Injectional anthrax infection due to heroin use induces strong immunological memory

Journal of Infection

Volumn 68, Issue 2, 2014, Pages 200-203

  Ascough, Stephanie ^a   Ingram, Rebecca J ^a,b   Abarra, Aula ^a   Holmes, Alison J ^a   Maillere, Bernard ^c   Altmann, Daniel M ^a   Boyton, Rosemary J ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c Institute Frederic Joliot   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX PROTECTIVE ANTIGEN; BACTERIAL ANTIGEN; CIPROFLOXACIN; CLINDAMYCIN; EPITOPE; FLUCLOXACILLIN; GAMMA INTERFERON; METRONIDAZOLE; PENICILLIN G; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ADULT; AMINO ACID SEQUENCE; ANEURYSM SURGERY; ANTHRAX; ANTIBIOTIC THERAPY; BINDING AFFINITY; BLOOD SAMPLING; CASE REPORT; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; DEBRIDEMENT; DRUG ABUSE; FALSE ANEURYSM; FEMORAL ARTERY; FEVER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOGICAL MEMORY; INJECTIONAL ANTHRAX; LETHAL GENE; LETTER; MALE; MIDDLE AGED; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; SEROLOGY; TISSUE CULTURE; TREATMENT DURATION;

AMINO ACID SEQUENCE; ANTHRAX; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; EPITOPES; HEROIN DEPENDENCE; HUMANS; IMMUNOLOGIC MEMORY; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; SUBSTANCE ABUSE, INTRAVENOUS;

EID: 84892433199     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2013.10.007     Document Type: Letter

References (12)

1. Palmateer N.E., Ramsay C.N., Browning L., Goldberg D.J., Hutchinson S.J. Anthrax infection among heroin users in Scotland during 2009-2010: a case-control study by linkage to a national drug treatment database. Clin Infect Dis 2012, 55:706-710.
2. Hicks C.W., Sweeney D.A., Cui X., Li Y., Eichacker P.Q. An overview of anthrax infection including the recently identified form of disease in injection drug users. Intensive Care Med 2012, 38:1092-1104.
3. Palmateer N.E., Hope V.D., Roy K., Marongiu A., White J.M., Grant K.A., et al. Infections with spore-forming bacteria in persons who inject drugs, 2000-2009. Emerg Infect Dis 2013, 19:29-34.
4. http://www.hpa.org.uk/NewsCentre/NationalPressReleases/2013PressReleases/130308SuffolkpatientwithAnthrax/.
5. Price E.P., Seymour M.L., Sarovich D.S., Latham J., Wolken S.R., Mason J., et al. Molecular epidemiologic investigation of an anthrax outbreak among heroin users, Europe. Emerg Infect Dis 2012, 18:1307-1313.
6. Grunow R., Klee S.R., Beyer W., George M., Grunow D., Barduhn A., et al. Anthrax among heroin users in Europe possibly caused by same Bacillus anthracis strain since 2000. Euro Surveill 2013 Mar 28, 18(13).
7. Wattiau P., Govaerts M., Frangoulidis D., Fretin D., Kissling E., Van Hessche M., et al. Immunologic response of unvaccinated workers exposed to anthrax. Belgium Emerg Infect Dis 2009, 15(10):1637-1640.
8. Dewan P.K., Fry A.M., Laserson K., Tierney B.C., Quinn C.P., Hayslett J.A., et al. Inhalational anthrax outbreak among postal workers, Washington, D.C., 2001. Emerg Infect Dis 2002, 8:1066-1072.
9. Agrawal A., Lingappa J., Leppla S.H., Agrawal S., Jabbar A., Quinn C., et al. Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin. Nature 2003, 424:329-334.
10. Ingram R.J., Metan G., Maillere B., Doganay M., Ozkul Y., Kim L.U., et al. Natural exposure to cutaneous anthrax gives long-lasting T cell immunity encompassing infection-specific epitopes. J Immunol 2010, 184:3814-3821.
11. Ingram R.J., Harris A., Ascough S., Metan G., Doganay M., Ballie L., et al. Exposure to anthrax toxin alters human leucocyte expression of anthrax toxin receptor 1. Clin Exp Immunol 2013, 173:84-91.
12. Ascough S., Ingram R.J., Altmann D.M. Anthrax lethal toxin and the induction of CD4 T cell immunity. Toxins 2012, 4:878-899.