Fibroblast growth factor-23 in obese, normotensive adolescents is associated with adverse cardiac structure

Journal of Pediatrics

Volumn 165, Issue 4, 2014, Pages 738-743.e1

  Ali, Farah N ^a   Falkner, Bonita ^b   Gidding, Samuel S ^b,c   Price, Heather E ^a,d   Keith, Scott W ^b   Langman, Craig B ^a,d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^d Stanley Manne Children's Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; FIBROBLAST GROWTH FACTOR 23; GLUCOSE; INSULIN; CREATININE; FIBROBLAST GROWTH FACTOR;

ADOLESCENT; ADULT; AFRICAN AMERICAN; ARTICLE; BLOOD LEVEL; BODY MASS; CARDIOMETABOLIC RISK; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HEART INJURY; HEART LEFT VENTRICLE MASS; HEART VENTRICLE HYPERTROPHY; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; M MODE ECHOCARDIOGRAPHY; MALE; OBESITY; RISK ASSESSMENT; WAIST CIRCUMFERENCE; AGE; BLOOD; BLOOD PRESSURE; CLINICAL TRIAL; COHORT ANALYSIS; CONGENITAL HEART MALFORMATION; ECHOCARDIOGRAPHY; ECHOGRAPHY; ETHNOLOGY; GLOMERULUS FILTRATION RATE; HEART DISEASE; METABOLISM; MULTICENTER STUDY; PROTEIN TERTIARY STRUCTURE;

ADOLESCENT; AFRICAN AMERICANS; AGE FACTORS; BIOMARKERS; BLOOD PRESSURE; C-REACTIVE PROTEIN; COHORT STUDIES; CREATININE; CROSS-SECTIONAL STUDIES; ECHOCARDIOGRAPHY; FEMALE; FIBROBLAST GROWTH FACTORS; GLOMERULAR FILTRATION RATE; HEART DEFECTS, CONGENITAL; HEART DISEASES; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; MALE; OBESITY; PROTEIN STRUCTURE, TERTIARY;

EID: 84908242751     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2014.06.027     Document Type: Article

References (30)

1. M. Wolf Update on fibroblast growth factor 23 in chronic kidney disease Kidney Int 82 2012 737 747
2. T.E. Larsson The role of FGF-23 in CKD-MBD and cardiovascular disease: friend or foe? Nephrol Dial Transplant 25 2010 1376 1381
3. O.M. Gutierrez, J.L. Januzzi, T. Isakova, K. Laliberte, K. Smith, and G. Collerone Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease Circulation 119 2009 2545 2552
4. M.A. Mirza, A. Larsson, H. Melhus, L. Lind, and T.E. Larsson Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population Atherosclerosis 207 2009 546 551
5. B. Falkner, S. DeLoach, S.W. Keith, and S.S. Gidding High risk blood pressure and obesity increase the risk for left ventricular hypertrophy in African-American adolescents J Pediatr 162 2013 94 100
6. K. Tsuji, T. Maeda, T. Kawane, A. Matsunuma, and N. Horiuchi Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1alpha,25-dihydroxyvitamin D3 synthesis in leptin-deficient mice J Bone Miner Res 25 2010 1711 1723
7. R.V. Considine, M.K. Sinha, M.L. Heiman, A. Kriauciunas, T.W. Stephens, and M.R. Nyce Serum immunoreactive-leptin concentrations in normal-weight and obese humans N Engl J Med 334 1996 292 295
8. P.L. Sanches, M.T. de Mello, N. Elias, F.A. Fonseca, R.M. Campos, and J. Carnier Hyperleptinemia: implications on the inflammatory state and vascular protection in obese adolescents submitted to an interdisciplinary therapy Inflammation 37 2014 35 43
9. P.R. Khoury, M. Mitsnefes, S.R. Daniels, and T.R. Kimball Age-specific reference intervals for indexed left ventricular mass in children J Am Soc Echocardiogr 22 2009 709 714
10. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419
11. R.M. Lang, M. Bierig, R.B. Devereux, F.A. Flachskampf, E. Foster, and P.A. Pellikka Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology J Am Soc Echocardiogr 18 2005 1440 1463
12. R.B. Devereux, D.R. Alonso, E.M. Lutas, G.J. Gottlieb, E. Campo, and I. Sachs Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings Am J Cardiol 57 1986 450 458
13. G.J. Schwartz, A. Munoz, M.F. Schneider, R.H. Mak, F. Kaskel, and B.A. Warady New equations to estimate GFR in children with CKD J Am Soc Nephrol 20 2009 629 637
14. T.M. Brady, B. Fivush, J.T. Flynn, and R. Parekh Ability of blood pressure to predict left ventricular hypertrophy in children with primary hypertension J Pediatr 152 2008 73 78 8.e1
15. A. Batalli-Kepuska, G. Bajraktari, M. Zejnullahu, M. Azemi, M. Shala, and A. Batalli Abnormal systolic and diastolic myocardial function in obese asymptomatic adolescents Int J Cardiol 168 2013 2347 2351
16. H. Hietalampi, K. Pahkala, E. Jokinen, T. Ronnemaa, J.S. Viikari, and H. Niinikoski Left ventricular mass and geometry in adolescence: early childhood determinants Hypertension 60 2012 1266 1272
17. J. Arnlov, A.C. Carlsson, J. Sundstrom, E. Ingelsson, A. Larsson, and L. Lind Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community Kidney Int 83 2013 160 166
18. J. Arnlov, A.C. Carlsson, J. Sundstrom, E. Ingelsson, A. Larsson, and L. Lind Serum FGF23 and risk of cardiovascular events in relation to mineral metabolism and cardiovascular pathology Clin J Am Soc Nephrol 8 2013 781 786
19. C. Faul, A.P. Amaral, B. Oskouei, M.C. Hu, A. Sloan, and T. Isakova FGF23 induces left ventricular hypertrophy J Clin Invest 121 2011 4393 4408
20. V. Shalhoub, E.M. Shatzen, S.C. Ward, J. Davis, J. Stevens, and V. Bi FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality J Clin Invest 122 2012 2543 2553
21. S. Seiler, B. Cremers, N.M. Rebling, F. Hornof, J. Jeken, and S. Kersting The phosphatonin fibroblast growth factor 23 links calcium-phosphate metabolism with left-ventricular dysfunction and atrial fibrillation Eur Heart J 32 2011 2688 2696
22. R. di Giuseppe, B. Buijsse, F. Hirche, J. Wirth, M. Arregui, and S. Westphal Plasma fibroblast growth factor 23, parathyroid hormone, 25-hydroxyvitamind3 and risk of heart failure: a prospective, case-cohort study J Clin Endocrinol Metab 99 2014 947 955
23. C. Hanevold, J. Waller, S. Daniels, R. Portman, and J. Sorof The effects of obesity, gender, and ethnic group on left ventricular hypertrophy and geometry in hypertensive children: a collaborative study of the International Pediatric Hypertension Association Pediatrics 113 2004 328 333
24. T.M. Brady, B. Fivush, R.S. Parekh, and J.T. Flynn Racial differences among children with primary hypertension Pediatrics 126 2010 931 937
25. C.S. Pruette, B.A. Fivush, J.T. Flynn, and T.M. Brady Effects of obesity and race on left ventricular geometry in hypertensive children Pediatr Nephrol 28 2013 2015 2022
26. D.I. Crowley, P.R. Khoury, E.M. Urbina, H.M. Ippisch, and T.R. Kimball Cardiovascular impact of the pediatric obesity epidemic: higher left ventricular mass is related to higher body mass index J Pediatr 158 2011 709 714.e1
27. O.M. Gutierrez, T. Isakova, K. Smith, M. Epstein, N. Patel, and M. Wolf Racial differences in postprandial mineral ion handling in health and in chronic kidney disease Nephrol Dial Transplant 25 2010 3970 3977
28. E. Grethen, K.M. Hill, R. Jones, B.M. Cacucci, C.E. Gupta, and A. Acton Serum leptin, parathyroid hormone, 1,25-dihydroxyvitamin D, fibroblast growth factor 23, bone alkaline phosphatase, and sclerostin relationships in obesity J Clin Endocrinol Metab 97 2012 1655 1662
29. I.S. Okosun, J.P. Seale, J.M. Boltri, and M. Davis-Smith Trends and clustering of cardiometabolic risk factors in American adolescents from 1999 to 2008 J Adolesc Health 50 2012 132 139
30. S. Lundberg, A.R. Qureshi, S. Olivecrona, I. Gunnarsson, S.H. Jacobson, and T.E. Larsson FGF23, albuminuria, and disease progression in patients with chronic IgA nephropathy Clin J Am Soc Nephrol 7 2012 727 734