The inflammatory response after out-of-hospital cardiac arrest is not modified by targeted temperature management at 33°C or 36°C

Resuscitation

Volumn 85, Issue 11, 2014, Pages 1480-1487

  Bro Jeppesen, John ^a   Kjaergaard, Jesper ^a   Wanscher, Michael ^a   Nielsen, Niklas ^b   Friberg, Hans ^c   Bjerre, Mette ^d   Hassager, Christian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b LUND UNIVERSITY   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

Cardiac arrest; Cytokines; Hypothermia; Inflammation; Post cardiac arrest syndrome

Indexed keywords

C REACTIVE PROTEIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; PROCALCITONIN; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CYTOKINE; INTERLEUKIN DERIVATIVE;

ADULT; ARTICLE; BODY TEMPERATURE MONITORING; FEMALE; HEART VENTRICLE FIBRILLATION; HUMAN; HYPOTHERMIA; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; OUT OF HOSPITAL CARDIAC ARREST; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; ADVERSE EFFECTS; AGED; ANALYSIS OF VARIANCE; BLOOD; BLOOD ANALYSIS; CAUSE OF DEATH; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED STUDY; FOLLOW UP; INDUCED HYPOTHERMIA; INTENSIVE CARE; INTENSIVE CARE UNIT; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; NONPARAMETRIC TEST; OUT-OF-HOSPITAL CARDIAC ARREST; PATHOPHYSIOLOGY; PHYSIOLOGIC MONITORING; PROCEDURES; RESUSCITATION; SINGLE BLIND PROCEDURE; STATISTICAL MODEL; SURVIVAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TEMPERATURE;

AGED; ANALYSIS OF VARIANCE; BLOOD CHEMICAL ANALYSIS; CARDIOPULMONARY RESUSCITATION; CAUSE OF DEATH; CYTOKINES; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPOTHERMIA, INDUCED; INFLAMMATION MEDIATORS; INTENSIVE CARE; INTENSIVE CARE UNITS; INTERLEUKINS; KAPLAN-MEIER ESTIMATE; LINEAR MODELS; MALE; MIDDLE AGED; MONITORING, PHYSIOLOGIC; OUT-OF-HOSPITAL CARDIAC ARREST; SINGLE-BLIND METHOD; STATISTICS, NONPARAMETRIC; SURVIVAL ANALYSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TEMPERATURE;

EID: 84908238128     PISSN: 03009572     EISSN: 18731570     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2014.08.007     Document Type: Article

References (40)

1. Gando S., Nanzaki S., Morimoto Y., Kobayashi S., Kemmotsu O. Alterations of soluble L- and P-selectins during cardiac arrest and CPR. Intensive Care Med 1999, 25:588-593.
2. Colletti L.M., Remick D.G., Burtch G.D., Kunkel S.L., Strieter R.M., Campbell D.A. Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. J Clin Invest 1990, 85:1936-1943.
3. Adrie C., Adib-Conquy M., Laurent I., et al. Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndrome. Circulation 2002, 106:562-568.
4. Adrie C., Laurent I., Monchi M., Cariou A., Dhainaou J.F., Spaulding C. Postresuscitation disease after cardiac arrest: a sepsis-like syndrome. Curr Opin Crit Care 2004, 10:208-212.
5. Ito T., Saitoh D., Takasu A., et al. Serum interleukin-8 as a predictive marker for a comparative neurologic outcome analysis of patients resuscitated after cardiopulmonary arrest. Crit Care Med 2003, 31:2415-2416. (author reply 6-7).
6. Nolan J.P., Neumar R.W., Adrie C., et al. Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A scientific statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke. Resuscitation 2008, 79:350-379.
7. Roberts B.W., Kilgannon J.H., Chansky M.E., et al. Multiple organ dysfunction after return of spontaneous circulation in postcardiac arrest syndrome. Crit Care Med 2013, 41:1492-1501.
8. Bernard S.A., Gray T.W., Buist M.D., et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346:557-563.
9. Hypothermia after Cardiac Arrest Study Group Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002, 346:549-556.
10. Deakin C.D., Nolan J.P., Soar J., et al. European Resuscitation Council Guidelines for Resuscitation 2010 Section 4. Adult advanced life support. Resuscitation 2010, 81:1305-1352.
11. Fries M., Stoppe C., Brucken D., Rossaint R., Kuhlen R. Influence of mild therapeutic hypothermia on the inflammatory response after successful resuscitation from cardiac arrest. J Crit Care 2009, 24:453-457.
12. Callaway C.W., Rittenberger J.C., Logue E.S., McMichael M.J. Hypothermia after cardiac arrest does not alter serum inflammatory markers. Crit Care Med 2008, 36:2607-2612.
13. Meybohm P., Gruenewald M., Zacharowski K.D., et al. Mild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation. Crit Care 2010, 14:R21.
14. Nielsen N., Wetterslev J., Cronberg T., et al. Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest. N Engl J Med 2013, 369:2197-2206.
15. Langhelle A., Nolan J., Herlitz J., et al. Recommended guidelines for reviewing, reporting, and conducting research on post-resuscitation care: the Utstein style. Resuscitation 2005, 66:271-283.
16. Nielsen N., Wetterslev J., al-Subaie N., et al. Target Temperature Management after out-of-hospital cardiac arrest-a randomized, parallel-group, assessor-blinded clinical trial-rationale and design. Am Heart J 2012, 163:541-548.
17. Trzeciak S., McCoy J.V., Phillip Dellinger R., et al. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24h in patients with sepsis. Intensive Care Med 2008, 34:2210-2217.
18. Engel H., Ben Hamouda N., Portmann K., et al. Serum procalcitonin as a marker of post-cardiac arrest syndrome and long-term neurological recovery, but not of early-onset infections, in comatose post-anoxic patients treated with therapeutic hypothermia. Resuscitation 2013, 84:776-781.
19. Rittenberger J.C., Tisherman S.A., Holm M.B., Guyette F.X., Callaway C.W. An early, novel illness severity score to predict outcome after cardiac arrest. Resuscitation 2011, 82:1399-1404.
20. Vincent J.L., Moreno R., Takala J., et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure, on behalf of the working group on sepsis-related problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996, 22:707-710.
21. Annborn M., Dankiewicz J., Erlinge D., et al. Procalcitonin after cardiac arrest-an indicator of severity of illness, ischemia-reperfusion injury and outcome. Resuscitation 2013, 84:782-787.
22. Karimova A., Pinsky D.J. The endothelial response to oxygen deprivation: biology and clinical implications. Intensive Care Med 2001, 27:19-31.
23. Shoemaker W.C., Appel P.L., Kram H.B. Role of oxygen debt in the development of organ failure sepsis, and death in high-risk surgical patients. Chest 1992, 102:208-215.
24. Wang P., Wu P., Siegel M.I., Egan R.W., Billah M.M. Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes, IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J Biol Chem 1995, 270:9558-9563.
25. Adrie C., Pinsky M.R. The inflammatory balance in human sepsis. Intensive Care Med 2000, 26:364-375.
26. Pinsky M.R. Dysregulation of the immune response in severe sepsis. Am J Med Sci 2004, 328:220-229.
27. Bisschops L.L., Hoedemaekers C.W., Mollnes T.E., van der Hoeven J.G. Rewarming after hypothermia after cardiac arrest shifts the inflammatory balance. Crit Care Med 2012, 40:1136-1142.
28. Meisner M. Pathobiochemistry and clinical use of procalcitonin. Clin Chim Acta 2002, 323:17-29.
29. Whang K.T., Vath S.D., Becker K.L., et al. Procalcitonin and proinflammatory cytokine interactions in sepsis. Shock 2000, 14:73-78.
30. Gornikiewicz A., Sautner T., Brostjan C., et al. Catecholamines up-regulate lipopolysaccharide-induced IL-6 production in human microvascular endothelial cells. FASEB J 2000, 14:1093-1100.
31. Ritchie P.K., Ashby M., Knight H.H., Judd A.M. Dopamine increases interleukin 6 release and inhibits tumor necrosis factor release from rat adrenal zona glomerulosa cells in vitro. Eur J Endocrinol 1996, 134:610-616.
32. Izeboud C.A., Monshouwer M., van Miert A.S., Witkamp R.F. The beta-adrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-induced production of TNF-alpha and IL-6 in vitro and in vivo. Inflamm Res 1999, 48:497-502. (Official Journal of the European Histamine Research Society [et al.]).
33. Bro-Jeppesen J., Kjaergaard J., Soholm H., et al. Hemodynamics and vasopressor support in therapeutic hypothermia after cardiac arrest: prognostic implications. Resuscitation 2014, 85:664-670.
34. Cartmell T., Poole S., Turnbull A.V., Rothwell N.J., Luheshi G.N. Circulating interleukin-6 mediates the febrile response to localised inflammation in rats. J Physiol 2000, 526:653-661.
35. Nielsen N., Hovdenes J., Nilsson F., et al. Outcome, timing and adverse events in therapeutic hypothermia after out-of-hospital cardiac arrest. Acta Anaesthesiol Scand 2009, 53:926-934.
36. Tsai M.S., Chiang W.C., Lee C.C., et al. Infections in the survivors of out-of-hospital cardiac arrest in the first 7 days. Intensive Care Med 2005, 31:621-626.
37. Feghali C.A., Wright T.M. Cytokines in acute and chronic inflammation. Front Biosci 1997, 2:d12-d26.
38. Brombacher F. The role of interleukin-13 in infectious diseases and allergy. BioEssays 2000, 22:646-656. (news and reviews in molecular, cellular and developmental biology).
39. Minty A., Chalon P., Derocq J.M., et al. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 1993, 362:248-250.
40. Hildebrand F., van Griensven M., Giannoudis P., et al. Effects of hypothermia and re-warming on the inflammatory response in a murine multiple hit model of trauma. Cytokine 2005, 31:382-393.