Astrocyte-dependent protective effect of quetiapine on GABAergic neuron is associated with the prevention of anxiety-like behaviors in aging mice after long-term treatment

Journal of Neurochemistry

Volumn 130, Issue 6, 2014, Pages 780-789

  Wang, Junhui ^a   Zhu, Shenghua ^c   Wang, Hongxing ^d   He, Jue ^e   Zhang, Yanbo ^f   Adilijiang, Abulimiti ^b   Zhang, Handi ^a   Hartle, Kelly ^b   Guo, Huining ^b   Kong, Jiming ^c   Huang, Qingjun ^a   Li, Xin Min ^b  

^a SHANTOU UNIVERSITY   (China)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF MANITOBA   (Canada)

^d CAPITAL MEDICAL UNIVERSITY   (China)

^e HENAN UNIVERSITY   (China)

^f UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

aging; anxiety; astrocyte; GABAergic neuron; quetiapine

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUTAMATE DECARBOXYLASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; QUETIAPINE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; DIBENZOTHIAZEPINE DERIVATIVE; NEUROLEPTIC AGENT; PROTECTIVE AGENT;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; APOPTOSIS; ARTICLE; ASTROCYTE; CELL ACTIVITY; CELL AGING; CELL COUNT; CELL DEATH; CELL DENSITY; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; FEMALE; GABAERGIC SYSTEM; GROUPS BY AGE; IN VITRO STUDY; IN VIVO STUDY; LONG TERM CARE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEUROPROTECTION; NEWBORN; NONHUMAN; NUCLEOTIDE METABOLISM; PROTEIN EXPRESSION; TREATMENT DURATION; UPREGULATION; ANIMAL; ANIMAL BEHAVIOR; ANXIETY; BIOSYNTHESIS; C57BL MOUSE; CULTURE MEDIUM; DARKNESS; EXPLORATORY BEHAVIOR; IMMUNOHISTOCHEMISTRY; LIGHT; METABOLISM; MOTOR ACTIVITY; NERVE CELL; PHYSIOLOGY; PRIMARY CELL CULTURE; PSYCHOLOGICAL ASPECT;

AGING; ANXIETY; ASTROCYTE; GABAERGIC NEURON; QUETIAPINE;

ADENOSINE TRIPHOSPHATE; AGING; ANIMALS; ANTIPSYCHOTIC AGENTS; ANXIETY; ASTROCYTES; BEHAVIOR, ANIMAL; CELL COUNT; CELL SURVIVAL; CULTURE MEDIA, CONDITIONED; DARKNESS; DIBENZOTHIAZEPINES; EXPLORATORY BEHAVIOR; FEMALE; GAMMA-AMINOBUTYRIC ACID; IMMUNOHISTOCHEMISTRY; LIGHT; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; NEURONS; PRIMARY CELL CULTURE; PROTECTIVE AGENTS; UP-REGULATION;

EID: 84908248555     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12771     Document Type: Article

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