Antenatal pharmacokinetics and placental transfer of n-acetylcysteine in chorioamnionitis for fetal neuroprotection

Journal of Pediatrics

Volumn 165, Issue 4, 2014, Pages 672-677.e2

  Wiest, Donald B ^a   Chang, Eugene ^b   Fanning, Deanna ^b   Garner, Sandra ^a   Cox, Toby ^a   Jenkins, Dorothea D ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; NEUROPROTECTIVE AGENT; SCAVENGER;

ARTICLE; CHORIOAMNIONITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; ELIMINATION HALF-LIFE; FEMALE; HUMAN; INFANT; MATERNAL BLOOD; NEUROPROTECTION; PILOT STUDY; PLACENTAL TRANSFER; PREMATURITY; PROSPECTIVE STUDY; UMBILICAL CORD BLOOD; VOLUME OF DISTRIBUTION; DRUG EFFECTS; FETOMATERNAL TRANSFUSION; FETUS BLOOD; INFLAMMATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOTHER; PLACENTA; PREGNANCY; RANDOMIZED CONTROLLED TRIAL; TIME;

ACETYLCYSTEINE; CHORIOAMNIONITIS; DOUBLE-BLIND METHOD; FEMALE; FETAL BLOOD; FREE RADICAL SCAVENGERS; HUMANS; INFLAMMATION; INFUSIONS, INTRAVENOUS; MALE; MATERNAL-FETAL EXCHANGE; MOTHERS; NEUROPROTECTIVE AGENTS; PILOT PROJECTS; PLACENTA; PREGNANCY; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 84908233403     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2014.06.044     Document Type: Article

References (35)

1. A.T. Tita, and W.W. Andrews Diagnosis and management of clinical chorioamnionitis Clin Perinatol 37 2010 339 354
2. L.M. Gaudet, M. Flavin, O. Islam, and G.N. Smith Diffusion MRI brain findings in neonates exposed to chorioamnionitis: a case series J Obstet Gynaecol Can 31 2009 497 503
3. Y.W. Wu, G.J. Escobar, J.K. Grether, L.A. Croen, J.D. Greene, and T.B. Newman Chorioamnionitis and cerebral palsy in term and near-term infants JAMA 290 2003 2677 2684
4. I. Burd, B. Balakrishnan, and S. Kannan Models of fetal brain injury, intrauterine inflammation, and preterm birth Am J Reprod Immunol 67 2012 287 294
5. J.A. Bastek, L.M. Gomez, and M.A. Elovitz The role of inflammation and infection in preterm birth Clin Perinatol 38 2011 385 406
6. Y.W. Wu, and J.M. Colford Jr. Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis JAMA 284 2000 1417 1424
7. B.H. Yoon, R. Romero, J.S. Park, C.J. Kim, S.H. Kim, and J.H. Choi Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years Am J Obstet Gynecol 182 2000 675 681
8. S. Rees, R. Harding, and D. Walker The biological basis of injury and neuroprotection in the fetal and neonatal brain Int J Dev Neurosci 29 2011 551 563
9. B.H. Yoon, J.K. Jun, R. Romero, K.H. Park, R. Gomez, and J.H. Choi Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha), neonatal brain white matter lesions, and cerebral palsy Am J Obstet Gynecol 177 1997 19 26
10. M.K. Paintlia, A.S. Paintlia, A.K. Singh, and I. Singh Attenuation of lipopolysaccharide-induced inflammatory response and phospholipids metabolism at the feto-maternal interface by N-acetyl cysteine Pediatr Res 64 2008 334 339
11. M.K. Paintlia, A.S. Paintlia, M.A. Contreras, I. Singh, and A.K. Singh Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: attenuation by N-acetyl cysteine Exp Neurol 210 2008 560 576
12. R. Beloosesky, D.A. Gayle, F. Amidi, S.E. Nunez, J. Babu, and M. Desai N-acetyl-cysteine suppresses amniotic fluid and placenta inflammatory cytokine responses to lipopolysaccharide in rats Am J Obstet Gynecol 194 2006 268 273
13. X. Wang, P. Svedin, C. Nie, R. Lapatto, C. Zhu, and M. Gustavsson N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury Ann Neurol 61 2007 263 271
14. M.K. Paintlia, A.S. Paintlia, E. Barbosa, I. Singh, and A.K. Singh N-acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain J Neurosci Res 78 2004 347 361
15. M. Jatana, I. Singh, A.K. Singh, and D. Jenkins Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats Pediatr Res 59 2006 684 689
16. R. Beloosesky, Y. Ginsberg, N. Khatib, N. Maravi, M.G. Ross, and J. Itskovitz-Eldor Prophylactic maternal N-acetylcysteine in rats prevents maternal inflammation-induced offspring cerebral injury shown on magnetic resonance imaging Am J Obstet Gynecol 208 2013 213.e1 213.e6
17. R. Beloosesky, Z. Weiner, Y. Ginsberg, and M.G. Ross Maternal N-acetyl-cysteine (NAC) protects the rat fetal brain from inflammatory cytokine responses to lipopolysaccharide (LPS) J Matern Fetal Neona 25 2012 1324 1328
18. D. Kelen, and N.J. Robertson Experimental treatments for hypoxic ischaemic encephalopathy Early Hum Dev 86 2010 369 377
19. N.J. Robertson, S. Tan, F. Groenendaal, F. van Bel, S.E. Juul, and L. Bennet Which neuroprotective agents are ready for bench to bedside translation in the newborn infant? J Pediatr 160 2012 544 552.e4
20. M.M. Rodriguez, A.H. Gomez, C.L. Abitbol, J.J. Chandar, S. Duara, and G.E. Zilleruelo Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants Pediatr Dev Pathol 7 2004 17 25
21. T. Ahola, V. Fellman, R. Laaksonen, J. Laitila, R. Lapatto, and P.J. Neuvonen Pharmacokinetics of intravenous N-acetylcysteine in pre-term new-born infants Eur J Clin Pharmacol 55 1999 645 650
22. L.F. Prescott, J.W. Donovan, D.R. Jarvie, and A.T. Proudfoot The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage Eur J Clin Pharmacol 37 1989 501 506
23. B. Olsson, M. Johansson, J. Gabrielsson, and P. Bolme Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine Eur J Clin Pharmacol 34 1988 77 82
24. T. Ahola, R. Lapatto, K.O. Raivio, B. Selander, L. Stigson, and B. Jonsson N-acetylcysteine does not prevent bronchopulmonary dysplasia in immature infants: a randomized controlled trial J Pediatr 143 2003 713 719
25. N. Ercal, S. Oztezcan, T.C. Hammond, R.H. Matthews, and D.R. Spitz High-performance liquid chromatography assay for N-acetylcysteine in biological samples following derivatization with N-(1-pyrenyl)maleimide J Chromatogr B Biomed Appl 685 1996 329 334
26. R.S. Horowitz, R.C. Dart, D.R. Jarvie, C.F. Bearer, and U. Gupta Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity J Toxicol Clin Toxicol 35 1997 447 451
27. S. Lager, and T.L. Powell Regulation of nutrient transport across the placenta J Pregnancy 2012 2012 179827
28. T.R. Regnault, B. de Vrijer, H.L. Galan, R.B. Wilkening, F.C. Battaglia, and G. Meschia Umbilical uptakes and transplacental concentration ratios of amino acids in severe fetal growth restriction Pediatr Res 73 2013 602 611
29. H.L. Galan, A.M. Marconi, C.L. Paolini, A. Cheung, and F.C. Battaglia The transplacental transport of essential amino acids in uncomplicated human pregnancies Am J Obstet Gynecol 200 2009 91.e1 91.e7
30. E.A. Neuwelt, M.A. Pagel, B.P. Hasler, T.G. Deloughery, and L.L. Muldoon Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model Cancer Res 61 2001 7868 7874
31. M.R. Syme, J.W. Paxton, and J.A. Keelan Drug transfer and metabolism by the human placenta Clin Pharmacokinet 43 2004 487 514
32. J.K. Cleal, and R.M. Lewis The mechanisms and regulation of placental amino acid transport to the human foetus J Neuroendocrinol 20 2008 419 426
33. P. Pavek, M. Ceckova, and F. Staud Variation of drug kinetics in pregnancy Curr Drug Metab 10 2009 520 529
34. D.M. Matsui Therapeutic drug monitoring in pregnancy Ther Drug Monit 34 2012 507 511
35. M.A. Arstall, J. Yang, I. Stafford, W.H. Betts, and J.D. Horowitz N-acetylcysteine in combination with nitroglycerin and streptokinase for the treatment of evolving acute myocardial infarction. Safety and biochemical effects Circulation 92 1995 2855 2862