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Volumn 25, Issue 5, 2010, Pages 1376-1381

The role of FGF-23 in CKD-MBD and cardiovascular disease: Friend or foe?

Author keywords

Chronic kidney disease; FGF 23; Fibroblast growth factor 23; Klotho; Mortality; Phosphorous

Indexed keywords

BIOLOGICAL MARKER; FIBROBLAST GROWTH FACTOR 23; PROTECTIVE AGENT; UREMIC TOXIN;

EID: 77951682465     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp784     Document Type: Review
Times cited : (46)

References (64)
  • 1
    • 0033763097 scopus 로고    scopus 로고
    • Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
    • Consortium ADHR. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 2000; 26: 345-348
    • (2000) Nat Genet , vol.26 , pp. 345-348
  • 7
    • 9244240970 scopus 로고    scopus 로고
    • Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders
    • DOI 10.1210/en.2004-0233
    • Bai X, Miao D, Li J, et al. Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology 2004; 145: 5269-5279 (Pubitemid 39551149)
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 5269-5279
    • Bai, X.1    Miao, D.2    Li, J.3    Goltzman, D.4    Karaplis, A.C.5
  • 8
    • 3042634460 scopus 로고    scopus 로고
    • Transgenic mice expressing fibroblast growth factor 23 under the control of the α1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis
    • DOI 10.1210/en.2003-1768
    • Larsson T, Marsell R, Schipani E, et al. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology 2004; 145: 3087-3094 (Pubitemid 38829975)
    • (2004) Endocrinology , vol.145 , Issue.7 , pp. 3087-3094
    • Larsson, T.1    Marsell, R.2    Schipani, E.3    Ohlsson, C.4    Ljunggren, O.5    Tenenhouse, H.S.6    Juppner, H.7    Jonsson, K.B.8
  • 11
    • 9644303231 scopus 로고    scopus 로고
    • Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice
    • DOI 10.1016/j.matbio.2004.09.007, PII S0945053X04001155
    • Sitara D, Razzaque MS, Hesse M, et al. Homozygous ablation of fi-broblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol 2004; 23: 421-432 (Pubitemid 39576657)
    • (2004) Matrix Biology , vol.23 , Issue.7 , pp. 421-432
    • Sitara, D.1    Razzaque, M.S.2    Hesse, M.3    Yoganathan, S.4    Taguchi, T.5    Erben, R.G.6    Juppner, H.7    Lanske, B.8
  • 17
    • 13544270218 scopus 로고    scopus 로고
    • An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia
    • DOI 10.1093/hmg/ddi034
    • Benet-Pages A, Orlik P, Strom TM, et al. An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet 2005; 14: 385-390 (Pubitemid 40220655)
    • (2005) Human Molecular Genetics , vol.14 , Issue.3 , pp. 385-390
    • Benet-Pages, A.1    Orlik, P.2    Strom, T.M.3    Lorenz-Depiereux, B.4
  • 23
    • 57149099628 scopus 로고    scopus 로고
    • FGFR3 and FGFR4 do not mediate renal effects of FGF23
    • Liu S, Vierthaler L, Tang W, et al. FGFR3 and FGFR4 do not mediate renal effects of FGF23. J Am Soc Nephrol 2008; 19: 2342-2350
    • (2008) J Am Soc Nephrol , vol.19 , pp. 2342-2350
    • Liu, S.1    Vierthaler, L.2    Tang, W.3
  • 24
    • 65649103814 scopus 로고    scopus 로고
    • Initial FGF23-mediated signaling occurs in the distal convoluted tubule
    • Farrow EG, Davis SI, Summers LJ, et al. Initial FGF23-mediated signaling occurs in the distal convoluted tubule. J Am Soc Nephrol 2009; 20: 955-960
    • (2009) J Am Soc Nephrol , vol.20 , pp. 955-960
    • Farrow, E.G.1    Davis, S.I.2    Summers, L.J.3
  • 26
    • 37149047561 scopus 로고    scopus 로고
    • Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice
    • DOI 10.1152/ajpendo.00396.2007
    • Liu S, Tang W, Zhou J, et al. Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice. Am J Physiol Endocrinol Metab 2007; 293: E1636-E1644 (Pubitemid 350255114)
    • (2007) American Journal of Physiology - Endocrinology and Metabolism , vol.293 , Issue.6
    • Liu, S.1    Tang, W.2    Zhou, J.3    Vierthaler, L.4    Quarles, L.D.5
  • 27
    • 50849104780 scopus 로고    scopus 로고
    • Genetic evidence of serum phosphate-independent functions of FGF-23 on bone
    • Sitara D, Kim S, Razzaque MS, et al. Genetic evidence of serum phosphate-independent functions of FGF-23 on bone. PLoS Genet 2008; 4: e1000154
    • (2008) PLoS Genet , vol.4
    • Sitara, D.1    Kim, S.2    Razzaque, M.S.3
  • 30
    • 28444486604 scopus 로고    scopus 로고
    • 1alpha 25-Dihydroxyvita-min D3 upregulates FGF23 gene expression in bone: The final link in a renal-gastrointestinal-skelet al axis that controls phosphate transport
    • Kolek OI, Hines ER, Jones MD, et al. 1alpha, 25-Dihydroxyvita-min D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skelet al axis that controls phosphate transport. Am J Physiol Gastrointest Liver Physiol 2005; 289: G1036-G1042
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.289
    • Kolek, O.I.1    Hines, E.R.2    Jones, M.D.3
  • 31
    • 33747719260 scopus 로고    scopus 로고
    • Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men
    • DOI 10.1210/jc.2006-0021
    • Antoniucci DM, Yamashita T, Portale AA. Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men. J Clin Endocrinol Metab 2006; 91: 3144-3149 (Pubitemid 44271770)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.8 , pp. 3144-3149
    • Antoniucci, D.M.1    Yamashita, T.2    Portale, A.A.3
  • 32
    • 33746406756 scopus 로고    scopus 로고
    • Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women
    • Burnett SM, Gunawardene SC, Bringhurst FR, et al. Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women. J Bone Miner Res 2006; 21: 1187-1196
    • (2006) J Bone Miner Res , vol.21 , pp. 1187-1196
    • Burnett, S.M.1    Gunawardene, S.C.2    Bringhurst, F.R.3
  • 35
    • 77951674493 scopus 로고    scopus 로고
    • A parathyroid hormone-1α, 25-dihydroxyvitamin D3-FGF23 loop regulating bone mineralization in cultured rat calvaria osteoblasts
    • Minamizaki T, Yoshiko Y, Yoshioka H, et al. A parathyroid hormone-1α, 25-dihydroxyvitamin D3-FGF23 loop regulating bone mineralization in cultured rat calvaria osteoblasts. ASBMR 31st Annual Meeting 2009
    • (2009) ASBMR 31st Annual Meeting
    • Minamizaki, T.1    Yoshiko, Y.2    Yoshioka, H.3
  • 36
    • 77951681545 scopus 로고    scopus 로고
    • Skelet al responses to PTH: A comparison between low and high turnover renal osteodystro-phy
    • Wesseling-Perry K, Gales B, Wang H, et al. Skelet al responses to PTH: a comparison between low and high turnover renal osteodystro-phy. ASN Renal Week 2009
    • (2009) ASN Renal Week
    • Wesseling-Perry, K.1    Gales, B.2    Wang, H.3
  • 39
    • 0344945402 scopus 로고    scopus 로고
    • Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers
    • DOI 10.1046/j.1523-1755.2003.00328.x
    • Larsson T, Nisbeth U, Ljunggren O, et al. Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers. Kidney Int 2003; 64: 2272-2279 (Pubitemid 37449564)
    • (2003) Kidney International , vol.64 , Issue.6 , pp. 2272-2279
    • Larsson, T.1    Nisbeth, U.2    Ljunggren, O.3    Juppner, H.4    Jonsson, K.B.5
  • 41
    • 3242661165 scopus 로고    scopus 로고
    • Possible involvement of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidism associated with renal insufficiency
    • DOI 10.1053/j.ajkd.2004.04.029, PII S027263860400664X
    • Shigematsu T, Kazama JJ, Yamashita T, et al. Possible involvement of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidism associated with renal insufficiency. Am J Kidney Dis 2004; 44: 250-256 (Pubitemid 38962552)
    • (2004) American Journal of Kidney Diseases , vol.44 , Issue.2 , pp. 250-256
    • Shigematsu, T.1    Kazama, J.J.2    Yamashita, T.3    Fukumoto, S.4    Hosoya, T.5    Gejyo, F.6    Fukagawa, M.7
  • 43
    • 67650892239 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community
    • Mirza MA, Larsson A, Lind L, et al. Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community. Atherosclerosis 2009; 205: 385-390
    • (2009) Atherosclerosis , vol.205 , pp. 385-390
    • Mirza, M.A.1    Larsson, A.2    Lind, L.3
  • 45
    • 34748860260 scopus 로고    scopus 로고
    • Early lethality in Hyp mice with targeted deletion of pth gene
    • DOI 10.1210/en.2007-0243
    • Bai X, Miao D, Goltzman D, et al. Early lethality in Hyp mice with targeted deletion of Pth gene. Endocrinology 2007; 148: 4974-4983 (Pubitemid 47481537)
    • (2007) Endocrinology , vol.148 , Issue.10 , pp. 4974-4983
    • Bai, X.1    Miao, D.2    Goltzman, D.3    Karaplis, A.C.4
  • 46
    • 74449086740 scopus 로고    scopus 로고
    • Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients
    • Komaba H, Goto S, Fujii H, et al. Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients. Kidney Int 2010; 77: 232-238
    • Kidney Int , vol.2010 , Issue.77 , pp. 232-238
    • Komaba, H.1    Goto, S.2    Fujii, H.3
  • 47
    • 3543139492 scopus 로고    scopus 로고
    • Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    • Block GA, Klassen PS, Lazarus JM, et al. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 2004; 15: 2208-2218
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2208-2218
    • Block, G.A.1    Klassen, P.S.2    Lazarus, J.M.3
  • 49
    • 49249104701 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    • Gutierrez OM, Mannstadt M, Isakova T, et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med 2008; 359: 584-592
    • (2008) N Engl J Med , vol.359 , pp. 584-592
    • Gutierrez, O.M.1    Mannstadt, M.2    Isakova, T.3
  • 50
    • 69249106380 scopus 로고    scopus 로고
    • High levels of serum fibroblast growth factor (FGF)-23 are associated with increased mortality in long haemodialysis patients
    • Jean G, Terrat JC, Vanel T, et al. High levels of serum fibroblast growth factor (FGF)-23 are associated with increased mortality in long haemodialysis patients. Nephrol Dial Transplant 2009; 24: 2792-2796
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 2792-2796
    • Jean, G.1    Terrat, J.C.2    Vanel, T.3
  • 51
    • 27444436252 scopus 로고    scopus 로고
    • Relation between serum phosphate level and cardiovascular event rate in people with coronary disease
    • DOI 10.1161/CIRCULATIONAHA.105.553198
    • Tonelli M, Sacks F, Pfeffer M, et al. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 2005; 112: 2627-2633 (Pubitemid 41532599)
    • (2005) Circulation , vol.112 , Issue.17 , pp. 2627-2633
    • Tonelli, M.1    Sacks, F.2    Pfeffer, M.3    Gao, Z.4    Curhan, G.5
  • 52
    • 77951692556 scopus 로고    scopus 로고
    • Conjoint effects of serum calcium and phosphate on risk of total, cardiovascular, and noncar-diovascular mortality in the community
    • November 30 Epub ahead of print
    • Larsson TE, Olauson H, Hagstrom E, et al. Conjoint effects of serum calcium and phosphate on risk of total, cardiovascular, and noncar-diovascular mortality in the community. Arterioscler Thromb Vasc Biol 2009; November 30 Epub ahead of print
    • (2009) Arterioscler Thromb Vasc Biol
    • Larsson, T.E.1    Olauson, H.2    Hagstrom, E.3
  • 54
    • 70349656941 scopus 로고    scopus 로고
    • Relationship between circulating FGF23 and total body atherosclerosis in the community
    • Mirza MA, Hansen T, Johansson L, et al. Relationship between circulating FGF23 and total body atherosclerosis in the community. Ne-phrol Dial Transplant 2009; 24: 3125-3131
    • (2009) Ne-phrol Dial Transplant , vol.24 , pp. 3125-3131
    • Mirza, M.A.1    Hansen, T.2    Johansson, L.3
  • 56
    • 40749145717 scopus 로고    scopus 로고
    • Relation between plasma fibroblast growth factor-23, serum fetuin-A levels and coronary artery calcification evaluated by multislice computed tomography in patients with normal kidney function
    • DOI 10.1111/j.1365-2265.2007.03074.x
    • Roos M, Lutz J, Salmhofer H, et al. Relation between plasma fibro-blast growth factor-23, serum fetuin-A levels and coronary artery calcification evaluated by multislice computed tomography in patients with normal kidney function. Clin Endocrinol (Oxf) 2008; 68: 660-665 (Pubitemid 351388700)
    • (2008) Clinical Endocrinology , vol.68 , Issue.4 , pp. 660-665
    • Roos, M.1    Lutz, J.2    Salmhofer, H.3    Luppa, P.4    Knauss, A.5    Braun, S.6    Martinof, S.7    Schomig, A.8    Heemann, U.9    Kastrati, A.10    Hausleiter, J.11
  • 57
    • 66349097180 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    • Gutierrez OM, Januzzi JL, Isakova T, et al. Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease. Circulation 2009; 119: 2545-2552
    • (2009) Circulation , vol.119 , pp. 2545-2552
    • Gutierrez, O.M.1    Januzzi, J.L.2    Isakova, T.3
  • 58
    • 60749133542 scopus 로고    scopus 로고
    • Peripheral vascular calcification in long-haemodialysis patients: Associated factors and survival consequences
    • Jean G, Bresson E, Terrat JC, et al. Peripheral vascular calcification in long-haemodialysis patients: associated factors and survival consequences. Nephrol Dial Transplant 2009; 24: 948-955
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 948-955
    • Jean, G.1    Bresson, E.2    Terrat, J.C.3
  • 59
    • 70450230670 scopus 로고    scopus 로고
    • Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population
    • Dec
    • Mirza MA, Larsson A, Melhus H, et al. Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population. Atherosclerosis 2009 Dec; 207: 546-551
    • (2009) Atherosclerosis , vol.207 , pp. 546-551
    • Mirza, M.A.1    Larsson, A.2    Melhus, H.3
  • 60
    • 61849155234 scopus 로고    scopus 로고
    • Fibroblast growth factor 23: A possible cause of left ventricular hypertrophy in hemodialysis patients
    • Hsu HJ, Wu MS. Fibroblast growth factor 23: a possible cause of left ventricular hypertrophy in hemodialysis patients. Am J Med Sci 2009; 337: 116-122
    • (2009) Am J Med Sci , vol.337 , pp. 116-122
    • Hsu, H.J.1    Wu, M.S.2
  • 61
    • 0030834170 scopus 로고    scopus 로고
    • Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues
    • Hughes SE. Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues. J Histochem Cytochem 1997; 45: 1005-1019
    • (1997) J Histochem Cytochem , vol.45 , pp. 1005-1019
    • Hughes, S.E.1
  • 62
    • 0029030841 scopus 로고
    • Adult cardiomyocytes express functional high-affinity receptors for basic fibroblast growth factor
    • Liu L, Pasumarthi KB, Padua RR, et al. Adult cardiomyocytes express functional high-affinity receptors for basic fibroblast growth factor. Am J Physiol 1995; 268: H1927-H1938
    • (1995) Am J Physiol , vol.268
    • Liu, L.1    Pasumarthi, K.B.2    Padua, R.R.3
  • 63
    • 77951695836 scopus 로고    scopus 로고
    • Fibroblast growth factor-23 inhibits inflammation-induced calcification in vitro in human vascular smooth muscle cells
    • Pan QW, Ruan RX, Wheeler DA, et al. Fibroblast growth factor-23 inhibits inflammation-induced calcification in vitro in human vascular smooth muscle cells. ASN Renal Week 2009
    • (2009) ASN Renal Week
    • Pan, Q.W.1    Ruan, R.X.2    Wheeler, D.A.3
  • 64
    • 67649099265 scopus 로고    scopus 로고
    • Regulation of fibroblast growth factor 23 production in bone in uremic rats
    • Saji F, Shiizaki K, Shimada S, et al. Regulation of fibroblast growth factor 23 production in bone in uremic rats. Nephron Physiol 2009; 111: 59-66
    • (2009) Nephron Physiol , vol.111 , pp. 59-66
    • Saji, F.1    Shiizaki, K.2    Shimada, S.3


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