메뉴 건너뛰기




Volumn 34, Issue 9, 2014, Pages 1322-1329

Cirrhosis and liver failure: Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats

Author keywords

Brain oedema; Dimethyl maleate; Hepatic encephalopathy; Oxidative stress; Portacaval shunt

Indexed keywords

AMMONIA; GLUTATHIONE; MALEIC ACID; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; BIOLOGICAL MARKER; DIMETHYL MALEATE; MALEIC ACID DERIVATIVE;

EID: 84908229620     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12414     Document Type: Article
Times cited : (18)

References (52)
  • 1
    • 75749105423 scopus 로고    scopus 로고
    • Review article: the modern management of hepatic encephalopathy
    • Bajaj JS. Review article: the modern management of hepatic encephalopathy. Aliment Pharmacol Ther 2010; 31:537-47.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 537-547
    • Bajaj, J.S.1
  • 2
    • 79954832002 scopus 로고    scopus 로고
    • New assessment of hepatic encephalopathy
    • Ćordoba J. New assessment of hepatic encephalopathy. J Hepatol 2011; 54: 1030-40.
    • (2011) J Hepatol , vol.54 , pp. 1030-1040
    • Ćordoba, J.1
  • 3
    • 73149120513 scopus 로고    scopus 로고
    • Spectrum of neurocognitive impairment in cirrhosis: implications for the assessment of hepatic encephalopathy
    • Bajaj JS, Wade JB, Sanyal AJ. Spectrum of neurocognitive impairment in cirrhosis: implications for the assessment of hepatic encephalopathy. Hepatology 2009; 50: 2014-21.
    • (2009) Hepatology , vol.50 , pp. 2014-2021
    • Bajaj, J.S.1    Wade, J.B.2    Sanyal, A.J.3
  • 4
    • 0033880058 scopus 로고    scopus 로고
    • The prognostic significance of subclinical hepatic encephalopathy
    • Hartmann IJ, Groeneweg M, Quero JC, et al. The prognostic significance of subclinical hepatic encephalopathy. Am J Gastroenterol 2000; 95: 2029-34.
    • (2000) Am J Gastroenterol , vol.95 , pp. 2029-2034
    • Hartmann, I.J.1    Groeneweg, M.2    Quero, J.C.3
  • 5
    • 84874638674 scopus 로고    scopus 로고
    • Brain edema in acute liver failure and chronic liver disease: similarities and differences
    • Bosoi CR, Rose CF. Brain edema in acute liver failure and chronic liver disease: similarities and differences. Neurochem Int 2013; 62: 446-57.
    • (2013) Neurochem Int , vol.62 , pp. 446-457
    • Bosoi, C.R.1    Rose, C.F.2
  • 6
    • 36348977996 scopus 로고    scopus 로고
    • Decreased white matter lesion volume and improved cognitive function after liver transplantation
    • Rovira A, Mínguez B, Aymerich FX, et al. Decreased white matter lesion volume and improved cognitive function after liver transplantation. Hepatology 2007; 46: 1485-90.
    • (2007) Hepatology , vol.46 , pp. 1485-1490
    • Rovira, A.1    Mínguez, B.2    Aymerich, F.X.3
  • 7
    • 44449142545 scopus 로고    scopus 로고
    • Quantitative cerebral water content mapping in hepatic encephalopathy
    • Shah NJ, Neeb H, Kircheis G, et al. Quantitative cerebral water content mapping in hepatic encephalopathy. Neuroimage 2008; 41: 706-17.
    • (2008) Neuroimage , vol.41 , pp. 706-717
    • Shah, N.J.1    Neeb, H.2    Kircheis, G.3
  • 8
    • 44949241302 scopus 로고    scopus 로고
    • Value of the apparent diffusion coefficient for quantification of low-grade hepatic encephalopathy
    • Sugimoto R, Iwasa M, Maeda M, et al. Value of the apparent diffusion coefficient for quantification of low-grade hepatic encephalopathy. Am J Gastroenterol 2008; 103:1413-20.
    • (2008) Am J Gastroenterol , vol.103 , pp. 1413-1420
    • Sugimoto, R.1    Iwasa, M.2    Maeda, M.3
  • 9
    • 79957530883 scopus 로고    scopus 로고
    • AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile ductligated rats
    • Bosoi CR, Parent-Robitaille C, Anderson K, Tremblay M, Rose CF. AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile ductligated rats. Hepatology 2011; 53: 1995-2002.
    • (2011) Hepatology , vol.53 , pp. 1995-2002
    • Bosoi, C.R.1    Parent-Robitaille, C.2    Anderson, K.3    Tremblay, M.4    Rose, C.F.5
  • 10
    • 67651146951 scopus 로고    scopus 로고
    • L-ornithine and phenylacetate synergistically produce sustained reduction in ammonia and brain water in cirrhotic rats
    • Davies NA, Wright G, Ytrebø LM, et al. L-ornithine and phenylacetate synergistically produce sustained reduction in ammonia and brain water in cirrhotic rats. Hepatology 2009; 50: 155-64.
    • (2009) Hepatology , vol.50 , pp. 155-164
    • Davies, N.A.1    Wright, G.2    Ytrebø, L.M.3
  • 11
    • 34250327519 scopus 로고    scopus 로고
    • Endotoxemia produces coma and brain swelling in bile duct ligated rats
    • Wright G, Davies NA, Shawcross DL, et al. Endotoxemia produces coma and brain swelling in bile duct ligated rats. Hepatology 2007; 45: 1517-26.
    • (2007) Hepatology , vol.45 , pp. 1517-1526
    • Wright, G.1    Davies, N.A.2    Shawcross, D.L.3
  • 12
    • 12844262177 scopus 로고    scopus 로고
    • Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts
    • Erceg S, Monfort P, Hernández-Viadel M, et al. Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts. Hepatology 2005; 41: 299-306.
    • (2005) Hepatology , vol.41 , pp. 299-306
    • Erceg, S.1    Monfort, P.2    Hernández-Viadel, M.3
  • 13
    • 65549166426 scopus 로고    scopus 로고
    • Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity
    • Cauli O, Rodrigo R, Piedrafita B, et al. Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity. J Neurosci Res 2009; 87: 1369-74.
    • (2009) J Neurosci Res , vol.87 , pp. 1369-1374
    • Cauli, O.1    Rodrigo, R.2    Piedrafita, B.3
  • 14
    • 10744224503 scopus 로고    scopus 로고
    • Diffusion MRI shows increased water apparent diffusion coefficient in the brains of cirrhotics
    • Lodi R, Tonon C, Stracciari A, et al. Diffusion MRI shows increased water apparent diffusion coefficient in the brains of cirrhotics. Neurology 2004; 62: 762-6.
    • (2004) Neurology , vol.62 , pp. 762-766
    • Lodi, R.1    Tonon, C.2    Stracciari, A.3
  • 15
    • 33645996033 scopus 로고    scopus 로고
    • Demonstration of interstitial cerebral edema with diffusion tensor MR imaging in type C hepatic encephalopathy
    • Kale RA, Gupta RK, Saraswat VA, et al. Demonstration of interstitial cerebral edema with diffusion tensor MR imaging in type C hepatic encephalopathy. Hepatology 2006; 43: 698-706.
    • (2006) Hepatology , vol.43 , pp. 698-706
    • Kale, R.A.1    Gupta, R.K.2    Saraswat, V.A.3
  • 16
    • 84856600252 scopus 로고    scopus 로고
    • Brain default-mode network abnormalities in hepatic encephalopathy: a resting-state functional MRI study
    • Zhang L, Qi R, Wu S, et al. Brain default-mode network abnormalities in hepatic encephalopathy: a resting-state functional MRI study. Hum Brain Mapp 2012; 33: 1384-92.
    • (2012) Hum Brain Mapp , vol.33 , pp. 1384-1392
    • Zhang, L.1    Qi, R.2    Wu, S.3
  • 17
    • 0037440759 scopus 로고    scopus 로고
    • Correlation between ammonia levels and the severity of hepatic encephalopathy
    • Ong JP, Aggarwal A, Krieger D, et al. Correlation between ammonia levels and the severity of hepatic encephalopathy. Am J Med 2003; 114: 188-93.
    • (2003) Am J Med , vol.114 , pp. 188-193
    • Ong, J.P.1    Aggarwal, A.2    Krieger, D.3
  • 18
    • 22544482372 scopus 로고    scopus 로고
    • Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension
    • Kundra A, Jain A, Banga A, Bajaj G, Kar P. Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension. Clin Biochem 2005; 38: 696-9.
    • (2005) Clin Biochem , vol.38 , pp. 696-699
    • Kundra, A.1    Jain, A.2    Banga, A.3    Bajaj, G.4    Kar, P.5
  • 19
    • 79960080504 scopus 로고    scopus 로고
    • Partial pressure of NH in cirrhotic patients with and without hepatic encephalopathy
    • He Y, Li G, Song H, et al. Partial pressure of NH in cirrhotic patients with and without hepatic encephalopathy. J Gastrointest Liver Dis 2011; 20: 169-74.
    • (2011) J Gastrointest Liver Dis , vol.20 , pp. 169-174
    • He, Y.1    Li, G.2    Song, H.3
  • 20
    • 0037385446 scopus 로고    scopus 로고
    • Role of determination of partial pressure of ammonia in cirrhotic patients with and without hepatic encephalopathy
    • Nicolao F, Efrati C, Masini A, et al. Role of determination of partial pressure of ammonia in cirrhotic patients with and without hepatic encephalopathy. J Hepatol 2003; 38:441-6.
    • (2003) J Hepatol , vol.38 , pp. 441-446
    • Nicolao, F.1    Efrati, C.2    Masini, A.3
  • 21
    • 36749033636 scopus 로고    scopus 로고
    • Correlations between magnetic resonance spectroscopy alterations and cerebral ammonia and glucose metabolism in cirrhotic patients with and without hepatic encephalopathy
    • Weissenborn K, Ahl B, Fischer-Wasels D, et al. Correlations between magnetic resonance spectroscopy alterations and cerebral ammonia and glucose metabolism in cirrhotic patients with and without hepatic encephalopathy. Gut 2007; 56: 1736-42.
    • (2007) Gut , vol.56 , pp. 1736-1742
    • Weissenborn, K.1    Ahl, B.2    Fischer-Wasels, D.3
  • 22
    • 77954836890 scopus 로고    scopus 로고
    • Changing face of hepatic encephalopathy: role of inflammation and oxidative stress
    • Seyan AS, Hughes RD, Shawcross DL. Changing face of hepatic encephalopathy: role of inflammation and oxidative stress. World J Gastroenterol 2010; 16: 3347-57.
    • (2010) World J Gastroenterol , vol.16 , pp. 3347-3357
    • Seyan, A.S.1    Hughes, R.D.2    Shawcross, D.L.3
  • 23
    • 84878013073 scopus 로고    scopus 로고
    • Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy
    • Bosoi CR, Rose CF. Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy. Metab Brain Dis 2013; 28: 175-8.
    • (2013) Metab Brain Dis , vol.28 , pp. 175-178
    • Bosoi, C.R.1    Rose, C.F.2
  • 24
    • 0030743306 scopus 로고    scopus 로고
    • Increase of resting levels of superoxide anion in the whole blood of patients with decompensated liver cirrhosis
    • Chen M-F, Mo L-R, Lin R-C, et al. Increase of resting levels of superoxide anion in the whole blood of patients with decompensated liver cirrhosis. Free Radic Biol Med 1997; 23: 672-9.
    • (1997) Free Radic Biol Med , vol.23 , pp. 672-679
    • Chen, M.-F.1    Mo, L.-R.2    Lin, R.-C.3
  • 25
    • 33846418814 scopus 로고    scopus 로고
    • Allopurinol, oxidative stress and intestinal permeability in patients with cirrhosis: an open-label pilot study
    • Spahr L, Bresson-Hadni S, Amann P, et al. Allopurinol, oxidative stress and intestinal permeability in patients with cirrhosis: an open-label pilot study. Liver Int 2007; 27:54-60.
    • (2007) Liver Int , vol.27 , pp. 54-60
    • Spahr, L.1    Bresson-Hadni, S.2    Amann, P.3
  • 27
    • 84862791514 scopus 로고    scopus 로고
    • Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure
    • Bosoi CR, Yang X, Huynh J, et al. Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure. Free Radic Biol Med 2012; 52:1228-35.
    • (2012) Free Radic Biol Med , vol.52 , pp. 1228-1235
    • Bosoi, C.R.1    Yang, X.2    Huynh, J.3
  • 29
    • 0023545356 scopus 로고
    • Decreased production of glutathione in patients with cirrhosis
    • Burgunder JM, Lauterburg BH. Decreased production of glutathione in patients with cirrhosis. Eur J Clin Invest 1987; 17: 408-14.
    • (1987) Eur J Clin Invest , vol.17 , pp. 408-414
    • Burgunder, J.M.1    Lauterburg, B.H.2
  • 30
    • 67149146685 scopus 로고    scopus 로고
    • Experimental models of hepatic encephalopathy: ISHEN guidelines
    • Butterworth RF, Norenberg MD, Felipo V, et al. Experimental models of hepatic encephalopathy: ISHEN guidelines. Liver Int 2009; 29: 783-8.
    • (2009) Liver Int , vol.29 , pp. 783-788
    • Butterworth, R.F.1    Norenberg, M.D.2    Felipo, V.3
  • 31
    • 77954144059 scopus 로고    scopus 로고
    • Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress
    • Yang X, Bosoi CR, Jiang W, Tremblay M, Rose CF. Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress. Metab Brain Dis 2010; 25: 11-5.
    • (2010) Metab Brain Dis , vol.25 , pp. 11-15
    • Yang, X.1    Bosoi, C.R.2    Jiang, W.3    Tremblay, M.4    Rose, C.F.5
  • 32
    • 0032752658 scopus 로고    scopus 로고
    • Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat
    • Agarwal R, Shukla GS. Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat. Neurochem Res 1999; 24: 1507-14.
    • (1999) Neurochem Res , vol.24 , pp. 1507-1514
    • Agarwal, R.1    Shukla, G.S.2
  • 34
    • 0018146391 scopus 로고
    • A simple gravimetric technique for measurement of cerebral edema
    • Marmarou A, Poll W, Shulman K, Bhagavan H. A simple gravimetric technique for measurement of cerebral edema. J Neurosurg 1978; 49: 530-7.
    • (1978) J Neurosurg , vol.49 , pp. 530-537
    • Marmarou, A.1    Poll, W.2    Shulman, K.3    Bhagavan, H.4
  • 36
    • 0025313258 scopus 로고
    • Depletion of tissue glutathione with diethyl maleate enhances hyperbaric oxygen toxicity
    • Weber CA, Duncan CA, Lyons MJ, Jenkinson SG. Depletion of tissue glutathione with diethyl maleate enhances hyperbaric oxygen toxicity. Am J Physiol 1990; 258: L308-12.
    • (1990) Am J Physiol , vol.258 , pp. L308-L312
    • Weber, C.A.1    Duncan, C.A.2    Lyons, M.J.3    Jenkinson, S.G.4
  • 37
    • 80052456669 scopus 로고    scopus 로고
    • 3-nitro-tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with liver cirrhosis
    • Montoliu C, Cauli O, Urios A, et al. 3-nitro-tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with liver cirrhosis. Am J Gastroenterol 2011; 106: 1629-37.
    • (2011) Am J Gastroenterol , vol.106 , pp. 1629-1637
    • Montoliu, C.1    Cauli, O.2    Urios, A.3
  • 38
    • 0033756534 scopus 로고    scopus 로고
    • Evidence of a systemic phenomenon for oxidative stress in cholestatic liver disease
    • Ljubuncic P, Tanne Z, Bomzon A. Evidence of a systemic phenomenon for oxidative stress in cholestatic liver disease. Gut 2000; 47: 710-6.
    • (2000) Gut , vol.47 , pp. 710-716
    • Ljubuncic, P.1    Tanne, Z.2    Bomzon, A.3
  • 39
    • 0035888288 scopus 로고    scopus 로고
    • Ammonia-induced production of free radicals in primary cultures of rat astrocytes
    • Murthy CR, Rama Rao KV, Bai G, Norenberg MD. Ammonia-induced production of free radicals in primary cultures of rat astrocytes. J Neurosci Res 2001; 66: 282-8.
    • (2001) J Neurosci Res , vol.66 , pp. 282-288
    • Murthy, C.R.1    Rama Rao, K.V.2    Bai, G.3    Norenberg, M.D.4
  • 40
    • 33646949200 scopus 로고    scopus 로고
    • Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes
    • Jayakumar AR, Panickar KS, Murthy CRK, Norenberg MD. Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. J Neurosci 2006; 26: 4774-84.
    • (2006) J Neurosci , vol.26 , pp. 4774-4784
    • Jayakumar, A.R.1    Panickar, K.S.2    Murthy, C.R.K.3    Norenberg, M.D.4
  • 41
    • 0031460097 scopus 로고    scopus 로고
    • Superoxide production and antioxidant enzymes in ammonia intoxication in rats
    • Kosenko E, Kaminsky Y, Kaminsky A, et al. Superoxide production and antioxidant enzymes in ammonia intoxication in rats. Free Radic Res 1997; 27: 637-44.
    • (1997) Free Radic Res , vol.27 , pp. 637-644
    • Kosenko, E.1    Kaminsky, Y.2    Kaminsky, A.3
  • 42
    • 0141686953 scopus 로고    scopus 로고
    • Sources of oxygen radicals in brain in acute ammonia intoxication in vivo
    • Kosenko E, Venediktova N, Kaminsky Y, Montoliu C, Felipo V. Sources of oxygen radicals in brain in acute ammonia intoxication in vivo. Brain Res 2003; 981: 193-200.
    • (2003) Brain Res , vol.981 , pp. 193-200
    • Kosenko, E.1    Venediktova, N.2    Kaminsky, Y.3    Montoliu, C.4    Felipo, V.5
  • 43
    • 49649103144 scopus 로고    scopus 로고
    • Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo
    • Görg B, Qvartskhava N, Keitel V, et al. Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo. Hepatology 2008; 48: 567-79.
    • (2008) Hepatology , vol.48 , pp. 567-579
    • Görg, B.1    Qvartskhava, N.2    Keitel, V.3
  • 44
    • 84856299837 scopus 로고    scopus 로고
    • Moderate grade hyperammonemia induced concordant activation of antioxidant enzymes is associated with prevention of oxidative stress in the brain slices
    • Mehrotra A, Trigun SK. Moderate grade hyperammonemia induced concordant activation of antioxidant enzymes is associated with prevention of oxidative stress in the brain slices. Neurochem Res 2012; 37: 171-81.
    • (2012) Neurochem Res , vol.37 , pp. 171-181
    • Mehrotra, A.1    Trigun, S.K.2
  • 45
    • 0036581130 scopus 로고    scopus 로고
    • Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes
    • Schliess F, Görg B, Fischer R, et al. Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes. FASEB J 2002; 16:739-41.
    • (2002) FASEB J , vol.16 , pp. 739-741
    • Schliess, F.1    Görg, B.2    Fischer, R.3
  • 46
    • 36948999820 scopus 로고    scopus 로고
    • Acute and chronic hyperammonemia modulate antioxidant enzymes differently in cerebral cortex and cerebellum
    • Singh S, Koiri RK, Trigun SK. Acute and chronic hyperammonemia modulate antioxidant enzymes differently in cerebral cortex and cerebellum. Neurochem Res 2008; 33:103-13.
    • (2008) Neurochem Res , vol.33 , pp. 103-113
    • Singh, S.1    Koiri, R.K.2    Trigun, S.K.3
  • 47
    • 64949131878 scopus 로고    scopus 로고
    • Hypothermia attenuates oxidative/nitrosative stress, encephalopathy and brain edema in acute (ischemic) liver failure
    • Jiang W, Desjardins P, Butterworth RF. Hypothermia attenuates oxidative/nitrosative stress, encephalopathy and brain edema in acute (ischemic) liver failure. Neurochem Int 2009; 55: 124-8.
    • (2009) Neurochem Int , vol.55 , pp. 124-128
    • Jiang, W.1    Desjardins, P.2    Butterworth, R.F.3
  • 48
    • 77954224523 scopus 로고    scopus 로고
    • Oxidative stress markers in the brain of patients with cirrhosis and hepatic encephalopathy
    • Görg B, Qvartskhava N, Bidmon H-J, et al. Oxidative stress markers in the brain of patients with cirrhosis and hepatic encephalopathy. Hepatology 2010; 52: 256-65.
    • (2010) Hepatology , vol.52 , pp. 256-265
    • Görg, B.1    Qvartskhava, N.2    Bidmon, H.-J.3
  • 49
    • 67650153191 scopus 로고    scopus 로고
    • Involvement of ROS in BBB dysfunction
    • Pun PBL, Lu J, Moochhala S. Involvement of ROS in BBB dysfunction. Free Radic Res 2009; 43: 348-64.
    • (2009) Free Radic Res , vol.43 , pp. 348-364
    • Pun, P.B.L.1    Lu, J.2    Moochhala, S.3
  • 50
    • 84883461678 scopus 로고    scopus 로고
    • The liver-brain axis in liver failure: neuroinflammation and encephalopathy
    • Butterworth RF. The liver-brain axis in liver failure: neuroinflammation and encephalopathy. Nat Rev Gastroenterol Hepatol 2013; 10: 522-8.
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , pp. 522-528
    • Butterworth, R.F.1
  • 51
    • 34548361564 scopus 로고    scopus 로고
    • Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts
    • Cauli O, Rodrigo R, Piedrafita B, Boix J, Felipo V. Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts. Hepatology 2007; 46: 514-9.
    • (2007) Hepatology , vol.46 , pp. 514-519
    • Cauli, O.1    Rodrigo, R.2    Piedrafita, B.3    Boix, J.4    Felipo, V.5
  • 52
    • 84866127947 scopus 로고    scopus 로고
    • Hepatic encephalopathy: an approach to its multiple pathophysiological features
    • Perazzo JC. Hepatic encephalopathy: an approach to its multiple pathophysiological features. World J Hepatol 2012; 4: 50.
    • (2012) World J Hepatol , vol.4 , pp. 50
    • Perazzo, J.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.