.07.030     Document Type: Article

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