The serodominant secreted effector protein of Salmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles

Immunology

Volumn 143, Issue 3, 2014, Pages 438-446

  Reynolds, Catherine J ^a   Jones, Claire ^b   Blohmke, Christoph J ^b   Darton, Thomas C ^b   Goudet, Amelie ^c   Sergeant, Ruhena ^a   Maillere, Bernard ^c   Pollard, Andrew J ^b   Altmann, Daniel M ^a   Boyton, Rosemary J ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c CEA SACLAY   (France)

Author keywords

CD4 epitope; HLA DR transgenic; Salmonella; SseB; Type 3 secretion system

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL PROTEIN SSEB; CD4 ANTIGEN; EPITOPE; ESCHERICHIA COLI SECRETED PROTEIN A; HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; HLA DR1 ANTIGEN; HLA DR4 ANTIGEN; TRANSLOCON; UNCLASSIFIED DRUG; CHAPERONE; PEPTIDE FRAGMENT; PROTEIN BINDING; SSEB PROTEIN, SALMONELLA TYPHIMURIUM;

ADAPTIVE IMMUNITY; ALLELE; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIGEN RECOGNITION; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; EXPERIMENTAL INFECTION; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IC50; MOUSE; NONHUMAN; PATHOGENICITY ISLAND; SALMONELLA; SALMONELLA ENTERICA; SALMONELLOSIS; SEROTYPE; TYPE III SECRETION SYSTEM; ANIMAL; ANTIGEN PRESENTATION; CHEMISTRY; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; TRANSGENIC MOUSE;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD4; BACTERIAL PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; GENOTYPE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DR ANTIGENS; HUMANS; IMMUNODOMINANT EPITOPES; MICE; MICE, TRANSGENIC; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; SEQUENCE ALIGNMENT;

EID: 84908270375     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12327     Document Type: Article

References (38)

1. Crump JA, Mintz ED. Global trends in typhoid and paratyphoid fever. Clin Infect Dis 2010; 50:241-6.
2. Feasey NA, Dougan G, Kingsley RA, Heyderman RS, Gordon MA. Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa. Lancet 2012; 379:2489-99.
3. Okoro CK, Kingsley RA, Connor TR et al. Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa. Nat Genet 2012; 44:1215-21.
4. Martin LB. Vaccines for typhoid fever and other salmonelloses. Curr Opin Infect Dis 2012; 25:489-99.
5. Pulickal AS, Pollard AJ. Vi polysaccharide-protein conjugate vaccine for the prevention of typhoid fever in children: hope or hype? Expert Rev Vaccines 2007; 6:293-5.
6. McGregor AC, Waddington CS, Pollard AJ. Prospects for prevention of Salmonella infection in children through vaccination. Curr Opin Infect Dis 2013; 26:254-62.
7. Dougan G, John V, Palmer S, Mastroeni P. Immunity to salmonellosis. Immunol Rev 2011; 240:196-210.
8. Gotuzzo E, Morris JG, Benavente L et al. Association between specific plasmids and relapse in typhoid fever. J Clin Microbiol 1987; 25:1779-81.
9. Ahmad KA, Khan LH, Roshan B, Bhutta ZA. Factors associated with typhoid relapse in the era of multiple drug resistant strains. J Infect Dev Ctries 2011; 5:727-31.
10. + NK cells to protective IFN-γ production during Salmonella typhimurium infections. Proc Natl Acad Sci U S A 2013; 110:2252-7.
11. Prando C, Samarina A, Bustamante J et al. Inherited IL-12p40 deficiency: genetic, immunologic, and clinical features of 49 patients from 30 kindreds. Medicine (Baltimore) 2013; 92:109-22.
12. Mastroeni P, Villarreal-Ramos B, Hormaeche CE. Role of T cells, TNF α and IFN γ in recall of immunity to oral challenge with virulent salmonellae in mice vaccinated with live attenuated aro- Salmonella vaccines. Microb Pathog 1992; 13:477-91.
13. -/- (B-cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens. Infect Immun 2000; 68:46-53.
14. Lee SJ, McLachlan JB, Kurtz JR, Fan D, Winter SE, Baumler AJ, Jenkins MK, McSorley SJ. Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development. PLoS Pathog 2012; 8:e1002499.
15. Lee SJ, Dunmire S, McSorley SJ. MHC class-I-restricted CD8 T cells play a protective role during primary Salmonella infection. Immunol Lett 2012; 148:138-43.
16. Barat S, Willer Y, Rizos K et al. Immunity to intracellular Salmonella depends on surface- associated antigens. PLoS Pathog 2012; 8:e1002966.
17. Liang L, Juarez S, Nga TV et al. Immune profiling with a Salmonella Typhi antigen microarray identifies new diagnostic biomarkers of human typhoid. Sci Rep 2013; 3:1043.
18. Lee SJ, Liang L, Juarez S et al. Identification of a common immune signature in murine and human systemic Salmonellosis. Proc Natl Acad Sci U S A 2012; 109:4998-5003.
19. Yang Y, Wan C, Xu H, Wei H. Identification and characterization of OmpL as a potential vaccine candidate for immune-protection against salmonellosis in mice. Vaccine 2013; 31:2930-6.
20. Yu XJ, Liu M, Holden DW. SsaM and SpiC interact and regulate secretion of Salmonella pathogenicity island 2 type III secretion system effectors and translocators. Mol Microbiol 2004; 54:604-19.
21. Yu XJ, Ruiz-Albert J, Unsworth KE, Garvis S, Liu M, Holden DW. SpiC is required for secretion of Salmonella Pathogenicity Island 2 type III secretion system proteins. Cell Microbiol 2002; 4:531-40.
22. Ruiz-Albert J, Mundy R, Yu XJ, Beuzón CR, Holden DW. SseA is a chaperone for the SseB and SseD translocon components of the Salmonella pathogenicity-island-2- encoded type III secretion system. Microbiology 2003; 149:1103-11.
23. Gu J, Liu Y, Yu S et al. Enterohemorrhagic Escherichia coli trivalent recombinant vaccine containing EspA, intimin and Stx2 induces strong humoral immune response and confers protection in mice. Microbes Infect 2009; 11:835-41.
24. Altmann DM, Douek DC, Frater AJ et al. The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4. J Exp Med 1995; 181:867-75.
25. Musson JA, Ingram R, Durand G et al. Repertoire of HLA-DR1-restricted CD4 T-cell responses to capsular Caf1 antigen of Yersinia pestis in human leukocyte antigen transgenic mice. Infect Immun 2010; 78:4356-62.
26. Ascough S, Ingram RJ, Abarra A et al. Injectional anthrax infection due to heroin use induces strong immunological memory. J Infect 2014; 68:200-3.
27. Cosgrove D, Gray D, Dierich A et al. Mice lacking MHC class II molecules. Cell 1991; 66:1051-6.
28. Waddington CS, Darton TC, Jones C et al. An outpatient, ambulant design, controlled human infection model using escalating doses of Salmonella typhi challenge delivered in sodium bicarbonate solution. Clin Infect Dis 2014; 58:1230-40.
29. Texier C, Pouvelle S, Busson M et al. HLA-DR restricted peptide candidates for bee venom immunotherapy. J Immunol 2000; 164:3177-84.
30. Till SJ, Raynsford EJ, Reynolds CJ et al., Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation. Thorax 2013; 69:335-45.
31. + T cells in volunteers following Ty21a typhoid immunization. PLoS ONE 2012; 7:e38408.
32. Sheikh A, Khanam F, Sayeed MA et al. Interferon-c and proliferation responses to Salmonella enterica Serotype Typhi proteins in patients with S. Typhi Bacteremia in Dhaka, Bangladesh. PLoS Negl Trop Dis 2011; 5:e1193.
33. + T cell responses to immunodominant epitopes correlate with disease activity of virulent Salmonella. PLoS ONE 2012; 7:e43481.
34. + T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 2007; 27:203-13.
35. + T cells correlates with immunodominance in the human memory repertoire. J Immunol 2012; 188:2537-44.
36. Jenkins MK, Moon JJ. The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude. J Immunol 2012; 188:4135-40.
37. Castelli FA, Szely N, Olivain A et al. Hierarchy of CD4 T cell epitopes of the ANRS Lipo5 synthetic vaccine relies on the frequencies of pre-existing peptide-specific T cells in healthy donors. J Immunol 2013; 190:5757-63.
38. Kunnath-Velayudhan S, Porcelli SA. Recent advances in defining the immunoproteome of Mycobacterium tuberculosis. Front Immunol 2013; 4:335. eCollection 2013.