Inhibition study of alanine aminotransferase enzyme using sequential online capillary electrophoresis analysis

Analytical Biochemistry

Volumn 467, Issue , 2014, Pages 28-30

  Liu, Lina ^a   Chen, Yuanfang ^a   Yang, Li ^a  

^a NORTHEAST NORMAL UNIVERSITY   (China)

Author keywords

Alanine aminotransferase; Capillary electrophoresis; Inhibition; Sequential analysis

Indexed keywords

AMINO ACIDS; CAPILLARY ELECTROPHORESIS; MEDICINE; METAL IONS; METALS; RATE CONSTANTS;

ALANINE AMINOTRANSFERASE; CAPILLARY ELECTROPHORESIS ANALYSIS; INHIBITION MECHANISMS; INHIBITION REACTIONS; PRODUCT FORMATION; SEQUENTIAL ANALYSIS; SUCCINIC ACIDS; TRADITIONAL CHINESE MEDICINE;

ENZYME INHIBITION;

ALANINE AMINOTRANSFERASE; CHINESE DRUG; LICORICE DIAMMONIUM INJECTION; MAGNESIUM ION; METAL ION; QINGKAILING INJECTION; SODIUM ION; SUCCINIC ACID; UNCLASSIFIED DRUG; ALANINE; ENZYME INHIBITOR; HERBACEOUS AGENT; QINGKAILING;

ARTICLE; AUTOMATION; CAPILLARY ELECTROPHORESIS; CHINESE MEDICINE; DRUG DETERMINATION; DRUG INHIBITION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; ONLINE ANALYSIS; REACTION TIME; SEQUENTIAL ANALYSIS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DEVICES; ENZYME ASSAY; HUMAN; KINETICS; METABOLISM; PROCEDURES;

ALANINE; ALANINE TRANSAMINASE; DRUGS, CHINESE HERBAL; ELECTROPHORESIS, CAPILLARY; ENZYME ASSAYS; ENZYME INHIBITORS; HUMANS; KINETICS; SUCCINIC ACID;

EID: 84908272866     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2014.08.035     Document Type: Article

References (14)

1. S.G. Welch Glutarate-pyruvate transaminase in blood stains J. Forensic Sci. Soc. 12 1972 605 607
2. P. Felig The glucose-alanine cycle Metabolism 22 1973 179 207
3. B. Rietz, and G.G. Guilbault Fluorimetric assay of serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, and α-hydroxybutyrate dehydrogenàse by solution and solid surface fluorescent method Anal. Chim. Acta 77 1975 191 198
4. F.W. Scheller, D. Pfeiffer, F. Schubert, R. Renneberg, and D. Kirstein Application of enzyme-based amperometric biosensors to the analysis of "real" samples A.P.F. Turner, I. Karube, G.S. Wilson, Biosensors: Fundamentals and Applications 1987 Oxford University Press New York 315 346
5. L.C. Eze, and C.O. Echetebu Some properties of aspartate and alanine aminotransferases from Trichoderma viride J. Gen. Microbiol. 120 1980 523 527
6. D. Walterová, J. Ulrichová, V. Preininger, and V. Šimánek Inhibition of liver alanine aminotransferase activity by some benzophenanthridine alkaloids J. Med. Chem. 24 1981 1100 1103
7. N.W. Cornell, P.F. Zuurendonk, M.J. Kerich, and C.B. Straight Selective inhibition of alanine aminotransferase and aspartate aminotransferase in rat hepatocytes Biochem. J. 220 1984 707 716
8. M. Miyazaki, J.S. Rosenblum, Y. Kasahara, I. Nakagawa, and M.P. Patricelli Determination of enzymatic source of alanine aminotransferase activity in serum from dogs with liver injury J. Pharmacol. Toxicol. Methods 60 2009 307 315
9. G. Beuster, K. Zarse, C. Kaleta, R. Thierbach, M. Kiehntopf, P. Steinberg, S. Schuster, and M. Ristow Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth J. Biol. Chem. 286 2011 22323 22330
10. J. Zhang, J. Hoogmartens, and A.V. Schepdael Recent developments and applications of EMMA in enzymatic and derivatization reactions Electrophoresis 31 2010 65 73
11. Y. Fan, and G.K.E. Scriba Advances in-capillary electrophoretic enzyme assays J. Pharm. Biomed. Anal. 53 2010 1076 1090
12. L. Yang, C.Y. Chen, Y.F. Chen, J. Shi, S.D. Liu, L.P. Guo, and H.F. Xu High temporal resolution monitoring of enzyme reaction and inhibition using optically gated vacancy capillary electrophoresis and immobilized enzyme Anal. Chim. Acta 683 2010 136 142
13. Y.F. Chen, L. Xu, W.W. Zhao, L.P. Guo, and L. Yang Method for the sequential online analysis of enzyme reactions based on capillary electrophoresis Anal. Chem. 84 2012 2961 2967
14. R. Fu, L.N. Liu, Y.N. Guo, L.P. Guo, and L. Yang Sequential micellar electrokinetic chromatography analysis of racemization reaction of alanine enantiomers J. Chromatogr. A 1331 2014 123 128