Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 43, 2014, Pages 15526-15531

  Hamabe, Atsushi ^a   Konno, Masamitsu ^a   Tanuma, Nobuhiro ^b   Shima, Hiroshi ^b   Tsunekuni, Kenta ^a,c   Kawamoto, Koichi ^a   Nishida, Naohiro ^a   Koseki, Jun ^a   Mimori, Koshi ^d   Gotoh, Noriko ^e   Yamamoto, Hirofumi ^a   Doki, Yuichiro ^a   Mori, Masaki ^a   Ishii, Hideshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b MIYAGI CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

^d KYUSHU UNIVERSITY BEPPU HOSPITAL   (Japan)

^e KANAZAWA UNIVERSITY   (Japan)

Author keywords

Colorectal cancer; Epithelial mesenchymal transition; Invasion; Pyruvate kinase M2; Transforming growth factor induced factor homeobox 2

Indexed keywords

HISTONE DEACETYLASE 3; HISTONE H3; PYRUVATE KINASE; PYRUVATE KINASE M2; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA INDUCED FACTOR HOMEOBOX 2; UNCLASSIFIED DRUG; UVOMORULIN; CHD1 PROTEIN, HUMAN; DNA BINDING PROTEIN; DNA HELICASE; HISTONE DEACETYLASE; HOMEODOMAIN PROTEIN; PROTEIN BINDING; REPRESSOR PROTEIN; TGIF2 PROTEIN, HUMAN;

ARTICLE; CANCER CELL; COLON CANCER; DEACETYLATION; DOWN REGULATION; ELECTROSPRAY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MOLECULAR INTERACTION; PROMOTER REGION; TRANSCRIPTION REGULATION; CELL NUCLEUS; COLORECTAL TUMOR; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; METASTASIS; PATHOLOGY; PROTEIN TRANSPORT; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL NUCLEUS; COLORECTAL NEOPLASMS; DNA HELICASES; DNA-BINDING PROTEINS; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HOMEODOMAIN PROTEINS; HUMANS; NEOPLASM METASTASIS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN TRANSPORT; PYRUVATE KINASE; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

EID: 84908270276     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1407717111     Document Type: Article

References (27)

1. Jemal A, et al. (2011) Global cancer statistics. CA Cancer J Clin 61(2):69-90.
2. Warburg O (1956) On the origin of cancer cells. Science 123(3191):309-314.
3. Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324(5930):1029-1033.
4. Christofk HR, et al. (2008) The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452(7184):230-233.
5. Hacker HJ, Steinberg P, Bannasch P (1998) Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet. Carcinogenesis 19(1):99-107.
6. Elbers JR, et al. (1991) Pyruvate kinase activity and isozyme composition in normal fibrous tissue and fibroblastic proliferations. Cancer 67(10):2552-2559.
7. Yang W, et al. (2011) Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature 480(7375):118-122.
8. Luo W, et al. (2011) Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 145(5):732-744.
9. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: The next generation. Cell 144(5):646-674.
10. Weinberg RA (2008) Mechanisms of malignant progression. Carcinogenesis 29(6):1092-1095.
11. Rees JR, Onwuegbusi BA, Save VE, Alderson D, Fitzgerald RC (2006) In vivo and in vitro evidence for transforming growth factor-beta1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma. Cancer Res 66(19):9583-9590.
12. Yokobori T, et al. (2013) Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis. Cancer Res 73(7):2059-2069.
13. Okada H, Danoff TM, Kalluri R, Neilson EG (1997) Early role of Fsp1 in epithelial-mesenchymal transformation. Am J Physiol 273(4 Pt 2):F563-F574.
14. Strutz F, et al. (2002) Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 61(5):1714-1728.
15. Gao X, Wang H, Yang JJ, Liu X, Liu ZR (2012) Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Mol Cell 45(5):598-609.
16. Goldberg MS, Sharp PA (2012) Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression. J Exp Med 209(2):217-224.
17. Melhuish TA, Gallo CM, Wotton D (2001) TGIF2 interacts with histone deacetylase 1 and represses transcription. J Biol Chem 276(34):32109-32114.
18. Lugli A, Karamitopoulou E, Zlobec I (2012) Tumour budding: A promising parameter in colorectal cancer. Br J Cancer 106(11):1713-1717.
19. Ueno H, et al. (2014) Novel risk factors for lymph node metastasis in early invasive colorectal cancer: A multi-institution pathology review. J Gastroenterol 49(9):1314-1323.
20. Clower CV, et al. (2010) The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci USA 107(5):1894-1899.
21. David CJ, Chen M, Assanah M, Canoll P, Manley JL (2010) HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 463(7279):364-368.
22. Imoto I, et al. (2000) Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines. Biochem Biophys Res Commun 276(1):264-270.
23. Lips EH, et al. (2008) Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis. BMC Cancer 8:314.
24. Roberts AB, Wakefield LM (2003) The two faces of transforming growth factor beta in carcinogenesis. Proc Natl Acad Sci USA 100(15):8621-8623.
25. Tian M, Schiemann WP (2009) The TGF-beta paradox in human cancer: An update. Future Oncol 5(2):259-271.
26. Rahimi RA, Leof EB (2007) TGF-beta signaling: A tale of two responses. J Cell Biochem 102(3):593-608.
27. Yang W, et al. (2012) ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol 14(12):1295-1304.